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Design of neural prosthetic system for lost sensory functions using microelectrode arrays

Research Project

Project/Area Number 13555039
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section展開研究
Research Field 設計工学・機械要素・トライボロジー
Research InstitutionThe University of Tokyo

Principal Investigator

MATSUMOTO Kiyoshi  The University of Tokyo, Graduate School of Infonnation Science and Technology, Associate Professor, 大学院・情報理工学系研究科, 助教授 (10282675)

Co-Investigator(Kenkyū-buntansha) ABE Keiko  The University of Tokyo, Graduate School of Agricultural and Life Sciences, Professor, 大学院・農学生命科学研究科, 教授 (10151094)
KAGA Kimitaka  The University of Tokyo, Graduate School of Medicine, Professor, 大学院・医学系研究科, 教授 (80082238)
NAKAO Masayuki  The University of Tokyo, Graduate School of Engineering, Professor, 大学院・工学系研究科, 教授 (90242007)
Project Period (FY) 2001 – 2003
Project Status Completed (Fiscal Year 2003)
Budget Amount *help
¥13,400,000 (Direct Cost: ¥13,400,000)
Fiscal Year 2003: ¥1,900,000 (Direct Cost: ¥1,900,000)
Fiscal Year 2002: ¥5,000,000 (Direct Cost: ¥5,000,000)
Fiscal Year 2001: ¥6,500,000 (Direct Cost: ¥6,500,000)
KeywordsAuditory Brainstem Implant / Neural Prosthesis / Auditory Cortex / Cochlear Nucleus / Spinal Cord / Nerve Equation / Independent Component Analysis / Functional Stimulation / 脳機能マッピング / 機能構造 / 微小多点電極 / 電気刺激 / 誘発電位 / 神経細胞モデル
Research Abstract

The objective of the present study is to establish design guidelines for developing neural prosthesis that restores lost sensory functions due to disorders of sensory cells or pathways. The achievements of the study are summarized as follows. First, we developed an experimental animal model of the auditory brainstem implant (ABI) that directly stimulates the cochlear nucleus in the brainstem to restore the hearing of deaf patients who had their auditory nerves removed. The model included a surface microelectrode array for auditory cortical recording and a spike microelectrode arrray for the microstimulation in the cochlear nucleus. Second, using the ABI model of rats, we demonstrated that the cochlear nuclear microstirnulation could evoke spatio-temporal neural activity in the auditory cortex and the proper stimulation could take after the pure-tone-evoked activation, suggesting that the stimulation could induce a pitch and intensity sensation and thus substantially verifying the capab … More ility of ABI Third, we proposed and verified "the multiple gating stimulation," which can selectively activate nerves placing in between electrodes. The technique broadly generated action potentials with "the cathodic sourte electrodes," and simultaneously blocked unnecessary propagation with "the anodic gate electrodes," resulting in selective propagation in between electrodes. We demonstrated the feasibility via simulations with nerve equations and in vivo experiments of rat spinal cord stimulation Forth, our cortical auditory evoked potential (AEP) mapping demonstrated that the rat auditory cortex is divided into the multiple auditory fields, which represent the information of test tones in their respective manner. Fifth, we combined theoretical and experimental works to better understand the spatio-tempomal neuronal activation. We interpreted the contradictory MLR neurogenesis and their various morphologies particularly within early latency, and finally suggested that they were determined by combination of three activities: cortical firing activities, cortical synaptic activities, and other activities far from cortex. Less

Report

(4 results)
  • 2003 Annual Research Report   Final Research Report Summary
  • 2002 Annual Research Report
  • 2001 Annual Research Report
  • Research Products

    (58 results)

All Other

All Publications (58 results)

