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The epidemiological study regarding the gene-lifestyle interaction on hypertension

Research Project

Project/Area Number 13470085
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Public health/Health science
Research InstitutionTohoku University

Principal Investigator

TSUJI Ichiro  Tohoku University, Graduate School of Medicine, Professor, 大学院・医学系研究科, 教授 (20171994)

Co-Investigator(Kenkyū-buntansha) MATSUBARA Mitsunobu  Tohoku University, Graduate School of Medicine, Associate Professor, 大学院・医学系研究科, 助教授 (30282073)
IMAI Yutaka  Tohoku University, Graduate School of Pharmaceutical Science, Professor, 大学院・薬学研究科, 教授 (40133946)
Project Period (FY) 2001 – 2003
Project Status Completed (Fiscal Year 2003)
Budget Amount *help
¥16,200,000 (Direct Cost: ¥16,200,000)
Fiscal Year 2003: ¥2,800,000 (Direct Cost: ¥2,800,000)
Fiscal Year 2002: ¥4,100,000 (Direct Cost: ¥4,100,000)
Fiscal Year 2001: ¥9,300,000 (Direct Cost: ¥9,300,000)
KeywordsHypertension / Community based study / Ambulatory blood pressure / Home blood pressure / Gene polymorphisms / Lifestyle / Circulatory disease epidemiology / Risk factors
Research Abstract

We investigated the relationship between gene polymorphisms and blood pressure (BP), especially BP measured at home (home EP, HBP) or ambulatory BP (ABP), using blood sample obtained from Ohasama residents. We showed the summary of articles which was published in last year.
1)Heat rate and outcome.
This review article summarizes the reports which investigated the relationship between heart rate (HR) and cardiovascular outcomes in Ohasama residents. Home measured HR linearly related to the cardiovascular disease mortality, while HR variability measured by device for ABP inversely related to the cardiovascular mortality. HR and HR variability must not be overlooked when evaluating hypertension.
2)Gene polymorphisms of rennin-angiotensin system and blood pressure.
The angiotensinogen gene polymorphisms (AGT) M235T has been investigated in association with essential hypertension based on conventional measurement of BP ; however, the results have been inconsistent. We investigated the relationship between AGT and HBP value. There was no significant difference among the genotypes in home BP values or in prevalence of hypertension. No difference was noted in the frequency of familial history of hypertension. Pulse pressure, however, was significantly different among the genotypes (P=0.049), and this association was prominent in the older population (Paper 2).
We also investigated the relationship between the angiotensin II type 1 receptor (AT1) gene and ABP. We investigated 802 subjects who were 40 years or over. Although daytime BP was higher in subjects with C allele, the difference was not statistically significant after adjusting possible confounders. No significant difference was noted in the prevalence of cardiovascular diseases of nocturnal decline between the groups. These results indicated that AT1 polymorphism was not associated with any clinical parameters associated with hypertension or atherosclerosis in the Japanese (Paper 3).

Report

(4 results)
  • 2003 Annual Research Report   Final Research Report Summary
  • 2002 Annual Research Report
  • 2001 Annual Research Report
  • Research Products

    (26 results)

All Other

All Publications (26 results)

