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Analysis of transforming mechanism of human synovial sarcoma oncogene SYT-SSX

Research Project

Project/Area Number 13557122
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section展開研究
Research Field Orthopaedic surgery
Research InstitutionHOKKAIDO UNIVERSITY

Principal Investigator

TANAKA Shinya  Hokkaido Univ., Grad School of Medicine, Assistant Prof, 大学院・医学研究科, 講師 (70261287)

Co-Investigator(Kenkyū-buntansha) AKAGI Tsuyoshi  Osaka Bioscience Institute, Associate Prof, 副部長 (90184077)
MINAMI Akio  Hokkaido Univ., Grad School of Medicine, Prof, 大学院・医学研究科, 教授 (20133738)
SAWA Hirofumi  Hokkaido Univ., Grad School of Medicine, Associate Prof, 大学院・医学研究科, 助教授 (30292006)
Project Period (FY) 2001 – 2002
Project Status Completed (Fiscal Year 2002)
Budget Amount *help
¥6,800,000 (Direct Cost: ¥6,800,000)
Fiscal Year 2002: ¥2,300,000 (Direct Cost: ¥2,300,000)
Fiscal Year 2001: ¥4,500,000 (Direct Cost: ¥4,500,000)
KeywordsChromatin remodeling / Synovial sarcoma / Gene Therapy / SYT-SSX / hBRM / transformation / クロマチリンリモデリング / 癌遺伝子
Research Abstract

Human synovial sarcoma occurs primarily around the joint of extremities and more than 90% of cases have chromosomal translocation t(X;18) resulting the formation of chimeric gene SYT-SSX (synovial sarcoma translocation-synovial sarcoma X break point). As both of SYT and SSX did not share any homology region of known functional proteins, the transforming mechanism of SYT-SSX has not yet been elucidated. In this project, we established rat fibroblast cell line 3Y1 expressing SYT, SSX, and SYT-SSX, and found that SYT-SSX induced anchorage-independent growth and tumor formation in nude mice. In this SYT-SSX expressing cell lines, one of the SWI/SNF type of chromatin remodeling factor hBRM has been shown to bind to SYT-SSX and this association was essential for the transformation of 3Y1 cells. Especially, as the disruption of the binding of SYT-SSX and hBRM by specific peptides composed of 50 amino acids corresponding to hBRM155-206, suppressed the growth of SYT-SSX-3Y1 cells, these peptides could be one of the basic technique for the establishment of gene therapy for synovial sarcoma. We also found that in contrast to 3Y1 cells, SYT-SSX induced growth suppression of human adenocarcinoma cell line SW13. In this cell line, SYT-SSX induced p21WAF1/CIP1 expression confirmed by immunoblotting. The luciferase assay using p21 promoter-regulated construction, SYT-SSX was found to activate p21 promoter by transcription factor Sp1-dependent and p53-independent mechanism. Thus, SYT-SSX has differential effect for cell growth such as growth positive and growth negative mechanism, in different cell lines. We are currently considering the augmentation of growth negative function of SYT-SSX may induce the tumor cell suppression as a specific therapy of synovial sarcoma.

Report

(3 results)
  • 2002 Annual Research Report   Final Research Report Summary
  • 2001 Annual Research Report
  • Research Products

    (112 results)

All Other

All Publications (112 results)

