| Project/Area Number |
13555259
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (B)
|
| Allocation Type | Single-year Grants |
|---|
| Section | 展開研究 |
|---|
| Research Field |
高分子合成
|
|---|
| Research Institution | Nagoya University |
|---|
Principal Investigator |
NISHIDA Yoshihiro Nagoya University, DEPARTMENT OF MOLECULAR DESIGN & ENGINEERING, GRADUATE SCHOOL OF ENGINEERING, ASSOCIATE PROFESSOR, PhD, 工学研究科, 助教授 (80183896)
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
MATSUDA Kazuhiro Nagoya University, DIVISON OF VIRUS, NATIONAL CANCER INSTITUTE, CHIEF RESEARCHER, PhD, ウイルス部, 主任研究官 (80251502)
KOBAYASHI Kazukiyo Nagoya University, DEPARTMENT OF MOLECULAR DESIGN & ENGINEERING, GRADUATE SCHOOL OF ENGINEERING, PROFESSOR, PhD, 工学研究科, 教授 (10023483)
|
|---|
| Project Period (FY) |
2001 – 2002
|
| Project Status |
Completed (Fiscal Year 2002)
|
| Budget Amount *help |
¥4,700,000 (Direct Cost: ¥4,700,000)
Fiscal Year 2002: ¥1,800,000 (Direct Cost: ¥1,800,000)
Fiscal Year 2001: ¥2,900,000 (Direct Cost: ¥2,900,000)
|
|---|
| Keywords | oligosaccharide / cell surface / mimic synthesis / carbohydrate module / polymerization / selectin / antagonist / sulfate / グルコシル化 |
|---|
| Research Abstract |
A novel method to mimic the biologically active structure of cell surface oligosaccharide has been investigated in terns of carbohydrate module method. The method, thus established in this project, involves the segmentation of an oligosaccharide antigen into two simpler saccharides and the regeneration of the bioactive structure by their radical copolymerization with acrylamide. A series of carbohydrate modules constructing each of Lewis-X, sialyl Lewis-X, and 6-sulfo-sialyl Lewis-X antigens were mimicked by the module approach and evaluated for their potential as L-selectin antgonists, in which multivalent 6-sulfo-D-GlcNAc was found to possess high biological potential.
|
