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Development of evaluation system for cancer chemopreventive agents based on DNA damage inhibition and gene expression

Research Project

Project/Area Number 13557030
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section展開研究
Research Field Hygiene
Research InstitutionMie University

Principal Investigator

KAWANISHI Shosuke  Mie University, Professor, 医学部, 教授 (10025637)

Co-Investigator(Kenkyū-buntansha) HIRAKU Yusuke  Mie University, Faculty of Medicine, Research Associate, 医学部, 助手 (30324510)
OIKAWA Shinji  Mie University, Faculty of Medicine, Assistant Professor, 医学部, 講師 (10277006)
MURATA Mariko  Mie University, Faculty of Medicine, Assistant Professor, 医学部, 講師 (10171141)
KAWANISHI Michiko  Kyoto University, Faculty of Medicine, Research Associate, 大学院・医学研究科, 助手 (60025616)
HIRAKAWA Kazutaka  Mie University, Faculty of Medicine, Research Associate, 生命科学研究支援センター, 助手 (60324513)
Project Period (FY) 2001 – 2003
Project Status Completed (Fiscal Year 2003)
Budget Amount *help
¥14,200,000 (Direct Cost: ¥14,200,000)
Fiscal Year 2003: ¥2,700,000 (Direct Cost: ¥2,700,000)
Fiscal Year 2002: ¥2,200,000 (Direct Cost: ¥2,200,000)
Fiscal Year 2001: ¥9,300,000 (Direct Cost: ¥9,300,000)
Keywordscancer chemoprevention / DNAdamage / reactive oxygen species / safety evaluation / efficacy evaluation / proteome analysis / catechins / isoflavones / 抗酸化物質 / クルクミン / グルタチオン / 第一次予防 / フィチン酸
Research Abstract

Antioxidantg, such as vitamins and flavonoids contained in vegetables and fruits, have been believed to play the key role in cancer prevention. However, epidemiological studies demonstrated that b-carotene increased the incidences of lung cancer. We reported that b-carotene metabolites induced oxidative DNA damage. To establish the method to promote effective and Safe cancer chemoprevention, we investigated DNA damage and gene expression induced by chemopreventive agents as follows
1. Phytic acid contained in cereals inhibited oxidative DNA damage in cultured cells. Phytic acid alone did not cause DNA damage. Thus, it can be a promising cancer chemopreventive agent.
2. Although curcumin exhibits antitumor activity, carcinogenic properties have been reported. Curcumin treated with CYP2D6 induced DNA damage in the presence of Cu(II). Therefore, curcumin may exhibit carcinogenic potential through oxidative DNA damage by its metabolite.
3. Whereas green tea catechins mediate cancer chemopreve … More ntive effects, epidemiological studies indicated positive relationship between green tea consumption and cancer. Catechins induced oxidative DNA damage in human cultured cells. Therefore, oxidative DNA damage may mediate carcinogenesis by catechins.
4. Soy isoflavones are representative phytoestrogens that function as cancer chemopreventive agents. However, recent studies indicated that these isoflavones induced cancer of reproductive organs. Our findings suggest that oxidative DNA damage by isoflavone metabolites participates in tumor initiation and that cell proliferation by isoflavones themselves induces tumor promotion.
5. we provided an extremely sensitive and specific method to quantify glutathione and other thiols using an electrochemical detector coupled to HPLC with a specially devised gold electrode.
6. To examine protein expression by chemopreventive agents, we are performing proteome analysis using peptide mass fingerprinting. In estrogen-sensitive human breast cancer cells, estrogenic compounds increased the expression of VEFG-C, whereas the expression of flotillin-1, hnRNP L and lamin was decreased. Proteome analysis enables to evaluate the safety and effectiveness of chemopreventive agents. Less

Report

(4 results)
  • 2003 Annual Research Report   Final Research Report Summary
  • 2002 Annual Research Report
  • 2001 Annual Research Report
  • Research Products

    (181 results)

All Other

All Publications (181 results)

  • [Publications] 及川伸二: "カテキン類による酸化的DNA損傷"医学のあゆみ. 208. 688-689 (2004)

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  • [Publications] 大西志保: "アクリロニトリルによる酸化的DNA損傷の増強作用と塩基特異性の変化;アクリロニトリル由来ラジカルの役割"磁気共鳴と医学(大和田繁, 吉川敏一 編). 17. 128-131 (2002)

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  • [Publications] 坂野克久: "発酵食品に含まれるウレタン代謝物によるDNA損傷の分子機構"磁気共鳴と医学(大和田繁, 吉川敏一 編). 17. 135-138 (2002)

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  • [Publications] 及川伸二: "環境因子による酸化的DNA損傷とがん、老化"Environmental Mutagen Research (環境変異原研究). 23. 207-213 (2001)

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  • [Publications] N.Ma: "Accumulation of 8-nitroguanine in human gastric epithelium induced by Helicobacter pylori infection"Biochem.Biophys.Res.Commun.. (in press). (2004)

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  • [Publications] S.Pinlaor: "Repeated infection with Opisthorchis viverrini induces accumulation of 8-nitroguanine and 8-oxo-7,8-dihydro-2'-deoxyguanine in the bile duct of hamsters via inducible nitric oxide synthase"Carcinogenesis. (in press). (2004)