  • [Publications] Nagai, M., et al.: "Analysis of transforming activity of human synovial sarcoma-associated chimeric protein SYT-SSX1 bound to chromatin remodeling factor hBRM/hSNF2α"Proc.Natl.Acad.Sci.USA. 98. 3843-3848 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Tanaka, S., et al.: "HHV8-negative primary effusion lymphoma of the peritoneal cavity presenting with a distinct immunohistochemical phenotype"Pathol. International. 51. 293-300 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Hayashi, H., et al.: "JC virus large T protein transforms rodent cells but is not involved in human medulloblastoma"Neuropathology. 21. 129-137 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Suzuki, S., et al.: "Broad distribution of the JC virus receptor contrasts with a marked cellular restriction of virus replication"Virology. 286. 100-112 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Ishimori, N., et al.: "Mixed allogeneic chimerism with wild-type strains ameliorates atherosclerosis in apoprotein E-deficeinet"mice J.Leukocyte Biol.. 69. 732-740 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Kamimura, E., et al.: "New rat model for attention deficit hyperactive disorder (ADHD)"Comparative Medicine. 51. 245-251 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Fujioka, Y., et al.: "MM-1, a c-Myc-binding protein, is a candidate for a tumor suppressor in Leukemia/Lymphoma and tongue cancer"J.Biol Chem.. 276. 45137-45144 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Ito, H., et al.: "Three-dimensionally corrective external fixator system for femoral osteotomy"J Pediatr Orthop. 21. 652-656 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Iwasaki, N., et al.: "Effects of major histocompatibility complex matching on graft survival in allogeneic rat limb transplantation"J Hand Surg[Am]. 26-A. 545-554 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Ito, H., et al.: "The sphericity of the bearing surface in total hip arthroplasty"J Arthroplasty. 16. 1024-1029 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Ito, H., et al.: "Destruction of acetabular bone caaused by early failure of a constrained acetabular component"J Arthroplasty. 16. 938-941 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Shimamoto, N., et al.: "Biomechanical evaluation of anterior spinal instrumentation systems for scoliosis : In vitro fatigue simulation"Spine. 26. 2701-2708 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Shimamoto, N., et al.: "Biomechanical evaluation of stand-alone interbody fusion cages in the cervical spine"Spine. 26. 432-436 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Shishido, T., et al.: "Crk family adaptor proteins trans-activate c-Abl kinase"Genes Cells. 6. 431-440 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Ohnishi, J., et al.: "Cloning and characterization of a rat ortholog of MMP-23 (matrix metalloproteinase-23), a unique type of metalloproteinase and conditional switching of its expression during the ovarian follicular development"Mol Endocrinol. 15. 747-764 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Zaman A.K., et al.: "Angiotensin-converting enzyme inhibition attenuates hypofibrinolysis and reduces cardiac perivascular fibrosis in genetically obese diabetic mice"Circulation. 103. 3123-3128 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Furuta, Y., et al.: "Quantitation of varicella-zoster virus DNA in patients with Ramsay Hunt syndrome and Zoster Sine Herpete"J Clin Microbiol. 39. 2856-2859 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Okada, Y., et al.: "Distribution and function of JCV agnoprotein"J Neurovirol. 7. 302-306 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Ohwatari, R., et al.: "Developmental and functional analyses of CD8+ NK1.1+ T cells in the class I restricted TCR transgenic mice"Cell Immunol. 213. 24-33 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Shirane, M., et al.: "Deficiency of phospholipase C-g1 impairs renal development and hematopoiesis"Development. 128. 5173-5180 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Xie, Z., et al.: "Different expression of Bcl-2 and Bax proteins, and cardiomyocyte apoptosis"Jpn Heart J. 42. 