| Project/Area Number |
13554024
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 展開研究 |
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| Research Field |
Inorganic chemistry
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| Research Institution | The University of Tokyo |
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Principal Investigator |
TANAKA Kentaro The University of Tokyo, Graduate School of Science, Associate Professor, 大学院・理学系研究科, 教授 (60187333)
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| Co-Investigator(Kenkyū-buntansha) |
ASAO Tetsuji Taiho Pharmaceutical Co. Ltd., Director (Researcher), 化学研究所, 所長(研究職)
HIRAOKA Shuichi The University of Tokyo, Graduate School of Science, Doctor, 大学院・理学系研究科, 助手 (10322538)
田中 健太郎 東京大学, 大学院・理学系研究科, 助教授 (40281589)
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| Project Period (FY) |
2001 – 2002
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| Project Status |
Completed (Fiscal Year 2002)
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| Budget Amount *help |
¥14,300,000 (Direct Cost: ¥14,300,000)
Fiscal Year 2002: ¥3,400,000 (Direct Cost: ¥3,400,000)
Fiscal Year 2001: ¥10,900,000 (Direct Cost: ¥10,900,000)
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| Keywords | Artifical DNA / Metal Complex / Self-Assebmly / Nucleoside / Oligonuclentide / DNA / 核酸塩基 / 遺伝子 / ピリジン |
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| Research Abstract |
DNA has a structural basis to array functionalized building blocks. In this study, one to five Cu^<2+>-mediated base pairs of hydroxypyridone nucleobases have been systematically incorporated into the middle of a DNA duplex, resulting in the formation of a magnetic chain by the line-up of mono- to pentanuclear Cu^<2+> complexes stacked within the DNA helix. The Cu^<2+> ions in each complex couple ferromagnetically with one another through unpaired d electrons. An outline of a right-handed, double-stranded structure with Cu^<2+> array inside the DNA is proposed, where the Cu^<2+>-Cu^<2+> distance is almost the same as that between natural base pairs. This strategy represents a new method for arranging metal ions in solution in a discrete and predictable fashion and contrasts with the non-biological approach of others, leading to the possibility of metal-based molecular devices such as molecular magnets and wires.
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