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Worksite cohort study for evaluation of lifestyle-related diseases risk : effect of lifestyle modification on the insulin level and the manifestation of metabolic syndrome

Research Project

Project/Area Number 13470087
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Public health/Health science
Research InstitutionNagoya University

Principal Investigator

TOYOSHIMA Hideaki  Nagoya University, Graduate School of Medicine, Professor, 大学院・医学系研究科, 教授 (10023657)

Co-Investigator(Kenkyū-buntansha) KONDO Takaaki  Nagoya University, School of Medicine, Associate Professor, 医学部, 助教授 (00195900)
TAMAKOSHI Koji  Nagoya University, Graduate School of Medicine, Associate Professor, 大学院・医学系研究科, 助教授 (30262900)
YATSUYA Hiroshi  Nagoya University, Graduate School of Medicine, Associate Professor, 大学院・医学系研究科, 助教授 (30324437)
Project Period (FY) 2001 – 2004
Project Status Completed (Fiscal Year 2004)
Budget Amount *help
¥11,900,000 (Direct Cost: ¥11,900,000)
Fiscal Year 2004: ¥2,000,000 (Direct Cost: ¥2,000,000)
Fiscal Year 2003: ¥1,700,000 (Direct Cost: ¥1,700,000)
Fiscal Year 2002: ¥6,300,000 (Direct Cost: ¥6,300,000)
Fiscal Year 2001: ¥1,900,000 (Direct Cost: ¥1,900,000)
Keywordslife-style related disease / work-site based cohort study / insulin / CRP / weight variability / metabolic syndrome / white blood cell counts / phospholipids transfer protein / アンケート調査 / 病歴 / インスリン抵抗性 / HOMA指数 / コホート研究 / 既往歴調査 / 循環器疾患 / 生活習慣 / 自覚的ストレス / 心電図 / ミネソタコード / 健診結果 / インスリン濃度 / 生活習慣の変化
Research Abstract

We started a worksite-based cohort study of 11,000 people in 1997 by constructing database consisting of annual health check-up data and affairs of coronary heart disease(CHD) and stroke under the approval of ethical committee. In 1997 and 2002,questionnaire survey on lifestyle and storage of frozen serum samples for later determination of insulin, leptin, CRP, etc was done.
The following results were obtained, 1)Self-reported incident cases of CHD and stroke during the first 5 years accounted 52 and 36,respectively, including 15 myocardial infarctions, 14 angina pectoris, etc according to questionnaire survey. Consistency of the report with the answers from their family doctors was 100% for myocardial infarction, cerebral infarction and subarachnoid hemorrhage as long as cases examined under informed consent were concerned. Consistency for hypertension, diabetes, hyperlipidemia, and hyperuricemia all exceeded 95%. 2)The weight variability during 20 to 40 years since the age of 20 was a … More significant predictor of subsequent appearance of elevated serum insulin and CRP levels and metabolic syndrome(MS) independent of weight change slope or resultant BMI in 2,000 people, suggesting the importance of maintaining constant weight since the youth to prevent atherosclerosis. 3)Although the development of MS was associated with the increase in white blood cell(WBC) counts and CRP, insulin levels was not associated with the WBC counts in 3,500 people. Insulin, hence, was supposed to cause low grade inflammation or atherosclerosis through development of MS. Leptin was associated with the increase of WBC counts independently of obesity. 4)The association of blood pressure with likeness of salty taste was intensified in females aged 50 years or older, suggesting the effects of menopause on the salt sensitivity. 5)Serum phospholipids transfer protein showed strong correlations with serum lipids and BMI and an inverse correlation with the development of CHD but no correlation with that of stroke during 37 months' follow up of 2,600 people. 6)The reproducibility and validity of simple check-list type questionnaire of food intake and dietary behavior used in this study was confirmed. From the comparison of self-reported and measured weights at age 20,reliability of self-reported weights was confirmed. Less

Report

(5 results)
  • 2004 Annual Research Report   Final Research Report Summary
  • 2003 Annual Research Report
  • 2002 Annual Research Report
  • 2001 Annual Research Report
  • Research Products

    (37 results)

All 2005 2004 2003 Other

All Journal Article (21 results) Publications (16 results)

  • [Journal Article] Long-term body weight fluctuation is associated with metabolic syndrome independent of current body mass index among Japanese men.2005

    • Author(s)
      Zhang H, Toyoshima H, et al.
    • Journal Title

      Circulation Journal 69・1

      Pages: 13-18

    • NAID

      110002696033

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Annual Research Report 2004 Final Research Report Summary
  • [Journal Article] Long-term body weight fluctuation is associated with metabolic syndrome independent of current body mass index among Japanese men.2005

    • Author(s)
      Zhang H, Tamakoshi K, Yatsuya H, Murata C, Wada K, Otsuka R, Nagasawa N, Ishikawa M, Sugiura K, Matsushita K, Hori Y, Kondo T, Toyoshima H.
    • Journal Title

      Circulation Journal 69(1)

