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Nutritional epidemiology of selenium by chemical forms

Research Project

Project/Area Number 13557032
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section展開研究
Research Field Public health/Health science
Research InstitutionGunma University

Principal Investigator

KOYAMA Hiroshi  Gunma University, Professor, 大学院・医学系研究科, 教授 (30143192)

Co-Investigator(Kenkyū-buntansha) SUZUKI Shosuke  Gunma Occupational Health Promotion Center, Director, センター長(研究職) (40010011)
HONGO Tetsuro  Yamanashi Institute of Environmental Sciences, Chief Researcher, 環境保健研究部, 主幹研究員 (90199563)
SASADA Yoko  Morioka University, Professor, 短期大学部, 教授 (30258769)
MIYAZAKI Yukiko  Jobu University, Professor, 看護学部, 教授 (00251190)
NOJIRI Masami  Chiba University, Professor, 看護学部, 教授 (70009520)
Project Period (FY) 2001 – 2004
Project Status Completed (Fiscal Year 2004)
Budget Amount *help
¥14,000,000 (Direct Cost: ¥14,000,000)
Fiscal Year 2004: ¥2,200,000 (Direct Cost: ¥2,200,000)
Fiscal Year 2003: ¥2,200,000 (Direct Cost: ¥2,200,000)
Fiscal Year 2002: ¥2,900,000 (Direct Cost: ¥2,900,000)
Fiscal Year 2001: ¥6,700,000 (Direct Cost: ¥6,700,000)
Keywordsselenium / speciation analysis / glutathione peroxidase / selenoprotein P / albumin / food frequency questionare / グルタチオンペルオキシターゼ / アルプミン / 簡易食品摂取頻度調査票 / 簡易食事接種頻度調査票 / セレン化学形別分析 / KKマウス
Research Abstract

To analyze which of the three selenium-containing proteins (albumin, glutathione peroxidase(GPx) and selenoprotein P) was responsible for the development of stroke. We conducted a population-based case-control study of 30 first-ever stroke cases who had undergone health examinations and blood sampling in 1992 to 1994 before the stroke, and 30 controls matched for their sex, age, total cholesterol, and the year of blood sampling. Total selenium in the serum was measured fluorometrically. Selenium-containing proteins were separated using two HPLC columns in tandem, and selenium was detected by ICP-MS.
The serum concentration-of selenium tended to be lower in the stroke cases than in the controls (105.2 vs 116.5 μg/l;p=0.054). Although the selenium contents in GPx and albumin did not show any significant difference, selenoprotein P was significantly lower in the stroke cases than in the controls (54.5 vs 63.0 μg/l;p=0.006). A multiple logistic analysis showed that selenoprotein P can reduce the risk of stroke (Odds Ratio=0.28;95% Confidence Interval:0.10-0.8).
The results of this study show that Selenoprotein P may play an important role in development of stroke.

Report

(5 results)
  • 2004 Annual Research Report   Final Research Report Summary
  • 2003 Annual Research Report
  • 2002 Annual Research Report
  • 2001 Annual Research Report
  • Research Products

    (16 results)

All 2004 2003 2002 Other

All Journal Article (9 results) Publications (7 results)

  • [Journal Article] セレン補充摂取による血液流動性の改善2004

    • Author(s)
      宮崎賀織, 笹沢吉明, 小山洋
    • Journal Title

      日本衛生学雑誌 59

      Pages: 183-183

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Dietary habits and selenium intake of residents in mountain and coastal communities in Japan2004

    • Author(s)
      Y.Miyazaki, H.Koyama, Y.Sasada, H.Satoh, M.Nojiri, S.Suzuki
    • Journal Title

      Journal of Nutritional Science and Vitaminology 50

      Pages: 309-319

    • NAID

      110002704006

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Dietary habits and selenium intake of residents in mountain and coastal communities in Japan.2004

    • Author(s)
      Y.Miyazaki, H.Koyama, Y.Sasada, H.Satoh, M.Nojiri, S.Suzuki
    • Journal Title

      Journal of Nutritional Science and Vitaminology 50

      Pages: 309-319

    • NAID

      110002704006

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Annual Research Report 2004 Final Research Report Summary
  • [Journal Article] Selenium supplementation and blood hemorheological change2004

    • Author(s)
      H.Koyama, K.Miyazaki, M.Nara, M.Murakami
    • Journal Title

      The 7^<th> International Society for Trace Element Research in Humans. Bangkok, Nov.

