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Analysis of suscebility genes and pathogenesis of HTLV-I-associated Sjogren's syndrome

Research Project

Project/Area Number 13557042
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section展開研究
Research Field 内科学一般
Research InstitutionNagasaki University

Principal Investigator

EGUCHI Katsumi  Nagasaki University, Graduate School of Biomedical Sciences, Professor, 大学院・医歯薬学総合研究科, 教授 (30128160)

Co-Investigator(Kenkyū-buntansha) MIGITA Kiyoshi  Nagasaki Medical Center, Research Center, Director Clinical, 臨床研究センター, 免疫研究部部長 (60264214)
NAMAMURA Tatsufumi  Nagasaki University, Graduate School of Biomedical Sciences, Assistant Professor, 大学院・医歯薬学総合研究所, 助教授 (00198219)
KUMAGAI Shunichi  Kobe University, Graduate School of Medicine, Professor, 大学院・医学系研究科, 教授 (00153346)
Project Period (FY) 2001 – 2003
Project Status Completed (Fiscal Year 2003)
Budget Amount *help
¥10,100,000 (Direct Cost: ¥10,100,000)
Fiscal Year 2003: ¥2,900,000 (Direct Cost: ¥2,900,000)
Fiscal Year 2002: ¥3,200,000 (Direct Cost: ¥3,200,000)
Fiscal Year 2001: ¥4,000,000 (Direct Cost: ¥4,000,000)
KeywordsSjogren's syndrome / IL-10 / polymorphism / HTLV-I / toll-like receptor / apoptosis / HTLV I-associated myelopathy / SS-B / La / HTLV-I tax / ミトコンドリア / IL-18 / GST / TAP / Sjogren症候群 / HTLV-1
Research Abstract

HTLV-I has been identified as a causative agent which initiates and/or perpetuates the process of Sjogren's syndrome (SS). A high seroprevalence of HTLV-I infection has been determined in SS patients in the HTLV I-endemic area of Nagasaki, Japan. Many patients with HTLV-I-associated myelopathy (HAM/TSP) have been complicated with SS. The present study was undertaken to clarify the involvement of HTLV-I infection on the development or perpetuation of SS. At first, we analyzed promoter region polymorphisms of the IL-10 gene. Our results suggest that the presence of the ATA haplotype of the IL-10 gene are associated with an increased susceptibility to primary SS. Moreover, IL-10 gene promoter region polymorphism affects the age at onset of SS, and the amounts of serum IgG. However, there is no association between the presence of anti-HTLV-I antibodies and IL-10 gene polymorphism. Next, two-color analysis by flow cytometry revealed a significantly high percentage of IL-12Rβl^+ cells in CD4 … More ^+T lymphocytes in HAM/TSP patients compared to the control. These results suggest Th1 immune activation in patients with HAM/TSP, which leads to chronic inflammation in the tissues, mediated by dysregulation of the IL-12/IL-12R. Furthermore, the sLe^<x+>+ cell population, which has features of activated Th1 cells with up-regulated expression of E-selectin and P-selectin ligands mediated by HTLV I infection, is increased in peripheral blood CD4^+T lymphocytes in HAM/TSP patients. These findings suggest their involvement in transmigration of T lymphocytes from peripheral blood into tissues. In addition, our results indicate that peripheral blood CD4^+T lymphocytes of HAM/TSP patients are resistant to apoptosis triggered through mitochondrial death pathway through up-regulations of expression of anti-apoptotic protein, Bcl-xL. We used HTLV-I tax transfectants to show that tax-mediated induction of Bcl-xL expression can protect cells from apoptotic stimuli in a mitochondria-dependent fashion. Compared with tax-negative JPX-9 cells, Bcl-xL expression was clearly augmented in tax-positive JPX-9 cells. These cells were resistant to both receptor-mediated apoptosis and chemical induced apoptosis. Theses results suggest that tax-mediated Bcl-xL expression inhibit apoptosis of activated T lymphocytes in HTLV-I-seropositive subjects, which consequently promotes the onset of autoimmune disorders such as SS. Finally, we demonstrated the expression of TLR-2, TLR-3 and TLR4 on the acinal and ductal cells, and infiltrated mononuclear cells from minor salivary glands of SS. When a human salivary glands (HSG) cell line were stimulated by peptidoglycan, poly I : C, or LPS, HSG cell line augmented the expression of CD54 and production of IL-6, through the phosphorylation of MAP kinase. From the above findings, the development and/or perpetuation of SS might be implicated with HTLV-I infection and the susceptibility genes. Less

Report

(4 results)
  • 2003 Annual Research Report   Final Research Report Summary
  • 2002 Annual Research Report
  • 2001 Annual Research Report
  • Research Products

    (180 results)

All Other

All Publications (180 results)

