| Project/Area Number |
13470520
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Laboratory medicine
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| Research Institution | Shiga University of Medical Science |
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Principal Investigator |
OKABE Hidetoshi OKABE,Hidetoshi, 医学部, 教授 (70079713)
|
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| Co-Investigator(Kenkyū-buntansha) |
CHANO Tokuhiro Shiga University of Medical Science, Faculty of Medicine, Associate Professor, 医学部, 助教授 (40346028)
佐伯 行一 滋賀医科大学, 医学部, 教授 (30025647)
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| Project Period (FY) |
2001 – 2003
|
| Project Status |
Completed (Fiscal Year 2003)
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| Budget Amount *help |
¥14,200,000 (Direct Cost: ¥14,200,000)
Fiscal Year 2003: ¥3,300,000 (Direct Cost: ¥3,300,000)
Fiscal Year 2002: ¥5,700,000 (Direct Cost: ¥5,700,000)
Fiscal Year 2001: ¥5,200,000 (Direct Cost: ¥5,200,000)
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| Keywords | MDR / RB1CC1 / RB1 / cancer / tumor suppressor / cloning / differentiation / mutation / がん抑制遺伝子 / 組織、器官発生 / がん制遺伝子 / 発生 / 悪性腫瘍 / 抗癌剤耐性 / mapping |
|---|
| Research Abstract |
With the application of anti-cancer chemotherapy, the prognosis of various malignant tumors including cancers, leukemia and sarcomas was greatly improved. However, those, that have presently become the barrier in order to treat the tumors, are the problems of multidrug resistance to anti-cancer agents. In order to the various biological events that are related to the drug resistance, and to apply the obtained findings to the tumor treatments, this research project had been started.
In the process of this project, we identified 5 candidate genes relating to the drug resistance, and one novel molecule among the those, RB1CC1 (RB1-inducible Coiled-Coil1), were closely associated with RB1 (retinoblastoma 1) tumor suppressor, and we also related RB1CC1 to the developments of various cancers. Therefore, the functional analysis of this novel molecule RB1CC1, and the mutation analysis of RB1CC1I gene in the cancers were mainly performed at the latter half of the project period. Then, we performed the achievements such as mentioned on the next page.
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