      Pages: 7-12

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] セレン補充摂取による血液流動性の改善2004

    • Author(s)
      宮崎賀織, 笹澤吉明, 小山洋
    • Journal Title

      日本衛生学雑誌 59・2

      Pages: 183-183

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Encephalopathy in megacystis-microcolon-intestinal hypoperistalsis syndrome patients on long-term total parenteral nutrition possibly due to selenium deficiency.2003

    • Author(s)
      J.Hirato, Y.Nakazato, H.Koyama, A.Yamada, N.Suzuki, M.Kuroiwa
    • Journal Title

      Acta Neuropathology 106

      Pages: 234-242

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Encephalopathy in megacystis-microcolon-intestinal hypoperistalsis syndrome patients on long-term total parenteral nutrition possibly due to selenium deficiency.2003

    • Author(s)
      J.Hirato, Y.Nakazato, H.Koyama, et al.
    • Journal Title

      Acta Neuropathology 106

      Pages: 234-242

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Relationship of dietary intake of fish and non-fish selenium to serum lipids in Japanese rural costal community.2002

    • Author(s)
      Y.Miyazaki, H.Koyama, M.Nojiri, S.Suzuki
    • Journal Title

      Journal of Trace Elements in Medicine and Biology 16

      Pages: 83-90

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Relationship of dietary intake of fish and non-fish selenium to serum2002

    • Author(s)
      Y.Miyazaki, H.Koyama, M.Nojiri, S.Suzuki.
    • Journal Title

      Journal of Trace Elements in Medicine and Biology 16

      Pages: 83-90

    • Related Report
      2004 Annual Research Report
  • [Publications] 宮崎賀織, 笹沢吉明, 小山洋: "セレン補充摂取による血液流動性の改善"日本衛生学雑誌. 59巻2号. 183-183 (2004)

    • Related Report
      2003 Annual Research Report
  • [Publications] 中森洋介, 小山洋: "グルタチオンペルオキシターゼ活性測定法の精度管理:グルタチオンレダクターゼを用いた間接的精度管理の試み"群馬保健学紀要. 22. 63-69 (2001)

    • Related Report
      2003 Annual Research Report
  • [Publications] Junko Hirato, Yoichi Nakazato, Hiroshi Koyama, Ami Yamada, Norio Suzuki, Minoru Kuroiwa, Atsushi Takahashi: "Encephalopathy in megacystis- microcolon-intestinal hypoperistalsis syndrome patients on long-term total parenteral nutrition possibly due to selenium deficiendy"Acta Neuropathol. 106. 234-242 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] Yukiko Miyazaki, Hiroshi Koyama, Masami Nojiri, Shosuke Suzuki: "Relationship of dietary intake of fish and non-fish selenium to serum lipids in Japanese rural coastal community"J.Trace Elem.Med.Biol.. 16. 83-90 (2002)

    • Related Report
      2003 Annual Research Report
  • [Publications] Yukiko Miyazaki, Hiroshi Koyania, Masami Nojiri, Shosuke Suzuki: "Relationship of dietary intake of fish and non-fish selenium to serum lipids in Japanese rural coastal community"Journal of Trace Elements in Medicine and Biology. 16. 83-90 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] 小山 洋, 鈴木 慶二: "糖尿病モデルマウスKKマウスの膵ラ島細胞におけるセレン補充のアポートシス制御効果"日本衛生学雑誌. 58・1. 209 (2003)

    • Related Report
      2002 Annual Research Report
  • [Publications] 蜂須賀 理絵, 小山 洋: "カドミウムの細胞障害作用に対するセレンの影響"群馬保健学紀要. 23巻(印刷中). (2003)

    • Related Report
      2002 Annual Research Report

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Published: 2001-04-01   Modified: 2016-04-21  

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