| Project/Area Number |
13470259
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Digestive surgery
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| Research Institution | Kyoto Prefectural University of Medicine |
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Principal Investigator |
YAMAGISHI Hisakazu Kyoto Prefectural University of Medicine, Department of Surgery, Division of Digestive Surgery, Professor, 医学研究科, 教授 (40128723)
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| Co-Investigator(Kenkyū-buntansha) |
UEDA Yuji Kyoto Prefectural University of Medicine, Department of Surgery, Division of Digestive Surgery, Assistant Professor, 医学研究科, 助手 (60254356)
TANIWAKI Masafumi Kyoto Prefectural University of Medicine, Department of Clinical Molecular Genetics and Laboratory Medicine, Professor, 医学研究科, 教授 (80163640)
SONODA Yoshiaki Kyoto Prefectural University of Medicine, Department of Molecular-targeting of Cancer Prevention, Associate Professor, 医学研究科, 助教授 (60206688)
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| Project Period (FY) |
2001 – 2003
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| Project Status |
Completed (Fiscal Year 2003)
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| Budget Amount *help |
¥5,400,000 (Direct Cost: ¥5,400,000)
Fiscal Year 2003: ¥1,400,000 (Direct Cost: ¥1,400,000)
Fiscal Year 2002: ¥1,800,000 (Direct Cost: ¥1,800,000)
Fiscal Year 2001: ¥2,200,000 (Direct Cost: ¥2,200,000)
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| Keywords | Gastrointestinal Cancer / A1logeneic_Hematopoietic Stem Cell Transplantation / Immunotherapy / Mini-transplantation / Graft-versus-Tumor Effect |
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| Research Abstract |
Non-myeloablative allogeneic hematopoietic stem cell transplantation for refractory colon cancer was performed. The patient was a 45-year-old female with metastatic colon cancer. Metastatic sites were located in the liver, lymph nodes, and intra-peritoneal cavity (peritoneal dissemination). The donor was her HLA full-matched elder brother. After non-myeloablative and immunosuppressive chemotherapy with cyclophosphamide and fludarabine, allogeneic peripheral blood stem cell transplantation was performed (mini-transplantation). Although graft-versus-host disease (GVHD) was recognized 35 days after transplantation, tumor shrinkage didn't occur and she died of cancer 64 days after transplantation.
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