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  • [Publications] T.Iwamoto: "DNA intrastrand cross-link at the 5'-GA-3' sequence formed by busulfan and a role in its cytotoxic effect."Cancer Sci.. (in press). (2004)

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  • [Publications] H.Kobayashi: "Metal-mediated oxidative damage to cellular and isolated DNA by gallic acid, a metabolite of antioxidant propyl gallate"Mutat.Res.. 558. 111-120 (2004)

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  • [Publications] M.Murata: "Oxidative DNA damage induced by nitrotyrosine, a biomarker of inflammation"Biochem.Biophys.Res.Commun.. 316. 123-128 (2004)

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  • [Publications] M.Murata: "Genistein and daidzein induce cell proliferation and their metabolites cause oxidative DNA damage in relation to isoflavone-induced cancer of estrogen-sensitive organs"Biochemistry. 43. 2569-2577 (2004)

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  • [Publications] K.Seike: "Oxidative DNA damage induced by benz[a]anthracene metabolites via redox cycles of quinone and unique non-quinone"Chem.Res.Toxicol.. 16. 1470-1476 (2003)

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  • [Publications] M.Murata: "Oxidative DNA damage by hyperglycemia-related aldehydes and its marked enhancement by hydrogen peroxide"FEBS Lett.. 554. 138-142 (2003)

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  • [Publications] S.Oikawa: "Catechins induce oxidative damage to cellular and isolated DNA through the generation of reactive oxygen species"Free Radic.Res.. 37. 881-890 (2003)

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  • [Publications] A.Fnrukawa: "(-)-Epigallocatechin gallate causes oxidative damage to isolated and cellular DNA"Biochem.Pharmacol.. 66. 1769-1778 (2003)

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  • [Publications] S.Nakashima: "Vacuolar H^+-ATPase Inhibitor induces apoptosis via lysosomal dysfunction in the human gastric cancer cell line MKN-1"J.Biochem.(Tokyo). 134. 359-364 (2003)

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  • [Publications] S.Tada-Oikawa: "Mechanism for generation of hydrogen peroxide and change of mitochondrial membrane potential during rotenone-induced apoptosis"Life Sci.. 73. 3277-3288 (2003)

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  • [Publications] S.Pinlaor: "8-nitroguanine formation in the liver of hamsters infected with Opisthorchis viverrini"Biochem.Biophys.Res.Commun.. 309. 567-571 (2003)

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  • [Publications] K.Ogawa: "Molecular mechanisms of DNA damage induced by procarbazine in the presence of Cu(II)"Mutat.Res.. 539. 145-155 (2003)

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  • [Publications] H.Mizutani: "Distinct mechanisms of site-specific oxidative DNA damage by doxorubicin in the presence of copper(II) and NADPH-cytochrome P450 reductase"Canser Sci.. 94. 686-691 (2003)

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  • [Publications] T.Iwamoto: "Oxidative DNA damage induced by photodegradation products of 3'-azido-3'-deoxythymidine"Arch.Biochem.Biophys.. 416. 155-163 (2003)

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  • [Publications] S.Oikawa: "Oxidative damage to cellular and isolated DNA by homocysteine : implications for carcinogenesis"Oncogene. 22. 3530-3538 (2003)

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  • [Publications] C.Toda: "DNA damage by ethylbenzenehydroperoxide formed from carcinogenic ethylbenzene by sunlight irradiation"Biochem.Biophys.Res.Commun.. 304. 638-642 (2003)

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  • [Publications] N.Nakai: "Oxidative DNA damage induced by toluene is involved in its male reproductive toxicity"Free Radic.Res.. 37. 69-76 (2003)

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  • [Publications] K.Hirakawa: "Carcinogenic semicarbazide induces sequence-specific DNA damage through the generation of reactive oxygen species and the derived organic radicals"Mutat.Res.. 536. 91-101 (2003)

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  • [Publications] K.Hirakawa: "Sequence-specific DNA damage induced by ultraviolet A-irradiated folic acid via its photolysis product"Arch.Biochem.Biophys. 410. 261-268 (2003)

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  • [Publications] K.Hirakawa: "Base oxidation at 5' site of GG sequence in double-stranded DNA induced by UVA in the presence of xanthone analogues : relationship between the DNA-damaging abilities of photosensitizers and their HOMO energies"Photochem.Photobiol.. 77. 349-355 (2003)

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  • [Publications] K.Sakano: "Metabolism of carcinogenic urethane to nitric oxide is involved in oxidative DNA damage"Free Radic.Biol.Med.. 33. 703-714 (2002)

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  • [Publications] Y.Hiraku: "Determination of intracellular glutathione and thiols by high performance liquid chromatography with a gold electrode at the femtomole level : comparison with a spectroscopic assay"Biochim.Biophys.Acta.. 1570. 47-52 (2002)

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  • [Publications] S.Kawanishi: "The role of metals in site-specific DNA damage with reference to carcinogenesis"Free Radic.Biol.Med.. 32. 822-832 (2002)

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  • [Publications] M.Murata: "Oxidation of 5'-site guanine at GG and GGG sequences induced by a metabolite of carcinogenic heterocyclic amine PhIP in the presence of Cu(II) and NADH"Carcinogenesis. 23. 855-860 (2002)