  • [Publications] 高橋宏知, 他7名: "微小多点表面電極と微小剣山電極の開発とそれらを用いた脳神経系活動の計測"SICE2001(第40回計測自動制御学会学術講演会)講演論文集. (CD-ROM). 110D-2 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] 高橋宏知, 他4名: "近接電場電位のモデル解析と微小表面多点電極で計測した脳神経活動の独立成分解析"SICE2001(第40回計測自動制御学会学術講演会)講演論文集. (CD-ROM). 110D-1 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] 高橋宏知, 他7名: "微小多点表面電極で計測した脳神経活動の独立成分分析法による解析"医用電子と生体工学. 39(特別号). 316 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] 高橋宏知, 他7名: "微小剣山電極を用いた蝸牛神経核における局所刺激および計測"医用電子と生体工学. 39(特別号). 317 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] 高橋宏知, 他7名: "微小多点表面電極で計測した脳神経活動をウェーブレット解析で特徴抽出する試み"医用電子と生体工学. 39(特別号). 318 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] H.Takahashi, 他3名: "Model analysis and independent component analysis of cortical data acquired with surface microelectrode"Proceedings of 23^<rd> annual international conference of the IEEE Engineering in Medicine & Biology Society. (CD-ROM). #691 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] F.Mase, 他6名: "Selective stimulation and measurement in the cochlear nucleus with the spike microelectrode array"Proceedings of 23^<rd> annual international conference of the IEEE Engineering in Medicine & Biology Society. (CD-ROM). #742 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] 高橋宏知, 他6名: "蝸牛神経核の微小電気刺激による聴覚再生技術の開発 -音刺激と電気刺激に対する聴皮質反応の多点計測による比較-"日本機械学会第14回バイオエンジニアリング講演会講演論文集. 43-44 (2002)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] 高橋宏知: "音刺激および電気刺激に対する誘発電位の多点同時計測による聴皮質の機能解明"医学のあゆみ. 200・2. 192-193 (2002)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] 高橋宏知, 他5: "皮質硬膜上から高空間分解能で誘発電位を計測するための微小多点ポリイミド表面電極の開発"電気学会電子情報システム部門誌. 122-C・9. 1459-1468 (2002)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] 高橋宏知, 他3名: "聴性誘発電位の多点計測データの独立成分解析"電気学会電子情報システム部門誌. 122-C・9. 1469-1480 (2002)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Hirokazu Takahashi, 他4: "Multiple gating stimulation for selective activation of nerves in between electrodes"Proceedings of the International Federation for Medical and Biological Engineering,2nd European Medical & Biological Engineering Conference. 3. 786-787 (2002)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Hirokazu Takahashi, 他5: "Auditory evoked-potential mappings unravel functional organizations of rat auditory cortex ; both the primary auditory field (AI) and anterior auditory field (AAF) show tonotopic organization and the latter has extreme loudness-dependence"Abstract of 3rd Forum of European Neuroscience. (CD-ROM). #184.18 (2002)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] 高橋宏知, 他7: "聴覚情報処理の理解とその再建"平成15年電気学会全国大会シンポジウム講演論文集. 3-S17. 18-21 (2003)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] H.Takahashi, et al.: "Microelectrode Array on Folding Polyimide Ribbon for Epidural Mapping of Functional Evoked Potentials"IEEE Transactions on Biomedical Engineering. 50・4. 510-516 (2003)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] H.Takahashi, et al.: "Different strategies for intensity coding in different cortical auditory fields"Proceedings of the International Conference on Auditory Cortex. 67 (2003)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] H.Takahashi, et al.: "Auditory evoked offset responses of rat auditory cortices reflect synchronous post-stimulus resumption of spontaneous discharges"Abstracts of 6th IBRO World Congress of Neuroscience. (CDROM). #2197 (2003)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] H.Takahashi, et al.: "Accessing Cortical Tonotopic Organization by Microstimulation of Cochlear Nucleus"Proceedings of 1st International IEEE EMBS Conference on Neural Engineering. 161-164 (2003)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] 岡野雄一郎, 他: "神経外からの多点同時刺激に対する神経束の挙動のシミュレーション"第18回生体・生理工学シンポジウム講演論文集. 177-180 (2003)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] 高橋宏知, 他: "電極間の神経を選択的に刺激する多点ゲート刺激法"生体医工学. 41(特別号). 