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Elucidation of features of jaw bone osteoporosis and establishment of preventive methods against it

Research Project

Project/Area Number 13470382
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Morphological basic dentistry
Research InstitutionNiigata University

Principal Investigator

EJIRI Sadakazu  NIIGATA UNIVERSITY, Graduate School of Medical and Dental Sciences, Associate Professor, 大学院・医歯学総合研究科, 助教授 (40160361)

Co-Investigator(Kenkyū-buntansha) IKEGAME Mika  NIIGATA UNIVERSITY, Graduate School of Medical and Dental Sciences, Assistant, 大学院・医歯学総合研究科, 助手 (70282986)
AMIZUKA Norio  NIIGATA UNIVERSITY, Graduate School of Medical and Dental Sciences, Associate Professor, 大学院・医歯学総合研究科, 助教授 (30242431)
KOHNO Shoji  NIIGATA UNIVERSITY, Graduate School of Medical and Dental Sciences, Professor, 大学院・医歯学総合研究科, 教授 (50014098)
TANAKA Mikako  NIIGATA UNIVERSITY, Medical and dental Hospital, Lecturer, 医歯学総合病院, 講師 (20361909)
Project Period (FY) 2001 – 2003
Project Status Completed (Fiscal Year 2003)
Budget Amount *help
¥8,600,000 (Direct Cost: ¥8,600,000)
Fiscal Year 2003: ¥700,000 (Direct Cost: ¥700,000)
Fiscal Year 2002: ¥1,000,000 (Direct Cost: ¥1,000,000)
Fiscal Year 2001: ¥6,900,000 (Direct Cost: ¥6,900,000)
Keywordsmandible / osteoporosis / ovariectomized monkey / estrogen deficiency / micro CT / カニクイザル
Research Abstract

We assessed ovariectomized monkey mandibles using pQCT and micro CT to clarify the features of jaw bone osteoporosis and examine the potentiality of intermittent administration of human parathyroid hormone (1-34) as preventive medicine in the treatment. Twenty four monkeys were divided into four groups depending on surgical procedure and hormone administration : sham + vehicle (SV), OVX + vehicle (OV), OVX + PTH 1.26μg/kg once per week (OP-low), OVX + PTH 6μg/kg once per week (OP-high). The OVX group was ovariectomized and the sham group was subjected to sham surgery. 52 or 78 weeds after surgery, the animals were sacrificed and the mandibles were excised. The coronal planes of the bones through the distal root of the first molar were assessed by pQCT and micro CT. The volume, thickness and number of trabecular bones in the OV significantly decreased as compared with those of the SV. The value of the trabecular separation in the OV was higher than that of SV. The node-strut analysis showed a statistically significant decrease in the values of TSL/TV and CtNd/TSL in the OV. Sever trabecular bone loss occurred in the basal part of the mandibular body of the OV. The number and volume of vascular spaces in the cortical bone of the OV significantly increased in comparison with that of the SV. The volume, thickness and number of trabecular bones in the OP-low. From these results, It is clearly demonstrated that estrogen deficiency caused trabecular bone loss and osteoporotic changes in the cortical bone of the monkey mandible, and that the intermittent administration of PTH (1-34) prevented trabecular bone loss of jaw bone osteoporosis.

Report

(4 results)
  • 2003 Annual Research Report   Final Research Report Summary
  • 2002 Annual Research Report
  • 2001 Annual Research Report
  • Research Products

    (32 results)

All Other

All Publications (32 results)

