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Pathogenomics of collagen disease using synthetic polymorphic proteins and BAG transgenic mice

Research Project

Project/Area Number 13557018
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section展開研究
Research Field Experimental pathology
Research InstitutionEhime University

Principal Investigator

NOSE Masato  Ehime Univ., Med., Pathol., Prof, 医学部, 教授 (70030913)

Co-Investigator(Kenkyū-buntansha) MIYAZAKI Tatsuhiko  Ehime Univ., Med., Pathol., Instructor, 医学部, 助手 (80239384)
ONO Masao  Ehime Univ., Med., Pathol., Ass.Prof, 医学部, 助教授 (20302218)
ENDO Yaeta  Ehie Univ.Eng., Appl.Chem., Prof., 工学部, 教授 (40093843)
TAKAHASHI Satoru  Univ.Tsukuba, Basic Med.Sci., Prof., 基礎医学系, 教授 (50271896)
Project Period (FY) 2001 – 2002
Project Status Completed (Fiscal Year 2002)
Budget Amount *help
¥13,400,000 (Direct Cost: ¥13,400,000)
Fiscal Year 2002: ¥5,700,000 (Direct Cost: ¥5,700,000)
Fiscal Year 2001: ¥7,700,000 (Direct Cost: ¥7,700,000)
Keywordscollagen discase / linkago analysis / collagen disease-susceptibility loci / protein synthesis in cell free system / synthetic polymorphic proteins / recombinant inbred strains of mice / BAC transgenic mice / pathogenomics / 自己抗体 / ポリジーン / リンケージ解析 / 位置的候補遺伝子 / RI系統マウス / BACコンティグ / 血管炎
Research Abstract

Collagen disease involving SLE and RA shows a complex pathological manifestation such as glomerulonephritis, vasculitis, arthritis and/or sialoadenitis, which seems to result from the cumulative effect of multiple gene loci with an allelic combination. In this research, we focused on to identify these genes in MRL model mice.
MRL/MpJ-lpr/lpr mice bearing a Fas deletion mutant gene lprr (MRL/lpr), spontaneously develop various forms of collagen disease in the same individuals, including glomerulonephritis, polyarteritis, arthritis and sialoadenitis, associated with an MRL background. Previously, we mapped susceptibility loci to each lesion with polymorphic microsatellite markers using N2 backcross and F2 intercross mice with C3H/lpr mice, and clarified that gene loci responsible for each lesion exist at different chromosomal positions and they have additive and hierarchical properties in a polygenic manner. To identify the candidate genes for each locus, we performed novel strategies. 1) functional analyses of synthetic polymorphic proteins corresponding to the candidate genes in vitro, 2) development of recombinant inbred strains of mice between MRL/lpr and C3H/lpr mice and the strain distribution pattern table, followed by the pathogenimics studies, 3) development of transgenic mice with BAG (bacterial artificial chromosomes) corresponding to the positional candidate loci, followed by the pathological analyses.
We conclude that these studies were efficient to clarify the susceptibility genes to polygenic diseases involving collagen disease based on functional genomics.

Report

(3 results)
  • 2002 Annual Research Report   Final Research Report Summary
  • 2001 Annual Research Report
  • Research Products

    (55 results)

All Other

All Publications (55 results)