276 (2003)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Hirokazu TAKAHALSHI, Takayuki EJIRI, Fumio MASE, Masayuki NAKAO, Yotaro HATAMURA, Naoya NAKAMURA, Kimitaka KAGA, Thierry HERVE: "Surface Microelectrode and Spike Microelectrode Array for Measuring Neuronal Activities"Proceedings of SICE 2001. 110D-2(CD-ROM). (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Hirokazu TAKAHASHI, Masayuki NAKAO, Yotaro HATAMURA, Kimitaka KAGA, Thierry HERVE: "Model Analysis of Near Field Potential and lndependent Component Analysis of Spatio-temporal Cortical Data Acquired with the Surface Microelectrode"Proceedings of SICE 2001. 110D-1CD-ROM. (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Hirokazu TAKAHASHI, Takayuki EJIRI Masayuki NAKAO, Fumio MASE, Yotaro HATAMURA, Naoya NAKAMURA, Kimitaka KAGA, Thierry HERVE: "Independent Component Analysis of Spatio-temporal Neuronal Data Acquired With the Surface Microelectrode"Proceeding of the 40th Canference of the Jqpan Society of Medical Electronics & Biologcal Engineering. 39(Suppl). 316 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Hirokazu TAKAHASHI, Fumio MASE, Masayuki NAKAO, Takayriki EJIRI, Yotaro HATAMURA, Naoya NAKAMURA, Kimitaka KAGA, Thierry HERVE: "Microelectrode Array for Local Stimulation and Measurement of Neuronal Activity at Cochlear Nucleus"Proceeding of the 40th Canference of the Jqpan Society of Medical Electronics & Biologcal Engineering. 39(Suppl). 317 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Hirokazu TAKAHASHI, Takayuki EJIRI Masayuki NAKAO, Fumio MASE, Yotaro HATAMURA, Naoya NAKAMURA, Kimitaka KAGA, Thierry HERVE: "Wavelet Analysis for Feature Extraction of Spatio-temporal Neuronal Data Acquired with the Surface Microelectrode"Proceeding of the 40th Canference of the Jqpan Society of Medical Electronics & Biologcal Engineering. 39(Suppl). 318 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Hirokazu TAKAHASHI, Masaiyuki NAKAO, Kimitaka KAGA, Thierry HERVE: "Model Analysis and Independent Component Analysis of Cortical Data Acquired with Surface Microelectrode"Proceeding of 23rd Annual Intemational Conference of the lEEE Engineeting in Medicine and Biology Society. CD-ROM. 691 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Fumio MASE, Hirokazu TAKAHASHI, Takayuki EJIRI, Masayuki NAKAO, Naoya NAKAMURA, Kimitaka KAGA, Thierry HERVE: "Selective Stimulation and Measurement in the Cochlear Nucleus with the Spike Microelectrode Array"Proceedings of 23rd Annual Intemational Conference of the lEEE Engineering in Medicine and Biology Society. CD-ROM. 742 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Hirokazu TAKAHASHI, Takayuki EJIRI, Fumio MASE, Masayuki NAKAO, Naoya NAKAMURA, Kimitaka KAGA, Thierry HERVE: "Cochlear nucleus micro-stimulation for heating rehabilitation -Comparative estimation of multi-point cortical responses evoked by acoustic and electric stimulation"Proceeding of the 14^<th> Bioengineering Conference 2001 Annual Meeting of BED/JSME. 43-44 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Hirokazu TAKAHASHI: "Functional Organization of Auditory Cortex Elucidated by Auditory and Electrical Evoked-potential Mapping"Journal of Clinical and Experimental Medicine. 200. 192-193 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Hirokazu Takahashi, Takayuki Ejiri Masayuki Nakao, Naoya Nakamura, Kimitaka Kaga, Thierry Herve: "Polyimide multiple-site surface microelectrode for epidural cortical recording of high spatial resolution evoked-potentia1s"Transaction of lEEJ of Japan. 122-C. 1459-1468 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Hirokazu Takahashi, Masayuki Nakao, Kimitaka Kaga, Thierry Herve: "Independent component analysis of multiple-site anditory evoked potentiaIs"Transaction of lEEJ of Japan. 122-C. 1469-1480 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Hirokazu TAKAHASHI, Masayuki NAKAO, yusuke YASUDA, Sheykholeslanmi KIANOUSHI, Kimitaka KAGA: "Multiple gating stimulation for selective activation of nerves in hetween electrodes"Proceedings of the International Federation for Mediail and Biological Engineering, 2nd European Medical & Biological Engineering Conference. 