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Development of intraoperative brain function endoscope with intrinsic optical imaging and fiber optics

Research Project

Project/Area Number 13557114
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section展開研究
Research Field Cerebral neurosurgery
Research InstitutionTokyo Medical and Dental University

Principal Investigator

SATO Katsushige  Tokyo Medical and Dental University, Graduate School, Lecturer, 大学院・医歯学総合研究科, 講師 (80291342)

Co-Investigator(Kenkyū-buntansha) MOMOSE Yoko (SATO Yoko)  Tokyo Medical and Dental University, Graduate School, Lecturer, 大学院・医歯学総合研究科, 講師 (70251501)
NARIAI Tadashi  Tokyo Medical and Dental University, Graduate School, Lecturer, 大学院・医歯学総合研究科, 講師 (00228090)
OHNO Kikuo  Tokyo Medical and Dental University, Graduate School, Professor, 大学院・医歯学総合研究科, 講師 (50014238)
TSUMURA Harukuni  Saikei, Co., System Engineering, システム機器部, 部長
Project Period (FY) 2001 – 2004
Project Status Completed (Fiscal Year 2004)
Budget Amount *help
¥13,400,000 (Direct Cost: ¥13,400,000)
Fiscal Year 2004: ¥2,100,000 (Direct Cost: ¥2,100,000)
Fiscal Year 2003: ¥2,500,000 (Direct Cost: ¥2,500,000)
Fiscal Year 2002: ¥2,700,000 (Direct Cost: ¥2,700,000)
Fiscal Year 2001: ¥6,100,000 (Direct Cost: ¥6,100,000)
Keywordsoptical recording / intrinsic signal / fiber optic / neurosurgery / imaging / brain function endoscope / intraoperative recording / neural function
Research Abstract

We applied the intrinsic optical imaging technique to the human primary somatosensory cortex during brain tumor/epilepsy surgery for nine patients. The cortical surface was illuminated with a Xenon light through an operating microscope, and the reflected light, which passed through a 605nm bandpass filter, was detected by a CCD camera-based optical imaging system. Individual electrical stimulation of five digits induced changes in the reflected light intensities. Visualizing the intrinsic optical responses, we constructed maps of finger representation in Brodmann's area 1. In the maps, response areas of Digit I to V were sequentially aligned along the central sulcus in the crown of the postcentral gyrus from the latero-inferior region (Digit I) to the medio-superior region (Digit V). The neighboring response areas partially overlapped each other, as previously described in the monkey somatosensory cortex. Similar results were obtained in the face region with stimulation of the three branches of the trigeminal nerve. These results suggest that the overlap of the response areas is a common feature in the somatosensory cortex not only in monkeys, but also in humans.

Report

(5 results)
  • 2004 Annual Research Report   Final Research Report Summary
  • 2003 Annual Research Report
  • 2002 Annual Research Report
  • 2001 Annual Research Report
  • Research Products

    (69 results)

All 2005 2004 2003 2002 2001 Other

All Journal Article (35 results) Book (3 results) Publications (31 results)

  • [Journal Article] Functional representation of the finger and face in the human somatosensory cortex : Intraoperative intrinsic optical imaging.2005

    • Author(s)
      Sato et al.
    • Journal Title

      NeuroImage (in press)

    • NAID

      130007039125

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Annual Research Report 2004 Final Research Report Summary
  • [Journal Article] Optical mapping of the functional organization of the rat trigeminal nucleus : Spatial and temporal dynamics of sensory information transfer during embryogenesis.2004

    • Author(s)
      Momose-Sato et al.
    • Journal Title

      Journal of Neuroscience 24

      Pages: 1366-1376

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Annual Research Report 2004 Final Research Report Summary
  • [Journal Article] Optical survey of neural circuit formation in the embryonic chick vagal pathway.2004

    • Author(s)
      Sato et al.
    • Journal Title

      European Journal of Neuroscience 19

      Pages: 1217-1225

    • NAID

      130005446923

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Annual Research Report 2004 Final Research Report Summary
  • [Journal Article] Optical mapping reveals developmental dynamics of Mg^<2+>-/APV-sensitive components of glossopharyngeal glutamatergic EPSPs in the embryonic chick NTS.2004

