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Development of a three-dimensional irradiation system for intensity-modulated radiotherapy and its clinical application.

Research Project

Project/Area Number 13470183
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Radiation science
Research InstitutionKYOTO UNIVERSITY

Principal Investigator

NAGATA Yasushi  Kyoto University, Associate Professor, 医学研究科, 助教授 (10228033)

Co-Investigator(Kenkyū-buntansha) MIZOWAKI Takashi  Kyoto University, Assistant Professor, 医学研究科, 助手 (90314210)
MITSUMORI Michihide  Kyoto University, Lector, 医学研究科, 講師 (10263089)
HIRAOKA Masahiro  Kyoto University, Professor, 医学研究科, 教授 (70173218)
根来 慶春  京都大学, 医学研究科, 助手 (20335277)
Project Period (FY) 2001 – 2003
Project Status Completed (Fiscal Year 2003)
Budget Amount *help
¥3,800,000 (Direct Cost: ¥3,800,000)
Fiscal Year 2003: ¥1,700,000 (Direct Cost: ¥1,700,000)
Fiscal Year 2002: ¥2,100,000 (Direct Cost: ¥2,100,000)
KeywordsIntensity modulated radiotherapy / IMRT / Three-dimensional radiotherapy / Prostate cancer / Body frame / Head and neck cancer / QA / Respiratory gating / QAシステム / ファントム
Research Abstract

To establish an integrated three-dimensional irradiation system for IMRT (intensity-modurated radiotherapy), the following research had been performed.
1. Respiratory gating system
To expand the stereotactic radiotherapy for a patient with poor respiratory function, a gating system is ideal. In this study, a flow and a pressure gated signal generators was established for this purpose.
2. Clinical application of stereotactic radiotherapy
As many as 95 patients have been treated with this technique. The clinical results of primary lung cancer and secondary lung cancer was evaluated respectively.
3. Quality assurance of IMRT
An original phantom for the clinical application of IMRT for head and neck cancer was developed, and its quality assarance was performed. In general, the dose discrepancy was maintained within 5% between planned dose and measured dose.
4. Clinical application of IMRT
IMRT have been performed mainly for prostate cancer and head & neck cancers : The setup error was measured for prostate cancer, and the effect of metallic artifact and change in outline were evaluated for head and neck cancer.

Report

(4 results)
  • 2003 Annual Research Report   Final Research Report Summary
  • 2002 Annual Research Report
  • 2001 Annual Research Report
  • Research Products

    (29 results)

All Other

All Publications (29 results)

  • [Publications] Tetsuya A., Nagata Y, et al.: "Evaluation of CT Appearance of Lung Injury after Three-Dimensional Conformal Stereotactic Radiotherapy for Solitary Lung Tumors"Radiology. 230. 101-108 (2004)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Tetsuya A, Nagata Y, et al.: "Clinical evaluation of dynamic conformal rediotherapy for paraaortic lymph node metastasis."Radiotherapy & Oncology. 67. 113-118 (2003)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Mizowaki T, Okajima K, Nagata Y, et al.: "Concurrent chemotherapy and radiotherapy with low-dose cisplatin for nasopharyngeal carcinoma."American Journal of Clinical Oncology. 26. 155-158 (2003)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Okumura S, Mitsumori M, Nagata Y, et al.: "Late skin and subcutaneous soft tissue changes after 10-Gy boost for breast conserving therapy."Breast cancer. 10. 129-133 (2003)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Nagata Y, Negoro Y, et al.: "Clinical outcomes of 3-D conformal hypofractionated single high dose radiotherapy for one or two lung tumors using a stereotactic body frame."Int.J.Radiat.Oncol.Biol.Phys.. 52. 1041-1046 (2002)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Tetsuya A, Nagata Y, Negoro Y, et al.: "Evaluation of CT Appearance of Lung Injury after Three-Dimensional Conformal Stereotactic Radiotherapy for Solitary Lung Tumors."Radiology. 230. 101-108 (2004)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Aoki T, Naagta Y, Mizowaki T, et al.: "Clinical evaluation of dynamic conformal radiotherapy for paraaortic lymph node metastasis."Radiother.Oncol.. 67. 113-118 (2003)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Mizowaki T, Okajima K, Nagata Y, et al.: "Concurrent chemotherapy and radiotherapy with low-dose cisplatin for nasopharyngeal carcinoma."AJCO. 26. 155-158 (2003)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Okumura S, Nagata Y, et al.: "Late skin and subcutaneous soft tissue changes after 10-Gy boost for breast conserving therapy."Breast cancer.. 10. 129-133 (2003)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Nagata Y, Negoro Y, et al.: "Clinical outcomes of 3-D conformal hypofractionated single high dose radiotherapy for one or two lung tumors using a stereotactic body frame."Int.J.Radiat.Oncol.Biol.Phys.. 52. 1041-1046 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Tetsuya A, Nagata Y, et al.: "Evaluation of CT Appearance of Lung Injury after Three-Dimensional Conformal Stereotactic Radiotherapy for Solitary Lung Tumors"Radiology. 230. 101-108 (2004)