      Pages: 13-18

    • NAID

      110002696033

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Association of white blood cell count and clustered components of metabolic syndrome in Japanese men.2004

    • Author(s)
      Nagasawa N, Toyoshima H, et al.
    • Journal Title

      Circulation Journal 68・10

      Pages: 892-897

    • NAID

      110002692132

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Annual Research Report 2004 Final Research Report Summary
  • [Journal Article] Serum phospholipid transfer protein mass as a possible protective factor for coronary heart diseases.2004

    • Author(s)
      Yatsuya H, Toyoshima H, et al.
    • Journal Title

      Circulation Journal 68・1

      Pages: 11-16

    • NAID

      110002667472

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Association of white blood cell count and clustered components of metabolic syndrome in Japanese men.2004

    • Author(s)
      Nagasawa N, Tamakoshi K, Yatsuya H, Hori Y, Ishikawa M, Murata C, Zhang H, Wada K, Otsuka R, Mabuchi T, Kondo T, Toyoshima H.
    • Journal Title

      Circulation Journal 68(10)

      Pages: 892-897

    • NAID

      110002692132

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Serum phospholipid transfer protein mass as a possible protective factor for coronary heart diseases.2004

    • Author(s)
      Yatsuya H, Tamakoshi K, Hattori H, Otsuka R, Wada K, Zhang H, Mabuchi T, Ishikawa M, Murata C, Yoshida T, Kondo T, Toyoshima H.
    • Journal Title

      Circulation Journal 68(1)

      Pages: 11-16

    • NAID

      110002667472

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Reproducibility and validity of a simple checklist-type questionnaire for food intake and dietary behavior.2003

    • Author(s)
      Yatsuya H, Toyoshima H, et al.
    • Journal Title

      Journal of Epidemiology 13・5

      Pages: 235-245

    • NAID

      130000797759

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Long-term weight variability is associated with elevated C-reactive protein independent of current body mass index among Japanese Men2003

    • Author(s)
      Tamakoshi K, Toyoshima H, et al.
    • Journal Title

      International Journal of Obesity And Related Metabolic Disorders 27・9

      Pages: 1059-1067

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Association between weight fluctuation and fasting insulin concentration in Japanese men.2003

    • Author(s)
      Yatsuya H, Toyoshima H, et al.
    • Journal Title

      International Journal of Obesity And Related Metabolic Disorders 27・4

      Pages: 478-483

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] The metabolic syndrome is associated with elevated circulating C-reactive protein in healthy reference range, a systemic low-grade inflammatory state.2003

    • Author(s)
      Tamakoshi K, Toyoshima H, et al.
    • Journal Title

      International Journal of Obesity and Related Metabolic Disorders 27・4

      Pages: 443-449

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Gender and age differences in lifestyle factors related to hyper-tension in middle-aged civil service employees2003

    • Author(s)
      Hori Y, Toyoshima H, et al.
    • Journal Title

      Journal of Epidemiology 13・1

      Pages: 38-47

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] The accuracy of long-term recall of past body weight in Japanese adult men2003

    • Author(s)
      Tamakoshi K, Toyoshima H, et al.
    • Journal Title

      International Journal of Obesity and Related Metabolic Disorders 27・2

      Pages: 247-252

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Reproducibility and validity of a simple checklist-type questionnaire for food intake and dietary behavior.2003

    • Author(s)
      Yatsuya H, Ohwaki A, Tamakoshi K, Wakai K, Koide K, Otsuka R, Mabuchi T, Murata C, Zhang H, Ishikawa M, Kondo T, Toyoshima H.
    • Journal Title

      Journal of Epidemiology 13(5)

      Pages: 235-245

    • NAID

      130000797759

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Long-term body weight variability is associated with elevated Oreactive protein independent of current body mass index among Japanese men.2003

    • Author(s)
      Tamakoshi K, Yatsuya H, Kondo T, Ishikawa M, Zhang H, Murata C, Otsuka R, Mabuchi T, Hori Y, Yoshida T, Toyoshima H.
    • Journal Title

      International Journal of Obesity and Related Metabolic Disorders 27(9)

      Pages: 1059-1065

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Association between weight fluctuation and fasting insulin concentration in Japanese men.2003

    • Author(s)
      Yatsuya H, Tamakoshi K, Yoshida T, Hori Y, Zhang H, Ishikawa M, Zhu S, Kondo T, Toyoshima H.
    • Journal Title

      International Journal of Obesity and Related Metabolic Disorders 27(4)

      Pages: 478-483

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] The metabolic syndrome is associated with elevated circulating Oreactive protein in healthy reference range, a systemic low-grade inflammatory state.2003

    • Author(s)
      Tamakoshi K, Yatsuya H, Kondo T, Hori Y, Ishikawa M, Zhang H, Murata C, Otsuka R, Zhu S, Toyoshima H.
    • Journal Title

      International Journal of Obesity and Related Metabolic Disorders 27(4)

      Pages: 443-449

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Gender and age differences in lifestyle factors related to hypertension in middle-aged civil service employees.2003