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  • [Publications] H.Mizutani: "Mechanism of apoptosis induced by a new topoisomerase inhibitor through the generation of hydrogen peroxide"J.Biol.Chem.. 277. 30684-30689 (2002)

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  • [Publications] S.Ohnishi: "Oxidative DNA damage induced by a metabolite of 2-naphthylamine, a smoking-related bladder carcinogen"Jpn.J.Cancer Res.. 93. 736-743 (2002)

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  • [Publications] S.Homma-Takeda: "2,4,6-Trinitrotoluene-indeced reproductive toxicity via oxidative DNA damage by its metabolite"Free Radic.Res.. 36. 555-566 (2002)

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  • [Publications] K.Midorikawa: "Hydroxylation of deoxyguanosine at 5' site of GG and GGG sequences in double-stranded DNA induced by carbamoyl radicals"Free Radic.Res.. 36. 667-675 (2002)

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  • [Publications] S.Oikawa: "Site-specific hydroxylation at polyguanosine in double-stranded DNA by nickel(II) in the presence of SH compounds : comparison with singlet oxygen-induced DNA damage"Chem.Res.Toxicol.. 15. 1017-1022 (2002)

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  • [Publications] K.Sakano: "Metal-mediated DNA damage induced by curcumin in the presence of human cytochrome P450 isozymes"Arch.Biochem.Biophys.. 405. 223-230 (2002)

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  • [Publications] M.Kawanishi: "Epstein-Barr virus BHRF1 functions downstream of Bid cleavage and upstream of mitochondrial dysfunction to inhibit TRAIL-induced apoptosis in BJAB cells"Biochem.Biophys.Res.Commun.. 297. 682-687 (2002)

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  • [Publications] M.Murata: "Oxidative DNA damage by a common metabolite of carcinogenic nitrofluorene and N-acetylaminofluorene"Int.J.Cancer. 102. 311-317 (2002)

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  • [Publications] S.Kawanishi: "Distinct mechanisms of oxidative DNA damage induced by carcinogenic nickel subsulfide and nickel oxides"Environ.Health Perspect.. 110, Suppl.5. 789-791 (2002)

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  • [Publications] K.Hirakawa: "Photohydrolysis of methotrexate produces pteridine, which induces poly-G-Specific DNA damage through photoinduced electron transfer"Photochem.Photobiol.. 76. 467-472 (2002)

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  • [Publications] S.Ohnishi: "DNA damage induced by hypochlorite and hypobromite with reference to inflammation-associated carcinogenesis"Cancer Lett.. 178. 37-42 (2002)

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  • [Publications] Y.Hiraku: "Distamycin A, a minor groove binder, changes enediyne-induced DNA cleavage sites and enhances apoptosis"Nucleic Acids Res.. Suppl.2. 95-96 (2002)

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  • [Publications] S.Ohnishi: "Double base lesions of DNA by a metabolite of carcinogenic benzo[a]pyrene"Biochem.Biophys.Res.Commun.. 290. 778-782 (2002)

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  • [Publications] K.Hirakawa: "Catechol and hydroquinone have different redox properties responsible for their differential DNA-damaging ability"Chem.Res.Toxicol.. 15. 76-82 (2002)

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  • [Publications] M.Murata: "Acrylonitrile enhances H_2O_2-mediated DNA damage via nitrogen-centered radical formation"Chem.Res.Toxicol.. 14. 1421-1427 (2001)

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  • [Publications] K.Midorikawa: "Protective effect of phytic acid on oxidative DNA damage with reference to cancer chemoprevention"Biochem.Biophys.Res.Commun.. 288. 552-557 (2001)

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  • [Publications] K.Sakano: "Hydroxyurea induces site-specific DNA damage via formation of hydrogen peroxide and nitric oxide"Jpn.J.Cancer Res.. 92. 1166-1174 (2001)

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  • [Publications] Y.Ohkuma: "Sequence-specific DNA damage induced by carcinogenic danthron and anthraquinone in the presence of Cu(II), cytochrome P450 reductase and NADPH"Free Radic.Res.. 34. 595-604 (2001)

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  • [Publications] M.Murata: "Requirement of glutathione and cysteine in guanine-specific oxidation of DNA by carcinogenic potassium bromate"Chem.Res.Toxicol.. 14. 678-685 (2001)

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  • [Publications] S.Ohnishi: "Oxidative DNA damage by an N-hydroxy metabolite of the mutagenic compound formed from norharman and aniline"Mutat.Res.. 494. 63-72 (2001)

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  • [Publications] S.Kawanishi: "Oxidative DNA damage in cultured cells and rat lungs by carcinogenic nickel compounds"Free Radic.Biol.Med.. 31. 108-116 (2001)

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  • [Publications] K.Sakano: "Mechanism of metal-mediated DNA damage induced by metabolites of carcinogenic 2-nitropropane"Mutat.Res.. 479. 101-111 (2001)

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  • [Publications] S.Oikawa: "Site specificity and mechanism of oxidative DNA damage induced by carcinogenic catechol"Carcinogenesis. 22. 1239-1245 (2001)

