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Therapeutic Cell-transplantation for Sever Heart Failure

Research Project

Project/Area Number 13470271
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Thoracic surgery
Research InstitutionKyoto University

Principal Investigator

KOMEDA Masashi  Kyoto University, Department of Cardiovascular Surgery, Professor, 医学研究科, 教授 (20303810)

Co-Investigator(Kenkyū-buntansha) TATSUTOSHI Nakahata  Kyoto University, Department of Pediatrics, Professor, 医学研究科, 教授 (20110744)
FUJITA Masatoshi  Kyoto University, College of Medical Technology, Professor, 医学部, 教授 (50190046)
NISHIMURA Kazunobu  Kyoto University, Department of Cardiovascular Surgery, Assistant Professor, 医学研究科, 助教授 (70252450)
Project Period (FY) 2001 – 2003
Project Status Completed (Fiscal Year 2003)
Budget Amount *help
¥13,100,000 (Direct Cost: ¥13,100,000)
Fiscal Year 2003: ¥4,000,000 (Direct Cost: ¥4,000,000)
Fiscal Year 2002: ¥4,000,000 (Direct Cost: ¥4,000,000)
Fiscal Year 2001: ¥5,100,000 (Direct Cost: ¥5,100,000)
Keywordscell transplantation / bone marrow stem cell / skeletal myoblast / heart failure / 骨格筋芽細胞移植 / 線維芽細胞増殖因子(bFGF) / 骨格筋筋芽細胞
Research Abstract

This study aimed to develop the ideal procedure for cellular cardiomyoplasty for severe cardiac failure. Fetal cardiomyocyte (FCM) transplantation prevents but does not reverse cardiac remodeling in rats with chronic MI. However, prevascularization with bFGF-incorporated microspheres could enhance the benefits of FCM transplantation. FCM transplantation exerted preventive effects against late LV dilation and dysfunction after LV repair surgery.
Autologous cells, such as skeletal myoblasts (SM) and bone marrow stem cells (BMSC), were more tolerant for ischemia as compared to CM. In the study of SM. transplantation to the MI heart, a large number of freshly-isolated neonatal SM can survive in the host heart and fully replace the infarcted myocardium with reverse LV remodelling in rats with MI. Intravenous (IV) and intramyocardial (IM) deliveries of BMSC transplantation. in mice were assessed echocardiographically and histologically in MI model and in dilated cardiomyopathy (DCM) model. Transplantation was performed either in acute or chronic phase. In acute phase, both IV and IM deliveries in BMSC transplantation were effective in both MI and DCM models, whereas in chronic phase, IM delivery was superior in. MI model, and IV administration was superior in DCM model.

Report

(4 results)
  • 2003 Annual Research Report   Final Research Report Summary
  • 2002 Annual Research Report
  • 2001 Annual Research Report
  • Research Products

    (48 results)

All Other

All Publications (48 results)