  • [Publications] Origuchi T, et al.: "Correlation between interleukin 10 gene promoter region polymorphisms and clinical manifestations in Japanese patients with Sjogren's syndrome."Ann Rheum Dis. 62. 1117-1118 (2003)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Nakashima K, et al.: "Protection of mitochondrial perturbation by human T-lymphotropic virus type 1 tax through induction of Bcl-xL expression."J Lab Clin Med. 142. 341-347 (2003)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Ida H, et al.: "Characterization of anticytoplasmic antibodies in patients with systemic autoimmune disease."Mod Rheumatol. 13. 333-338 (2003)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Ida H, et al.: "Granzyme B leakage-induced cell death : a new type of activation-induced natural killer cell death."Eur J Immunol. 33. 3284-3292 (2003)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Miyashita T, et al.: "Akt is an endogenous inhibitor toward tumor necrosis factor-related apoptosis inducing ligand-mediated apoptosis in rheumatoid synovial cells."Biochem Biophys Res Commun. 312. 397-404 (2003)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Kita-Furuyama M, et al.: "Dendritic cells infected with adenovirus expressing the thyrotrophin receptor induce Graves' hyperthyroidism in BALB/c mice."Clin Exp Immunol. 131. 234-240 (2003)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Tanaka F, et al.: "Clinical outcome and survival of secondary (AA) amyloidosis."Clin Exp Rheumatol. 21. 343-346 (2003)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Kusumoto K, et al.: "A case of amyloidosis secondary to rheumatoid arthritis complicated with Graves' ophthalmopathy."Mod Rheumatol. 13. 261-264 (2003)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Migita K, et al.: "FK506:anti-inflammatory properties."Curr Med Chem-Anti-Inflammatory & Anti-Allergy Agents. 2. 260-264 (2003)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Ashizawa K, et al.: "Serum anti-myeloperoxidase antineutrophil cytoplasmic antibodies (MPO-ANCA) in patients with Graves' disease receiving anti-thyroid medication."Intern Med. 42. 463-464 (2003)

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      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Ide A, et al.: "Stromal-cell derived factor-1 chemokine gene variant is associated with type 1 diabetes age at onset in Japanese population."Hum Immunol. 64. 973-978 (2003)

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      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Yamasaki S, et al.: "Functional changes in rheumatoid fibroblast-like synovial cells through activation of peroxisome proliferator-activatcd receptor y-mediated signalling pathway."Clin Exp Immunol. 129. 379-384 (2002)

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      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Kawakami A, et al.: "Modulation of the expression of membrane-bound CD54 (mCD54) and soluble form of CD54 (sCD54) in endothelial cells by glucosyl transferase inhibitor : possible role of ceramide for the shedding of mCD54."Biochem Biophys Res Commun. 296. 26-31 (2002)

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      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Kawakami A, et al.: "Involvement of apoptotic cell death in autoimmune diseases."Med Electron Microsc. 35. 1-8 (2002)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Kambara C, et al.: "Increased sialyl Lewis(x) antigen-positive cells mediated by HTLV-1 infection in peripheral blood CD4^+T lymphocytes in patients with HTLV-1-associated myelopathy."J Neuroimmunol. 125. 179-184 (2002)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Fujimoto T, et al.: "Up-regulation of interleukin-12 receptor expression in peripheral blood mononuclear cells of patients with HTLV-I-associated myelopathy/tropical spastic paraparesis."J Neural Sci. 196. 21-26 (2002)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Nagayama Y, et al.: "A novel murine model of Graves' hyperthyroidism with intramuscular injection of adenovirus expressing the thyrotropin receptor."J Immunol. 168. 2789-2794 (2002)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Kamachi M, et al.: "Regulation of apoptotic cell death by cytokines in a human salivary gland cell line : distinct and synergistic mechanisms in apoplosis induced by tumor necrosis factor a and interferon γ."Lab Clin Med. 139. 13-19 (2002)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Yonetsu K, et al.: "Sonography as a replacement for sialography for the diagnosis of salivary glands affected by Sjogren's syndrome."Ann Rheum Dis. 61. 276-277 (2002)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Origuchi T, et al.: "A typical mycobacteriosis in two patients with rheumatoid arthritis."Mod Rheumatol. 12. 76-79 (2002)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Nakashima M, et al.: "A case of eosinophilic myositis associated with orbital myositis."Mod Rheumatol. 12. 80-83 (2002)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Ida H, et al.: "Increased levels of interleukin-18 (IL-18) in patients with systemic lupus erythematosus : Comment on the article by Shibatomi et al.,Reply to the editor."Arthritis Rheum. 45. 1411-1412 (2002)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Migita K, et al.: "Association of subacute cutaneous lupus erythematosus in rheumatoid arthritis patient with Sjogren 's syndrome."Mod Rheumatol. 12. 354-356 (2002)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Ide A, et al.: "Genetic association between interleukin-10 gene promoter region polymorphisms and type 1 diabetes age-at-onset."Hum Immunol. 63. 690-695 (2002)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Ishikawa H, et al.: "Amyloid A protein amyloidosis in a patient with plasma cell dyscrasia."Intern Med. 41. 386-391 (2002)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Kawasaki E, et al.: "Autoantibodies to IA-2 in type 1 diabetes: measurements with a new enzyme-linked immunosorbent assay."Ann NY Acad Sci. 958. 241-246 (2002)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Kawasaki E, et al.: "Distinct IA-2 autoantibody epitope recognition between childhood-onset and adult-onset type 1 diabetes."Ann NY Acad Sci. 958. 235-240 (2002)