759-770 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Nishihara, H., et al.: "Molecular and immunohistochemical analysis of adaptor protein Crk in human cancers"Cancer Letter. 180. 55-61 (2002)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Okamoto, T., et al.: "Advanced glycation end products induce angiogenesis in vivo"Microvascular Res.. 63. 186-195 (2002)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Tsuda, M., et al.: "Signalling adaptor protein v-Crk activates Rho and regulates cell motility in 3Y1 rat fibroblast cell line"Cell Growth Differ. 13. 131-139 (2002)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Nishihara, H., et al.: "DOCK2 associates with CrkL and regulates Rac1 in hematopoietic cells"Blood. 100. 3968-3974 (2002)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Okada, Y., et al.: "Expression of JC virus agnoprotein in progressive multifocal leukoencephalopathy"Acta Neuropathol. 104. 130-136 (2002)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Nishihara, H., et al.: "DOCK2 mediates T cell receptor-induced activation of Rac2 and IL-2"Biochem Biophys Res Comm. 296. 716-720 (2002)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Komagome, R., et al.: "Oliosaccharides as receptors for JC virus"J. Virol.. 76. 12992-13000 (2002)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Onodera, S., et al.: "Macrophage migration inhibitory factor up-regulates matrix metalloproteinase-9 and -13 in rat osteoblasts. Relevance to intracellular signaling pathways"J Biol Chem. 277. 7865-7874 (2002)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Suenaga, N., et al.: "The correlation between bursoscopic and histologic findings of the acromion undersurface in patients with subacromial impingement syndrome"Arthroplasty. 18. 16-20 (2002)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Iwasaki, N., et al.: "Feasibility of immunosuppression in composite tissue allografts by systemic administration of CTLA4Ig"Transplantation. 73. 334-340 (2002)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Ito, H., et al.: "Fixation with poly-L-lactic acid screws in hip osteotomy-68 hips followed for 18-46 months"Acta Orthop Scand. 73. 60-64 (2002)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Ito, M., et al.: "Complications related to hydroxyapatite vertebral spacer in anterior cervical spine surgery"Spine. 27. 428-431 (2002)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Majima, T., et al.: "Rehabilitation after hamstring anterior cruciate ligament reconstruction"Clin Orthop. 397. 370-380 (2002)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Minami, A., et al.: "Vascularized fibular graft after excision of giabt-cell tumor of the distal radius : Wrist arthroplasty versus partial wrist arthrodesis"Plast Reconstr Surg. 110. 112-117 (2002)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Kato, H., et al.: "Callotasis lengthening in patients with brachymetacarpia"J. Pediatr. Orthop.. 22. 497-500 (2002)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Yamazaki, S.: "The effect of graft-tunnel diameter disparity on intraosseous healing of the flexor tendon graft in anterior cruciate ligamant reconstruction"Am. J. Sports Med. 30. 498-505 (2002)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Minami, A.: "Is there a role for radial osteotomy in advanced Kienbock's disease?"Current Opinion in Orthopaedics. 13. 246-250 (2002)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Kato, H.: "Cubital tunnel syndrome associated with medial elbow ganglia and osteoarthritis of the elbow"J. Bone Joint Surg.[Am]. 84-A. 1413-1419 (2002)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Iwasaki, N.: "Radial osteotomy for late-stage Kienbock's disease -Wdge osteotomy versus radial shortening-"J.Bone Joint Surg.[Br]. 84-B. 673-677 (2002)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Akagi T: "v-Crk Activates the Phosphoinositide 3-Kinase/AKT Pathway by Utilizing Focal Adhesion Kinase and H-Ras"Mol Cell Biol. 22. 7015-7023 (2002)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Kobayashi Y: "Hydrocephalus, situs inversus, chronic sinusitis, and male infertility in DNA polymerase λ-deficient mice : possible implication for the pathogenesis of immotile cilia syndrome"Mol Cell Biol. 22. 