  • [Publications] Tsuneyama K, Nose M, Nisihara M, Katayanagi K, Harada K, Nakanuma Y.: "Spontaneous occurrence of chronic non-suppurative destructive cholangitis and antimitochondrial autoantibodies in MRL/lpr mice: possible animal model for primary biliary cirrhosis"Pathol Int. 51. 418-424 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Kanemoto N, Kondo M, Iwanaga T, Hishigaki H, Ono T, Mizoguchi-Miyata A, Oga K, Tsuji A, Okuno S, Watanabe TK, Nose M, Tanigami A.: "Genetic analysis of pancreatic duct hyperplasia in Otsuka Long-Evans Tokushima Fatty rats: Possible association with a region on rat chromosome 14 that includes the disrupted cholecystokinin-A receptor gene.:"Pathol Int. 51. 133-139 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Yamada M, Takeshita T, Miura S, Murata K, Kimura Y, Ishii N, Nose M, Sakagami H, Kondo H, Tashiro F, Miyazaki JI, Sasaki H, Sugamura K.: "Loss of hippocampal CA3 pyramidal neurons in mice lacking STAM1"Mol Cell Biol. 21. 3807-3819 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Kuroda Y, Nakata M, Nose M, Kojima N, Mizuochi T.: "Abnormal IgG galactosylation and arthritis in MRL-Fas lpr of MRL-FAS Lgld mice are under the control of the MRL genetic background"FEBS Letters. 507. 210-214 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Sawasaki T, Oka T, Endo Y.: "Liver perchloric acid-soluble ribonuclease"Methods Enzymol. 34. 44-54 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Yoh K, Itoh K, Enomoto A, Hirayama A, Yamaguchi N, Kobayashi M, Morito N, Koyama A, Yamamoto M, Takahashi S.: "Nrf2-deficient female mice develop lupus-like autoimmune nephritis"Kidney Int. 60. 343-345 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Yuasa T, Ono M, Watanabe T, Takai F.: "Lyn is essential for Fcγ receptor III-mediated systemic anaphylaxis but not for the Arthus reaction"J Exp Med. 193. 563-571 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Takai T, Ono M.: "Activating and inhibitory nature of the murine paired immunoglobulin-like receptor family"Immunol Rev. 181. 215-222 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Ito RM, Nose M.: "A case of segmental mediolytic arteriopathy involving both intracranial and intraabdominal arteries"Pathol Res Pract. 198. 499-500 (2002)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Takahashi S, Araki K, Araki M, Ito MR, Nakatani K, Fujii H, Izui S, Vassalli P, Nose M.: "Suppression of experimental lupus nephritis by aberrant expression of the solublu E-selectin gene"Pathol Int. 52. 175-180 (2002)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Kamogawa J, Terada M, Mizuki S, Nishihara M, Yamamoto H, Mori S, Abe Y, Morimoto K, Nakatsuru S, Nakamura Y, Nose M.: "Arthritis in MRL/lpr mice is under the control of multiple gene loci with an allelic combination derived from the original inbred strains"Arthritis Rheum. 46. 1067-1074 (2002)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Qu WM, Miyazaki T, Terada M, Okada K, Mori S, Kanno H, Nose M.: "A novel autoimmune pancreatitis model in MRL mice treated with polyinosinic:polycytidylic acid"Clin Exp Immunol. 129. 27-34 (2002)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Masui N, Takagi Y, Nishikawa T, Yanabe M, Nose M, Sato K.: "New PCR-RFLP analysis for the mouse Tnfsf6gld gene caused by a point mutation in the Tnfsf6 (tumor necrosis factor (Ligand) superfamily, member 6) locus"Exp Anim. 51. 501-503 (2002)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Sawasaki T, Ogasawara T, Morishita R, Endo Y.: "A cell-free protein synthesis system for high-throughput proteomics"Proc Natl Acad Sci U S A. 99. 4652-4657 (2002)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Sawasaki T, Hasegawa Y, Tsuchimochi M, Kamura N, Ogasawara T, Kuroita T, Endo Y.: "A bilayer cell-free protein synthesis system for high-throughput screening of gene products"FEBS Lett. 514. 102-105 (2002)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Xiu Y, Nakamura K, Abe M, Li N, Wen XS, Jiang Y, Zhang D, Tsurui H, Matsuoka S, Hamano Y, Fujii H, Ono M, Takai T, Shimokawa T, Ra C, Shirai T, Hirose S.: "Transcriptional regulation of Fcvgr2b gene by polymorphic promoter region and its contribution to humoral immune responses"J Immunol. 169. 4340-4346 (2002)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Hirasawa R, Shimizu R, Osawa M, Takayanagi S, Kato Y, Onodera M, Minegishi N, Takahashi S, Yamamoto M, Fukao K, Nakauchi H, Iwama A.: "Essential and instructive roles of GATA-1 in eosinophil development"J Exp Med. 195. 1379-1386 (2002)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Fujino T, Asaba H, Kang MJ, Ikeda Y, Sone H, Takada S, Kim DH, Ioka RX, Ono M, Tomoyori H, Okubo M, Murase T, Kamataki A, Yamamoto J, Magoori K, Takahashi S, Miyamoto Y, Oishi H, Nose M. Okazaki M, Usui S, Imaizumi K, Yanagisawa M, Sakai J, Yamamoto TT.: "Low-density lipoprotein receptor-related protein 5 (LRP5) is essential for normal cholesterol metabolism and glucose-induced insulin secretion"Proc Natl Acad Sci U S A. 100. 229-234 (2003)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Yamada A, Miyazaki T, Lu LM, Ono M, Ito MR, Terada M, Mori S, Hata K, Nozaki Y, Nakatsuru S, Nakamura Y, Onji M, Nose M.: "Genetic basis of tissue-specificity of vasculitis in MRL/lprmice"Arthritis Rheum. (in press).