  • [Publications] Imai Y, et al.: "Heart rate measurement and outcome"Blood Pressure Monitoring. 8. 53-55 (2003)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Matsubara M, et al.: "T+31C polymorphism (M235T) of the angiotensinogen gene and home blood pressure in the Japanese general population : the Ohasama Study."Hypertension Research. 26. 47-52 (2003)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Kikuya M, et al.: "A/C1166 gene polymorphism of the angiotensin II type 1 receptor (AT1) and ambulatory blood pressure : the Ohasama Study."Hypertension Research. 26. 141-145 (2003)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Imai Y, et al.: "Heart rate measurement and outcome"Blood Pressure Monitoring. 8. 53-55 (2003)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Matsubara M, et al.: "T+31IC polymorphism (M235T) of the angiotensinogen gene and home blood pressure in the Japanese general population : the Ohasama Study"Hypertension Research. 26. 47-52 (2003)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Kikuya M, et al.: "A/C 1166 gene polymorphism of the angiotensin II type 1 receptor (AT1) and ambulatory blood pressure : the Ohasama Study."Hypertension Research. 26. 141-145 (2003)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Imai Y, et al.: "Heart rate measurement and outcome"Blood Pressure Monitoring. 8. 53-55 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] Matsubara M, et al.: "T+31C polymorphism (M235T) of the angiotensinogen gene and home blood pressure in the Japanese general population : the Ohasama Study"Hypertension Research. 26. 47-52 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] Kikuya M, et al.: "A/C1166 gene polymorphism of the angiotensin II type 1 receptor (At1) and ambulatory blood pressure : the Ohasama Study"Hypertension Research. 26. 141-145 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] Sugimoto K, et al.: "Alpha-Adducin GIy46OTrp polymorphism is associated with low rennin hypertension in younger subjects in the Ohasama study"Journal of Hypertension. 20. 1779-1784 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] Fujiwara T, et al.: "T+31C polymorphism of angiotensinogen gene and nocturnal blood pressure decline : the Ohasama study"American Journal of Hypertension. 15. 628-632 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] Fukuda M, et al.: "Association of a mast cell chymase gene variant with HDL cholesterol, but not with blood pressure in the Ohasama study"Hypertension Research. 25. 179-184 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] Ohkubo T, et al.: "Prognostic significance of the nocturnal decline in blood pressure in individuals with and without high 24-h blood pressure : the Ohasama study"Journal of Hypertension. 20. 2183-2189 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] Chonan K, et al.: "Insufficient duration of action of antihypertensive drugs mediates high blood pressure in the morning in hypertensive population : the Ohasama study"Clinical and Experimental Hypertension. 24. 261-275 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] Matsubara M, et al.: "Angiotensin-converting enzyme I/D polymorphism and hypertension : the Ohasama study"Journal of Hypertension. 20. 1121-1126 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] Hozawa A, et al.: "Blood pressure control assessed by home, ambulatory and conventional blood pressure measurements in the Japanese general population : the Ohasama study"Hypertension Research. 25. 57-63 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] Hozawa A, et al.: "Relationship between personality and self-measured blood pressure value at home : the Ohasama study"Clinical and Experimental Hypertension. 24. 115-123 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] Matsubara M, et al.: "Genotype of the βENaC gene have little influence on blood pressure : the Ohasama Study"American Journal Hypertension. 15. 189-192 (2002)

    • Related Report
      2001 Annual Research Report
  • [Publications] Matsubara M, et al.: "Aldosterone synthase gene (CYP11B2) C-334T polymorphism, ambulatory blood pressure and nocturnal decline in blood pressure in the general Japanese population : the Ohasama Study"Journal of Hypertension. 19. 2179-2184 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] Matsubara M, et al.: "Haplotypes of aldosterone synthase (CYP11B2) gene in the general population of Japan : the Ohasama study"Clinical and Experimental Hypertension. 23. 603-610 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] Asai T, et al.: "Endothelin-1 gene variant associates with blood pressure in obese Japanese subjects : the Ohasama study"Hypertension. 38. 1321-1324 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] Hozawa A, et al.: "Factors affecting the difference between screening and home blood pressure measurements : the Ohasama Study"Journal of Hypertension. 19. 13-19 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] Imai Y, et al.: "Usefulness of home blood pressure measurements in assessing the effect of treatment in a single-blind placebo-controlled open trial"Journal of Hypertension. 19. 179-185 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] Kato J, et al.: "Risk factors and predictors of coronary arterial lesions in Japanese hypertensive patients"Hypertension Research. 24. 3-11 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] Chonan K, et al.: "Device for the self-measurement of blood pressure that can monitor blood pressure during sleep"Blood Pressure Monitoring. 6. 203-205 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] Ohkubo T, et al.: "Prognostic impact of 24-hour mean blood pressure and pulse pressure on stroke"Circulation. 18. E160 (2001)

    • Related Report
      2001 Annual Research Report

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Published: 2001-04-01   Modified: 2016-04-21  

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