    • Related Report
      2003 Annual Research Report
  • [Publications] Tetsuya A, Nagata Y, et al.: "Clinical evaluation of dynamic conformal radiotherapy for paraaortic lymph node metastasis."Radiotherapy & Oncology. 67. 113-118 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] Mizowaki T, Okajina K, Nagata Y, et al.: "Concurrent chemotherapy and radiotherapy with low-dose cisplatin for nasopharyngeal carcinoma"American Journal of Clinical Oncology. 26. 155-158 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] Okumura S, Mitsumori M, Nagata Y, et al.: "Late skin and subcutaneous soft tissue changes after 10-Gy boost for breast conserving therapy。"Breast cancer. 10. 129-133 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] 赤沢博之, 中森伸行, 永田 靖, 他: "放射線治療におけるポータルイメージの自動照合プログラムの開発"日本放射線技術学会誌. 60. 101-110 (2004)

    • Related Report
      2003 Annual Research Report
  • [Publications] Nagata Y, Negoro Y, et al.: "Clinical outcomes of 3-D conformal hypofractionated single high dose radiotherapy for one or two lung tumors using a stereotactic body frame"Int. J. Radiat. Oncol. Biol. Phys.. 52. 1041-1046 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] Oya N, Shibamoto Y, Nagata Y, Negoro Y, Hiraoka M.: "Postoperative radiotherapy for intracranial ependymoma : analysis of prognotic factors and patterns of failure"Neuro-oncol. 56. 87-94 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] 根来慶春, 永田靖, 他: "リニアックによる三次元照射とIMRT"臨床放射線. 47. 277-282 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] 水田靖, 根来慶春, 他: "日常診療のコツと工夫 体幹部腫瘍に対する定位放射線照射"Radiology Frontier. 5. 45-48 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] 永田靖, 根来慶春, 他: "画像診断と放射線治療の統合化にむけて 体幹部腫瘍に対する定位放射線照射"映像情報メディカル. 34. 1346-1350 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] 永田靖, 根来慶春, 他: "IMRTの臨床応用 前立腺癌"臨床放射線. 47. 1687-1692 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] 矢野慎輔, 岡田孝, 赤沢博之, 永田靖, 平岡真寛: "治療技術上の問題点とQA/QC"臨床放射線. 47. 1669-1677 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] 永田靖, 青木徹哉, 溝脇尚志, 平岡真寛, 他: "頭頸部腫瘍に対する強度変調放射線治療の初期経験(特に治療計画と精度管理について)"頭頸部腫瘍. 29. 1-8 (2003)

    • Related Report
      2002 Annual Research Report
  • [Publications] Mizowaki T., Nagata Y., et al.: "The use of a permanent magnetic resonance imaging system for radiotherapy treatment planning of bone metastases"Int. J. Radiat. Oncol. Biol. Phys.. 49. 605-611 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] Negoro Y, Nagata Y, et al.: "The effectiveness of an immobilization device in conformal radiotherapy for lung tumor: reduction of respiratory tumor movement and evaluation of daily set-up accuracy"Int. J. Radiat. Oncol. Biol. Phys.. 50. 889-898 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] Nagata Y, Negoro Y, et al.: "Clinical outcomes of 3-D conformal hypofractionated single high dose radiotherapy for one or two lung tumors using a stereotactic body frame"Int. J. Radiat. Oncol. Biol. Phys.. 52. 1041-1046 (2002)

    • Related Report
      2001 Annual Research Report
  • [Publications] 永田 靖, 根来慶春, 他: "体幹部腫瘍に対する定位放射線照射"医学物理学会誌. 21. 28-33 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] 古賀祐子, 永田 靖, 他: "体幹部用固定具を用いた定位放射線治療-有効照射角および線量補正に関する研究-"日本放射線技術学会誌. 57. 1395-1405 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] 高山賢二, 永田 靖, 他: "直腸バルーン挿入による前立腺固定精度の臨床的検討"臨床放射線. 46. 1491-1498 (2001)

    • Related Report
      2001 Annual Research Report

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Published: 2002-04-01   Modified: 2016-04-21  

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