    • Author(s)
      Sato et al.
    • Journal Title

      Journal of Neurophysiology 92

      Pages: 2538-2547

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Annual Research Report 2004 Final Research Report Summary
  • [Journal Article] Optical detection of neural function in the chick visual pathway in the early stages of embryogenesis.2004

    • Author(s)
      Miyakawa et al.
    • Journal Title

      European Journal of Neuroscience 20

      Pages: 1133-1144

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Annual Research Report 2004 Final Research Report Summary
  • [Journal Article] Optical detection of convergent projections in the embryonic chick NTS.2004

    • Author(s)
      Sato et al.
    • Journal Title

      Neuroscience Letters 371

      Pages: 97-101

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Annual Research Report 2004 Final Research Report Summary
  • [Journal Article] 神経興奮と神経回路網の形成2004

    • Author(s)
      佐藤容子
    • Journal Title

      Clinical Neuroscience 22

      Pages: 1214-1214

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Annual Research Report 2004 Final Research Report Summary
  • [Journal Article] Optical mapping of the functional organization of the rat trigeminal nucleus : Spatial and temporal dynamics of sensory information transfer during embryogenesis.2004

    • Author(s)
      Momose-Sato, Y., Honda, Y., Sasaki, H., Sato, K.
    • Journal Title

      Journal of Neuroscience 24

      Pages: 1366-1376

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Optical survey of neural circuit formation in the embryonic chick vagal pathway.2004

    • Author(s)
      Sato, K., Miyakawa N., Momose-Sato, Y.
    • Journal Title

      European Journal of Neuroscience 19

      Pages: 1217-1225

    • NAID

      130005446923

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Optical mapping reveals developmental dynamics of Mg^<2+>-/APV-sensitive components of glossopharyngeal glutamatergic EPSPs in the embryonic chick NTS.2004

    • Author(s)
      Sato, K., Momose-Sato, Y.
    • Journal Title

      Journal of Neurophysiology 92

      Pages: 2538-2547

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Optical detection of neural function in the chick visual pathway in the early stages of embryogenesis.2004

    • Author(s)
      Miyakawa, N., Sato, K., Momose-Sato, Y.
    • Journal Title

      European Journal of neuroscience 20

      Pages: 1133-1144

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Optical detection of convergent projections in the embryonic chick NTS.2004

    • Author(s)
      Sato, K., Momose-Sato, Y.
    • Journal Title

      Neuroscience Letters 371

      Pages: 97-101

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Light-scattering signals related to neural functions.2004

    • Author(s)
      Sato, K., Momose-Sato, Y., Kamino, K.
    • Journal Title

      Recent Research Developments in Membrane Biology. (Eds.Fagan, J., Davidson, J., N., Shimizu, N.)(Research Signpost, Kerara) Vol.2

      Pages: 21-45

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Optical analysis of large-scale depolarization waves in the embryonic brain : a dual network of gap junctions and chemical synapses.2003

    • Author(s)
      Momose-Sato, Y., Miyakawa, N., Mochida, H., Sasaki, S., Sato, K.
    • Journal Title

      Journal of Neurophysiology 89

      Pages: 600-614

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Depolarization waves in the embryonic CNS triggered by multiple sensory inputs and spontaneous activity : optical imaging with a voltage-sensitive dye2003

    • Author(s)
      Momose-Sato, Y., Mochida, H., Sasaki, S., Sato, K.
    • Journal Title

      Neuroscience 116

      Pages: 407-423

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Optical detection of developmental origin of synaptic function in the embryonic chick vestibulocochlear nuclei.2003

    • Author(s)
      Sato, K., Momose-Sato, Y.
    • Journal Title

      Journal of Neurophysiology 89

      Pages: 2315-3224

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Optical analysis of acute spontaneous epileptiform discharges in the in vivo rat cerebral cortex.2003

    • Author(s)
      Miyakawa, N., Yazawa, I., Sasaki, S., Momose-Sato, Y, Sato, K.
    • Journal Title

      NeuroImage 18

      Pages: 622-632

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Postnatal changes in intrinsic optical responses to peripheral nerve stimulation in the in vivo rat spinal cord.2003

    • Author(s)
      Sasaki, S., Sato, K., Shinomiya, K., Momose-Sato, Y.
    • Journal Title

      NeuroImage 20

      Pages: 2126-2134

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Functional mapping of neural activity in the embryonic avian visual system : optical recording with a voltage-sensitive dye.2003