  • [Publications] 豊岡英一: "対合歯喪失後のラット歯槽骨の変化とエストロゲン欠乏の影響-マイクロフォーカスX線CTを用いた検索-"日骨形態誌. 11. 53-61 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Ejiri S: "Structural Analysis of ovariectomized monkey mandible using micro CT"Bone. 28. s217 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Kawamoto S: "Effects of estrogen deficiency on osteoclastgenesis in rat periodontium"Archives of Oral Biology. 47. 67-73 (2002)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Tanaka M: "Effects of ovariectomy on trabecular structures of rat alveolar bone"Journal of Periodontal Research. 37. 1-5 (2002)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Lin Gong: "Bisphosphonate Incadronate inhibits maturation of ectopic bones induced by recombinant human bone morphogenetic protein-2"Journal Bone and Mineral Metabolism. 22. 5-11 (2003)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Tanaka M: "Long-term changes on trabecular structure in aged rat alveolar bone following ovariectomy"Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 95. 495-502 (2003)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] 河野正司: "ラット歯槽骨の骨梁構造に対する卵巣摘出の影響"Clinical Calcium. 13. 604-607 (2003)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Ito M: "Bone structure and mineralization demonstrated using synchrotron radiation computed tomography (SR-CT) in animal models : Preliminary finding"J Bone Miner Metab. 21. 287-293 (2003)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Ejiri S: "Effects of alendronate and prostaglandin E receptor (EP4) agonist on ovariectomized monkey mandible"Bone. 32. s208 (2003)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Tanaka M: "Possiblity of screening for systemic osteoporosis using jaw bone"Bone. 32. s171 (2003)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] 江尻貞一: "骨粗鬆症ナビゲーター"メディカルレビュー社. 267 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Toyooka, E.: "Changes of rat alveolar bone following loss of antagonistic tooth and the influence of estrogen deficiency on the changes -Analysis using micro focus X-ray computed tomography-"J.Jpn.Soc.Bone Morphom.. 11. 53-61 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Ejiri S: "The navigator of osteoporosis"Medical review publisher. 267. (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Ejiri S: "Structural Analysis of ovariectomized monkey mandible using micro CT"Bone. 28. s217 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Kawamoto S: "Effects of estrogen deficiency on osteoclastgenesis in rat periodontium"Archives of Oral Biology. 47. 67-73 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Tanaka M: "Effects of ovariectomy on trabecular structures of rat alveolar bone"J Periodont res. 37. 1-5 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Lin Gong: "Bisphosphonate Incadronate inhibits maturation of ectopic bones induced by recombinant human bone morphogenetic protein-2"J Bone and Miner Metab. 22. 5-11 (2003)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Tanaka M: "Long-term changes on trabecular structure in aged rat alveolar bone following ovariectomy"Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 95. 495-502 (2003)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Kohno S: "Effect of ovariectomized on trabecular structure of rat alveolar bone"Clinical Calcium. 13. 604-607 (2003)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Ito M: "Bone structure and mineralization demonstrated using synchrotron radiation computed tomography (SR-CT) in animal models : Preliminary finding"J Bone Miner Metab. 21. 287-293 (2003)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Ejiri S: "Effects of alendronate and prostaglandin E receptor (EP4) agonist on ovariectomized monkey mandible"Bone. 32. s208 (2003)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Tanaka M: "Possiblity of screening for systemic osteoporosis using jaw bone"Bone. 32. s171 (2003)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Mikako Tanaka: "Long-term changes on trabecular structure in aged rat alveolar bone following ovariectomy"Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 95. 495-502 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] Ito M: "Bone structure and mineralization demonstrated using synchrotron radiation computed tomography (SR-CT)in animal models : Preliminary findings"J Bone Miner Metab. 21. 287-293 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] 江尻貞一: "Alendronateとprostaglandin E(EP4)agonistのが骨粗鬆化に対する予防効果-加齢に伴う顎骨反応-"解剖学雑誌. 78. 191 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] Ejiri S: "Effects of alendronate and prostaglandin E receptor (EP4) agonist on ovariectomi zed monkey mandible"Bone. 32. s208 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] Tanaka M: "Possiblity of screening for systemic osteoporosis using jaw bone"Bone. 32. s171 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] Mikako Tanaka: "Effects of ovariectomy on trabecular structures of rat alveolar bone"Journal of Periodontal Research. 37. 161-165 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] Minako Tanaka: "Long-term changes on trabecular structure in aged rat alveolar bone following ovariectomy"Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 95(印刷中). (2003)

    • Related Report
      2002 Annual Research Report
  • [Publications] 伊東昌子: "シンクロトンX線CTを用いた骨質評価の可能性の検討"日本骨代謝学会雑誌. 19・(2). 17 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] 浅輪幸世: "卵巣摘出ラットにおけるメナテトレノン(MK・4)投与時の組織学的検討"日本骨代謝学会雑誌. 19・(2). 34 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] 江尻貞一: "骨粗鬆症ナビゲーター"メディカルレビュー社. 267 (2001)

    • Related Report
      2001 Annual Research Report

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Published: 2001-04-01   Modified: 2016-04-21  

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