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Role of terminal Schwann cells of periodontal Ruffini endings during development and regeneration

Research Project

Project/Area Number 13470383
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Morphological basic dentistry
Research InstitutionOsaka University

Principal Investigator

SWAKISAKA Satoshi  Osaka University, Graduate School of Dentistry, Professor, 大学院・歯学研究科, 教授 (40158598)

Co-Investigator(Kenkyū-buntansha) OHISHI Tomoyuki  Osaka University, Dental Hospital, Instructor, 歯学部附属病院, 助手 (30303978)
ATSUMI Yukako  ATSUMI,Yukako, 大学院・歯学研究科, 講師 (90346164)
TOYOSAWA Satoru  TOYOSAWA,Satoru, 大学院・歯学研究科, 講師 (30243249)
加藤 穣慈  大阪大学, 大学院・歯学研究科, 助手 (90243245)
田畑 純  鹿児島大学, 歯学部, 助教授 (20243248)
岩本 容泰  大阪大学, 大学院・歯学研究科, 講師 (30223431)
Project Period (FY) 2001 – 2003
Project Status Completed (Fiscal Year 2003)
Budget Amount *help
¥16,300,000 (Direct Cost: ¥16,300,000)
Fiscal Year 2003: ¥2,800,000 (Direct Cost: ¥2,800,000)
Fiscal Year 2002: ¥4,900,000 (Direct Cost: ¥4,900,000)
Fiscal Year 2001: ¥8,600,000 (Direct Cost: ¥8,600,000)
KeywordsRuffini endings / terminal Schwann cells / nerve regeneration / development / brain-deraived nerve trophic factor / occlusal force / heat shock protein / immunohistochemistry / 歯根膜機械受容器 / 発生 / 形態維持 / 再生 / ラット / 熱ショック蛋白質 / 交叉吻合 / 歯根膜 / 神経損傷 / GTP結合タンパク質
Research Abstract

The Ruffini endings, a primary mechanoreceptor in the ligament, consists of axonal element and specialized Schwann cells, termed terminal Schwann cells. Morphologically, axonal terminals are extensively expanded, and possessed finger-like projections, called axonal spines or axonal microprojections which are important for perception of mechanical stimulation. Schwann cells are divided into two phenotypes ; myelin-forming Schwann cells and non-myelin-forming Schwann cells. The terminal Schwann cells of the periodontal Ruffini endings belong to non-myelin-forming Schwann cells. Although roles of ordinary Schwann cells, i.e. myelin-forming Schwann cells, are well understood, little is known on the functional roles of non-myelin-forming Schwann cells. In the present project, the role of terminal Schwann cells of periodontal Ruffini endings during regeneration and development is investigated. During the regeneration, the terminal Schwann cells express 25 kDa of heat shock protein (HSP25) transiently, indicating that HSP25 has the important roles in the maintenance of morphology of terminal Schwann cells. It is known that brain derived neurotrophic factor (BDNF) is one of the key molecule for development and maintenance of periodontal Ruffini endings. In the BDNF +/-mice, the regeneration of periodontal Ruffini endings following nerve injury delayed, suggesting that BDNF is also important for nerve regeneration.

Report

(4 results)
  • 2003 Annual Research Report   Final Research Report Summary
  • 2002 Annual Research Report
  • 2001 Annual Research Report
  • Research Products

    (42 results)

All Other

All Publications (42 results)