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  • [Publications] K.Midorikawa: "Superoxide dismutases enhance H_2O_2-induced DNA damage and alter its site specificity"FEBS Lett.. 495. 187-190 (2001)

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  • [Publications] Y.Ohkuma: "Oxidative DNA damage induced by a metabolite of carcinogenic o-anisidine : enhancement of DNA damage and alteration in its sequence-specificity by superoxide dismutase"Arch.Biochem.Biophys.. 389. 49-56 (2001)

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  • [Publications] S.Oikawa: "Site-specific DNA damage at the GGG sequence by UVA involves acceleration of telomere shortening"Biochemistry. 40. 4763-4768 (2001)

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  • [Publications] T.Hishita: "Caspase-3 activation by lysosomal enzymes in cytochrome c-independent apoptosis in myelodysplastic syndrome-derived cell line P39"Cabcer Res.. 61. 2878-2884 (2001)

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  • [Publications] Y.Hiraku: "Catechol estrogens induce oxidative DNA damage and estradiol enhances cell proliferation"Int.J.Cancer. 92. 333-337 (2001)

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  • [Publications] M.Murata: "Mechanism of oxidative DNA damage induced by carcinogenic 4-aminobiphenyl"Free Radic.Biol.Med.. 30. 765-773 (2001)

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  • [Publications] S.Kawanishi: "Mechanism of guanine-specific DNA damage by oxidative stress and its role in carcinogenesis and aging"Mutat.Res.. 488. 65-76 (2001)

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  • [Publications] Y.Hiraku: "Amplification of bleomycin-induced DNA cleavage at cytosine residues 3' to GGG sequences by pyrrole triamide"Biochem.Pharmacol.. 61. 351-356 (2001)

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  • [Publications] S.Ohnishi: "Oxidative DNA damage induced by an N-hydroxy metabolite of carcinogenic 4-dimethylaminoazobenzene"Jpn.J.Cancer Res.. 92. 23-29 (2001)

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  • [Publications] S.Ohnishi: "Oxidative DNA damage by a metabolite of carcinogenic 1-nitropyrene"Biochem.Biophys.Res.Commun.. 280. 48-52 (2001)

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  • [Publications] 川西正祐: "分子予防環境医学"本の泉社(分子予防環境医学研究会 編). 768 (2003)

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  • [Publications] 川西正祐: "ミネラルの事典"朝倉書店(糸川嘉則 編). 712 (2003)

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  • [Publications] 及川伸二: "食と生活習慣病"昭和堂(菅原努 監修). 213 (2003)

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  • [Publications] 川西正祐: "中毒学 -基礎・臨床・社会医学-"朝倉書店(荒記俊一 編). 408 (2002)

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  • [Publications] 川西正祐: "別冊 医学のあゆみ 酸化ストレス-フリーラジカル医学生物学の最前線"医歯薬出版(吉川敏一 編). 326 (2001)

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  • [Publications] S.Kawanishi: "Current Problems in Dermatology Vol.29, Oxidants and Antioxidants in Cutaneous Biology"Karger (J.Thiele and P.Elsner, Eds.). 193 (2001)

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  • [Publications] N.Ma: "Accumulation of 8-nitroguanine in human gastric epithelium induced by Helicobacter pylori infection."Biochem. Biophys. res. Commun.. (in press).

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] S.Pinlaor: "Repeated infection with Opisthorchis viverrini induces accumulation of 8-nitroguanine and 8-oxo-7, 8-dihydro-2'-deoxyguanine in the bile duct of hamsters vie inducible nitric oxide synthase."Carcinogenesis. (in press).

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] T.Iwamoto: "DNA intrastrand cross-link at the 5'-GA-3' sequence formed by busulfan and a role in its cytotoxic effect"Cancer Sci.. (in press).