2769-2776 (2002)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Takahashi H., et al.: "Reconstitution of cleavage of human immunodeficiency virus type-1 (HIV-1) RNAs"Biochem Biophys Res Commun. 293. 1084-1091 (2002)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Matsumoto, K., et al.: "Distribution of extracellular matrix tenascin-X in sciatic nerves"Acta Neuropathol. 104. 448-454 (2002)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Takahashi, H., et al.: "Topoisomerase I and ATP activate cDNA synthesis of human immunodeficiency virus type-1 (HIV-1)"Biochem Biophys Res Commun. 294. 509-517 (2002)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Makita, N., et al.: "Drug-induced long-QT syndrome associated with a subclinical SCN5A mutation"Circulation. 106. 1269-1274 (2002)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Hasegawa, H., et al.: "Processing of the HTLV-II envelope precursor glycoprotein, gp63 by furin is essential for cell fusion activity"AIDS Res Hum Retroviruses. 18. 1253-1260 (2002)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Yoshida, H., et al.: "Differential requirement for Apaf1 and Bcl-X_L in the regulation of programmed cell death during development"Cell Death Differ. 9. 1273-1276 (2002)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Takai, H., et al.: "Chk2-deficient mice exhibit increased radioresistance and defective p53-mediated transcription"EMBO J. 21. 5195-5205 (2002)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Takahashi, H., et al.: "Binding and dissociation of human topoisomerase I with hair-pin loop RNAs implications for the regulation of HIV-1 replication"Biochem Biophys Res Commun. 297. 593-599 (2002)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Nagai, M., *Tanaka, S., Tsuda, M., Endo, S., Kato, H., Sonobe, H., Minami, A., Hiraga, H., Yamawaki, S., Nishihara, H., Sawa, H., Nagashima, K.: "Analysis of transforming activity of human synovial sarcoma-associated chimeric protein SYT-SSX1 bound to chromatin remodeling factor Hbrm/hSNF2α"Proc. Natl. Acad. Sci. USA. 98. 3843-3848 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Tanaka, S., Katano, H., Tsukamoto, K., Jin, M., Nishihara, H., Sawa, H., Osaka, M., Tarumi, T., Sawada, K., Shimizu, M., Sata, T., Fujioka, Y., Nagashima, K.: "HHV8-negative primary effusion lymphoma of the peritoneal cavity presenting with a distinct immunohistochemical phenotype"Pathol. International. 51. 293-300 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Hayashi, H., Endo, S., Suzuki, S., Tanaka, S., Hirofumi, S., Ozaki, Y., Sawamura, Y., Nagashima, K.: "JC virus large T protein transforms rodent cells but is not involved in human medulloblastoma"Neuropathology. 21. 129-137 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Suzuki, S., Komagome, R., Sawa, H., Yamada, M., Okada, Y., Ishida, Y., Nishihara, H., Tanaka, S., Nagashima, K.: "Broad distribution of the JC virus receptor contrasts with marked cellular restriction of virus replication"Virology. 286. 100-112 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Ishimori, N., Iwabuchi, K., Fujii, S., Watano, K., Iwabuchi, C., Ato, M., Chiba, H., Tanaka, S., Kitabatake, A., Onoe, K.: "Mixed allogeneic chimerism with wild-type strains ameliorates atherosclerosis in apoprotein E-deficeinet mice"J. Leukocyte Biol.. 69. 732-740 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Kamimura, E., Ueno, Y., Tanaka, S., Sawa, H., Yoshioka, M., Ueno, K., Inoue T., Li, X, Koyama, T., Ishikawa, R., Nagashima, K.: "New rat model for attention deficit hyperactive disorder (ADHD)"Comparative Medicine. 51. 245-251 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Fujioka, Y., Taira, T., Maeda, Y., Tanaka, S., Nishihara, H., Iguchi-Ariga, S. M. M., Nagashima, K., Ariga, H.: "MM-1, a c-Myc-binding Protein, Is a Candidate for a Tumor Suppressor in Leukemia/Lymphoma and Tongue Cancer"J. Biol Chem.. 276. 45137-45144 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Ito, H., Minami, A., Suzuki, K., Matsuno, T.: "Three-dimensionally corrective external fixator system for femoral ostetomy"J Pediatr Orthop. 