| Project/Area Number |
13555234
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 展開研究 |
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| Research Field |
工業分析化学
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| Research Institution | Kyushu University (2003)
Kumamoto University (2001-2002) |
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Principal Investigator |
IHARA Hirotaka Kyushu University, Inst.Mater.Chem. & Eng., Prof., 先導物質化学研究所, 教授 (10151648)
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| Co-Investigator(Kenkyū-buntansha) |
SAKURAI Toshihiko Kumamoto Univ., Appl.Chem. & Biochem., Assist.Prof., 工学部, 助手 (10332868)
TAKFUJI Makoto Kumamoto Univ., Appl.Chem. & Biochem., Assist.Prof., 工学部, 助手 (50332086)
石原 晋一郎 (株)興人, 新事業開発部, 主任企画員
永岡 昭二 熊本県工業技術センター, 材料開発部, 主任研究員
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| Project Period (FY) |
2001 – 2003
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| Project Status |
Completed (Fiscal Year 2003)
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| Budget Amount *help |
¥11,000,000 (Direct Cost: ¥11,000,000)
Fiscal Year 2003: ¥1,900,000 (Direct Cost: ¥1,900,000)
Fiscal Year 2002: ¥4,200,000 (Direct Cost: ¥4,200,000)
Fiscal Year 2001: ¥4,900,000 (Direct Cost: ¥4,900,000)
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| Keywords | Self-assembling systems / Chirality / Enantiomer / Diastereomer / Ordered structure / Liquid chromatography / Polymer grafting / 塩基性ポリマー / グラフトポリマー / 逆相分配 / 液体クロマトグラフィー / 光学活性 / トリプトファン / ダンシル基 / クシ型ポリマー / シリカゲル / 有機-無機ハイブリッド / グルタミン酸 / 分子認識 / 円二色スペクトル |
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| Research Abstract |
Chiral separation is still significant target in analytical chemistry and separation technology because each enantiomer provides absolutely different action in biosystems. HPLC with chiral stationary phase has been recognized as a facile method to perform it. However, there are few examples those were accomplished with a reversed phase-HPLC mode as the most convenient HPLC. This is due to no hydrophobicity difference in each enantiomer. Therefore, we focused on self-assembled systems to enhance microenvironmental effect in molecular recognition and applied these systems for functional organic stationary phases. Our research project clarified that (1)poly(octadecyl acrylate)-grafted silica showed distinct enhanced selectivity to recognize small difference in the molecular shape of polyaromatic hydrocarbons through disordered-to-ordered stale phase transition of the long-chain alkyl moieties, (2)the enhanced selectivity was brought about from multiple carbonyl-π interaction between the stationary phase and solutes, and (3)combination of this HPLC with diastereomerizing agents showed enhanced selectivity for the resultant diastereomers.
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