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] ak.Kobasahi: "metal mediate oxidative damage to cellular and isolated DNA by gallic acid, a metabolite of antioxidant propy1 gallate."Mutai. Res.. 558. 111-120 (2004)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] M.Murata: "Oxidative DNA damage induced by nitrotyrosine, a biomarker of inflammation."Biochem. Biophys. Res. Commun.. 316. 123-128 (2004)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] M.Murata: "Genistein and daidzein induce cell proliferation and their metabolites cause oxidative DNA damage in relation to isoflavone-induced cancer of estrogen-sensitive organs."Biochemistry. 43. 2569-2577 (2004)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] K.Seike: "Oxidative DNA damage induced by benz[a]anthracene metabolites via redox cycles of quinone and unique non-quinone."Chem. Res. Toxicol.. 16. 1470-1476 (2003)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] M.Murata: "Oxidative DNA damage by hyperglycemiarelated aldehydes and its marked enhancement by hydrogen peroxide."FEBS Lett.. 554. 138-142 (2003)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] S.Oikawa: "Catechins induce oxidative damage to cellular and isolated DNA through the generation of reactive oxygen species."Free Radic. Res.. 37. 881-890 (2003)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] A.Furukawa: "(-)-Epigallocatechin gallate causes oxidative damage to isolated and cellular DNA."Biochem. Pharmacol.. 66. 1769-1778 (2003)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] S.Nakashima: "Vacuolar H^+-ATPase inhibitor induces apoptosis via lysosomal dysfunction in the human gastric cancer cell line MKN-1."J.Biochem.(TOKYO). 134. 359-364 (2003)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] S.Tada-Oikawa: "Mechanism for generation of hydrogen peroxide and change of mitochondrial membrane potential during rotenone-induced apoptosis."Life Sci.. 73. 3277-3288 (2003)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] S.Pinlaor: "8-nitroguanine formation the liver of hamsters infected with Opisthorchis viverrini."Biochem. Biophys. Res. Commun.. 309. 567-571 (2003)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] K.Ogawa: "Molecular mechanisms of DNA damage induced by procarbazine in the presence of CU(II)"Mutat. Res.. 539. 145-155 (2003)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] H.Mizutani: "Distinct mechanisms of site-specific oxidative DNA damage by doxorubicin in the presence of copper(II) and NADPH-cytochrome P450 reductase."Cancer Sci.. 94. 686-691 (2003)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] T.Iwamoto: "Oxidative DNA damage induced by photodegradation products of 3'-azido-3'deoxythymidine."Arch. Biochem. Biophys.. 416. 155-163 (2003)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] S.Oikawa: "Oxidative damage to cellular and isolated DNA by homocysteine : implications for carcinogenesis."Oncogene. 22. 3530-3538 (2003)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] C.Toda: "DNA damage by ethylbenzenehydroperoxide formed from carcinogenic ethylbenzene by sunlight irradiation."Biochem. Biophys. Res. Commun.. 304. 638-642 (2003)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] N.Nakai: "Oxidative DNA damage induced by toluene is involved in its male reproductive toxicity."Free Radic. Res.. 37. 69-76 (2003)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] K.Hirakawa: "Carcinogenic semicarbazide induces sequence-specific DNA damage Through the generation of reactive oxygen species and the derived organic radicals."Mutat.Res.. 536. 91-101 (2003)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] K.Hirakawa: "Sequence-specific DNA damage induced by ultraviolet A-irradiated folic acid via its photolysis product."Arch. Biochem. Biophys.. 410. 261-268 (2003)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] K.Hirakawa: "Base oxidation at 5'site of GG sequence in double-stranded DNA induced by UVA in the presence of xanthone analogues : relationship between the DNA0damaging abilities of photosensitizers and their HIMO energies."Photochem. Photobiol.. 77. 349-355 (2003)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] K.Sakano: "Metabolism of carcinogenic urethane to nitric oxide is involved in oxidative DNA damage."Free Radic. Biol. Med.. 33. 703-714 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Y.Hiraku: "Determination of intracellular glutathione and thiols by high performance liquid chromatography with a gold electrode at the femtomole level : comparison with a spectroscopic assay"Biochim. Biophys. Acta.. 1570. 47-52 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] S.Kawanishi: "The role of metals in site-specific DNA damage with reference to carcinogenesis."Free radic. Biol. Med. (Reveiew). 32. 822-832 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] M.Murata: "Oxidation of 5'-site guanine at GG and GGG sequences induced by a metabolite of carcinogenic heterocyclic amine PhIP in the presence of Cu(II) and NADH."Carcinogenesis. 23. 855-860 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] H.Mizutani: "Mechanism of apoptosis induced by a metabolite of 2-naphthylamine, a smoking-related bladder carcinogen."Jpn. J. Cancer Res.. 277. 30684-30689 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] S.Ohnishi: "Oxidative DNA damage induced by a metabolite of 2-naphthylamine, a smoking-related bladder carcinogen."Jpn. J. Cancer Res.. 93. 736-743 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] S.Homma-Takeda: "2,4,6-Trinitrotoluene-induced reproductive toxicity via oxidative DNA damage by its metabolite."Free Radic. Res.. 36. 555-566 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] K.Midorikawa: "Hydroxylation of deoxyguanosine at 5' site of GG and GGG sequences in double-stranded DNA induced by carbamoyl radicals."Free Radic.Res.. 36. 667-675 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] S.Oikawa: "Site-specific hydroxylation at polyguanosine in double-stranded DNA by nickel(II) in the presence of SH compounds : comparison with singlet oxygen-induced DNA damage."Chem. Res. Toxicol.. 15. 