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Molecular Targeting Therapy with Intelligent Drug Delivery System using Transporter

Research Project

Project/Area Number 13557104
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section展開研究
Research Field Digestive surgery
Research InstitutionTHE UNIVERSITY OF TOKYO

Principal Investigator

YANAGIE Hironobu (2003)  THE UNIVERSITY OG TOKYO, RESEARCH CENTER FOR ADVANCED SIENCE AND TECHNOLOGY, ASSOCIATE PROFESSOR, 先端科学技術研究センター, 科学技術振興特任教員(特任教授) (30212278)

吉崎 巖 (2001-2002)  東京大学, 医科学研究所, 助手 (70200970)

Co-Investigator(Kenkyū-buntansha) ERIGUCHI Masazumi  THE UNIVERSITY OF TOKYO, RESEARCH CENTER FOR ADVANCED SIENCE AND TECHNOLOGY, PROFESSOR, 先端科学技術研究センター, 科学技術振興特任教員(特任教授) (10114406)
MARUYAMA Kazuo  TEIKYO UNIVERSITY, FACULTY OF PHARMACEUTICAL SCIENCES, PROFESSOR, 薬学部, 教授 (30130040)
KIZU Ryoichi  KANAZAWA UNIVERSITY, GRADUATE SCHOOL OF NATURAL SCIENCE AND TECHNOLOGY, ASSOCIATE PROFESSOR, 大学院・自然科学研究科, 助教授 (80143915)
TAMAI Ikumi  TOKYO UNIVERSITY OF SCIENCE, FACULTY OF PHARMACEUTICAL, PROFESSOR, 薬学部, 教授 (20155237)
KIDANI Yoshinori  NAGOYA CITY UNIVERSITY, FACULTY OF PHARMACEUTICAL SCIENCES, PROFESSOR EMERITUS, 薬学部, 名誉教授
喜谷 喜徳  名古屋市立大学, 薬学部, 名誉教授
柳衛 宏宣  東京大学, 先端科学技術研究センター, 科学技術振興特任教員(常勤形態)特任助教授 (30212278)
Project Period (FY) 2001 – 2003
Project Status Completed (Fiscal Year 2003)
Budget Amount *help
¥14,000,000 (Direct Cost: ¥14,000,000)
Fiscal Year 2003: ¥4,100,000 (Direct Cost: ¥4,100,000)
Fiscal Year 2002: ¥4,100,000 (Direct Cost: ¥4,100,000)
Fiscal Year 2001: ¥5,800,000 (Direct Cost: ¥5,800,000)
KeywordsTransporter / Anticancer resistant gene / DNA Microarray / Molecular targeting therapy / Anionic Polyethylene glycol / JTS-1 / Drug Delivery System / Transfferin binding PEG-Liposome / 分子標的治療 / ドラッグデリバリーシステム / インテリジェント化 / トランスフェリン-PEG-リポソーム / Oxaliplatin / Qplex / 癌抑制遺伝子 / 遺伝子治療
Research Abstract

We performed the research works for enhancement the therapeutic effects of anti-cancer agents with the selective transfection of transporter genes into cancer cells in tumor bearing bodies. We elongated survival days with the administrations of Cisplatin entrapped transfferin binding PEG liposome for cancer peritonitis of gastric cancers, and with Oxaliplatin entrapped transfferin binding PEG liposome for cancer peritonitis of pancreatic cancers. We also developed the gene delivery systems of transporter genes. Anionic polyethylene glycol(PEG-C) binding polyethyleneimine with JTS-1, an pH sensitive fusogenic peptide was showed the enhancement of expression efficiency of Luciferase gene(6 x 10E9 RLU/mg protein). In the analysis of DNA microarray comparing with oxaliplatin sensitive cancer cell lines and resistant cancer cell lines, Tublin specific chaperon and CBP/P300-Interacting Transactivator (CITED2) genes were enhanced in the resistant cell lines. PEPT1, OATP-C and OCTN1 genes were founded with the analysis of transporter genes. PEPT1 is related the absorption of βlactum antibiotics, inhibitor of angiotensin converting enzyme, vestatin. OATP-C is related with exflux of peptide of hepatocytes. OCTN-1 is related to movement of pH dependent cationic electorates.