  • [Publications] Sakakibara Y, Nishimura K, Tambara K, Yamamoto M, Lu F, Tabata Y, Komeda M.: "Prevascularization with Gelatin Microspheres Containing Basic Fibroblast Growth Factor Enhances the Benefits of Cardiomyocyte Transplantation."J Thorac Cardiovasc Surg.. 124. 50-56 (2002)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Sakakibara Y, Tambara K, Lu F, Nishina T, Nagaya N, Nishimura K, Komeda M: "Cardiomyocyte transplantation dose not reverse cardiac remodeling in rats with chronic myocardial infarction."Ann Thorac Cardiovasc Surg.. 74. 25-30 (2002)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Sakakibara Y, Tambara K, Lu F, Nishina T, Sakaguchi G, Nishimura K, Komeda M: "Combined Procedure of Surgical Repair and Cell Transplantation for Left Ventricular Aneurysm : An Experimental Study."Circulation. 106. 193-197 (2002)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Sakaguchi G, Sakakibara Y, Tambara K, Komeda M, et al.: "A Pig Model of Chronic Heart Failure by Intracoronary Embolization with Gelatin Sponge"Ann Thorac Cardiovasc Surg.. 75. 1942-1947 (2003)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Sakakibara Y, Tambara K, Sakaguchi G, Tabata Y, Nishimura K, Komeda M: "Toward surgical angiogenesis using slow-released basic fibroblast growth factor"Eur J Cardiothorac Surg.. 24. 105-112 (2003)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] 丹原圭一, 米田正始: "虚血性心筋症に対する血管新生療法-塩基性線維芽細胞増殖因子徐放化システムの有用性-"医学の歩み(別冊). 206巻・10号. 824-828 (2003)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Keiichi Tambara, Yutaka Sakakibara, Masashi Komeda, et al.: "Transplanted skeletal myoblasts can fully replace the infarcted myocardiumwhen they survive in the host is large numbers"Circulation. 108(Suppl II). II259-II263 (2003)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Keiichi Tambara, Godith Premaratne, Masashi Komeda, et al.: "Simultaneous admonistration of control-released basic fibroblast growth factor enhances the efficacy of skeletal myoblast transplantation by increasing vascular density and graft volume"Circulation. 108(Suppl IV). IV332 (2003)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Keiichi Tambara, Taiko Horii, Masashi Komeda, et al.: "Epicardial admonistration of control-released basic fibroblast growth factor induces angiogenesis and improves left ventricular function in dilated cardiomypopathy"Circulation. 108(Suppl IV). IV399 (2003)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] 丹原圭一, 田畑泰彦, 米田正始: "心臓血管領域の再生医療-徐放化ペプチドを用いた局所療法-"遺伝子医学別冊 ドラッグデリバリーシステム-DDS技術の新たな展開とその活用法. 131-135 (2003)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Keiichi Tambara, Yutaka Sakakibara, Masashi Komeda, et al.: "Transplanting cells for the treatment of cardiomyopathy"Cardiomyopathies and heart failure. 481-489 (2003)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Hiroyuki Nakajima, Tatsutoshi Nakahata, Masashi Komeda, et al.: "Optimal delivery route and timing in bone marrow cell transplantation should be selected according to the etiology of heart disease."Circulation. 108(Suppl IV). IV622 (2003)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Hiroyuki Nakajima, Yutaka Sakakibara, Tatsutoshi Nakahata, et al.: "Comparison of efficacy between stem cell mobilization by G-CSF and bone marrow cell transplantation in doxorubicin-induced cardiomyopathy"Circulation. 108(Suppl IV). IV288 (2003)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Hiroyuki Nakajima, Yutaka Sakakibara, Kazunobu Nishimura, et al.: "Hematopoietic stem cell transplantation improved cardiac function of doxorubicin-induced cardiomyopathy mouse."Circulation. 108(Suppl IV). IV342 (2003)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Yutaka Sakakibara Hiroyuki Nakajima, Kazunobu Nishimura, et al.: "Comparison of efficacy between bone marrow cell transplantation and stem cell mobilization by G-CSF in post-infarct remodeling."Circulation. 108(Suppl IV). IV218 (2003)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] 中島博之, 米田正始: "心不全に対する細胞移植療法"Ischemic Heart Disease Frontier. 4. 