1017-1022 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] K.Sakano: "Metal-mediated DNA damage induced by curcumin in the presence of human cytochrome P450 isozymes."Arch.Biochem.Biophys.. 405. 223-230 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] M.Kawanishi: "Epstein-Barr virus BHRF1 functions downstream of Bid cleavage and upstream of mitochondrial dysfunction to inhibit TRAIL-induced apoptosis in BJAB cells."Biochem. Biophys. Res. Commun.. 297. 682-687 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] M.Murata: "oxidative DNA damage by a common metabolite of carcinogenic nitrofluorene and N-acetylaminofluorene."Int. J. Cancer. 102. 311-317 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] S.Kawanishi: "Distinct mechanisms of oxidative DNA damage induced by carcinogenic nickel subsulfide and nickel oxides."Environ. Health Perspect.. 110(suppl.5). 789-791 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] K.Hirakawa: "Photohydrolysis of methotrexate produces pteridine, which induces poly-G-Specific DNA damage through photoinduced electron transfer."Photochem. Photobiol.. 76. 467-472 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] S.Ohnishi: "DNA damage induced by hypochlorite and hypobromite with reference to inflammation-associated carcinogenesis."Cancer Lett.. 178. 37-42 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Y.Hiraku: "Distamycin A, a minor groove binder, changes enediyne-induced DNA cleavage sites and enhances apoptosis."Nucleic Acids Res.. (Suppl.2). 95-96 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] S.Ohnishi: "double base lesions of DNA by a metabolite of carcinogenic benzo[a]pyrene."Biochem. Biophys. Res. Commun.. 290. 778-782 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] K.Hirakawa: "Catechol and hydroquinone have different redox properties responsible for their differential DNAdamaging ability"Chem. Res. Toxicol.. 15. 76-82 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] M.Murata: "Acrylonitrile enhances H_2O_2-mediated DNAdamage via nitrogen-centered radical formation."Chem. Res. Toxicol.. 14. 1421-1427 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] K.Midorikawa: "Protective effect of phytic acid on oxidative DNA damage with reference to cancer chemoprevention."Biochem. Biophys. Res. Commun.. 288. 552-557 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] K.Sakano: "Hydroxyurea induces site-specific DNA damage via formation of hydrogen peroxide and nitric oxide."Jpn. J. Cancer Res.. 92. 1166-1174 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Y.Ohkuma: "Sequence-specific DNA damage induced by carcinogenic danthron and anthraquinone in the presence of Cu(II), cytochrome P450 reductase and NADPH."Free Radic. Res.. 34. 595-604 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] M.Murata: "Requirement of glutathione and cysteine in guanine-specific oxidation of DNA by carcinogenic potassium bromate."Chem. Res. Toxicol.. 14. 647-685 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] S.Ohnishi: "Oxidative DNA damage by an N-hydroxy metabolite of the mutagenic compound formed from norharman and aniline."Mutat. Res.. 494. 63-72 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] S.Kawanishi: "Oxidative DNA damage in cultured cells and rat lungs by carcinogenic nickel compounds."Free Radic. Biol. Med.. 31. 108-116 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] K.Sakano: "Mechanism of metal-mediated DNA damage induced by metabolites of carcinogenic 2-nitropropane."Mutat. Res.. 479. 101-111 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] S.Oikawa: "Site specificity and mechanism of oxidative DNA damage induced by carcinogenic catechol."Carcinogenesis. 22. 1239-1245 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] K.Midorikawa: "Superoxide dismutases enhance H_2O_2-induced DNA damage and alter its site specificity."FEBS Lett.. 495. 187-190 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Y.Ohkuma: "Oxidative DNA damage induced by a metabolite of carcinogenic o-anisidine : enhancement of DNA damage and alteration in its sequence-specificity by superoxide dismutase."Arch. Biochem. Biophys.. 389. 49-56 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] S.Oikawa: "Site-specific DNA damage at the GGG sequence by UVA involves acceleration of telomere shortening."Biochemistry. 40. 4763-4768 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] T.Hishita: "Caspase-3 activation by lysosomal enzymes in cytochrome c-independent apoptosis in myelodysplastic syndrome-derived cell line P39."Cancer Res.. 61. 2878-2884 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Y.Hiraku: "Catechol estrogens induce oxidative DNA damage and estradiol enhances cell proliferation."Int. J. Cancer. 92. 333-337 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] M.Murata: "Mechanism of oxidative DNA damage induced by carcinogenic 4-aminobiphenyl."Free Radic. Biol. Med.. 30. 765-773 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] S.Kawanishi: "Mechanism of guanine-specific DNA damage by oxidative stress and its role in carcinogenesis and again."Mutat. Res. (Reviews in Mutation Research). 488. 65-76 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Y.Hikaru: "Amplification of bleomycin-induced DNA cleavage at cytosine residues 3' to GGG sequences by pyrrole triamide."Biochem. Pharmacol.. 61. 351-356 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] S.Ohnishi: "Oxidative DNA damage induced by an N-hydroxy metabolite of carcinogenic 4-dimethylaminoazo-benzene."Jpn. J. Cancer Res.. 92. 23-29 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] S.Ohnishi: "Oxidative DNA damage by a metabolite of carcinogenic 1-nitropyrene."Biochem. Biophys. Res. Commun.. 280. 48-52 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] S.Kawanishi: "Sequence-Specific DNA Damage Induced by UVA Radiation in the Presence of Endogeous and Exogenous Photosensitizers : in "Oxidants and Anitoxidants in Cutaneous Biology""Curr. Probl. Dermatol.. 29(Karger). 74-82 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Murata, M: "Genistein and daidzein induce cell proliferation and their metabolites cause oxidative DNA damage in relation to isoflavone-induced cancer of estrogen-sensitive organs."Biochemistry. 43. 2569-2577 (2004)

