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Development of safety methods for adult to adult living donor liver transplantation focused on cyclic AMP signal pathway.

Research Project

Project/Area Number 13557102
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section展開研究
Research Field Digestive surgery
Research InstitutionHOKKAIDO UNIVERSITY

Principal Investigator

FURUKAWA Hiroyuki  Hokkaido Univ., Grad. School of Med., Corporate Donated Chair Teacher, 大学院・医学研究科, 寄附講座教員 (70292026)

Co-Investigator(Kenkyū-buntansha) SHIMAMURA Tsuyoshi  Hokkaido Univ., Hokkaido University Hospital, Lec., 医学部・歯学部附属病院, 助手 (00333617)
JIN Maeng bong  Hokkaido Univ., Grad. School of Med., Corporate Donated Chair Teacher, 大学院・医学研究科, 寄附講座教員 (40333603)
TODO Satoru  Hokkaido Univ., Grad. School of Med., Pro., 大学院・医学研究科, 教授 (60136463)
Project Period (FY) 2001 – 2003
Project Status Completed (Fiscal Year 2003)
Budget Amount *help
¥13,700,000 (Direct Cost: ¥13,700,000)
Fiscal Year 2003: ¥2,200,000 (Direct Cost: ¥2,200,000)
Fiscal Year 2002: ¥5,500,000 (Direct Cost: ¥5,500,000)
Fiscal Year 2001: ¥6,000,000 (Direct Cost: ¥6,000,000)
Keywordssmall-for-size graft / right hepatic vein reconstruction / clinical pass / alubumin product / post transplant graft dysfunction / 70%肝切除 / ヒアルロン酸 / エンドセリン / 門脈圧 / 門脈血流 / 動脈血流 / 類洞内皮障害 / 成人生体肝移植 / エンドセリン-1 / ヒアルリン酸 / Small-for-size graft / 類洞内皮機能 / 成人間生体肝移植 / small-for-sizeグラフト / 肝類洞内皮障害 / 肝微小循環障害 / 門脈・下大静脈シャント / ホスホジエステラーゼIII阻害剤 / 肝再生因子
Research Abstract

First of all, small-for size graft syndrome is probably due to relative liver ischemia. Although, to dissolve this problem, port-caval shunt, splenic ligation, and splenectomy are used as surgical interventions, there have been few cases treated by pharmacological pre-conditioning. We try to improve liver damage caused by congestion using 2hr-canine warm ischemic model.
Secondly, while right lobe grafting is the most effective alternative for the strategy against small-for-size liver syndrome, the suboptimal hepatic venous outflow may lead to serious graft function. The 3 dimensional (3D) images constructed by multiditector CT were used for pre-operative virtual donor hepatectomy and grafting with reconstruction of MHV tributaries. The emphasizing point in our 3D images is that this method can calculate each volume of the are, of which each hepatic vein drains.
Thirdly, the reason why we made up clinical pathways for adult to adult living donor liver transplantation is not only for developing theoretical and technical surgical performance, but also for verifying the validity of our patient care strategy in the other liver transplantation programs.
Fourthly, the patients after liver transplantation suffered from small-for-size syndrome, basically, need much amount of albumin product, because the ability of the small liver allografts seem to require long time to get mature productivity. In such situation, young surgeons are likely to use much more albumin product than appropriate dose. To lead them to proper direction, we showed our manual haw to use albumin product.
Finally, we summarized present status of adult to adult liver transplantation in both Japanese and western countries. In addition, we compared the treatments of graft dysfunction between our program and the others.

