| Project/Area Number |
13470397
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
病態科学系歯学(含放射線系歯学)
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| Research Institution | Tohoku University |
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Principal Investigator |
SAKAMOTO Maya Tohoku University, Hospital, Lecturer, 医学部附属病院, 講師 (90157686)
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| Co-Investigator(Kenkyū-buntansha) |
INUKAI Ken Tohoku University, Graduate School of Dentistry, Assistant, 大学院・歯学研究科, 助手 (10333824)
SHINODA Hisashi Tohoku University, Graduate School of Dentistry, Professor, 大学院・歯学研究科, 教授 (80014025)
MORI Shiro Tohoku University, Hospital, Lecturer, 医学部附属病院, 講師 (80230069)
FUKUMOTO Manabu Tohoku University, Institute of Development, Aging and Cancer, Professor, 加齢医学研究所, 教授 (60156809)
SASANO Takashi Tohoku University, Graduate School of Dentistry, Professor, 大学院・歯学研究科, 教授 (10125560)
駒井 伸也 東北大学, 歯学部附属病院, 助手 (90234864)
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| Project Period (FY) |
2001 – 2003
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| Project Status |
Completed (Fiscal Year 2003)
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| Budget Amount *help |
¥10,300,000 (Direct Cost: ¥10,300,000)
Fiscal Year 2003: ¥1,100,000 (Direct Cost: ¥1,100,000)
Fiscal Year 2002: ¥3,600,000 (Direct Cost: ¥3,600,000)
Fiscal Year 2001: ¥5,600,000 (Direct Cost: ¥5,600,000)
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| Keywords | Osteoporosis / CT / Bone mineral density / Ovariectomy / micro-CT / monkey / Temporomandibular disorder / Periodontitis / μ-CT / Chronic Periodontitis / osteoporosis / bone mineral density / ovariectomy / Periodontal disease / Mandible / X-ray CT / Radiography / Ovarectomy |
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| Research Abstract |
Objectives:
The purpose of this study was to assess the change of the jaw and periodontal tissues after ovariectomy in monkeys.
Methods:
Forty-two cynomolgus monkeys with estimated age of 9 to 15 years were divided into two groups : a group that underwent ovariectomy (OVX group, n=2l) and a sham-operated group (SHAM group, n=21). Two years after the operation, the animals mere killed, and the maxillo-facial bones mere dissected. Each bone was examined with cepharogram, CT, micro-CT, soft X-ray, and periapical radiograph.
Results:
(1)In densitometric analysis of cephalogram, the OVX group showed a significant decrease in the bone mineral contents (BMCs) of the alveolar bone and the marginal bone of the mandibular angle.
(2)The OVE group showed a significant decrease in CT value of mandibular condyle.
(3)In the BMG of mandibular body on soft X-ray film, a significant difference was not observed between OVX and Sham groups.
(4)In morphological analysis of temporomandibular joint (TMJ), a significant difference was not observed between OVX and Sham groups.
(5)On periapical radiograph, a significant difference was not observed in the thickness of the lamina dura and periodontal space.
(6)On micro-CT of TMJ, the OVE group showed a significant decrease in bone volume fraction, trabecular number, and trabecular thickness of the trabecular bone in the condyle and mandibular fossa.
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