Report

(4 results)
  • 2003 Annual Research Report   Final Research Report Summary
  • 2002 Annual Research Report
  • 2001 Annual Research Report
  • Research Products

    (17 results)

All 2004 2003 Other

All Journal Article (11 results) Publications (6 results)

  • [Journal Article] Intracellular targeting of sodium mercaptoundecahydrododecaborate(BHS) to solid tumors by transferring-PEG liposomes. for boron neutron-capture therapy (BNCT)2004

    • Author(s)
      Kazuo Maruyama
    • Journal Title

      J.Control.Release 98(2)

      Pages: 195-207

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Journal Article] Intracellular targeting of sodium mercaptounde cahydrododecaborate(BHS) to solid tumors by transferring-PEG liposomes, for boron neurton-capture therapy(BNCT)2004

    • Author(s)
      Kazuo Maruyama
    • Journal Title

      J.Control.Release 98(2)

      Pages: 195-207

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Journal Article] Choronotherapy for cancer2003

    • Author(s)
      Hironobu Yanagie
    • Journal Title

      Biomed Pharmacother 57

      Pages: 92-95

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Journal Article] 大腸癌転移に対する遺伝子治療の現状と将来2003

    • Author(s)
      柳衛 宏宣
    • Journal Title

      臨床外科 58

      Pages: 795-798

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Journal Article] Targeting of post-ischemic cerebral endothelium in rat by liposomes bearing polyethylene glycol-coupled transferrin.2003

    • Author(s)
      Kazuo Maruyama
    • Journal Title

      Pharmaceutical Reseach 25

      Pages: 275-279

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Journal Article] Involvement of OCTN1 (SLC22A4) in pH-Dependent Transport of Organic2003

    • Author(s)
      Ikumi Tamai
    • Journal Title

      Molecular Pharmaceutidcs Vol.11, No.1

      Pages: 55-66

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Journal Article] Enhanced Intestinal Absorption of Drugs by Activation of Peptide Transporter PEPT1 Using Proton-Releasing Polymer.2003

    • Author(s)
      Ikumi Tamai
    • Journal Title

      Journal Of Pharmaceutical Science Vol.92, No.11

      Pages: 2208-2216

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Journal Article] Gene therapy for liver metastasis of colon cancer2003

    • Author(s)
      Hironobu Yanagie
    • Journal Title

      GEKARINSYO 58

      Pages: 795-798

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Journal Article] Targeting of post-ischemic cerebral endothelium in rat by liposomes bearing polyethylene glycol-coupled transferrin2003

    • Author(s)
      Kazuo Maruyama
    • Journal Title

      Pharmaceutical Research 25

      Pages: 275-279

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Journal Article] Involvement of OCTN1(SLC22A4) in pH-Dependent Transport of Organic Cation2003

    • Author(s)
      Ikumi Tamai
    • Journal Title

      Molecular Pharmaceutidcs Vol.11, No.1

      Pages: 55-66

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Journal Article] Enhanced Intestinal Absorption of Drugs by Activation of Peptide Transporter PEPT1 Using Proton-Releasing Polymer2003

    • Author(s)
      Ikumi Tamai
    • Journal Title

      J.Pharmaceutical Science Vol.92 No.11

      Pages: 2208-2216

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Hironobu Yanagie: "Choronotherapy for cancer."Biomed Pharmacother. 57. 92-95 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] 柳衛 宏宣: "大腸癌転移に対する遺伝子治療の現状と将来"臨床外科. 58. 793-798 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] Kazuo Maruyama: "Intracellular targeting of sodium mercaptoundecahydrododecaborate (BHS) to solid tumors by transferring-PEG liposomes, for boron neutron-capture therapy (BNCT)"J.Control.Release. (in press). (2004)

    • Related Report
      2003 Annual Research Report
  • [Publications] Kazuo Maruyama: "Targeting of post-ischemic cerebral endothelium in rat by liposomes bearing polyethylene glycol-coupled transferrin."Pharmaceutical Research. 25. 275-279 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] Ikumi Tamai: "Involvement of OCTN1(SLC22A4) in pH-Dependent Transport of Organic Cation."Molecular Pharmaceutides. Vol.11, No.1. 55-66 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] Ikumi Tamai: "Enhanced Intestinal Absorption of Drugs by Activation of Peptide Trans porter PEPT1 Using Proton-Releasing Polymer"Journal Of Pharmaceutical Science. Vol.92, No.11. 2208-2216 (2003)

    • Related Report
      2003 Annual Research Report

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Published: 2001-04-01   Modified: 2016-04-21  

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