| Project/Area Number |
13557001
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 展開研究 |
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| Research Field |
General anatomy (including Histology/Embryology)
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| Research Institution | Kyoto University |
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Principal Investigator |
SHIOTA Kohei Kyoto Univ, Grad Sch of Medicine, Professor, 医学研究科, 教授 (80109529)
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| Co-Investigator(Kenkyū-buntansha) |
MIZUTA Shinobu Kyoto Univ, Academic Center for Computing and Media Studies, Professor, 学術情報メディアセンター, 助手 (40314265)
MINO Michihiko Professor, Academic Center for Computing and Media Studies, Assistant Professor, 学術情報メディアセンター, 教授 (70166099)
MATSUDA Tetsuya Kyoto Univ, Grad Sch of Medicine, Professor, 情報学研究科, 教授 (00209561)
KOSE Katsumi Kose Univ of Tsukuba, Institute of Applied Physics, Professor, 物理工学系, 教授 (60186690)
TOGASHI Kaori Kyoto Univ, Grad Sch of Medicine, Professor, 医学研究科, 教授 (90135484)
中津 智子 京都大学, 医学研究科, 助手 (60335271)
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| Project Period (FY) |
2001 – 2003
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| Project Status |
Completed (Fiscal Year 2003)
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| Budget Amount *help |
¥13,600,000 (Direct Cost: ¥13,600,000)
Fiscal Year 2003: ¥4,000,000 (Direct Cost: ¥4,000,000)
Fiscal Year 2002: ¥3,800,000 (Direct Cost: ¥3,800,000)
Fiscal Year 2001: ¥5,800,000 (Direct Cost: ¥5,800,000)
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| Keywords | Human embryo / 3D image / Human fetus / Database / MR microscope / Embryology / MR顕微鏡 / 器官発生 / 画像データベース |
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| Research Abstract |
1) Three-dimensional (3D) MR microscope images of staged human embryos (Kyoto Collection of Human Embryos) were acquired using an MR microscope with a 1.OT permanent magnet T1 weighted 3D spin-echo imaging sequences,(TR=l00ms, TE =8-12ms, 128X128X128 image voxels) were used and 4-16 signals were accumulated to improve the SNR of the images. The spatial resolutions of 50-200 micron cube were obtained within 8 hours, which enabled to observe detailed external and internal structures of human embryos. To facilitate imaging of a large number of human embryos (over 4,000 cases), we developed a four-cal parallel MR microscope (super-parallel MR microscope) with a 234T/40cm superconducting magnet to achieve higher spatial resolutions. We aim at establishing a database of 3D MR images of 4,000 embryos within the next few years.
2) Based on MR microscopic images, we developed a computer graphic (CG) animaltion and a VRML system for constructing educational softwares on human prenatal development for biomedical education. We established a method to automatically extract the MR image of specific organs such as the brain, heart, and liver.
3) We made 3D models and movie demonstration systems of human development for embryological education. So far, tentative educational programs have been made for the development of the body, craniofacial structures, limbs, heart and great vessels, digestive tract, and central nervous system. The method developed is applicable to various fields in medical education.
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