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Clarification of transmission mechanism of urinary sensation in pontine micturition center and central effect of drugs for voiding dysfunction.

Research Project

Project/Area Number 13470340
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Urology
Research InstitutionKyoto Prefectural University of Medicine (KPUM)

Principal Investigator

KAWAUCHI Akihiro  KPUM Urology, Assistant Professor, 医学部, 講師 (90240952)

Co-Investigator(Kenkyū-buntansha) MIZUTANI Yoichi  KPUM Urology, Assistant Professor, 医学部, 講師 (10243031)
MIKI Tsuneharu  KPUM Urology, Professor, 医学部, 教授 (10243239)
KOYAMA Yoshimasa  Fukushima Medical Univ, School of Medicine Associate Professor, 医学部, 助教授 (80183812)
UKIMURA Osamu  KPUM Urology, Lecture, 医学部, 助手 (70275220)
Project Period (FY) 2001 – 2002
Project Status Completed (Fiscal Year 2002)
Budget Amount *help
¥10,200,000 (Direct Cost: ¥10,200,000)
Fiscal Year 2002: ¥2,300,000 (Direct Cost: ¥2,300,000)
Fiscal Year 2001: ¥7,900,000 (Direct Cost: ¥7,900,000)
KeywordsPoms / Micturition center / Barrington's nuclens / Neurons / Firing / oxybutynin / Clomipramine / Desmopressin
Research Abstract

We performed electrophysiological studies in order to clarify the relationship between the pontine micturition center and micturition. A catheter was inserted into the bladder and saline was injected until spontaneous contraction was induced. A glass pipette microelectrode was inserted through the cerebellum. Single neural activity was recorded in the mesopontine tegmentum including the Barrington's nucleus and simultaneously its precise timing in relation to bladder contraction was observed. Three types of neuron were distinguished ; those which fired only prior to the start of contraction (E1), those whose firing started shortly prior to and was maintained during contraction (E2), and those whose firing, was strongly suppressed during contraction (I). The results showed that direct neural signals to induce bladder contraction might arise from the Barrington's nucleus. The neurons were classified into three types with different functional roles.
In order to clarify the effects of drugs for voiding dysfunction on the micturition center, an anticholinergic drug (oxybutynin hydrochloride) and a tricyclic antidepressant (clomipramine hydrochloride) were administered intravenously during the recording of E1 and E2 neurons. With the administration of oxybutynin, neural firing increased in accordance with the suppression of bladder contraction. On the other hand, neural firing decreased with the administration of clomipramine. From these results, it seemed that oxbutynin and clomipramine had similar peripheral effects and different central effects. In order to clarify the effects of desmopressin on the micturition center, it was administered intravenously and intraventriculary. With the administration, neurons were observed in which the firing changed in accordance with the suppression of bladder contraction. From these results, the possibility of the central effect of desmopressin was suggested

Report

(3 results)
  • 2002 Annual Research Report   Final Research Report Summary
  • 2001 Annual Research Report
  • Research Products

    (20 results)

All Other

All Publications (20 results)

  • [Publications] Yamao Y., et al.: "Discrete regions in the laterodorsal tegmental area of the rat regulating the urinary bladder and external urethral sphincter"Brain Res. 912. 162-170 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Tanaka Y., et al.: "Effects of the acupuncture to the sacral segment on the bladder activity and EEG"Psychiat Clin Neuros. 56. 249-250 (2002)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Kawauchi A., et al.: "Relationships among nocturnal urinary volume, bladder capacity and nocturia with and without water load in nonenuretio children"Urology. 59. 433-437 (2002)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Tanaka Y., et al.: "Vesicoureteral reflux detected among patients with nocturnal enuresis"European Urology. 43. 80-83 (2003)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Kawauchi A., et al.: "Bladder capacity at the time of enuresis"Urology. 61(in press). (2003)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Tanaka Y., et al.: "Firing of micturition center neurons in the rat mesopontine tegmentum during urinary bladder contraction"Brain Res. 965. 146-154 (2003)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Yamao Y., et al.: "Discrete regions in the laterodorsal tegmental area of the rat regulating the urinary bladder and external urethral sphincter"Brain Research. 912. 162-170 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Tanaka Y., et al.: "Effects of the acupuncture to the sacral segment on the bladder activity and electroencephalogram"Psychiatry and Clinical Neurosciences. 56. 249-250 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Kawauchi A., et al.: "Relationships among nocturnal urinary volume, bladder capacity, and nocturia with and without water load in nonenuretic children"UROLOGY. 59. 433-437 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Tanaka Y., et al.: "Vesicoureteral Reflux Detected among Patients with Nocturnal Enuresis"European Urology. 43. 80-83 (2003)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Kawauchi A., et al.: "Bladder capacity at the time of enuresis"UROLOGY. 61:in press. (2003)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Tanaka Y., et al.: "Firing of micturition cecter neurons in the rat mesopontine tigmentum during urinary bladder contraction"Brain Research. 965. 146-154 (2003)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Kawauchi A., et al.: "Relationships among nocturnal urinary volume, bladder capacity and nocturia with and without load in nonenuretic children"Urology. 59. 433-437 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] Honjo H., et al.: "Treatment of monosymptomatic nocturnal enuresis by acupuncture : A preliminary study"International Journal of Urology. 9. 672-676 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] Kanemitsu N., et al.: "Familial central diabetes insipidus detected by nocturnal enuresis"Pediatric Nephrology. 17. 1063-1065 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] Tanaka Y., et al.: "Vesicoureteral reflux detected among patients with nocturnal enuresis"European Urology. 43. 80-83 (2003)

    • Related Report
      2002 Annual Research Report
  • [Publications] Tanaka Y., et al.: "Firing of micturition center neurons in the rat mesopontine tegmentum during urinary bladder contraction"Brain Res. 965. 146-154 (2003)

    • Related Report
      2002 Annual Research Report
  • [Publications] Kawauchi A., et al.: "Bladder capacity at the time of enuresis"Urology. 61(in press). (2003)

    • Related Report
      2002 Annual Research Report
  • [Publications] Yamao Y.: "Discrete regions in the laterodorsal tegmental area of the rat regulating the urinary bladder and external urethral sphincter"Brain Research. 912. 162-170 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] Tanaka Y.: "Effects of the acupuncture to the sacral segment on the bladder activity and EEG"Psychiatry and Clinical Neurosciences. (in press). (2002)

    • Related Report
      2001 Annual Research Report

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Published: 2001-04-01   Modified: 2016-04-21  

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