    • Related Report
      2003 Annual Research Report
  • [Publications] Murata, M: "Oxidative DNA damage induced by nitrotyrosine, a biomarker of inflammation"Biochem.Biophys.Res.Commun.. 316. 123-128 (2004)

    • Related Report
      2003 Annual Research Report
  • [Publications] Furukawa, A: "(-)-Epigallocatechin gallate causes oxidative damage to isolated and cellular DNA"Biochem.Pharmacol. 66. 1769-1778 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] Oikawa, S: "Catechins induce oxidative damage to cellular and isolated DNA through the generation of reactive oxygen species"Free Radic.Res. 37. 881-890 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] Oikawa, S: "Oxidative damage to cellular and isolated DNA by homocysteine : implications for carcinogenesis"Oncogene. 22. 3530-3538 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] Murata, M: "Oxidative DNA damage by hyperglycemia-related aldehydes and its marked enhancement by hydrogen peroxide"FEBS Lett.. 554. 138-142 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] 及川伸二: "食と生活習慣病(菅原努 監修)"昭和堂. 213 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] S.Oikawa: "Oxidative damage to cellular and isolated DNA by homocysteine : implications for carcinogenesis"Oncogene. (in press). (2003)

    • Related Report
      2002 Annual Research Report
  • [Publications] K.Hirakawa: "Base oxidation at 5' Site of GG sequence in double-stranded DNA induced by UVA in the presence of xanthone analogues : relationship between the DNA-damaging abilities of photosensitizers and their HOMO energies"Photochem Photobiol. (in press). (2003)

    • Related Report
      2002 Annual Research Report
  • [Publications] K.Hirakawa: "Carcinogenic semicarbazide induces sequence-specific DNA damage through the generation of reactive oxygen species and the derived organic radicals"Mutat. Res. (in press). (2003)

    • Related Report
      2002 Annual Research Report
  • [Publications] K.Hirakawa: "Sequence-specific DNA damage induced by ultraviolet A-irradiated folic acid via its photolysis product"Arch. Biochem. Biophys. 410. 261-268 (2003)

    • Related Report
      2002 Annual Research Report
  • [Publications] H.Mizutani: "Mechanism of apoptosis induced by a new topoisomerase inhibitor through the generation of hydrogen peroxide"J. Biol. Chem. 277. 30684-30689 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] K.Sakano: "Metal-mediated DNA damage induced by curcumin in the presence of human cytochrome P450 isozymes"Arch. Biochem. Biophys. 405. 223-230 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] K.Sakano: "Metabolism of carcinogenic urethane to nitric oxide is involved in oxidative DNA damage"Free Radic. Biol. Med. 33. 703-714 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] S.Kawanishi: "The role of metals in site-specific DNA damage with reference to carcinogenesis"Free Radic. Biol. Med. 32. 822-832 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] Y.Hiraku: "Determination of intracellular glutathione and thiols by high performance liquid chromatography with a gold electrode at the femtomole level : comparison with a spectroscopic assay"Biochim. Biophys. Acta. 1570. 47-52 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] M.Murata: "Oxidation of 5'-site guanine at GG and GGG sequences induced by a metabolite of carcinogenic heterocyclic amine PhIP in the presence of Cu(II) and NADH"Carcinogenesis. 23. 855-860 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] S.Ohnishi: "Oxidative DNA Damage Induced by a Metabolite of 2-Naphthylamine, a Smoking-related Bladder Carcinogen"Jpn. J. Cancer Res. 93. 736-743 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] S.Homma-Takeda: "2, 4, 6-trinitrotoluene-induced reproductive toxicity via oxidative DNA damage by its metabolite"Free Radic. Res. 36. 555-566 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] K.Midorikawa: "Hydroxylation of deoxyguanosine at 5' site of GG and GGG sequences in double-stranded DNA induced by carbamoyl radicals"Free Radic. Res. 36. 667-675 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] S.Oikawa: "Site-specific hydroxylation at polyguanosine in double-stranded DNA by nickel(II) in the presence of SH compounds : comparison with singlet oxygen-induced DNA damage"Chem. Res. Toxicol. 15. 1017-1022 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] M.Kawanishi: "Epstein-Barr virus BHRF1 functions downstream of Bid cleavage and upstream of mitochondrial dysfunction to inhibit TRAIL-induced apoptosis in BJAB cells"Biochem Biophys Res Commun. 297. 682-687 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] M.Murata: "Oxidative DNA damage by a common metabolite of carcinogenic nitrofluorene and N-acetylaminofluorene"Int J Cancer. 102. 311-317 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] S.Kawanishi: "Distinct mechanisms of oxidative DNA damage induced by carcinogenic nickel subsulfide and nickel oxides"Environ Health Perspect. 110. 789S-791S (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] K.Hirakawa: "Photohydrolysis of methotrexate produces pteridine, which induces poly-G-specific DNA damage through photoinduced electron transfer"Photochem Photobiol. 76. 467-472 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] 及川 伸二: "食と生活習慣病"昭和堂(菅原努 監修). 213 (2003)

    • Related Report
      2002 Annual Research Report
  • [Publications] S.Ohnishi: "DNA damage induced by hypochlorite and hypobromite with reference to inflammation-associated carcinogenesis"Cancer Lett.. 178. 37-42 (2002)

    • Related Report
      2001 Annual Research Report
  • [Publications] K.Hirakawa: "Catechol and Hydroquinone Have Different Redox Properties Responsible for Their Differential DNA-damaging Ability"Chem.Res.Toxicol. 15. 76-82 (2002)

    • Related Report
      2001 Annual Research Report
  • [Publications] S.Ohnishi: "Double Base Lesions of DNA by a Metabolite of Carcinogenic Benzo[a]pyrene"Biochem.Biophys.Res.Commun.. 290. 778-782 (2002)