  • [Publications] 脇坂 聡 他: "三叉神経中脳路核ニューロンのシナプスと感覚受容器"脳の科学. 25. 899-907 (2003)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] 脇坂 聡: "歯根膜機械受容器の再生"阪大歯学誌. 48. 1-3 (2003)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] A.El-Sharaby et al.: "Development and maturation of taste buds in the palatal epithelium of the rat : A histological and immunohistochemical study"Anatomical Record. 263. 260-268 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] S.Wakisaka, Y.Atsumi: "Regeneration of periodontal Ruffini endings in adults and neonates"Microscopy Research and Technique. 60. 516-527 (2003)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] K.Hiroshima et al.: "Fos protein in the parabrachial nucleus neurons during experimental tooth movement of the rat molar."Brain Research. 908. 161-173 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Y.Yamazaki et al.: "Temporal and spatial distribution of Fos protein in the lumbar spinal dorsal horn neurons in the rat with chronic constriction injury to the sciatic nerve."Brain Research. 914. 106-114 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] A.El-Sharaby et al.: "Differentiation of the lingual and palatal gustatory epithelium of the rat as revealed by immunohistochemistry of α-gustducin."Archives of Histology and Cytology. 64. 401-409 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] S.Honma et al.: "Postnatal development of synaptic inputs to rat masseter motoneurons"Developmental Brain Research. 139. 67-71 (2002)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] T.Inoue et al.: "Involvement of 5-HT7 receptors in serotonergic effects on spike afterpotentials in presumed jaw-closing motoneurons of rats."Brain Research. 60. 202-211 (2002)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] N.Munekawa et al.: "NADPH-diaphorase and calcium binding proteins in the trigeminal nucleus oralis of rats"Somatosensory and Motor Research. 19. 173-180 (2002)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] S.Wakisaka et al.: "Immunocytochemical localization of anion exchanger-2 (AE-2) in the dorsal root ganglion of adult rats."Biomedical Research. 23. 213-219 (2002)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] F.Harada et al.: "Involvement of brain-derived neurotrophic factor (BDNF) in the regeneration of periodontal Ruffini endings following transaction of the inferior alveolar nerve"Archives of Histology and Cytology. 66. 183-194 (2003)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] K.Iijima et al.: "Temporal expression of immunoreactivity for heat shock protein 25 (Hsp25) in the rat periodontal ligament following transection of the inferior alveolar nerve"Brain Research. 979. 146-152 (2003)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] T.Imai et al.: "Regeneration of periodontal Ruffini endings of rat lower incisors following nerve cross-anastomosis with mental nerve"Brain Research. 992. 20-29 (2003)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] A.El-Sharaby, K.Ueda, K.Kurisu, S.Wakisaka: "Development and maturation of taste buds in the palatal epithelium of the rat"A histological and immunohistochemical study.. 263. 260-268 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] K.Hiroshima, T.Maeda, K.Hanada, S.Wakisaka: "Temporal and spatial distribution of Fos protein in the parabrachial nucleus neurons during experimental tooth movement of the rat molar"Brain Res.. 908. 161-173 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] A.El-Sharaby, K.Ueda, S.Wakisaka: "Differentiation of the lingual and palatal gustatory epithelium of the rat as revealed by immunohistochemistry of a-gustducin."Arch.Histol.Cytol.. 64. 401-409 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] S.Honma, V.Varathan, S.Wakisaka: "Postnatal development of synaptic inputs to rat masseter motoneurons."Dev.Brain Res.. 139. 67-71 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] T.Inoue, S.Itoh, S.Wakisaka, S.Ogawa, M.Saito, T.Morimoto: "Involvement of 5-HT7 receptors in serotonergic effects on spike afterpotentials in presumed jaw-closing motoneurons of rats."Brain Res.. 954. 202-211 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] N.Munekawa, S.Sugiyo, V.Varathan, H.Fukami, S.Wakisaka, Y.Shigenaga, M.Takemura: "NADPH-diaphorase and calcium binding proteins in the trigeminal nucleus oralis of rats."Somatosens. Motor Res. 19. 173-180 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] S.Wakisaka, S.Honma, T.Onishi, S.Toyosawa, Y.Ogawa: "Immunocytochemical localization of anion exchanger-2 (AE-2) in the dorsal root ganglion of adult rats."Biomed. Res.. 23. 213-219 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] S.Wakisaka, Y.Atsumi: "Regeneration of periodontal Ruffini endings in adults and neonates."Microscop Res Tech. 60. 516-527 (2003)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] F.Harada, N.Hoshino, K.Hanada, Y.Kawano, Y.Atsumi, S.Wakisaka, T.Maeda: "The involvement of brain-derived neurotrophic factor (BDNF) in the regeneration of periodontal Ruffini endings following transection of inferior alveolar nerve"Arch. Histol. Cytol.. 66. 183-194 (2003)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] K.Iijima, F.Harada, K.Hanada, K.Nozawa-Inoue, M.Aita, Y.Atsumi, S.Wakisaka, T.Maeda: "Temporal expression of immunoreactivity for heat shock protein (Hsp25) in the rat periodontal ligament following transection of inferior alveolar nerve"Brain Res.. 979. 146-152 (2003)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] T.Imai, Y.Atsumi, K.Matsumoto, Y.Yura, S.Wakisaka: "Regeneration of periodontal Ruffini endings of rat lower incisors following nerve cross-anastomosis with mental nerve"Brain Res.. 992. 20-29 (2003)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] K.Ueda, M.Fujii, A.El-Sharaby, S.Honma, S.Wakisaka: "Human blood antigen H is not the specific marker for type I cells of the taste buds."Arch Histol Cytol.. 66. 469-473 (2003)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] 脇坂 聡他: "三叉神経中脳路核ニューロンのシナプスと感覚受容器"脳の科学. 25. 899-907 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] 脇坂 聡: "歯根膜機械受容器の再生"阪大歯学誌. 48. 1-3 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] S.Wakisaka, Y.Atsumi: "Regeneration of periodontal Ruffini endings in adults and neonates"Microscopy Research and Technique. 60. 516-527 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] F.Harada et al.: "Involvement of brain-derived neurotrophic factor (BDNF) in the regeneration of periodontal Ruffini endings following transection of the inferior alveolar nerve"Archives of Histology and Cytology. 66. 183-194 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] K.Iijima et al.: "Temporal expression of immunoreactivity for heat shock protein 25 (Hsp25) in the rat periodontal ligament following transection of the inferior alveolar nerve"Brain Research. 979. 146-152 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] T.Imai et al.: "Regeneration of periodontal Ruffini endings of rat lower incisors following nerve cross-anastomosis with mental nerve"Brain Research. 992. 20-29 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] T.Imai et al.: "Regeneration of periodontal Ruffini endings of rat lower incisor following cross-anastomosis of mental nerve and inferior alveolar nerve"32nd Annual Meeting of Society for Neuroscience. (CD-ROM). (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] F.Harada et al.: "Depletion of BDNF induces delay of regeneration of the periodontal Ruffini endings"32nd Annual Meeting of Society for Neuroscience. (CD-ROM). (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] S.Wakisaka, Y.Atsumi: "Regeneration of periodontal Ruffini ending of the adults and neonates"Microscopy and Research Technique. (In press). (2003)