15-19 (2003)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Sakakibara Y, Nishimura K, Tambara K, Yamamoto M, Lu F, Tabata Y, Komeda M.: "Prevascularization with Gelatin Microspheres Containing Basic Fibroblast Growth Factor Enhances the Benefits of Cardiomyocyte Transplantation."J Thorac Cardiovasc Surg.. 124. 50-56 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Sakakibara Y, Tambara K, Lu F, Nishina T, Nagaya N, Nishimura K, Komeda M.: "Cardiomyocyte transplantation dose not reverse cardiac remodeling in rats with chronic myocardial infarction."Ann Thorac Surg.. 74. 25-30 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Sakakibara Y, Tambara K, Lu F, Nishina T, Sakaguchi G, Nagaya N, Nishimura K, Li RK, Weisel RD, Komeda M.: "Combined Procedure of Surgical Repair and Cell Transplantation for Left Ventricular Aneurysm An Experimental Study."Circulation.. 106 Suppl I. 193-197 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Tambara K, Sakakibara Y, Sakaguchi G, Lu F, Premaratne U.G, Lin X, Nishimura K, Komeda M.: "Transplanted skeletal myoblasts can fully replace the infarcted myocardium when they survive in the host in large numbers."Circulation.. 108 Suppl II. 259-263 (2003)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Sakakibara Y, Tambara K, Sakaguchi G, Lu F, Yamamoto M, Nishimura K, Tabata Y, Komeda M.: "Toward surgical angiogenesis using slow-released basic fibroblast growth factor."Eur J Cardiothorac Surg.. 24(1). 105-112 (2003)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Tambara K, Komeda M.: "Therapeutic angiogenesis for ischemic heart disease -Effectiveness of controlled-release system of basic fibroblast growth factor-"Igakuno Ayumi.. 206(10). 824-828 (2003)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Tambara K, Sakakibara Y, Komeda M, et al.: "Transplanted skeletal myoblasts can fully replace the infarcted myocardium when they survive in the host in large numbers."Circulation.. 108(Suppl II). II259-II263 (2003)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Tambara K, Premaratne G, Komeda K, et al.: "Simultaneous admonistration of control-released basic fibroblast growth factor enhances the efficacy of skeletal myoblast transplantation by increasing vascular density and graft volume."Circulation.. 108(Suppl IV). IV332 (2003)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Tambara K, Horii T, Komeda M, et al.: "Epicardial admonistration of control-released basic, fibroblast growth factor induces angiogenesis and improves left ventricular function in dilated cardiomyopathy"Circulation.. 108(Suppl IV). IV399 (2003)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Tambara K, Tabata Y, Komeda K.: "Regeneration therapy in cardiovascular disease field -The local therapy system using controlled-released of peptide -"Idenshi-Igaku.. Suppl. 131-135 (2003)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Keiichi Tambara, Yutaka Sakakibara, Masashi Komeda, et al.: "Transplanting cells for the treatment of cardiomyopathy."Cardiomyopathies and Heart Failure.. 481-489 (2003)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Nakajima H, Nakahata T, Komeda M, et al.: "Optimal delivery route and timing in bone marrow cell transplantation should be selected according to the etiology of heart disease."Circulation.. 108(Suppl IV). IV622 (2003)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Nakajima H, Sakakibara Y, Nakahata T, et al.: "Comparison of efficacy between stem cell mobilization by G-CSF and bone marrow cell transplantation in doxorubicin-induced cardiomyopathy"Circulation.. 108(Suppl IV). IV288 (2003)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Nakajima H, Nishimura K, et al.: "Hematopoietic stem cell transplantation improved cardiac function of doxorubicin-induced cardiomyopathy mouse."Circulation.. 108(Suppl IV). IV342 (2003)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Sakakibara Y, Nakajima H, Nishimura K, et al.: "Comparison of efficacy between bone marrow cell transplantation and stem cell mobilization by G-CSF in post-infarct remodeling."Circulation.. 108(Suppl IV). IV218 (2003)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Nakajima H, Komeda M.: "Therapy with Cell Transplantation for Heart Failure."Ischemic Heart Disease Frontier.. 4. 15-19 (2003)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] 丹原圭一, 米田正始: "虚血性心筋症に対する血管新生療法-塩基性線維芽細胞増殖因子徐放化システムの有用性-"医学の歩み(別冊). 