| Project/Area Number |
13470024
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
General medical chemistry
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| Research Institution | HIROSHIMA UNIVERSITY |
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Principal Investigator |
IGARASHI Kazuhiko Graduate School of Biomedical Sciences, Professor, 大学院・医歯薬学総合研究科, 教授 (00250738)
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| Co-Investigator(Kenkyū-buntansha) |
TASHIRO Satoshi Graduate School of Biomedical Sciences, Asistant Professor, 大学院・医歯薬学総合研究科, 講師 (20243610)
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| Project Period (FY) |
2001 – 2002
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| Project Status |
Completed (Fiscal Year 2002)
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| Budget Amount *help |
¥12,500,000 (Direct Cost: ¥12,500,000)
Fiscal Year 2002: ¥4,800,000 (Direct Cost: ¥4,800,000)
Fiscal Year 2001: ¥7,700,000 (Direct Cost: ¥7,700,000)
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| Keywords | chromatin / transcription factor / globin / LCR / BTB domain |
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| Research Abstract |
We found :
1. Binding of Bach1 to the globin LCR is regulated by heme, the prothetic group of hemoglobin.
2. Heme oxygenase-1 (HO-1) is another physiological target gene of Bach1.
3. Heme regulates binding of Bach1 to the LCR of HO-1 gene through direct binding to Bach1. The BTB domain of Bach1 is essential for the Bach1 binding to the HO-1 LCR.
4. Bach1 regulates HO-1 gene expression through mechanisms that are distinct from regulation of histone acetylation-deacetylation.
5. Bach2 accumulates within the PML nuclear bodies to repress gene expression there.
6. The BTB domain of Bach2 is essential for the targeting of Bach2 to PML bodies.
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