786-787 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Hirokazu TAKAHASHI, Takayuki EJIRI, Masayuki NAKAO, Naoya NAKAMURA, Thierry HERVE, Kimitaka KAGA: "Auditory evoked-potential mappings unravel functional organizations of rat auditory cortex; both the primary auditory field (AI) and anterior auditory field (AAF) show tonotopic organization and the latter has extreme loudness-dependence"Abstract of 3rd Forun of European Neuroscience. CD-ROM. 184.18 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Hirokazu TAKAHASHI, Masayuki NAKAO, Fumio MASE, Takayuki FJIRI, Tetsuji OTA, Thierry Herve, Sebastien Schmerber, Kimitaka KAGA: "Understanding and Restoring Auditory Signal Processing"2003 National Convention Record IEE Japan. 3-S17. 18-21 (2003)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Hirokazu Takahashi, Takayuki Ejiri, Masayuki Nakao, Naoya Nakamura, Kimitaka Kaga, Thierry Herve: "Microelectrode Array on Folding Polyimide Ribbon for Epidural Mapping of Functional Evoked Potentials"IEEE Transactions on Biomedical Engineering. 50. 510-516 (2003)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Takahashu H, Nakao M, Ejiri T, Kaga K: "Different strategies for intensity coding in different cortical anditory fields"Proceedingx of the International Conferece on Auditory, Cortex. 67 (2003)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Takahashi H, Nakao M, Ejiri T, Kaga K: "Auditory evoked offset responses of rat auditory cortices reflect synchronous post-stimulus resumption of spontaneous discharges"Abstracts of 6th IBRO World Congress of Neuroscience. CD-ROM. 2197 (2003)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Hirokazu Takahashi, Fumio Mase, Masayuki Nakao, Takaynki Ejiri, Tetsuji Ota, Thierry Herve, Sebastien A Schmerber, Kimitaka Kaga: "Accessing Cortical Tonotopic Organization by Microstimulation of Cochlear Nucleus"Proceedings of 1st Intenrational IEEE EMBS Conference on Neural Engineering. 161-164 (2003)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Yuichiro OKANO, Hirokazu TAKAHASHI, Nasavuki NAKAO, Kiinitaka KAGA: "Simnlation of nerve bundle behavior induced by simultaneous multipoint extracellular stimulation"Proceedings of 18^<th> BPES. 177-180 (2003)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Hirokazu TAKAHASHI, Yuichiro OKANO, Masayuki NAKAO, Kimitaka KAGA: "Gating stimulation for selective activation of nerves placing in between electrodes"Proceedings of the 41th Conference of the Japan Society of Medical Electronics, & Biological Engineering. 276 (2003)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] H.Takahashi, et al.: "Microelectrode Array on Folding Polyimide Ribbon for Epidural Mapping of Functional Evoked Potentials."IEEE Transactions on Biomedical Engineering. 50・4. 510-516 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] H.Takahashi, et al.: "Different strategies for intensity coding in different cortical auditory fields."Proceedings of the International Conference on Auditory Cortex. 67 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] H.Takahashi, et al.: "Auditory evoked offset responses of rat auditory cortices reflect synchronous post-stimulus resumption of spontaneous discharges."Abstracts of 6th IBRO World Congress of Neuroscience. (CDROM). 2197 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] H.Takahashi, et al.: "Accessing Cortical Tonotopic Organization by Microstimulation of Cochlear Nucleus."Proceedings of 1st International IEEE EMBS Conference on Neural Engineering. 161-164 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] 岡野雄一郎, 他: "神経外からの多点同時刺激に対する神経束の挙動のシミュレーション"第18回生体・生理工学シンポジウム講演論文集. 177-180 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] 高橋宏知, 他: "電極間の神経を選択的に刺激する多点ゲート刺激法"生体医工学. 41(特別号). 276 (2004)