    • Author(s)
      Miyakawa, N., Sato, K., Mochida, H., Sasaki.S., Momose-Sato, Y.
    • Journal Title

      The Neural Basis of Early Vision. (Ed.Kaneko, A.)(Keio University International Symposia for Life Sciences and Medicine)(Springer-Verlag, Tokyo) Vol.11

      Pages: 194-198

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Intraoperative intrinsic optical imaging of neuronal activity from subdivisions of the human primary somatosensory cortex.2002

    • Author(s)
      Sato, K., Nariai, I., Sasaki, S., Yazawa, I., Mochida, H., Miyakawa, N., Momose-Sato, Y., Kamino, K., Ohta, Y., Hirakawa, K., Ohno, K.
    • Journal Title

      Cerebral Cortex 12

      Pages: 269-280

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Optical approaches to functional organization of glossopharyngeal and vagal motor nuclei in the embryonic chick hindbrain.2002

    • Author(s)
      Sato, K., Mochida, H., Yazawa, I., Sasaki, S., Momose-Sato, Y.
    • Journal Title

      Journal of Neurophysiology 88

      Pages: 383-393

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Multiple-site optical recording for characterization of functional synaptic organization of the optic tectum of rainbow trout.2002

    • Author(s)
      Kinoshita, M., Ueda, R., Kojima, S., Sato, K., Watanabe, M., Urano, A., Ito, E.
    • Journal Title

      European Journal of Neuroscience 16

      Pages: 868-876

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Optical imaging of intrinsic signals induced by peripheral nerve stimulation in the in vivo rat spinal cord.2002

    • Author(s)
      Sasaki, S., Yazawa, I., Miyakawa, N., Mochida, H., Shinomiya, K., Kamino, K., Momose-Sato, Y., Sato, K.
    • Journal Title

      NeuroImage 17

      Pages: 1240-1255

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Developmental organization of the glossopharyngeal nucleus in the embryonic chick brainstem slice as revealed by optical sectioning recording.2002

    • Author(s)
      Sato, K., Mochida, H., Sasaki, S., Momose-Sato, Y.
    • Journal Title

      Neuroscience Letters 327

      Pages: 157-160

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Application of voltage-sensitive dyes to the embryonic central nervous system.2002

    • Author(s)
      Momose-Sato, Y., Sato, K., Kamino, K.
    • Journal Title

      Recent Research Developments in Membrane Biology. (Eds.Fagan, J., Davidson, J., N., Shimizu, N.)(Research Signpost, Kerara) Vol.1

      Pages: 159-181

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Optical approaches to embryonic development of neural function in the brainstem.2001

    • Author(s)
      Momose-Sato, Y., Sato, K., Kamino, K.
    • Journal Title

      Progress in Neurobiology 63

      Pages: 151-197

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Spreading depolarization waves triggered by vagal stimulation in the embryonic chick brain : optical evidence for intercellular communication in the developing CNS.2001

    • Author(s)
      Momose-Sato, Y., Sato, K., Mochida, H., Yazawa, I., Sasaki, S., Kamino, K.
    • Journal Title

      Neuroscience 102

      Pages: 245-262

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Multiple-site optical recording reveals embryonic organization of synaptic networks in the chick spinal cord.2001

    • Author(s)
      Mochida, H., Sato, K., Arai, Y., Sasaki, S., Yazawa, I., Kamino, K., Momose-Sato, Y.
    • Journal Title

      European Journal of Neuroscience 13

      Pages: 1547-1558

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Optical imaging of spreading depolarization waves triggered by spinal nerve stimulation in the chick embryo : Possible mechanisms for large-scale coactivation of the CNS.2001

    • Author(s)
      Mochida, H., Sato, K., Arai, Y., Sasaki, S., Kamino, K., Momose-Sato, Y.
    • Journal Title

      European Journal of Neuroscience 14

      Pages: 809-820

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Developmental changes in trial-to-trial variations in whisker barrel responses studied using intrinsic optical imaging : Comparison between normal and de-whiskered rats.2001

    • Author(s)
      Yazawa, I., Sasaki, S., Mochida, H., Kamino, K., Momose-Sato, Y., Sato, K.
    • Journal Title

      Journal of Neurophysiology 86

      Pages: 392-401

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Optical responses to micro-application of GABA agonists in the embryonic chick brain stem.2001