21. 652-656 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Iwasaki, N., Gohda, T., Itoga, H., Minami, A.: "Effects of major histocompatibility complex matching on graft survival in allogeneic rat limb transplantation"J Hand Surg[Am]. 26-A. 545-554 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Ito, H., Minami, A., Matsuno, T., Tanino, H., Yuhta, T., Nishimura, I.: "The sphericity of the bearing surface in total hip arthroplasty"J Arthroplasty. 16. 1024-1029 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Ito, H., Minami, A., Kondo, F., Fujita M., Ubayama, Y., Matsuno, T.: "Destruction of acetabular bone caused by early failure of a constrained acetabular component"J Arthroplasty. 16. 938-941 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Shimamoto, N., Kotani, Y., Shono, Y., Kadoya, K., Abumi, K., Kaneda, K., Minami, A.: "Biomechanical evaluation of anterior spinal instrumentation system for scoliosis : In vitro fatigue simulation"Spine. 26. 2701-2708 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Shimamoto, N., Cunningham, B.W., Dmitriev, A.E., Minami, A., McAfee, P.C.: "Biomechanical evaluation of stand-alone interbody fusion cages in the cervical spine"Spine. 26. 432-436 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Shishido, T, Akagi T, Chalmers A, Maeda M, Terada T, Georgescu MM, Hanafusa H.: "Crk family adaptor proteins trans-activate c-Ab1 kinase"Genes Cells. May. 6(5). 431-440 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Ohnishi J, Ohnishi E, Hirano W, Nakane D, Matsui H, Kimura A, Sawa H, Nakayama K, Shibuya H, Nagashima K, Takahasi T: "Cloning and characterization of a rat ortholog of MMP-23 (matrix metalloproteinase-23), a unique type of membrane-anchored matrix metalloproteinase and conditioned switching of its expression during the ovarian follicular development"Mol Endocrinol. 15. 747-764 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Zaman Ak, Fujii S, Sawa H, Goto D, Ishimori N, Watano K, Kaneko T, Furumoto T, Sugawara T, Sakuma I, Kitabatake A, Sobel BE: "Angiotensin-converting enzyme inhibition attenuate shypofibrinolysis and reduces cardiac perivascular fibrinolysis in genetically obese diabetic mice"Circulation. 103. 3123-3128 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Furuta Y, Ohtani F, Sawa H, Fukuda S, Inuyama Y: "Quantitation of varicella-zoster virus DNA in patients with Ramsay Hunt syndrome and Zoster Sine Herpete"J Clin Microbiol. 39. 2856-2859 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Okada Y, Endo S, Takahashi H, Sawa H, Umemura T, Nagashima K: "Distribution and function of JCV agnoprotein"J Neurovirol. 7. 302-306 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Ohwatari R, Iwabuchi K, Iwabuchi C, Morohashi T, Sawa H, Hioki K, Kobayashi K, Fukuda S, Inuyama Y, Onoe K: "Developmental and functional analyses of CD8+NK1.1+T cells in the class I restricted TCR transgenic mice"Cell Immunol.. 213. 24-33 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Shirane M, Sawa H, Kobayashi Y, Nakano T, Shinkai Y, Nagashima K, Negishi I: "Deficiency of phospholipase C-□1 impairs renal development and hematopoiesis"Development. 128. 5173-5180 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Xie Z, Koyama T, Suzuki J, Fujii Y, Togashi H, Sawa H, Nagashima K: "Coronary reperfusion following ischemia. Different expression of Bc1-2 and Bax proteins, and cardiomyocyte apoptosis"Jpn Heart J. 42. 759-770 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Nishihara, H., ^*Tanaka, S., Tsuda, M., Oikawa, S., Maeda, M., Shimizu, M., Shimoyama, H., Tanigami, A., Sawa, H., Nagashima, K.: "Molecular and immunohistochemical analysis of adaptor protein Crk in human cancers"Cancer Letter. 180. 55-61 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Okamoto, T., ^*Tanaka, S., Stan, A.C., Koike, T., Kase, M., Makita, Z., Sawa, H., Nagashima, K.: "Advanced glycation end products induce angiogenesis in vivo"Microvascular Res.. 63. 186-195 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Tsuda, M., ^*Tanaka, S., Sawa, H., Hanafusa, H., Nagashima, K.: "Signalling adaptor protein v-Crk activates Rho and regulates cell motility in 3Y1 rat fibroblast cell line"Cell Growth Differ. 