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Research for Improving Effects of Clinical after Left Ventricle Repair Surgery on Chronic Cardiac Failure

Research Project

Project/Area Number 13557108
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section展開研究
Research Field Thoracic surgery
Research InstitutionKYOTO UNIVERSITY

Principal Investigator

KOMEDA Masashi  Kyoto University, Cardiovascular Surgery, Professor, 医学研究科, 教授 (20303810)

Co-Investigator(Kenkyū-buntansha) SUGA Hiroyuki  National Cardiovascular Center, Research Section, Chief, 所長 (90014117)
KIHARA Yasuki  Kyoto University, Internal Medicine, Assistant Professor, 医学研究科, 講師 (40214853)
NISHIMURA Kazunobu  Kyoto University, Cardiovascular Surgery, Associate Professor, 医学研究科, 助教授 (70252450)
Project Period (FY) 2001 – 2002
Project Status Completed (Fiscal Year 2002)
Budget Amount *help
¥2,900,000 (Direct Cost: ¥2,900,000)
Fiscal Year 2002: ¥2,900,000 (Direct Cost: ¥2,900,000)
KeywordsHeart Failure / Surgical treatment / LV repair surgery / Ischemic cardiomyopathy / Dor method / Batista method / 左心室瘤 / リモデリング / ACE阻害薬 / 心筋梗塞 / 酸化ストレス
Research Abstract

Background: We reported that the initial effects of left ventricular repair surgery (LVR) for ischemic cardiomyopathy were not long lasting. Angiotensin-converting enzyme inhibitor (ACE-I) and Angiotensin-II receptor blocker (ARB) are known to attenuate remodeling after MI. Addition, the effect to attenuate remodeling of human atrial natriuretic peptide (hANP) after MI was estimated. Method: (1) ACE- I administration: Ischemic cardiomyopathy rats were developed after LAD ligation. Rats were divided 2groups, LVR with ACE-I (ACE Group) and LVR with placebo (LVR Group) at 4weeks after LAD ligation, and rats in 2 groups were underwent LVR by plication. LV function was evaluated by echocardiography and catheterization. (2) ABR administration: Rats were divided 2groups, LVR with ARB (ARB Group) and LVR with placebo (LVR Group). Other methods were underwent same as above. (3) Rats were divided into 2 groups after LAD ligation, an ANP group were intravenously administrated with hANP, Control group were with saline. LV function was estimated by echocardiography and catheter 1 or 2 week after administration. Results: (1)(2) LV end diastolic area in ACE Group and ARB Group was smaller than LVR Group, significantly. E-max in ACE Group was significant higher than LVR Group 4 weeks after LVR. (3) LVEDA in hANP Group was small than Control Group and FAC in hANP Group was significant higher 1 and 2 weeks after MI. Conclusion: 1. Administration of ACE or ARB after LVR was preventing re-dilation and maintaining LV function. 2. Intravenous administration of ANP reduced infarct size and maintained LV function.

Report

(3 results)
  • 2002 Annual Research Report   Final Research Report Summary
  • 2001 Annual Research Report
  • Research Products

    (18 results)

All Other

All Publications (18 results)

  • [Publications] 仁科 健: "虚血性心筋症の外科治療"Cardiovascular Med-Surg. 3. 228-233 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Sadatoshi Yuasa: "A rat model of dilated cardiomyopathy to investigate partial left ventriculectomy"J Card Surg. 16. 40-47 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Takeshi Nishina: "Initial effects of the left ventricular repair by plication may not last long in a rat ischemic cardiomyopathy model"Circulation. 104(suppl I). I-241-I-245 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Takeshi Nishina: "A rats model of ischemic cardiomyopathy for investigating left ventricular volume reduction model"J Card Surg. 17. 155-162 (2002)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Takeshi Nishina: "A rat model of ischemic or dilated cardiomyopathy for investigating left ventricular repair surgery"CEPP. 29. 728-730 (2002)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Takuya Nomoto: "Angiotensin-Converting enzyme inhibitor helps prevent late remodeling after Left ventricular aneurysm repair in rats"Circulation. 106(Suppl I). I-115-I-119 (2002)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Takeshi Nishina, Masashi Komeda: "Surgical Treatment of Ischemic cardiomyopathy"Cardiovascular Med-Surg. 3. 228-233 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Sadatoshi Yuasa, Takeshi Nishina, Kazunobu Nishimura, Senri Miwa, Tadashi Ikeda, Michiya Hanyu, Yasutada Fujioka, Yasuki Kihara, Sigetake Sasayama, Masashi Komeda: "A rat model of dilated cardiomyopathy to investigate partial left ventriculectomy"J Card Surg. 16. 40-47 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Takeshi Nishina, Kazunobu Nishimura, Sadatoshi Yuasa, Senri Miwa, Takuya Nomoto, Yutaka Sakakibara, Nobuhiro Handa, Ichiro Hamanaka, Yoshihiko Saito, Masashi Komeda: "Initial effects of the left ventricular repair by plication may not last long in a rat ischemic cardiomyopathy model"Circulation. 104[suppl I]. I-241-I-245 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Takeshi Nishina, Kazunobu Nishimura, Sadatoshi Yuasa, Senri Miwa, Yutaka Sakakibara, Tadashi Ikeda, Masashi Komeda: "A rats model of ischemic cardiomyopathy for investigating left ventricular volume reduction surgery"J Card Surg. 17. 155-162 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Takeshi Nishina, Senri Miwa, Sadatoshi Yuasa, Kazunobu Nishimura, Masashi Komeda: "A rats model of ischemic or dilated dardiomyopathy for investigating left ventricular repair surgery"CEPP. 29. 728-730 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Takuya Nomoto, Takeshi Nishina, Senri Miwa, Hiroshi Tsuneyoshi, Izumi Maruyama, Kazunobu Nishimura, Masashi Komeda: "Angiotennshinn-Converting enzyme inhibitor helps prevent late remodeling after left ventricular aneurysm repair in rats"Circulation. 106[suppl I]. I-115-I-119 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Nomoto T, Nishina T, Sakakibara Y, Tambara K, Miwa S, Nishimura K, Komeda M.: "Adjuvant therapies to improve outcome of left ventricule repair for left ventricle aneurysme"Circulation Journal. 66 [suppl I]. 45 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Hiroshi Tsuneyoshi, Takuya Nomoto, Takeshi Nishina, Hideo Kanemitu, Kazunobu Nishimura, Masashi Komeda: "Dose longer term intravenous administration of Atrial Natiuretic Peptide prevent left ventricular remodeling after myocardial infarction in rats?"Circulation Journal. [suppl I]. 305 (2003)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Takuya Nomoto: "Angiotensin-Converting enzyme inhibitor helps prevent late remodeling after Left ventricular aneurysm renair in rats"Circulation. 106(Suppl I). I115-I119 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] Takeshi Nishina: "Initial Effects of the Left Ventricular Repair by Plication May Not Last Long in a Rat Ischemic Cardiomyopathy Model"Circulation. 104 suppl I. I-241-I-245 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] Takeshi Nishina: "A Rat Model of Ischemic Cardiomyopathy for Investigating Left Ventricular Volume Reduction Surgery"Journal of Cardiac Surgery. (in press).

    • Related Report
      2001 Annual Research Report
  • [Publications] 仁科 健: "虚血性心筋症の外科治療"Cardiovascular Med-Surg. 3. 228-233 (2001)

    • Related Report
      2001 Annual Research Report

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Published: 2002-04-01   Modified: 2016-04-21  

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