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Magoori K, Kang MJ, Iwasaki MI, Kakuuchi H, Ioka RX, Kamataki A, Kim DH, Asaba H, Iwasaki S.Takei YA, Sasaki M, Usui S, Okazaki M, Takahashi S, Ono M, Nose M, Sakai J, Fujino T, Yamamoto TT.: "Severe Hypercholesterolemia, impaired fat tolerance and advanced atherosclerosis in mice lacking both LDL receptor-related protein 5 (LRP5) and apolipoprotein E"J Biol Chem. (in press).

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Tsuneyama K, Nose M, Nisihara M, Katayanagi K, Harada K, Nakanuma Y: "Spontaneous occurrence of chronic non-suppurative destructive cholangitis and antimitochondrial autoantibodies in MRL/lpr mice : possible animal model for primary billary cirrhosis"Pathol Int. 51. 418-424 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Kanemoto N, Kondo M, Iwanaga T, Hishigaki H, Ono T, Mizoguchi-Miyata A, Oga K, Tsuji A, Okuno S, Watanabe TK, Nose M, Tanigami A: "Genetic analysis of pancreatic duct hyperplasia in Otsuka Long-Evans Tokushima Fatty rats : Possible association with a region on rat chromosome 14 that includes the disrupted cholecystokinin- A receptor gene"Pathol Int. 51. 133-139 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Yamada M, Takeshita T, Miura S, Murata K, Kimura Y, Ishii N, Nose M, Sakagami H, Kondo H, Tashiro F, Miyazaki JI, Sasaki H, Sugamura K: "Loss of hippocampal CA3 pyramidal neurons in mice lacking STAM1"Mol Cell Biol. 21. 3807-3819 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Kuroda Y, Nakata M, Nose M, Kojima N, Mizuochi T: "Abnormal IgG galactosylation and arthritis in MRL-Fas lpr of MRL-FAS Lgid mice are under the control of the MRL genetic background"FEBS Letters. 507. 210-214 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Sawasaki T, Oka T, Endo Y: "Liver perchloric acid-soluble ribonuclease"Methods Enzymol. 34. 44-54 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Yoh K, Itoh K, Enomoto A, Hirayama A, Yamaguchi N, Kobayashi M, Morito N, Koyama A, Yamamoto M, Takahashi S: "Nrf2-deficient female mice develop lupus-like autoimmune nephritis"Kidney Int. 60. 343-345 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Yuasa T, Ono M, Watanabe T, Takai T: "Lyn is essential for Fcγ receptor III-mediated systemic anaphylaxis but not for the Arthus reaction"J Exp Med. 193. 563-571 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Takai T, Ono M: "Activating and inhibitory nature of the murine paired immunoglobulin-like receptor family"Immunol Rev. 181. 215-222 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Ito RM, Nose M: "A case of segmental mediolytic arteriopathy involving both intracranial and intraabdominal arteries"Pathol Res Pract. 198. 499-500 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Takahashi S, Araki K, Arakl M, Ito MR, Nakatani K, Fujii H, Izui S, Vassalli P, Nose M: "Suppression of experimental lupus nephritis by aberrant expression of the solublu E-selectin gene"Pathol Int. 52. 175-180 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Kamogawa J, Terada M, Mizuki S, Nishihara M, Yamamoto H, Mori S, Abe Y, Morimoto K, Nakatsuru S, Nakamura Y, Nose M.: "Arthritis in MRL/lpr mice is under the control of multiple gene loci with an alielic combination derived from the original inbred strains"Arthritis Rheum. 46. 1067-1074 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Qu WM, Miyazaki T, Terada M, Okada K, Mori S, Kanno H, Nose M: "A novel autoimmune pancreatitis model in MRL mice treated with polyinosinic : poly cytidylic acid"Clin Exp Immunol. 129. 27-34 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Masui N, Takagi Y, Nishikawa T, Yanabe M, Nose M, Sato K: "New PCR-RFLP analysis for the mouse Tnfsf6gld gene caused by a point mutation in the Tnfsf6 (tumor necrosis factor (Ligand) superfamily, member 6) locus"Exp Anim. 51. 501-503 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Sawasaki T, Ogasawara T, Morishita R, Endo Y: "A cell-free protein synthesis system for high-throughput proteomics"Proc Natl Acad Sci USA. 9923. 4652-4657 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Sawasaki T, Hasegawa Y, Tsuchimochi M, Kamura N, Ogasawara T, Kuroita T, Endo Y: "A bilayer cell-free protein synthesis system for high-throughput screening of gene products"FEBS Lett. 514. 102-105 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Xiu Y, Nakamura K, Abe M, Li N, Wen XS, Jiang Y, Zhang D, Tsurui H, Matsuoka S, Hamano Y, Fujii H, Ono M, Takai T, Shimokawa T, Ra C, Shirai T, Hirose S: "Transcriptional regulation of Fcvgr2b gene by polymorphic promoter region and its contribution to humoral immune responses"J Immunol. 169. 4340-4346 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Hirasawa R, Shimizu R, Osawa M, Takayanagi S, Kato Y, Onodera M, Minegishi N, Takahashi S, Yamamoto M, Fukao K, Nakauchi H, Iwama A: "Essential and instructive roles of GATA-1 in eosinophil development"J Exp Med. 195. 1379-1386 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Fujino T, Asaba H, Kang MJ, Ikeda Y, Sone H, Takada S, Kim DH, Ioka RX, Ono M, Tomoyori H, Okubo M, Murase T, Kamataki A, Yamamoto J, Magoori K, Takahashi S, Miyamoto Y, Oishi H, Nose M, Okazaki M, Usui S, Imaizumi K, Yanagisawa M, Sakai J, Yamamoto TT: "Low-density lipoprotein receptor-related protein 5 (LRP5) is essential for normal cholesterol metabolism and glucose-induced insulin secretion"Proc Natl Acad Sci USA. 100. 229-234 (2003)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Yamada A, Miyazaki T, Lu LM, Ono M, Ito MR, Terada M, Mori S, Hata K, Nozaki Y, Nakatsuru S, Nakamura Y, Onji M, Nose M: "Genetic basis of tissue-specificity of vasculitis in MRL/lprmice"Arthritis Rheum. (in press).