206巻・10号. 824-828 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] Keiichi Tambara, Yutaka Sakakibara, Masashi Komeda, et al.: "Transplanted skeletal myoblasts can fully replace the infarcted myocardiumwhen they survive in the host in large numbers"Circulation. 108(Suppl II). II259-II263 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] Keiichi Tambara, Godith U.Premaratne, Masashi Komeda, et al.: "Simultaneous admonistration of control-released basic fibroblast growth factor enhances the efficacy of skeletal myoblast transplantation by increasing vascular density and graft volum"Circulation. 108(Suppl IV). IV332 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] Keiichi Tambara, Taiko Horii, Masashi Komeda, et al.: "Epicardial admonnistration of control-released basic fibroblast growth factor induces angiogenesis and improves left ventricular function in dilated cardiomyopath"Circulation. 108(Suppl IV). IV399 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] 丹原圭一, 田畑泰彦, 米田正始: "心臓血管領域の再生医療-徐放化ペプチドを用いた局所療法-"遺伝子医学別冊 ドラッグデリバリーシステム-DDS技術の新たな展開とその活用法. 131-135 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] Keiichi Tambara, Yutaka Sakakibara, Masashi Komeda, et al.: "Transplanting cells for the treatment of cardiomyopathy"Cardiomyopathies and heart failure. 481-489 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] Hiroyuki Nakajima, Tatsutoshi Nakahata, Masashi Komeda, et al.: "Optimal delivery route and timing in bone marrow cell transplantation should be selected according to the etiology of heart disease"Circulation. 108(Suppl IV):. IV622 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] Hiroyuki Nakajima, Yutaka Sakakibara, Tatsutoshi Nakahata, et al.: "Comparison of efficacy between stem cell mobilization by G-CSF and bone marrow cell transplantation in doxorubicin-induced cardiomyopathy"Circulation. 108(Suppl IV):. IV288 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] Hiroyuki Nakajina, Yutaka Sakakibara, Kazunobu Nishimura, et al.: "Hematopoietic stem cell transplantation improved cardiac function of doxorubicin-induced cardiomyopathy mouse"Circulation. 108(Suppl IV):. IV342 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] Yutaka Sakakibara, Hiroyuki Nakajima, Kazunobu Nishimura, et al.: "Comparison of efficacy between bone marrow cell transplantation and stem cell mobilization by G-CSF in post-infarct remodeling"Circulation. 108(Suppl IV):. IV218 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] 中島博之, 米田正始: "心不全に対する細胞移植療法"Ischemic Heart Disease Frontier. 4. 15-19 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] Sakakibara Y, Nishimura K, Tambara K, Yamamoto M, Lu F, Tabata Y, Komeda M.: "Prevascularization with Gelatin Microspheres Containing Basic Fibroblast Growth Factor Enhances of Cardiomvocvte Transnlantaion"J Thorac Cardiovasc Surg. 124. 50-56 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] Sakakibara Y, Tambara K, Lu F, Nishina T, Nagaya N, Nishimura K, Komeda M: "Cardiomyocyte transplantation dose not reverse cardiac remodeling in rats with chronic myocardial infarction"Ann Thorac Cardiovasc Surg. 74. 25-30 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] Sakakibara Y, Tambara K, Lu F, Nishina T, Sakaguchi G, Nishimura K, Komeda M: "Combined Procedure of Surgical Repair and Cell Transplantation for Left Ventricular Aneurysm : An Experimental Study"Circulation. 106. 193-197 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] Sakaguchi G, Sakakibara Y, Tambara K, Lu F, Premaratene G, Nishimura K, Komeda M: "A Pig Model of Chronic Heart Failure by Intracoronary Embolization with Gelatin Sponge"Ann Thorac Cardiovasc Surg.. (in press).

    • Related Report
      2002 Annual Research Report
  • [Publications] Sakakibara Y, Tambara K, Sakaguchi G, Tabata Y, Nishimura K, Komeda M: "Toward surgical angiogenesis using slow-released basic fibroblast growth factor"Eur J Cardiothorac Surg.. (in press).

    • Related Report
      2002 Annual Research Report

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Published: 2001-04-01   Modified: 2016-04-21  

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