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      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Yamasaki S, et al.: "Effect of filtration leukocytapheresis therapy : modulation of white blood cell enzyme activities in patients with rheumatoid arthritis."Artif Organs. 26. 378-384 (2002)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Ueki Y, et al.: "NOR-1:a nitric oxide releasing agent for calibrating low levels of nitric oxide by the chemiluminescence method."Blood Coagul Fibrinolysis. 13. 75-80 (2002)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Migita K, et al.: "The role of peroxynitrite in cyclooxygenase-2 expression of rheumatoid synovium."Clin Exp Rheumatol. 20. 59-62 (2002)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Eguchi K.: "Systemic lupus erythematosus complicated by cytomegalovirus-induced hemophagocytic syndrome and colitis."Intern Med. 41. 77-78 (2002)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Eguchi K.: "A poptosis in autoimmune diseases."Intern Med. 40. 275-284 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Sera N, et al.: "Fas/FasL mediated apoptosis of thyrocytes in Graves' disease."Clin Exp Immunol. 124. 197-207 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Hamasaki S, et al.: "Resistance of CD4-positive T lymphocytes to etoposide-induced apoptosis mediated by upregulation of Bcl-xL expression in patients with HTLV-I-associated myelopathy."J Neuroimmunol. 117. 143-148 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Shibatomi K, et al.: "A novel role for interleukin-18 in human natural killer cell death."Arthritis Rheum. 44. 884-892 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Kawakami A, et al.: "Role of HTLV-I infection in the pathogenesis of Sjogren's syndrome and rheumatoid arthritis."Mod Rheumatol. 11. 87-90 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Yamasaki S, et al.: "Importance of NF-κB in rheumatoid synovial tissues : in situ NF-κB expression and in vitro study using cultured synovial cells."Ann Rheum Dis. 60. 678-684 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Hashimoto Y, et al.: "Novel immunosuppressive effect of FK506 by augmentation of T cell apoptosis."Clin Exp Immunol. 125. 19-24 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Hirai Y, et al.: "Effects of nitric oxide on matrix metalloproteinase-2 production by rheumatoid synovial cells."Life Sci. 68. 913-920 (2001)

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      2003 Final Research Report Summary
  • [Publications] Migita K, et al.: "Impaired degradation of serum amyloid A (SAA) protein by cytokine-stimulated monocytes."Clin Exp Immunol. 123. 408-411 (2001)

    • Description
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      2003 Final Research Report Summary
  • [Publications] Migita K, et al.: "Mixed connective tissue disease associated with von Recklinghausen's nurofibromatosis."Internal Med. 40. 363-364 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Migita K, et al.: "FK506-mediated T-cell apoptosis induction."Transplant P. 33. 2292-2293 (2001)

    • Description
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    • Related Report
      2003 Final Research Report Summary
  • [Publications] Migita K, et al.: "Nitric oxide protects cultured rheumatoid synovial cells from Fas-induced apoptosis by inhibiting caspase-3."Immunology. 103. 362-367 (2001)

    • Description
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    • Related Report
      2003 Final Research Report Summary
  • [Publications] Migita K, et al.: "Regulation of rheumatoid synoviocyte proliferation by endogenous p53 induction."Clin Exp Immunol. 126. 334-338 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Shiraishi H, et al.: "Successful plasmapheresis in alveolar hemorrhage associated with systemic lupus erythematosus."Mod Rhematol. 11. 340-343 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Nakamura H, et al.: "Vasculo-Bechet's syndrome with widespread arterial involvement."Mod Rhematol. 11. 332-335 (2001)

    • Description
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    • Related Report
      2003 Final Research Report Summary
  • [Publications] Migita K, et al.: "Effects of hemodialysis on advanced bony tophi in a tophaceous gout patient with chronic renal failure."Clin Exp Rheum. 19. 359-360 (2001)

    • Description
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    • Related Report
      2003 Final Research Report Summary
  • [Publications] Yamasaki S, et al.: "Polyarteritis nodosa complicated by thrombotic thrombocytopenic purpura."Ann Rheum Dis. 60. 541-542 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Urayama S, et al.: "New disease-modifying antirheumatic drug 2-acetylthiomethyl-4- (4-methylphenyl) -4-oxobutanoic acid (KE-298) selectively augments activation-induced T cell death."J Lab Clin Med. 138. 11-17 (2001)

    • Description
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    • Related Report
      2003 Final Research Report Summary
  • [Publications] Migita K, et al.: "Induction of Apoptosis : How do tacrolimus and ciclosporin compare?"Mechanistic Differences of Cornerstone Immunosuppressants. 14-19 (2001)

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    • Related Report
      2003 Final Research Report Summary
  • [Publications] 江口勝美: "Sjogren症候群"医学の歩み. 別冊. 84-89 (2003)

    • Description
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    • Related Report
      2003 Final Research Report Summary
  • [Publications] 江口勝美: "シューグレン症候群の病型分類と疫学"シューグレン症候群の基礎と臨床. 12-21 (2003)

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      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] 西浦義博: "セレクチンリガンド・クロスリンキングによるHTLV-I感染細胞におけるTh1/Th2関連因子の変化とHTLV-I tax発現の亢進"神経免疫学. 11. 110 (2003)

