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Clinical Research on the Development of Non-myeloablative Allogeneic Hematopoietic Stem Cell Transplantation for Refractory Gastrointestinal

Research Project

Project/Area Number 13470259
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Digestive surgery
Research InstitutionKyoto Prefectural University of Medicine

Principal Investigator

YAMAGISHI Hisakazu  Kyoto Prefectural University of Medicine, Department of Surgery, Division of Digestive Surgery, Professor, 医学研究科, 教授 (40128723)

Co-Investigator(Kenkyū-buntansha) UEDA Yuji  Kyoto Prefectural University of Medicine, Department of Surgery, Division of Digestive Surgery, Assistant Professor, 医学研究科, 助手 (60254356)
TANIWAKI Masafumi  Kyoto Prefectural University of Medicine, Department of Clinical Molecular Genetics and Laboratory Medicine, Professor, 医学研究科, 教授 (80163640)
SONODA Yoshiaki  Kyoto Prefectural University of Medicine, Department of Molecular-targeting of Cancer Prevention, Associate Professor, 医学研究科, 助教授 (60206688)
Project Period (FY) 2001 – 2003
Project Status Completed (Fiscal Year 2003)
Budget Amount *help
¥5,400,000 (Direct Cost: ¥5,400,000)
Fiscal Year 2003: ¥1,400,000 (Direct Cost: ¥1,400,000)
Fiscal Year 2002: ¥1,800,000 (Direct Cost: ¥1,800,000)
Fiscal Year 2001: ¥2,200,000 (Direct Cost: ¥2,200,000)
KeywordsGastrointestinal Cancer / A1logeneic_Hematopoietic Stem Cell Transplantation / Immunotherapy / Mini-transplantation / Graft-versus-Tumor Effect
Research Abstract

Non-myeloablative allogeneic hematopoietic stem cell transplantation for refractory colon cancer was performed. The patient was a 45-year-old female with metastatic colon cancer. Metastatic sites were located in the liver, lymph nodes, and intra-peritoneal cavity (peritoneal dissemination). The donor was her HLA full-matched elder brother. After non-myeloablative and immunosuppressive chemotherapy with cyclophosphamide and fludarabine, allogeneic peripheral blood stem cell transplantation was performed (mini-transplantation). Although graft-versus-host disease (GVHD) was recognized 35 days after transplantation, tumor shrinkage didn't occur and she died of cancer 64 days after transplantation.

Report

(4 results)
  • 2003 Annual Research Report   Final Research Report Summary
  • 2002 Annual Research Report
  • 2001 Annual Research Report
  • Research Products

    (11 results)

All Other

All Publications (11 results)

  • [Publications] Yuji Ueda, et al.: "Mobilization of peripheral blood stem cells after original etoposide, adriamycin, and cisplatin (EAP) therapy and a multimodal cell therapy approach."Oncology Reports. (in press). (2004)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Kenichi Nomura, et al.: "Detection of t(11;18)(q21;q21) in marginal zone lymphoma of mucosa-associated lymphocytic tissue type on paraffin-embedded tissue sectione."Cancer Genetics Cytogenetics. 140. 49-54 (2003)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Shinsaku Imashuku, et al.: "Effectiveness of RITUXIMAB for chemotherapy-resistant multiple tumoral B-LPD in a haematopoietic stem cell recipient."British Journal of Hematology. 117. 771-773 (2002)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Ueda Y, Sonoda Y, Fujiki H, Harada S, Kimura T, Itoh T, Kenichiro I, Naito K, Nomura K, Taniwaki M, Yamagishi H.: "Mobilization of peripheral blood stem cells (PBSCs) after original etoposide, adriamycin, and cisplatin (EAP) therapy and a multimodal cell therapy approach with PBSCs in advanced gastric cancer."Oncol Rep. Vol.11(accepted). (2004)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Nomura K, Yoshino T, Nakamura S, Akano Y, Tagawa H, Nishida K, Seto M, Nakamura S, Ueda R, Yamagishi H, Taniwaki M.: "Detection of t(11;18)(q21;q21) in marginal zone lymphoma of mucosa-associated lymphocytic tissue type on paraffin-embedded tissue sections by using fluorescence in situ hybridization"Cancer Genetics Cytogenetics. 140. 49-54 (2003)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Imashuku S, Naya M, Tamura S, An B, Teramura T, Kobayashi M, Nomura K, Taniwaki M.: "Effectiveness of Rituximab for chemotherapy-resistant multiple tumoral B-LPD in a hematopoietic stem cell recipient"Br J Haematol. 117. 768-774 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Yuji Ueda, et al.: "Mobilization of peripheral blood stem cells (PBSCs) after original etoposide, adriamycin, and cisplatin (EAP) therapy and a multimodal cell therapy approach."Oncology Reports. (in press). (2004)

    • Related Report
      2003 Annual Research Report
  • [Publications] Kenichi Nomura, et al.: "Detection of t(11;18)(q21;q21) in marginal zone lymphoma of mucosa-associated lymphocytic tissue type on paraffin-embedded tissue sections."Cancer Genetics Cytogenetics. 140. 49-54 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] Shinsaku Imashuku, et al.: "Effectiveness of RITUXIMAB for chemotherapy-resistant multiple tumoral B-LPD in a haematopoietic stem cell recipient."British Journal of Hematology. 117. 771-773 (2002)

    • Related Report
      2003 Annual Research Report
  • [Publications] 上田 祐二: "「癌化学療法-最近の進歩-」消化器癌"京都府立医科大学雑誌. 110(7). 617-625 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] 上田 祐二: "造血幹細胞移植の現状と今後の展望〜樹状細胞を用いて免疫細胞療法〜"医薬ジャーナル37(3). 37(3). 179-183 (2001)

    • Related Report
      2001 Annual Research Report

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Published: 2001-04-01   Modified: 2016-04-21  

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