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Magoori K, Kang MJ, Iwasaki MI, Kakuuchi H, loka RX, Kamataki A, Kim DH, Asaba H, Iwasaki S, Takei YA, Sasaki M, Usui S, Okazaki M, Takahashi S, Ono M, Nose M, Sakai J, Fujino T, Yamamoto TT: "Severe Hypercholesterolemia, impaired fat tolerance and advanced atherosclerosis in mice lacking both LDL receptor-related protein 5 (LRP5) and apolipoprotein E"J Biol Chem. (in press).

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Yamada A, Miyazaki T, Lu LM, Ono M, Ito MR, Terada M, Mori S, Hata K, Nozaki Y, Nakatsuru S, Nakamura Y, Onji M, Nose M.: "Genetic basis of tissue-specificity of vasculitis in MRL/lprmice"Arthritis Rheum. (in press).

    • Related Report
      2002 Annual Research Report
  • [Publications] Magoori K, Kang MJ, Iwasaki MI, Kakuuchi H, Ioka RX, Kamataki A, Kim DH, Asaba H, Iwasaki S.Takei YA, Sasaki M, Usui S, Okazaki M, Takahashi S, Ono M, Nose M, Sakai J, Fujino T, Yamamoto TT.: "Severe hypercholesterolemia, impaired fat tolerance and advanced atherosclerosis in mice lacking both LDL receptor-related protein 5 (LRP5) and apolipoprotein E"J Biol Chem. (in press).