    • Description
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      2003 Final Research Report Summary
  • [Publications] 川上純 他: "シェーグレン症候群"看護アセスメントに役立つ検査の読み方. 433-438 (2003)

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      2003 Final Research Report Summary
  • [Publications] 井田弘明 他: "NK細胞における活性化誘導細胞死の機序"臨床免疫. 40. 232-236 (2003)

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      2003 Final Research Report Summary
  • [Publications] 江口勝美: "HTLV-I感染とリウマチ性疾患"リウマチ科. 27. 238-246 (2002)

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      2003 Final Research Report Summary
  • [Publications] 川上純 他: "HTLV-I感染によるシューグレン症候群・慢性関節リウマチの発症機序"臨床リウマチ. 13. 11-17 (2001)

    • Description
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      2003 Final Research Report Summary
  • [Publications] 江口勝美: "炎症におけるHTLV-I感染の役割"血液・免疫・腫瘍. 6. 61-71 (2001)

    • Description
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    • Related Report
      2003 Final Research Report Summary
  • [Publications] 江口勝美: "シェーグレン症候群の病型分類と疫学"アレルギー・免疫. 8. 14-21 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] 江口勝美: "Sjoren症候群"医学のあゆみ. 199. 387-392 (2001)

    • Description
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    • Related Report
      2003 Final Research Report Summary
  • [Publications] 江口勝美: "自己免疫疾患におけるアポトーシスの意義"MINOPHAGEN MEDICAL REVIEW. 46. 309-330 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Origuchi T, et al.: "Correlation between interleukm 10 gene promoter region polymorphisms and clinical manifestations in Japanese patients with Sjogren's syndrome."Ann Rheum Dis. 62(11). 1117-1118 (2003)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Nakashima K, et al.: "Protection of mitochondrial perturbation by human T lymphotropic virus type 1 tax through induction of Bcl-xL expression"J Lab Clin Med. 142(5). 341-347 (2003)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Ida H, et al.: "Characterization of anticytoplasmic antibodies in patients with systemic autoimmune disease."Mod Rheumatol. 13(4). 341-347 (2003)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Ida H, et al.: "Granzyme B leakage-induced cell death : a new type of activation-induced natural killer cell death"Eur J Immunol. 33(12). 3284-3292 (2003)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Miyashita T, et al.: "Akt is an endogenous inhibitor toward tumor necrosis factor-related apoptosis inducing ligand-mediated apoptosis in rheumatoid synovial cells."Biochem Biophys Res Commun. 312(2). 397-404 (2003)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Kita-Furuyama M, et al.: "Dendritic cells infected with adenovirus expressing the thyrotrophin receptor induce Graves' hyperthyroidism in BALB/c mice"Clin Exp Immunol. 131(2). 234-240 (2003)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Tanaka F, et al.: "Clinical outcome and survival of secondary (AA) amyloidosis."Clin Exp Rheumatol. 21(3). 343-346 (2003)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Kusumoto K, et al.: "A case of amyloidosis secondary to rheumatoid arthritis complicated with Graves ophthalmopathy."Mod Rheumatol. 13. 261-264 (2003)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Migita K, et al.: "FK506 : anti-inflammatory properties."Curr Med Chem-Anti-Inflammatory & Anti Allergy Agents. 2(3). 260-264 (2003)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Ashizawa K, et al.: "Serum anti-myeloperoxidase antineutrophil cytoplasmic antibodies (MPO-ANCA) in patients with Graves disease receiving anti thjiroid medication."Intern Med. 42(6). 463-464 (2003)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Ide A, et al.: "Stromal-cell derived factor-1 chemokine gene variant is associated with type 1 diabetes age at onset in Japanese population."Hum Immunol. 64(10). 973-978 (2003)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Yamasaki S, et al.: "Functional changes in rheumatoid fibroblast-like synovial cells through activation of peroxisome proliferator-activated receptor γ-mediated signalling pathway."Clin Exp Immunol. 129(2). 379-384 (2003)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Kawakami A, et al.: "Modulation of the expression of membrane-bound CD54 (mCD54) and soluble form of CD54 (sCD54) in endothelial cells by glucosyl transferase inhibitor : possible role of ceramide f_or the shedding of mCD54."Biochem Biophys Res Commun. 296(1). 26-31 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Kawakami A, et al.: "Involvement of optotic cell death in autoimmune diseases."Med Electron Microsc. 35(1). 1-8 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Kambara C, et al.: "Increased sialyl Lewis(x) antigen-positive cells mediated by HTLV-1 infection in peripheral blood CD4^+T lymphocytes in patients with HTLV-1-associated myelopathy."J Neuroimmunol. 125(1-2). 179-184 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Fujimoto T, et al.: "Up-regulation off interleukin-12 receptor expression in peripheral blood mononuclear cells of patients with HTLV I-associated myelopathy/tropical spastic paraparesis"J Neurol Sci. 196(1-2). 21-26 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Nagayama Y, et al.: "A novel murine model of Graves' hyperthyroidism with intramuscular injection of adenovirus a expressing the thyrotropin receptor"J Immunol. 168(6). 2789-2794 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Kamachi M, et al.: "Regulation of apoptotic cell death by cytokines in a human salivary gland cell line : distinct and synergistic mechanisms in apoptosis induced by tumor necrosis factor α and interferon γ."J Lab Clin Med. 139(1). 13-19 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Yonetsu K, et al.: "Sonography as a replacement for sialography for the diagnosis of salivary glands affected by Sjbgren's syndrome."Ann Rheum Dis. 61(3). 276-277 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Origuchi T, et al.: "A typical mycobacteriosis in two patients with rheumatoid arthritis."Mod Rheumatol. 12. 76-79 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Nakashima M, et al.: "A case of eosinophilic myositis associated with orbital myositis."Mod Rheumatol. 12. 80-83 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Ida H, et al.: "Increased levels of interleukm-18 (IL-18) in patients with systemic lupus erythematosus Comment on the article by Shibatomi."Arthritis Rheum. 