| Project/Area Number |
13470079
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Hygiene
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| Research Institution | Kanazawa University |
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Principal Investigator |
NAKAMURA Hiroyuki Kanazawa University, Graduate School of Medical Science, Associate professor, 医学系研究科, 助教授 (30231476)
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| Co-Investigator(Kenkyū-buntansha) |
KAMBAYASHI Yasuhiro Kanazawa University, Graduate School of Medical Science, Instructor, 医学系研究科, 助手 (20345630)
NOBUKUNI Yoshitaka Kanazawa University, Graduate School of Medical Science, Assistant Professor, 医学系研究科, 講師 (80295641)
OGINO Keiki Kanazawa University, Graduate School of Medical Science, Professor, 医学系研究科, 教授 (70204104)
長瀬 博文 金沢大学, 大学院・医学系研究科, 講師 (00251918)
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| Project Period (FY) |
2001 – 2002
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| Project Status |
Completed (Fiscal Year 2002)
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| Budget Amount *help |
¥14,500,000 (Direct Cost: ¥14,500,000)
Fiscal Year 2002: ¥3,100,000 (Direct Cost: ¥3,100,000)
Fiscal Year 2001: ¥11,400,000 (Direct Cost: ¥11,400,000)
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| Keywords | CRH / microwaves / uteroplacental blood flow / pregnancy / indomethacin / heat / SAR / fetus |
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| Research Abstract |
We tried to clarify preventing mechanisms including neuroendocrine systems of fetus for uteroplacental circulatory disturbances and uteroplacental dysfunctions produced by microwaves. We simulated the microwave condition in pregnant rats for the specific absorption ratio (SAR) of 0.4 W/kg, which is the maximum permissible exposure level recommended by the American Conference of Industrial Hygienists (ACGIH) and the American National Institute (ANSI). The pretreatment of intravenous (iv) administration of CRH receptor antagonist, α-helical CRH (9-41) as well as a cyclooxygenase inhibitor indomethacin prevented the uteroplacental circulatory disturbances during microwaves. Although microwaves did not induce fetal hypothalamic CRH mRNA change, the administration of bosentan or indomethacin before microwave exposure did it These results suggest a preventing system of uteroplacenta-fetus against microwaves in which fetal hypothalarnic CRH is involved in mediating uteroplacental circulation during microwaves at 0.4 W/kg. By contrast, we found that the preventing systems did not work during microwaves at 2.0 W/kg, subsequently resulting a significant increase in colonic temperature and decrease in uteroplacental blood flow. These results suggest microwaves at the SAR of 0.4 W/kg, which is the maximum permissible exposure level, is within safety levels without producing uteroplacental dysfunctions. Microwaves much above the maximum permissible level may show some harmful changes during pregnancy associated with an increase in colonic temperature produced microwaves.
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