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Development of cancer specific viral vector for carcinoma by inducing the plural genes

Research Project

Project/Area Number 13470230
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field General surgery
Research InstitutionHOKKAIDO UNIVERSITY

Principal Investigator

KONDO Satoshi  Hokkaido University Graduate of School of Med, Asso. Prof., 大学院・医学研究科, 助教授 (30215454)

Co-Investigator(Kenkyū-buntansha) MORIUCHI Tetsuya  Hokkaido University, Institute For Genetic Medicine, Prof, 遺伝子病制御研究所, 教授 (20174394)
TADA Mitsuhiro  Hokkaido University, Institute For Genetic Medicine, Asso, Prof, 遺伝子病制御研究所, 助教授 (10241316)
KATOH Hiroyuki  Hokkaido University Graduate of School of Med, Prof, 大学院・医学研究科, 教授 (80002369)
Project Period (FY) 2001 – 2002
Project Status Completed (Fiscal Year 2002)
Budget Amount *help
¥14,000,000 (Direct Cost: ¥14,000,000)
Fiscal Year 2002: ¥2,500,000 (Direct Cost: ¥2,500,000)
Fiscal Year 2001: ¥11,500,000 (Direct Cost: ¥11,500,000)
Keywordscancer gene therapy / specific promotor / adenoviralvector / RCAS1 / Caveolin-1 / SCCA / IRRES / 癌 / SCCA2 / hTERT / 遺伝子治療
Research Abstract

We studied the cancer specific antigens expressed in the several organ tumors. In pancreatic cancer, 90% were positive for RCAS1 gene. Moreover, overexpression of RCAS1 gene was correlated with the prognosis of patients with pancreatic cancer, extrahepatic bile duct carcinoma and esophageal cancer. Caveolin-1 expression was also correlated with with the prognosis of patients with pancreatic cancer.
We made a replication-deficient recombinant KLAKLAK2 or Bax adenovirus driven by the RCAS1promoter (Ad RCAS1-KLAKLAK2, Ad RCAS1-Bax) or the SCCA promoter (Ad SCCA-KLAKLAK2). We demonstrated that the expression of KLAKLAK2 and growth inhibition were all specific to the cancer cell lines that were SCCA positive, whereas no growth retardation was observed in human normal cell lines after Ad SCCA-KLAKLAK2 infection.

Report

(3 results)
  • 2002 Annual Research Report   Final Research Report Summary
  • 2001 Annual Research Report

Research Products

(21 results)

All Other

All Publications

  • [Publications] 「研究成果報告書概要(和文)」より

    • Related Report
      2002 Final Research Report Summary
  • [Publications] 「研究成果報告書概要(和文)」より

    • Related Report
      2002 Final Research Report Summary
  • [Publications] 「研究成果報告書概要(和文)」より

    • Related Report
      2002 Final Research Report Summary
  • [Publications] 「研究成果報告書概要(和文)」より

    • Related Report
      2002 Final Research Report Summary
  • [Publications] 「研究成果報告書概要(和文)」より

    • Related Report
      2002 Final Research Report Summary
  • [Publications] 「研究成果報告書概要(和文)」より

    • Related Report
      2002 Final Research Report Summary
  • [Publications] 「研究成果報告書概要(欧文)」より

    • Related Report
      2002 Final Research Report Summary
  • [Publications] 「研究成果報告書概要(欧文)」より

    • Related Report
      2002 Final Research Report Summary
  • [Publications] 「研究成果報告書概要(欧文)」より

    • Related Report
      2002 Final Research Report Summary
  • [Publications] 「研究成果報告書概要(欧文)」より

    • Related Report
      2002 Final Research Report Summary
  • [Publications] 「研究成果報告書概要(欧文)」より

    • Related Report
      2002 Final Research Report Summary
  • [Publications] 「研究成果報告書概要(欧文)」より

    • Related Report
      2002 Final Research Report Summary
  • [Publications]

    • Related Report
      2002 Annual Research Report
  • [Publications]

    • Related Report
      2002 Annual Research Report
  • [Publications]

    • Related Report
      2002 Annual Research Report
  • [Publications]

    • Related Report
      2002 Annual Research Report
  • [Publications]

    • Related Report
      2001 Annual Research Report
  • [Publications]

    • Related Report
      2001 Annual Research Report
  • [Publications]

    • Related Report
      2001 Annual Research Report
  • [Publications]

    • Related Report
      2001 Annual Research Report
  • [Publications]

    • Related Report
      2001 Annual Research Report

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Published: 2001-04-01   Modified: 2016-04-21  

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