45(5). 1411-1412 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Migita K, et al.: "Association of subacute cutaneous lupus erythematosus in rheumatoid arthritis patient with Sjpgren's syndrome."Mod Rheumatol. 12(4). 354-356 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Ide A, et al.: "Genetic association between interleukin-10 gene promoter region"Hum Immunol. 63(8). 690-695 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Ishikawa H, et al.: "Amyloid A protein amyloidosis in apatient with plasma cell dyscrasia."Intern Med. 41(5). 386-391 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Kawasaki E, et al.: "Autoantibodies to IA-2 in type 1 diabetes : measurements with a new enzyme-linked immunosorbent assay."Ann NY Acad Sci. 958. 241-246 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Kawasaki E, et al.: "Distinct IA-2 autoantibody epitope recognition between childhood-onset and adult-onset type 1 diabetes."Ann NY Acad Sci. 958. 235-240 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Yamasaki S, et al.: "Effect of filtration leukocytapheresis therapy : modulation of white blood cell enzyme activities in Patients with rhematoid arthritis."Artif Organs. 26(4). 378-384 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Ueki Y, et al.: "NOR-1 : a nitric oxide releasing agent for calibrating low levels of nitric oxide by the chemiluminescence method."Blood Coagul Fibrinolysis. 13(2). 75-80 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Migita K, et al.: "The role of peroxynitrite in cyclooxygenase-2 expression of rheumatoid synovium."Cim Exp Rheumatol. 20(1). 59-62 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Eguchi K.: "Systemic lupus erythematosus complicated by cytomegalovirus-induced hemophagoytic syndrome and colitis."Intern Med. 41(2). 77-78 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Eguchi K.: "Apoptosis in autoimmune diseases."Internal Med. 40(4). 275-284 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Sera N, et al.: "Fas/FasL mediated apoptosis of thyrocytes in Graves' disease"Clin Exp Immunol. 124. 197-207 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Hamasaki S, et al.: "Resistance of CD4-positive T lymphocytes to etoposide-induced apoptosis mediated by upregulation of Bcl-xL expression in patients with HTLV-I-associated myelopathy"J Neuroimmunol. 117. 143-148 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Shibatomi K, et al.: "A novel role for interleukin-18 in human natural killer cell death."Arthritis Rheum. 44(4). 884-892 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Kawakami A, et al.: "Role of HTLV-I infection in the pathogenesis of Sjogren's syndrome and rheumatoid arthritis."Mod Rheumatol. 11(2). 87-90 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Yamasaki S, et al.: "Importance of NF-κB in rheumatoid synovial tissues: in situ NF-κB expression and in vitro study using cultured synovial cells."Ann Rheum Dis. 60(7). 678-684 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Hashimoto Y, et al.: "Novel immunosuppressive effect of FK506 by augmentation of T cell apoptosis"Clin Exp Immunol. 125. 19-24 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Hirai Y, et al.: "Effects of nitric oxide on matrix metalloproteinase-2 production by rheumatoid synovial cells."Life Sci. 68. 913-920 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Migita K, et al.: "Impaired degradation of serum amyloid A (SAA) protein by cytokine-stimulated monocytes."Clin Exp Immunol. 123(3). 408-411 (2004)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Migita K, et al.: "Mixed connective tissue disease associated with von Recklinghausen's nurofibromatosis."Internal Med. 40(4). 363-364 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Migita K, et al.: "FK506-mediated T-cell apoptosis induction."Transplant P. 33. 2292-2293 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Migita K, et al.: "Nitric oxide protects cultured rheumatoid synovial cells from Fas-induced apojtosis by inhibiting caspase-3."Immunology. 103. 362-367 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Migita K, et al.: "Regulation of rheumatoid synoviocyte proliferation by endogenous induction"Clin Exp Immunol. 126(2). 334-338 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Shiraishi H, et al.: "Successful plasmapheresis in alveolar hemorrhage associated with systemic lupus erythematosus."Mod Rhematol. 11. 340-343 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Nakamura H, et al.: "Vasculo-Beehet's syndrome with widespread arterial involvement."Mod Rheumatol. 11. 332-335 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Migita K, et al.: "Effects of hemodialysis on advanced bony tophi in a tophaceous gout patient with chronic renal failure."Clm Exp Rheum. 19. 359-360 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Yamasaki S, et al.: "Poyarteritis nodosa complicated by thrombotic thrombocytopenic puryura."Ann Rheum Dis. 60(5). 541-542 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Urayama S, et al.: "New disease-modifying antirheumatic drug 2-acetylthiomethyl-4-(4-methylphenyl) -4-oxobutanoic acid (KE-298) selectively augments activation-induced T cell death."J Lab Clin Med. 138. 11-17 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Migita K, et al.: "Induction of Apoptosis : How do tacrolimus and ciclosporin compare?"Mechanistic Differences of Cornerstone Immunosuppressants (Fujisawa). 14-19 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Nakashima K: "Protection of mitochondrial perturbation by human T-lymphotropic virus type 1 tax through induction of Bcl-xL expression"J Lab Clin Med. 142(5). 341-347 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] Ida H: "Granzyme B leakage-induced cell death : a new type of activation-induced natural killer cell death"Eur J Immunol. 33(12). 3284-3292 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] Miyashita T: "Akt is an endogenous inhibitor toward tumor necrosis factor-related apoptosis inducing ligand-mediated apoptosis in rheumatoid synovial cells"Biochem Biophys Res Commun. 312(2). 397-404 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] Ida H: "Increased levels of interleukin-18 (IL-18) in patients with systemic lupus erythematosus : Comment on the article by Shibatomi et al., Reply to the editor"Arthritis Rheum. 45(5). 1411-1412 (2002)

