| Project/Area Number |
13480072
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Statistical science
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| Research Institution | National Institute of Public Health |
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Principal Investigator |
TANGO Toshiro National Institute of Public Health, Department of Technology Assessment and Biostatistics, Director, 技術評価部, 部長 (70124477)
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| Co-Investigator(Kenkyū-buntansha) |
YAMAOKA Kazue National Institute of Public Health, Department of Technology Assessment and Biostatistics, Section Chief, 技術評価部, 室長 (50091038)
OGATA Hiromitsu National Institute of Public Health, Center for Information Research and Library, Section Chief, 研究情報センター, 室長 (50185500)
池口 孝 国立環境研, 循環型社会形成推進廃棄物研究センター, 室長 (40094255)
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| Project Period (FY) |
2001 – 2003
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| Project Status |
Completed (Fiscal Year 2003)
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| Budget Amount *help |
¥15,200,000 (Direct Cost: ¥15,200,000)
Fiscal Year 2003: ¥2,300,000 (Direct Cost: ¥2,300,000)
Fiscal Year 2002: ¥5,600,000 (Direct Cost: ¥5,600,000)
Fiscal Year 2001: ¥7,300,000 (Direct Cost: ¥7,300,000)
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| Keywords | dioxins / Poisson distribution / score test / Monte Carlo simulation / GIS / ポアソン分布 |
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| Research Abstract |
There has been great public concern that adverse reproductive health effects may be associated with dioxins in emission gases from municipal solid waste (MSW) incinerators. Recently, Japan's first-ever large scale nationwide epidemiological study has begun to examine the association of adverse reproductive outcomes with mothers living within 10km from 63 MSW incinerators with high dioxin emission levels (above 80ng international toxic equivalents TEQ/m^3) in Japan. The primary purpose of our study was to investigate the statistical method to analyze the data collected in the above study and also to propose a method applicable to more general problems of raised disease risk around putative point sources.
As statistical method to detect such clusters, Stone's maximum likelihood ratio test and score tests which score each case the reciprocal of the distance from a point source are popular. In our study, we have proposed extensions of score tests based on small area data in that (i)it allows us to select the best among prespecified parametric exposure functions to avoid multiple testing problems and (ii)it can be applied to a possible situation where the hazardous substance levels tend to peak at some distance from a point source. The properties of the proposed tests and their power have been examined and illustrated with hypothetical data and also the power calculation has been conducted on the study design of above-stated epidemiological study. Simulation study shows that the powers of the proposed tests are higher than that of Stone's test over all the alternatives considered.
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