    • Related Report
      2002 Annual Research Report
  • [Publications] Fujino T, Asaba H, Kang MJ, Ikeda Y, Sone H, Takada S, Kim DH, Ioka RX, Ono M, Tomoyori H, Okubo M, Murase T, Kamataki A, Yamamoto J, Magoori K, Takahashi S, Miyamoto Y, Oishi H, Nose M. Okazaki M, Usui S, Imaizumi K, Yanagisawa M, Sakai J, Yamamoto TT.: "Low-density lipoprotein receptor-related protein 5 (LRP5) is essential for normal cholesterol metabolism and glucose-induced insulin secretion"Proc Natl Acad Sci U S A. 100. 229-234 (2003)

    • Related Report
      2002 Annual Research Report
  • [Publications] Ito MR, Nose M.: "A case of segmental mediolytic arteriopathy involving both intracranial and intraabdominal arteries"Pathol Res Pract. 198. 499-500 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] Takahashi S.Araki K, Araki M, Ito MR, Nakatani K, Fujii H, Izui S, Vassalli P, Nose M.: "Suppression of experimental lupus nephritis by aberrant expression of the solublu E-selectin gene"Pathol Int. 52. 175-180 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] Kamogawa J, Terada M, Mizuki S, Nishihara M, Yamamoto H, Mori S, Abe Y, Morimoto K, Nakatsuru S, Nakamura Y, Nose M.: "Arthritis in MRL/lpr mice is under the control of multiple gene loci with an allelic combination derived from the original inbred strains"Arthritis Rheum. 46. 1067-1074 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] Yamada M, Takeshita T, Miura S, Murata K, Kimura Y, Ishii N, Nose M, Sakagami H, Kondo H, Tashiro F, Miyazaki JI, Sasaki H, Sugamura K: "Loss of hippocampal CA3 pyramidal neurons in mice lacking STAM1"Mol Cell Biol.. 21. 3807-3819 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] Kuroda Y, Nakata M, Nose M, Kojima N, Mizuochi T: "Abnormal, IgG galactosylation and arthritis in MRL-Fas^<lpr> of MRL-FASL^<gld> mice are under the control of the MRL genetic background"FEBS Letters. 507. 210-214 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] Takahashi S, Araki K, Araki M, Ito MR, Nakatani K, Fujii H, Izui S, Vassalli P, Nose M: "Suppression of experimental lupus nephritis by aberrant expression of the solublu E-selectin gene"Pathol Int.. (in press).

    • Related Report
      2001 Annual Research Report
  • [Publications] Kamogawa J, Terada M, Mizuki S, Nishihara M, Yamamoto H, Mori S, Abe Y, Morimoto K, Nakatsuru S, Nakamura Y, Nose M: "Arthritis in MRL/lpr mice is under the control of multiple gene loci with an allelic combination derived from the original inbred strains"Arthritis Rheum. (in press).

    • Related Report
      2001 Annual Research Report
  • [Publications] Sawasaki T, Oka T, Endo Y: "Liver perchloric acid-soluble ribonuclease"Methods Enzymol. 342. 44-54 (2000)

    • Related Report
      2001 Annual Research Report
  • [Publications] Takai T, Ono M: "Activating and Inhibitory nature of the murine paired Immunoglobulin-like receptor family"Immunol Rev.. 181. 215-222 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] Yuasa T, Ono M, Watanabe T, Takai T: "Lyn is essential for fcgamma receptor III-mediated systemic anaphylaxis but not for the Arthus reaction"J Exp Med.. 193. 563-572 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] Yoh K, Sugawara T, Motohashi H, Takahama Y, Koyama A, Yamamoto M, Takahashi S: "Transgenic over-expression of MafK suppresses T cell proliferation and function in vivo"Genes Cells. 6. 1055-1066 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] Yoh K, Itoh K, Enomoto A, Hirayama A, Yamaguchi N, Kobayashi M, Morito N, Koyama A, Yamamoto M, Takahashi S: "Nrf2-deficient female mice develop lupus-like autoimmune nephritis"Kidney Int.. 60. 1343-1353 (2001)

    • Related Report
      2001 Annual Research Report

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Published: 2001-04-01   Modified: 2016-04-21  

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