| Project/Area Number |
13470370
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (B)
|
| Allocation Type | Single-year Grants |
|---|
| Section | 一般 |
|---|
| Research Field |
Ophthalmology
|
|---|
| Research Institution | Sapporo Medical University |
|---|
Principal Investigator |
OHTSUKA Kenji Sapporo Medical University, School of Medicine, Professor, 医学部, 教授 (60203832)
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
HASHIMOTO Masato Sapporo Medical University, School of Medicine, Assistant Professor, 医学部, 講師 (90295353)
OHBA Masahiro Sapporo Medical University, School of Medicine, Assistant Professor, 医学部, 講師 (00244343)
SUZUKI Yasuo Sapporo Medical University, School of Medicine, Assistant Professor, 医学部, 講師 (40221329)
|
|---|
| Project Period (FY) |
2001 – 2002
|
| Project Status |
Completed (Fiscal Year 2002)
|
| Budget Amount *help |
¥8,000,000 (Direct Cost: ¥8,000,000)
Fiscal Year 2002: ¥1,200,000 (Direct Cost: ¥1,200,000)
Fiscal Year 2001: ¥6,800,000 (Direct Cost: ¥6,800,000)
|
|---|
| Keywords | Superior Colliculus / vergence / accommodation / fixation / fixation zone / disconjugate eve movement / near reflex / strabismus |
|---|
| Research Abstract |
We have repented that the rostral superior colliculus (the rostral SC) of cats is involved in the control of accommodation (Ohtsuka et al., 1993 ; 1994 ; 1996), and that the rostral SC receives descending projections from the cortical area related to accommodation and vergence (Ohtsuka et al., 1996). In the present study, we investigated the role of the rostral SC on the control of vergence eye movements. Two alert cats were used in this study. Binocular eye movements were recorded using magnetic search coils. The SC was identified and mapped by a single-unit activity mat showed correlation with visual stimuli and/or saccades. Disconjugate eye movements (3.9deg.+/-0.9deg., mean+/-SD) were evoked by the electrical micro-stimulation of the rostral SC (10-40 μA, 125-500Hz, 125-500ms). We inactivated the rostral SC of an alert cat trained to track a vergence target by 0.5%muscimol injections (0.5μl). Convergence eye movements were almost abolished by the injection of muscimol in the unilateral rostral SC. Spontaneous saccades were inhibited by stimulation of the same area where disconjugate eye movements were evoked. These findings suggest that the rostral SC is involved in the control of vergence eye movements. We think that the rostral SC is an important neural substrate for the functional linkage of accommodation, vergence and visual fixation
|