Report

(4 results)
  • 2003 Annual Research Report   Final Research Report Summary
  • 2002 Annual Research Report
  • 2001 Annual Research Report
  • Research Products

    (22 results)

All Other

All Publications (22 results)

  • [Publications] Masuko H: "Protective effect of angiotensin II type I receptor antagonist, CV-11974, on ischemia and reperfusion injury of the liver."Transplantation. 71(8). 1034-1039 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Ogata K: "Attenuation of ischemia and reperfusion injury of canine livers by inhibition of type II phospholipase A_2 with LY329722"Transplantation. 71(8). 1040-1046 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Ishikawa H: "Role of cyclic nucleotides in ischemia and reperfusion injury of canine livers"Transplantation. 73(7). 1041-1048 (2002)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Jin MB: "A Novel Iefunomide derivative, FK778, for immunosuppression after kidney transplantation in dogs"Surgery. 132(1). 72-79 (2002)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Takeda T: "A novel inhibitor of Rho-associated protein kinase, Y-27632, ameliorates hepatic ischemia and reperfusion injury in rats."Surgery. 133. 197-206 (2003)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] 陳 孟鳳: "肝臓移植の現況"北海道外科雑誌. 48. 2-8 (2003)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] 陳 孟鳳: "山本保博編アルブミン臨床マニュアル、成人生体肝移植"メディカルレビュー社、東京. 6 (2003)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Masuko H, Jin MB, Horiuchi H, Suzuki Masuko H, Jin MB, Horiuchi H, Suzuki T, Taniguchi M, Shimamura T, Fukai M, Magata S, Ogata K, Ishikawa H, Fujita M, Nagashima K, Furukawa H, Todo S: "Protective effect of angiotensin II type I receptor antagonist, CV-11974, on ischemia and reperfusion injury of the liver."Transplantation. 71(8). 1034-1039 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Ogata K, Jin MB, Taniguchi M, Suzuki T, Shimamura T, Kitagawa N, Magata S, Fukai M, Ishikawa H, Ono T, Furukawa H, Fujita M, Todo S: "Attenuation of ischemia and reperfusion iniury of canine livers by inhibition of type II phospholipase A_2 with LY329722."Transnlantation. 71(8). 1040-1046 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Ishikawa H, Jin MB, Ogata T, Taniguchi M, Suzuki T, Shimamura T, Magata S, Horiuchi H, Ogata K, Masuko H, Fujita M, Furukawa H, Todo S: "Role of cyclic nucleotides in ischemia and reperfusion injury of canine livers"Transplantation. 73(7). 1041-1048 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Jin MB, Nakayama M, Ogata T, Fujita M, Mino K, Taniguchi M, Suzuki T, Shimamura T, Furukawa H, Todo S: "A Novel lefunomide derivative, FK778, for immunosuppression after kidney transplantation in dogs"Surgery. 132(1). 72-79 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Takeda T, Jin MB, Fujita M, Sakurai T, Nakayama M, Taniguchi M, Suzuki T, Shimamura T, Furukawa H, Todo S.: "A novel inhibitor of Rho-associated protein kinase, Y-27632, ameliorates hepatic ischemia and reperfusion injury in rats."Surgery. 133. 197-206 (2003)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Jin MB et al.: "Present status in liver transplantation"Hokkaido J.Surg. 48. 2-8 (2003)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Jin MB, et al.: "Manual for use of albumin product in Living donor liver transplantation"Medical Review, Tokyo. (2003)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Ishikawa H: "Role of cyclic nucleotides in ischemia and reperfusion injury of canine livers"Transplantation. 73(7). 1041-1048 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] 古川博之: "小児肝移植と成人肝移植"小児外科. 33(4). 370-375 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] 古川博之: "肝臓移植(5)肝移植の後遺症"臨床消化器内科. 16(13). 1753-1764 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] 古川博之: "肝臓移植"小児内科. 34(1). 57-62 (2002)

    • Related Report
      2001 Annual Research Report
  • [Publications] 嶋村 剛: "肝移植"総合臨床. 50(1). 57-65 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] 嶋村 剛: "肝移植:現況と展望"日本内科学会雑誌. 90(1). 21-28 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] 嶋村 剛: "脳死ドナーからの全肝切除"臨床雑誌「外科」. 63(11). 57-65 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] 古川博之: "ドナー手術"肝・胆・膵フロンテイア12肝移植のup to date. 114-120 (2001)

    • Related Report
      2001 Annual Research Report

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Published: 2001-04-01   Modified: 2016-04-21  

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