    • Author(s)
      Hori Y, Toyoshima H, Kondo T, Tamakoshi K, Yatsuya H, Zhu S. Kawamura T, Toyama J, Okamoto N.
    • Journal Title

      Journal of Epidemiology 13(1)

      Pages: 38-47

    • NAID

      130000797682

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] The accuracy of long-term recall of past body weight in Japanese adult men.2003

    • Author(s)
      Tamakoshi K, Yatsuya H, Kondo T, Hirano T, Hori Y, Yoshida T, Toyoshima H.
    • Journal Title

      International Journal of Obesity and Related Metabolic Disorders 27(2)

      Pages: 247-252

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Association between serum leptin concentration and white blood cell count in middle-aged Japanese men and women

    • Author(s)
      Mabuchi T, Toyoshima H, et al.
    • Journal Title

      Diabetes/Metabolism Research and Reviews (in press)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Association between serum leptin concentration and white blood cell count in middle-aged Japanese men and women.

    • Author(s)
      Mabuchi T, Yatsuya H, Tamakoshi K, Otsuka R, Nagasawa N, Zhang H, Murata C, Wada K, Ishikawa M, Hori Y, Kondo T, Hashimoto S, Toyoshima H.
    • Journal Title

      Diabetes/Metabolism Research and Reviews (in press)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Association between serum leptin concentration and white blood cell count in middle-aged Japanese men and women.

    • Author(s)
      Mabuchi T, Toyoshima H, et al.
    • Journal Title

      Diabetes/Metabolism Research and Reviews in press

    • Related Report
      2004 Annual Research Report
  • [Publications] Yatsuya H: "Serum phospholipid transfer protein mass as a possible protective factor for coronary heart diseases."Circulation Journal. 68・1. 11-16 (2004)

    • Related Report
      2003 Annual Research Report
  • [Publications] Yatsuya H: "Reproducibility and validity of simple checklist-type questionnaire for food intake and dietary behavior."Journal of Epidemiology. 17・5. 235-245 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] Tamakoshi K: "Long-term body weight variability is associated with elevated C-reactive protein independent of current body mass index among Japanese men."International Journal of Obesity. 27・9. 1059-1065 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] Yatsuya H: "Association between weight fluctuation and fasting insulin concentration in Japanese men."International Journal of Obesity. 27・4. 478-483 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] Tamakoshi K: "U-shaped association between white blood cell count and fasting plasma glucose level"Diabetes Care. 26・3. 950-950 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] Hori Y: "Gender and age differences in lifestyle factors related to hypertension in middle-aged civil service employees."Journal of Epidemiology. 13・1. 38-47 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] Tamakoshi K: "The metabolic syndrome is associated with elevated circulating C-reactive protein in healthy reference range, systemic low-grade inflammatory state"International Journal of Obesity. (in press). (2003)

    • Related Report
      2002 Annual Research Report
  • [Publications] Yatsuya H: "Association between weight fluctuation and fasting insulin concentration in Japanese men"International Journal of Obesity. (in press). (2003)

    • Related Report
      2002 Annual Research Report
  • [Publications] Tamakoshi K: "U-shaped Association Between White Blood Cell Count and Fasting Plasma Glucose Level"Diabetes Care. 26・3. 950 (2003)

    • Related Report
      2002 Annual Research Report
  • [Publications] Tamakoshi K: "The accuracy of long-term recall of past body weight in Japanese adult men"International Journal Obesity. 27・2. 247-252 (2003)

    • Related Report
      2002 Annual Research Report
  • [Publications] Hori Y: "Gender and age differences in lifestyle factors related to hypertension in middle-aged civil service employees"Journal of Epidemiology. 13・1. 38-47 (2003)

    • Related Report
      2002 Annual Research Report
  • [Publications] Zhu SK: "Short-and long-term reliability of information on previous and family history as compared with that smoking and drinking habits in questionnaire surveys"Journal of Epidemiology. 12・2. 120-125 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] 豊嶋英明, 八谷 寛, 近藤高明, 玉腰浩司: "産業保健における循環器疾患の一次予防対策"産業医学レビュー. 13. 155-182 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] Uchiyama M, Kondo T, Tamakoshi K, Toyoshima H et al.: "Difference in the occurrence of cardiovascular events according to class of anti-hypertensive agent, based on a follow-up study of Japanese hypertension patients"Japanese Heart Journal. 42. 585-595 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] Zhu SK, Toyoshima H, Kondo T, Tamakoshi K, et al.: "Short- and long-term reliability of information on previous and family history as compared with that of smoking and drinking habits in questionnaire surveys"Journal of Epidemiology. 12(in press). (2002)

    • Related Report
      2001 Annual Research Report
  • [Publications] 豊嶋英明, 宇佐美隆廣, 八谷 寛他: "上島博嗣、小澤利男編 動脈硬化・老年病予防検診マニュアル:心不全と突然死(p172-174)、心電図(ミネソタコード)(p75-81)、胸部X線(p90-91)"メジガルビュー社. 222 (2001)

    • Related Report
      2001 Annual Research Report

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Published: 2001-04-01   Modified: 2016-04-21  

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