    • Related Report
      2003 Annual Research Report
  • [Publications] Migita K: "Association of subacute cutaneous lupus erythematosus in rheumatoid arthritis patient with Sjogren's syndrome"Mod Rheumatol. 12(4). 354-356 (2002)

    • Related Report
      2003 Annual Research Report
  • [Publications] Kawakami A: "Modulation of the expression of membrane-bound CD54 (mCD54) and soluble form of CD54 (sCD54) in endothelial cells by glucosyl transferase inhibitor : possible role of ceramide for the shedding of mCD54"Biochem Biophys Res Commun. 296(1). 26-31 (2002)

    • Related Report
      2003 Annual Research Report
  • [Publications] Kawakami A: "Involvement of apoptotic cell death in autoimmune diseases"Med Electron Microsc. 35(1). 1-8 (2002)

    • Related Report
      2003 Annual Research Report
  • [Publications] Kambara C: "Increased sialyl Lewis(x) antigen-positive cells mediated by HTLV-1 infection in peripheral blood CD4(+) T lymphocytes in patients with HTLV-1-associated myelopathy"J Neuroimmunol. 125(1-2). 179-184 (2002)

    • Related Report
      2003 Annual Research Report
  • [Publications] Fujimoto T: "Up-regulation of interleukin-12 receptor expression in peripheral blood mononuclear cells of patients with HTLV-I-associated myelopathy/tropical spastic paraparesis"J Neurol Sci. 196(1-2). 21-26 (2002)

    • Related Report
      2003 Annual Research Report
  • [Publications] Kamachi M: "Regulation of apoptotic cell death by cytokines in a human salivary gland cell line : distinct and synergistic mechanisms in apoptosis induced by tumor necrosis factor α and interferon γ"J Lab Clin Med. 139(1). 13-19 (2002)

    • Related Report
      2003 Annual Research Report
  • [Publications] Yonetsu K: "Sonography as a replacement for sialography for the diagnosis of salivary glands affected by Sjogren's syndrome"Ann Rheum Dis. 61(3). 276-277 (2002)

    • Related Report
      2003 Annual Research Report
  • [Publications] Eguchi K: "A poptosis in autoimmune diseases"Internal Med. 40(4). 275-284 (2001)

    • Related Report
      2003 Annual Research Report
  • [Publications] Hamasaki S: "Resistance of CD4-positive T lymphocytes to etoposide-induced apoptosis mediated by upregulation of Bcl-xL expression in patients with HTLV-I-associated myelopathy"J Neuroimmunol. 117. 143-148 (2001)

    • Related Report
      2003 Annual Research Report
  • [Publications] Kawakami A: "Role of HTLV-I infection in the pathogenesis of Sjoren's syndrome and rheumatoid arthritis"Mod Rheumatol. 11(2). 87-90 (2001)

    • Related Report
      2003 Annual Research Report
  • [Publications] 江口勝美: "Sjogren症候群"医学の歩み. 別冊. 84-89 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] 西浦義博: "セレクチンリガンド・クロスリンキングによるHTLV-I感染細胞におけるTh1/Th2関連因子の変化とHTLV-I tax発現の亢進"神経免疫学. 11(1). 110 (2003)

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  • [Publications] 江口勝美: "HTLV-I感染とリウマチ性疾患"リウマチ科. 27(3). 238-246 (2002)

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  • [Publications] 江口勝美: "特集リウマチ性疾患とウイルスHTLV-I感染とリウマチ性疾患"リウマチ科. 27(3). 238-246 (2002)

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  • [Publications] 江口勝美: "厚生科学研究費補助金特定疾患対策研究事業自己免疫疾患に関する調査研究平成14年度総括・分担研究報告書"厚生科学研究費補助金特定疾患対策研究事業自己免疫疾患に関する調査研究班. 8 (2003)

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  • [Publications] 江口勝美: "シェーグレン症候群の基礎と臨床"医薬ジャーナル社. 10 (2003)

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  • [Publications] 中村龍文: "厚生科学研究費補助金免疫性神経疾患に関する調査研究平成14年度総括・分担研究報告書"厚生科学研究費補助金免疫性神経疾患に関する調査研究班. 3 (2003)

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  • [Publications] Ida H: "Granzyme B leakage-induced cell death: a new type of activation -induced natural killer cell death"J Immunol. (accepted).