    • Related Report
      2001 Annual Research Report
  • [Publications] S.Kawanishi: "Mechanism of Guanine-specific DNA Damage by Oxidative Stress and Its Role in Carcinogenesis and Aging"Mutation Res.(Reviews in Mutation Research). 488. 65-76 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] S.Kawanishi: "Oxidative DNA damage in cultured cells and rat lungs by carcinogenic nickel compounds"Free.Radic.Biol.Med.. 31. 108-116 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] T.Hishita: "Caspase-3 Activation by Lysosomal Enzymes in Cytochrome c-independent Apoptosis in a Myelodysplastic Syndrome (MDS)-derived Cell Line P39"Cancer Res.. 61. 2878-2884 (2001)

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  • [Publications] S.Oikawa: "Site-specific DNA Damage at GGG Sequence by UVA Involves Acceleration of Telomere Shortening"Biochemistry. 40. 4763-4768 (2001)

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  • [Publications] K.Midorikawa: "Superoxide dismutases enhance H_2O_2-induced DNA damage and alter its site specificity"FEBS Lett.. 495. 187-190 (2001)

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  • [Publications] M.Murata: "Acrylonitril Enhances H_2O_2-Mediated DNA Damage via Nitrogen-Centered Radical Formation"Chem.Res.Toxicol.. 14. 1421-1427 (2001)

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  • [Publications] S.Oikawa: "Site Specificity and Mechanism of Oxidative DNA Damage Induced by Carcinogenic Catechol"Carcinogenesis. 22. 1239-1245 (2001)

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  • [Publications] M.Murata: "Mechanism of Oxidative DNA Damage Induced by Carcinogenic 4-Aminobiphenyl"Free Radic.Biol Med.. 30. 765-773 (2001)

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  • [Publications] M.Murata: "Requirement of Glutathione and Cysteine in Guanine-specific Oxidation of DNA by Carcinogenic Potassium Bromate"Chem.Res.Toxicol.. 14. 678-685 (2001)

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  • [Publications] K.Sakano: "Hydroxyurea Induces Site-specific DNA Damage via Formation of Hydrogen Peroxide and Nitric Oxide"Jpn.J.Cancer Res.. 92. 1166-1174 (2001)

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  • [Publications] Y.Ohkuma: "Sequence-specific DNA damage induced by carcinogenic danthron and anthraquinone in the presence of Cu(II),cytochrome P450 reductase and NADPH"Free.Radic.Res.. 34. 595-604 (2001)

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  • [Publications] S.Ohnishi: "Oxidative DNA damage induced by an N-hydroxy metabolite of carcinogenic 4-dimethylaminoazobenzene"Jpn.J.Cancer Res. 92. 23-29 (2001)

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  • [Publications] K.Sakano: "Mechanism of Metal-mediated DNA Damage Induced by Metabolites of Carcinogenic 2-Nitropropane"Mutat.Res.. 479. 101-111 (2001)

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  • [Publications] S.Ohnishi: "Oxidative DNA Damage by an N-Hydroxy Metabolite of the Mutagenic Compound Formed from Norharman and Aniline"Mutat.Res.. 494. 63-72 (2001)

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  • [Publications] K.Midorikawa: "Protective Effect of Phytic Acid on Oxidative Damage with Reference to Cancer Chemoprevention"Biochem.Biophys.Res.Commun. 288. 552-557 (2001)

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  • [Publications] Y.Ohkuma: "Oxidative DNA Damage Induced by a Metabolite of Carcinogenic o-Anisidine: Enhancement of DNA Damage and Alteration in its Sequence-Specificity by Superoxide Dismutase"Arch Biochem.Biophys.. 389. 49-56 (2001)

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  • [Publications] S.Ohnishi: "Oxidative DNA Damage by a Metabolite of Carcinogenic 1-Nitropyrene"Biochem.Biophys.Res.Commun.. 280. 48-52 (2001)

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  • [Publications] Y.Hiraku: "Amplification of Bleomycin-induced DNA Cleavage at Cytosine Residues 3' to GGG Sequences by Pyrrole Triamide"Biochem.Pharmaco. 61. 351-356 (2001)

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  • [Publications] Y.Hiraku: "Catechol Estrogens Induce Oxidative DNA Damage and Estradiol Enhances Cell Proliferation"Int.J.Cancer. 92. 333-337 (2001)

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  • [Publications] 及川伸二: "環境因子による酸化的DNA損傷とがん、老化"Environ.Mut.Res.Commun.. 23. 207-213 (2001)

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  • [Publications] S.Kawanishi: "Current Problems in Dermatology Vol.29,Oxidants and Antioxidants in Cutaneous Biology"Karger(J.Thiele and P.Elsner,Eds.). 193 (2001)

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  • [Publications] 川西正祐: "中毒学-基礎・臨床・社会医学-"朝倉書店(荒記俊一 編). 408 (2002)

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  • [Publications] 川西正祐: "別冊 医学のあゆみ 酸化ストレス-フリーラジカル医学生物学の最前線"医歯薬出版(吉川敏一 編). 326 (2001)

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Published: 2001-04-01   Modified: 2016-04-21  

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