    • Author(s)
      Sato, K., Mochida, H., Sasaki, S., Yazawa, I., Kamino, K., Momose-Sato, Y.
    • Journal Title

      Neuro Report 12

      Pages: 95-98

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Effects of anisomycin on LIP in the hippocampal CA1 : Long-term analysis using optical recording.2001

    • Author(s)
      Mochida, H., Sato, K., Sasaki, S., Yazawa, I., Kamino, K., Momose-Sato, Y.
    • Journal Title

      Neuro Report 12

      Pages: 987-991

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Functional representation of the finger and face in the human somatosensory cortex : Intraoperative intrinsic optical imaging.

    • Author(s)
      Sato, K., Nariai, T., Tanaka, Y., Maehara, T., Miyakawa, N., Sasaki, S., Momose-Sato, Y., Ohno, K.
    • Journal Title

      NeuroImage (in press)

    • NAID

      130007039125

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Visualization of somatotopic representation of sensory cortex with intrinsic optical signals as guides for brain tumor surgery

    • Author(s)
      Nariai, T., Sato, K., Hirakawa, K., Ohta, Y., Tanaka, Y., Ishiwata, K., Ishii, K., Kamino, K., Ohno, K.
    • Journal Title

      Journal of Neurosurgery (in press)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Application of voltage-sensitive dyes to the embryonic nervous systems.

    • Author(s)
      Sato, K., Momose-Sato Y., Kamino, K.
    • Journal Title

      Light Scattering Imaging of Neural Tissue Function. (Eds.Rector, D., M., George, J., S.)(The Humana Press Inc, Totowa) (in press)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Book] Light Scattering Imaging of Neural Tissue Function2005

    • Author(s)
      Sato et al.
    • Publisher
      The Humana Press Inc (in press)
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Book] Light Scattering Imaging of Neural Tissue Function2005

    • Author(s)
      Sato et al.
    • Publisher
      The Humana Press Inc(in press)
    • Related Report
      2004 Annual Research Report
  • [Book] Light Scattering Imaging of Neural Tissue Function2004

    • Author(s)
      Sato et al.
    • Total Pages
      25
    • Publisher
      Research Signpost
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Annual Research Report 2004 Final Research Report Summary
  • [Publications] Momose-Sato, Y. et al.: "Optical analysis of large-scale depolarization waves in the embryonic brain : a dual network of gap junctions and chemical synapses."Journal of Neurophysiology. 89. 600-614 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] Momose-Sato, Y. et al.: "Depolarization waves in the embryonic CNS triggered by multiple sensory inputs and spontaneous activity : optical imaging with a voltage-sensitive dye."Neuroscience. 116. 407-423 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] Sato, K., Momose-Sato, Y.: "Optical detection of developmental origin of synaptic function in the embryonic chick vestibulocochlear nuclei."Journal of Neurophysiology. 89. 2315-3224 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] Miyakawa, N. et al.: "Optical analysis of acute spontaneous epileptiform discharges in the in vivo rat cerebral cortex."NeuroImage. 18. 622-632 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] Sasaki, S. et al.: "Postnatal changes in intrinsic optical responses to peripheral nerve stimulation in the in vivo rat spinal cord."NeuroImage. 20. 2126-2134 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] Momose-Sato, Y. et al.: "Optical mapping of the functional organization of the rat trigeminal nucleus : Spatial and temporal dynamics of sensory information transfer during embryogenesis."Journal of Neuroscience. (in press). (2004)

    • Related Report
      2003 Annual Research Report
  • [Publications] Sato, K. et al.: "Optical survey of neural circuit formation in the embryonic chick vagal pathway."European Journal of Neuroscience. (in press). (2004)

    • Related Report
      2003 Annual Research Report
  • [Publications] Miyakawa, N. et al.: "Keio University International Symposia for Life Sciences and Medicine Vol.11,The Neural Basis of Early Vision"Springer-Verlag. 5 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] Sato, K. et al.: "Light Scattering Imaging of Neural Tissue Function"The Humana Press Inc (in press). (2004)