    • Related Report
      2002 Annual Research Report
  • [Publications] Kita-Furuyama M: "Dendritic cells infected with adenovirus expressing the thyrotrophin receptor induce Graves' hyperthyroidism in BALB/c mice"Clin Exp Immunol. 131. 234-240 (2003)

    • Related Report
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  • [Publications] Yanagi K: "Immuno-gene therapy with adenoviruses expressing fms-like tyrosine kinase 3 ligand and CD40 ligand for mouse hepatoma cells in vivo"Int J Oncol. 22. 345-351 (2003)

    • Related Report
      2002 Annual Research Report
  • [Publications] Ida H: "Increased levels of interleukin-18(IL-18) in patients with systemic lupus erythematosus : Comment on the article by Shibatomi et al., Reply to the editor"Arthritis Rheum. 45・5. 1411-1412 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] Yamasaki S: "Functional changes in rheumatoid fibroblast-like synovial cells through activation of peroxisome proliferator-activated receptor γ-mediated signalling"Clin Exp Immunol. 129・2. 379-384 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] Kawakami A: "Modulation of the expression of membrance-bound CD54(mCD54) and soluble from of CD54(sCD54) in endothelial cells by glucosyl transferase inhibitor;"Biochem Biophys Res Commun. 296・1. 26-31 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] Ide A: "Genetic association between interleukin-10 gene promoter region polymorphisms and type 1 diabetes age-at-onset"Hum Immunol. 63・8. 690-695 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] Kawakami A: "Involvement of apoptotic cell death in autoimmune diseases"Med Electron Microsc. 35・1. 1-8 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] Ueki Y: "NOR-1 : a nitric oxide releasing agent for calibrating low levels of nitric oxide by the chemiluminescence method"Blood Coagul Fibrinolysis. 13・2. 75-80 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] Migita K: "The role of peroxynitrite in cyclooxygenase-2 expression of rheumatoid synovium"Clin Exp Rheumatol. 20・1. 59-62 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] Nagayama Y: "A novel murine model of Graves' hyperthyroidism with intramuscular injection of adenovirus expressing the thyrotropin receptor"J Immunol. 168・6. 2789-2794 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] Kamachi M: "Regulation of apoptotic cell death by cytokines in a human salivary gland cell line : distinct and synergistic mechanisms in apoptosis induced by tumor necrosis factor α and interferon γ"J Lab Clin Med. 139・1. 13-19 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] Yonetsu K: "Sonography as a replacement for sialography for the diagnosis of salivary glands affected by Sjogren's syndrome"Ann Rheum Dis. 61・3. 276-277 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] Hashimoto Y: "Novel Immunosuppressive effect of FK506 by augmentation of T cell apoptosis"Clin Exp Immunol. 125. 19-24 (2001)

    • Related Report
      2002 Annual Research Report
  • [Publications] Eguchi K: "A Poptosis in autoimmune diseases"Internal Med. 40・4. 275-284 (2001)

    • Related Report
      2002 Annual Research Report
  • [Publications] Sera N: "Fas/FasL mediated apoptosis of thyrocytes in Graves' disease"Clin Exp Immunol. 124. 197-207 (2001)

    • Related Report
      2002 Annual Research Report
  • [Publications] Hamasaki S: "Resistance of CD4-positive T lymphocytes to etoposide-induced apoptosis mediated by upregulation of Bcl-xL expression in patients with HTLV-I-associated myelopathy"J Neuroimmunol. 117. 143-148 (2001)

    • Related Report
      2002 Annual Research Report
  • [Publications] Hirai Y: "Effects of nitric oxide on matrix metalloproteinase-2 production by rheumatoid synovial cells"Life Sci. 68. 913-920 (2001)

    • Related Report
      2002 Annual Research Report
  • [Publications] Migita K: "Impaired degradation of serum amyloid A (SAA) protein by cytokine-stimulated monocytes"Clin Exp Immunol. 123・3. 408-411 (2001)

    • Related Report
      2002 Annual Research Report
  • [Publications] Shibatomi K: "A Novel Role for Interleukin-18 in Human Natural Killer Cell Death"Arthritis Rheum. 44・4. 884-892 (2001)

    • Related Report
      2002 Annual Research Report
  • [Publications] Kawakami A: "Role of HTLV-I Infection in the pathogenesis of Sjoren's syndrome and rheumatoid arthritis"Mod Rheumatol. 11・2. 87-90 (2001)

    • Related Report
      2002 Annual Research Report
  • [Publications] Migita K: "FK506-Mediated T-Cell Apoptosis Induction"Transplant P. 33. 2292-2293 (2001)

    • Related Report
      2002 Annual Research Report
  • [Publications] Yamasaki S: "Importance of NF-κB in rheumatoid synovial tissues : in situ NF-κB expression and in vitro study using cultured synovial cells"Ann Rheum Dis. 60・7. 678-684 (2001)

