| Project/Area Number |
13470447
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
矯正・小児・社会系歯学
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| Research Institution | Tokyo Medical and Dental University |
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Principal Investigator |
TAKAGI Yuzo Tokyo Medical and Dental University, Graduate School, Development Oral Health Sciences, Professor, 大学院・医歯学総合研究科, 教授 (30124697)
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| Co-Investigator(Kenkyū-buntansha) |
MIYASHIN Michiyo Tokyo Medical and Dental University, Dental Hospital, Pediatric Dentistry, Instructor, 歯学部附属病院, 助手 (90229849)
加藤 純二 東京医科歯科大学, 大学院・医歯学総合研究科, 助手 (80177451)
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| Project Period (FY) |
2001 – 2003
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| Project Status |
Completed (Fiscal Year 2003)
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| Budget Amount *help |
¥9,900,000 (Direct Cost: ¥9,900,000)
Fiscal Year 2003: ¥1,400,000 (Direct Cost: ¥1,400,000)
Fiscal Year 2002: ¥1,500,000 (Direct Cost: ¥1,500,000)
Fiscal Year 2001: ¥7,000,000 (Direct Cost: ¥7,000,000)
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| Keywords | Pulpotomy / Direct pulp capping / Calcium phosphate cemment / Self setting / Biomaterial / Dentin bridge / Endodontic Treatment / Pediatric Dentistry / 即時硬化性 / 生活断髄糊剤 / DCPD系硬化体 / OCP硬化体 / 水酸化アパタイト / 庇蓋硬組織形成 |
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| Research Abstract |
If there is a substance which has physical propaties favorable for use in dental material and biocompatibility, it can be more suitable for the dressing of pulpotomy than calcium hydroxide (CH). In the present study, biocompatibility. chemical stability, and ability to promote hard tissue formation of a new calcium phosphate cement (CPC) setting composed of octacalcium phosphate (OCP) and alpha-tricalcium phosphate (alpha-TCP) are examined using in vitro and in vivo assessment systems.
In the first year, polarized hydroxyapatite crystals were implanted in to bone marrow of rat tibiae to examine its ability to promote hard tissue formation. The results showed that the abilities to promote hard tissue formation were different between positively charged surface and negatively charged surface. We, therefore, reserved to use in the new material. On the other hand, a CPC which was composed of OCP and alpha-TOP in 31 % and 69 % respectively showed physical propaties most favorable for use in dental material in vitro experiments. From second year of this project, therefore, this CPC selling was used as a pulp capping agent in rats, and the tissue reaction was examined histopathologically. The results showed that the reparative dentin formation was more prominent in OH used group in the early stage of the experiment. 5 weeks after pulp capping, however, formation of reparative dentin was prominent in the CPC setting group. Furthermore, reparative dentin consisting of regular dentinal tubules was observed more frequently in the OOP-based cement group. OCP-based cement may be useful in endodontic treatment because it allowed favorable healing processes to occur in the dental pulp.
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