    • Related Report
      2003 Annual Research Report
  • [Publications] Sato, K. et al.: "lntraoperative intrinsic optical imaging of neuronal activity from subdivisions of the human primary somatosensory cortex"Cerebral Cortex. 12. 269-280 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] Sato, K. et al.: "Optical approaches to functional organization of glossopharyngeal and vagal motor nuclei in the embryonic chick hindbrain"Journal of Neurophysiology. 88. 383-393 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] Sato, K. et al.: "Developmental organization of the glossopharyngeal nucleus in the embryonic chick brainstem slice as revealed by optical sectioning recording"Neuroscience Letters. 327. 157-160 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] Sasaki, S. et al.: "Optical imaging of intrinsic signals induced by peripheral nerve stimulation in the in vivo rat spinal cord"NeuroImage. 17. 1240-1255 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] Momose-Sato, Y. et al.: "Optical analysis of large-scale depolarization waves in the embryonic brain : a dual network of gap junctions and chemical synapses"Journal of Neurophysiology. 18. 600-614 (2003)

    • Related Report
      2002 Annual Research Report
  • [Publications] Momose-Sato, Y. et al.: "Depolarization waves in the embryonic CNS triggered by multiple sensory inputs and spontaneous activity : optical imaging with a voltage-sensitive dye"Neuroscience. 116. 406-423 (2003)

    • Related Report
      2002 Annual Research Report
  • [Publications] Miyakawa, N. et al.: "Optical analysis of acute spontaneous epileptiform discharges in the in vivo rat cerebral cortex"NeuroImage. (in press). (2003)

    • Related Report
      2002 Annual Research Report
  • [Publications] Kinoshita, M. et al.: "Multiple-site optical recording for characterization of functional synaptic organization of the optic tectum of rainbow trout"European Journal of Neuroscience. 16. 868-876 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] Momose-Sato, Y. et al.: "Recent Research Developments in Membrane Biology"Research Signpost(in press). (2003)

    • Related Report
      2002 Annual Research Report
  • [Publications] Sato, K. et al.: "Light Scattering Imaging of Neural Tissue Function"The Humana Press Inc(in press). (2003)

    • Related Report
      2002 Annual Research Report
  • [Publications] Momose-Sato Y. et al.: "Optical approaches to embryonic development of neural function in the brainstem"Progress in Neurobiology. 63. 151-197 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] Momose-Sato Y. et al.: "Spreading depolarization waves triggered by vagal stimulation in the embryonic chick brain : optical cvidence for intercellular communication in the developing CNS"Neuroscience. 102. 245-162 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] Mochida H. et al.: "Multiple-site optical recording reveals embryonic organization of synaptic networks in the chick spinal cord"European Journal of Neuroscience. 13. 1547-1558 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] Mochida H. et al.: "Optical imaging of spreading depolarization waves triggered by spinal nerve stimulation in the chick embryo : Possible mechunisms for large-scale coactivation of the CNS"European Journal of Neuroscience. 14. 809-820 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] Yazawa I, et al.: "Devclopmental changes in trial-to-trial variations in whisker barrel responses studied using intrinsic optical imaging : Comparison between noral and de-whiskered rats"Joumal of Neurophysiology. 86. 392-401 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] Sato K. et al.: "Optical responses to micro-application of GABA agonists in the embryonic chick brain stem"Neuro Report. 12. 95-98 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] Mochida H. et al.: "Effects of anisomycin on LTP in the hippocampal CAl : Long-term analysis using optical recording"Neuro Report. 12. 987-991 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] Satt K. et al.: "Intraoperative intrinsic optical imaging of neuronal activity from subdivisions of the human primary somatosensory cortex"Cerebral Cortex. 12. 269-280 (2002)

    • Related Report
      2001 Annual Research Report
  • [Publications] Sato K. et al.: "Optical approaches to functional organization of glossopharyngeal and vagal motor nuclci in the embry onick hindbrain"Journal of Neurophysiology. (in press). (2002)

    • Related Report
      2001 Annual Research Report
  • [Publications] 佐藤容子, 他: "自律神経系の機能的解析における光学的計測法の適用"自律神経. 38. 270-278 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] 佐々木真一, 他: "末梢神経刺激により脊髄に誘発されたニューロン応答の内因性光学イメージング"脊髄電気診断学. 23. 38-42 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] 佐藤勝重: "ブレインサイエンス・レビュー2001"医学書院. 292 (2001)

    • Related Report
      2001 Annual Research Report

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Published: 2001-04-01   Modified: 2016-04-21  

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