    • Related Report
      2002 Annual Research Report
  • [Publications] Migita K: "Nitric oxide protects cultured rheumatoid synovial cells from Fas-induced apoptosis by inhibiting caspase-3"Immunology. 103. 362-367 (2001)

    • Related Report
      2002 Annual Research Report
  • [Publications] Migita K: "Regulation of rheumatoid synoviocyte proliferation by endogenous p53 induction"Clin Exp Immunol. 126・2. 334-338 (2001)

    • Related Report
      2002 Annual Research Report
  • [Publications] Urayama S: "New disease-modifying antirheumatic drug 2-acetylthiomethyl-4-(4-methylphenyl)-4-oxobutanoic acid(KE-298) selectively augments activation-induced T cell death"J Lab Clin Med. 138. 11-17 (2001)

    • Related Report
      2002 Annual Research Report
  • [Publications] 江口勝美: "特集 リウマチ性疾患とウイルスHTLV-I感染とリウマチ性疾患"リウマチ科. 27・3. 238-246 (2002)

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      2002 Annual Research Report
  • [Publications] 川上 純: "HTLV-I感染によるシェーグレン症候群・慢性関節リウマチの発症機序"臨床リウマチ. 13. 11-17 (2001)

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  • [Publications] 江口勝美: "炎症におけるHTLV-I感染の役割"血液・免疫・腫瘍. 6・2. 61-71 (2001)

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  • [Publications] Migita K: "Mechanistic Difference of Cornerstone Immunosuppressants"Fujisawa. 6 (2001)

    • Related Report
      2002 Annual Research Report
  • [Publications] Hashimoto Y.: "Novel immunosuppressive effect of FK506 by augmentation of T cell apoptosis"Clin Exp Immunol. 125(1). 19-24 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] Migita K.: "Nitric oxide protects cultured rheumatoid synovial cells from Fas-induced apoptosis by inhibiting caspase-3"Immunology. 103(3). 362-367 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] Urayama S.: "New disease-modifying antirheumatic drug 2 acetylthiomethyl-4-(4-methylphenyl)-4-oxobutanoic acid (KE-298) selectively augments activation-induced T cell death"J Lad Clin Med. 138(1). 11-17 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] Hamasaki S.: "Resistance of CD4-positive T lymphocytes to etoposide-induced apoptosis mediated by upregulation of Bcl-xL expression in patients with HTLV-I-associated myelopathy"J Neuroimmunol. 117(1-2). 143-148 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] Sera N.: "Fas/FasL mediated apoptosis of thyrocytes in Graves' disease"Clin Exp Immunol. 124(2). 197-207 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] Yamasaki S.: "Importance of NF-kB in rheumatoid synovial tissues : in situ NF-κB expression and in vitro study using cultured synovial cells"Ann Rheum Dis. 60(7). 678-684 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] Migita K.: "Effects of hemodialysis on advanced bony tophi in a tophaceous gout patient with chronic renal failure"Clin Exp Rheumatol. 19(3). 359-360 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] Migita K.: "FK 506-mediated T-cell apoptosis induction"Transplant Proc. 33(3). 2292-2293 (2001)

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      2001 Annual Research Report
  • [Publications] Shibatomi K.: "A novel role for interleukin-18 in human natural killer cell death : high serum levels and low natural killer cell numbers in patients with systemic autoimmune diseases"Arthritis Rheum. 44(4). 884-892 (2001)

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      2001 Annual Research Report
  • [Publications] Kawakami A.: "Role of HTLV-I infection in the pathogenesis of Sjogren's syndrome and rheumatoid arthritis"Modern Rheumatology. 11(2). 87-90 (2001)

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      2001 Annual Research Report
  • [Publications] Migita K.: "Regulation of rheumatoid synoviocyte proliferation by endogenous p53 induction"Clin Exp Immunol. 126(2). 334-338 (2001)

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      2001 Annual Research Report
  • [Publications] 江口勝美: "炎症におけるHTLV-I感染の役割"血液・免疫・腫瘍. 6(2). 61-71 (2001)

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      2001 Annual Research Report
  • [Publications] 江口勝美: "シェーグレン症候群の病型分類と疫学"アレルギー・免疫. 8(9). 14-21 (2001)

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      2001 Annual Research Report
  • [Publications] 江口勝美: "Sjogren症候群"医学のあゆみ. 199(5). 387-392 (2001)

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      2001 Annual Research Report
  • [Publications] 江口勝美: "自己免疫疾患におけるアポトーシス"MINOPHAGEN MEDICAL REVIEW. 46(6). 309-330 (2001)

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      2001 Annual Research Report
  • [Publications] 川上 純: "HTLV-I感染によるシェーグレン症候群・慢性関節リウマチの発症機序"臨床リウマチ. 13. 11-17 (2001)

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  • [Publications] 川上 純: "NF-κBと炎症"炎症と免疫. 9(6). 77-84 (2001)

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      2001 Annual Research Report
  • [Publications] 川上 純: "T細胞特異的NF-κB阻害薬によるコラーゲン誘発関節炎発症阻止"臨床免疫. 36(3). 444-448 (2001)

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      2001 Annual Research Report

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Published: 2001-04-01   Modified: 2016-04-21  

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