Identification of candidate genes for bipolar disorder and schizophrenia using DNA microarray
| Project/Area Number |
13470194
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Psychiatric science
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| Research Institution | Brain Science Institute, RIKEN |
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Principal Investigator |
KATO Tadafumi Laboratory for Molecular Dynamics of Mental Disorders, Brain Science Institute, RIKEN, Laboratory Head, 精神疾患動態研究チーム, チームリーダー (30214381)
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| Project Period (FY) |
2001 – 2002
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| Project Status |
Completed (Fiscal Year 2002)
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| Budget Amount *help |
¥13,000,000 (Direct Cost: ¥13,000,000)
Fiscal Year 2002: ¥6,300,000 (Direct Cost: ¥6,300,000)
Fiscal Year 2001: ¥6,700,000 (Direct Cost: ¥6,700,000)
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| Keywords | Bipolar Disorder / Schizophrenia / DNA microarray / Gene Expression / 遺伝子発現 / DNAマイクロアレイ / 脳 / 躁うつ病 / 精神分裂病 |
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| Research Abstract |
Using DNA microarray, we examined gene expression patterns in postmortem brain samples of patients with bipolar disorder and schizophrenia, and controls. Differentially expressed genes were compared with each other. By the cluster analysis, bipolar disorder and controls were well separated. The genes identified by this study needs to be verified further.
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Report
(3 results)
Research Products
(8 results)
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[Publications] Kato, T., Iwamoto, K., Washizuka, S., Mori, K., Tajima, O., Akiyama, T., Nanko, S., Kunugi, H., Kato, N.: "No association of mutations and mRNA expression of WFS1/wolframin with bipolar disorder"Neuroscience Letters. (in press).
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