| Project/Area Number |
13470279
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Thoracic surgery
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| Research Institution | Tokyo Women's Medical University |
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Principal Investigator |
ENDO Masahiro Tokyo Women's Medical University, Dept of Cardiovascular Surgery, Professor, 医学部, 教授 (20075302)
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| Co-Investigator(Kenkyū-buntansha) |
TOMIZAWA Yasuko Tokyo Women's Medical University, Dept of Cardiovascular Surgery, Instructor, 医学部, 助手 (00159047)
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| Project Period (FY) |
2001 – 2003
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| Project Status |
Completed (Fiscal Year 2003)
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| Budget Amount *help |
¥5,000,000 (Direct Cost: ¥5,000,000)
Fiscal Year 2003: ¥1,400,000 (Direct Cost: ¥1,400,000)
Fiscal Year 2002: ¥1,400,000 (Direct Cost: ¥1,400,000)
Fiscal Year 2001: ¥2,200,000 (Direct Cost: ¥2,200,000)
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| Keywords | CABG / coronary revascularization / angiogenesis / bFGF / scaffold / tissue engineering / sprout / vessel / 血管壁 / 血管新生 / 線維芽細胞増殖因子 / 足場(scaffold) / 組織再構築 / 血管誘導 / RECモデル / ウサギ / angiogenesis / coronary / 虚血 / 心筋 / 三次元 / 壁細胞 |
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| Research Abstract |
For patients who can not have surgical revascularization because of atheromatous small coronary artery in severe ischemic heart disease, therapeutic angiogenesis is demanded. For angiogenesis, combination of cells, extracellular matrix and growth factor is important. However, in clinic, TMLR and angiogenic factors have not been satisfactory. In therapeutic angiogenesis, it is difficult to distinguish newly formed vessels from existing ones in the heart because there are so may capillaries, such as four capillaries for one cardiomyo-bundle. In this research period, we planned 1)evaluate the process of angiogenesis from sprout formation to mature vessels using angiogenic factor and scaffold, 2)reconstruction of vessel image into 3-dimentional to understand cells in the vessel wall. In a newly formed vessel, sprout formation occur from venous side. Spouts have one layer of cells, endothelium. However, at pint of differentiation, vessels become artery and vein was not recognized. However, direct observation of angiogenesis in rabbits was possible.
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