    • Related Report
      2002 Annual Research Report
  • [Publications] S.Wakisaka et al.: "Immunocytochemical localization of anion exchanger-2 (AE-2) in the dorsal root ganglion of the adult rat"Biomedical Research. (In press). (2003)

    • Related Report
      2002 Annual Research Report
  • [Publications] S.Honma et al.: "Postnatal development of synapse inputs to rat masseter motoneurons"Developmental Brain Research. 139. 67-71 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] Hiroshima, K. et al.: "Temporal and spatial distribution of Fos protein in the parabrachial nucleus neurons during experimental tooth movement of the rat molar"Brain Research. 908. 161-173 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] El-Sharaby, A. et al.: "Development and maturation of taste buds of the palatal epithelium of the rat : histological and immunohistochemical study"Anatomical Record. 263. 260-268 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] Yamazaki, Y. et al.: "Temporal and spatial distribution of Fos protein in the lumbar spinal dorsal horn neurons in the rat with chronic constriction injury to the sciatic nerve"Brain Research. 914. 106-114 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] El-Sharaby, A. et al.: "Differentiation of the lingual and palatal gustatory epithelium of the rat as revealed by immunohistochemistry ofα-gustducin"Archives of Histology and Cytology. 64. 401-409 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] Wakisaka, S. et al.: "Regeneration of periodontal Ruffini endings in neonates and adults"Microscopic Research Technique. (in press). (2002)

    • Related Report
      2001 Annual Research Report

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Published: 2001-04-01   Modified: 2016-04-21  

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