    • Related Report
      2003 Annual Research Report
  • [Publications] Hirokazu Takahashi, 他5: "Multiple-site polyimide surface microelectrode with fold-structure for less-invasive epidural cortical mapping of functional evoked-potentials"IEEE Transactions on Biomedical Engineering. 50・4(印刷中). (2003)

    • Related Report
      2002 Annual Research Report
  • [Publications] 高橋宏知, 他5: "皮質硬膜上から高空間分解能で誘発電位を計測するための微小多点ポリイミド表面電極の開発"電気学会電子情報システム部門誌. 122-C・9. 1459-1468 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] 高橋宏知, 他3: "聴性誘発電位の多点計測データの独立成分解析"電気学会電子情報システム部門誌. 122-C・9. 1469-1480 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] Hirokazu Takahashi, 他4: "Multiple gating stimulation for selective activation of nerves in between electrodes"Proceedings of the International Federation for Medical & Biological Engineering. 3. 786-787 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] Hirokazu Takahashi, 他7: "Accessing Cortical Tonotopic Organization by Microstimulation of Cochlear Nucleus"Proceedings of 1st International IEEE EMBS Conference on Neural Engineering. (印刷中). (2003)

    • Related Report
      2002 Annual Research Report
  • [Publications] Hirokazu Takahashi, 他5: "Auditory evoked-potential mappings unravel functional organizations of rat auditory cortex ; both the primary auditory field (AI) and anterior auditory field (AAF) show tonotopic organization and the latter has extreme loudness-dependence"Abstract of 3rd Forum of European Neuroscience. (CD-ROM). 184.18 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] 高橋宏知: "音刺激および電気刺激に対する誘発電位の多点同時計測による聴皮質の機能解明"医学のあゆみ. 200・2. 192-193 (2002)

    • Related Report
      2001 Annual Research Report
  • [Publications] 高橋宏知, 他7名: "微小多点表面電極と微小剣山電極の開発とそれらを用いた脳神経系活動の計測"SICE2001(第40回計測自動制御学会学術講演会)講演論文集. (CD-ROM). 110D-2 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] 高橋宏知, 他4名: "近接電場電位のモデル解析と微小表面多点電極で計測した脳神経活動の独立成分解析"SICE2001(第40回計測自動制御学会学術講演会)講演論文集. (CD-ROM). 110D-1 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] 高橋宏知, 他7名: "微小多点表面電極で計測した脳神経活動の独立成分分析法による解析"医用電子と生体工学. 39(特別号). 316 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] 高橋宏知, 他7名: "微小剣山電極を用いた蝸牛神経核における局所刺激および計測"医用電子と生体工学. 39(特別号). 317 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] 高橋宏知, 他7名: "微小多点表面電極で計測した脳神経活動をウェーブレット解析で特徴抽出する試み"医用電子と生体工学. 39(特別号). 318 (2001)

    • Related Report
      2001 Annual Research Report

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Published: 2001-04-01   Modified: 2016-04-21  

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