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Effects of combined administration of alcohol and abused drugs (methamphetamine, cocaine) on the central nervous system

Research Project

Project/Area Number 13470103
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Legal medicine
Research InstitutionHyogo College of Medicine

Principal Investigator

HISHIDA Shigeru  Hyogo College of Medicine, Department of Legal Medicine, Professor, 医学部, 教授 (10068463)

Co-Investigator(Kenkyū-buntansha) KINOSHITA Hiroshi  Hyogo College of Medicine, Department of Legal Medicine, Associate Professor, 医学部, 助教授 (00284357)
Project Period (FY) 2001 – 2002
Project Status Completed (Fiscal Year 2002)
Budget Amount *help
¥8,200,000 (Direct Cost: ¥8,200,000)
Fiscal Year 2002: ¥2,400,000 (Direct Cost: ¥2,400,000)
Fiscal Year 2001: ¥5,800,000 (Direct Cost: ¥5,800,000)
Keywordschronic ethanol administration / methamphetamine / ethanol / brain microdialysis / dopamine / serotonin / alcohol preference / transporter / 覚せい剤 / コカイン / ドーパミン
Research Abstract

We have investigated the effects of single administration of methamphetamine (MAP) and of combined administration of ethanol (EtOH) and MAP on striatal extracellular dopamine (DA) and serotonin (5-HT) levels in chronic alcohol treated rats using a brain-microdialysis method. We used two different lines of rats with high and low alcohol preferences, (high alcohol preference rat (HAP) and low alcohol preference rat (LAP), respectively), which were chronically fed an alcohol containing liquid diet for 6 to 8 weeks.
The percent change in DA and 5-HT in striatum following single administration of MAP was significantly higher in control-fed LAP than HAP. However, in the alcohol-fed group, the percent changes in DA and 5-HT were significantly elevated in the alcohol-fed HAP compared to LAP. There were no significant increases in striatal extracellular DA and 5-HT in alcohol-fed LAP.
In combined administration of MAP and EtOH, extracellular DA and 5-HT levels increased slightly following EtOH administration in chronic alcohol-fed rats, especially in HAP. Dramatic increases of DA and 5-HT levels were observed in alcohol-fed HAP following EtOH and MAP administration. These percent changes ware higher than that observed with a single administration of MAP. Meanwhile, LAP were less sensitive to the influence of chronic EtOH administration and to single administration of MAP.
These results demonstrate that a chronic treatment of EtOH enhances the sensitivity to MAP in a HAP, when two drugs were administrated simultaneously, and that a significant difference of responsiveness to abused drugs was indicated between these two lines. It is necessary to consider the alcohol preference when investigating the interaction of alcohol and/or other abused drugs.

Report

(3 results)
  • 2002 Annual Research Report   Final Research Report Summary
  • 2001 Annual Research Report
  • Research Products

    (8 results)

All Other

All Publications (8 results)

  • [Publications] 西口美紀他: "慢性アルコール摂取が覚せい剤の脳内ドパミンおよびセロトニン変化に及ぼす影響-アルコール嗜好性の異なるラツト間での比較検討-"日本アルコール・薬物医学会雑誌. 37. 555-576 (2002)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Nishiguchi M, et al.: "Effects of chronic alcohol administration on changes of extracellular dopamine and serotonin concentration induced by methamphetamine"Japanese Journal of Alcohol Studies & Drug Dependence. 37(6). 555-576 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] 西口美紀 他: "慢性アルコール摂取が覚せい剤の脳内ドパミンおよびセロトニン変化に及ぼす影響 -アルコール嗜好性の異なるラット間での比較検討-"日本アルコール・薬物医学会雑誌. 37. 555-576 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] 菱田 繁: "乱用薬物の身体に及ぼす形響について"中毒研究. 14. 271 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] 菱田 繁: "ラットにおける肝細胞質アルデヒド脱水素酵素の多型性とアルコール嗜好性について"Jpn.J Alcohol & Drug Dependence. 36(4). 280-281 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] H.Kinoshita, et al.: "Acetaldehyde, a metabolite of ethanol, activates the hypothalamo-pitutary adrenal axis in the rat"Alcohol & Alcoholism. 36. 59-64 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] M.Nishiguchi, et al.: "Different blood acetaldehyde concentration following ethanol administration in a newly developed high alcohol preference and low alcohol preference rat model system"Alcohol & Alcoholism. 37. 9-12 (2002)

    • Related Report
      2001 Annual Research Report
  • [Publications] 西口美紀 他: "ラットのアルコール嗜好性とエタノール慢性投与との関係"Jpn. J Alcohol & Drug Dependence. 36(4). 326-327 (2001)

    • Related Report
      2001 Annual Research Report

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Published: 2001-04-01   Modified: 2016-04-21  

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