13. 131-139 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Nishihara, H., Maeda, M., Oda, A., Tsuda, M., Sawa, H., Nagashima, K., ^*Tanaka, S.: "DOCK2 associates with CrkL and regulates Rac1 in hematopoietic cells"Blood. 100. 3968-3974 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Okada, Y., Sawa, H, Endo, S., Umemura, T., Nishihara, H, Stan, A.C., Tanaka, S., Takahashi, H., Nagashima, K.: "Expression of JC virus agnoprotein in progressive multifocal leukoencephalopathy"Acta Neuropathol. 104. 130-136 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Nishihara, H., Maeda, M., Tsuda, M., Makino, Y., Sawa, H., Nagashima, K., ^*Tanaka, S.: "DOCK2 mediates T cell receptor-induced activation of Rac2 and IL-2 transcription"Biochem Biophys Res Comm. 296. 716-720 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Komagome, R., Sawa, H., Suzuki, T., Suzuki, Y., Tanaka, S., Atwood, W.J., Nagashima, K.: "Oliosaccharides as receptors for JC virus"J. Virol.. 76. 12992-13000 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Onodera, S., Nishihira, J., Iwabuchi, K., Koyama Y., Yoshida, K., Tanaka, S., Minami, A.: "Macrophase migration inhibitory factor up-regulates matrix metalloproteinase-9 and -13 in rat osteoblasts. Relevance to intracellular signaling pathways"J Biol Chem. 277. 7865-7874 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Suenaga, N., Minami, A., Fukuda, K., Kaneda, K.: "The correlation between bursoscopic and histologic findings of the acromion undersurface in patients with subacromial impingement syndrome"Arthroplasty. 18. 16-20 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Iwasaki, N., Gohda, T., Yoshioka, C., Murakami, M., Inobe, M., Minami, A., Uede, H.: "Feasibility of immunosupression in composite tissue allografts by systemic administration of CTLA4Ig"Transplantation. 73. 334-340 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Ito, H., Minami, A., Tanino, H., Matusno, T.: "Fixation with poly-L-lactic acid screws in hip osteotomy-68 hips followed for 18-46 months-"Acta Orthop Scand. 73. 60-64 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Ito, M., Abumi, K., Shono, Y., Kotani, Y., Minami, A., Kaneda, K.: "Complications related to hydroxyapatite vertebral spacer in anterior cervical spine surgery"Spine. 27. 428-431 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Majima, T., Yasuda, K., Tago, H., Tanabe, Y., Minami, A.: "Rehabilitation after hamstring anterior cruciate ligament reconstruction"Clin Orthop. 397. 370-380 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Minami, A., Kato, H., Iwasaki, N.: "Vascularized fibular graft after excision of giabt-cell tumor of the distal radius : Wrist arthroplasty versus partial wrist arthrodesis"Plast Reconstr Surg. 110. 112-117 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Kato, H., Minami, A., Suenaga, N., Iwasaki, N., Kimura, T.: "Callotasis lengthening in patients with brachymetacarpia"J. Pediatr. Orthop.. 22. 497-500 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Yamazaki, S., Yasuda, K., Tomita, F., Minami, A., Tohyama, H.: "The effect of graft-tunnel diameter disparity on intraosseous healing of the flexor tendon graft in anterior cruciate ligamant reconstruction"Am. J. Sports Med.. 30. 498-505 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Minami, A., Iwasaki, N.: "Is there a role for radial osteotomy in advanced Kienbock's disease?"Current Opinion in Orthopaedics. 13. 246-250 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Kato, H., Hirayama, T., Minami, A., Iwasaki, N., Hirachi, K.: "Cubital tunnel syndrome associated with medial elbow ganglia and osteoarthritis of the elbow"J. Bone Joint Surg. [Am]. 84-A. 1413-1419 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Iwasaki, N., Minami, A., Oizumi, N., Suenaga, H., Kato, H,. Minami, M.: "Radial osteotomy for late-stage Kienbock's disease- Wedge osteotomy versus radial shortening-"J. Bone Joint Surg. [Br]. 84-B. 673-677 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Akagi T, Murata K, Shishido T, Hanafusa H.: "v-Crk Activates the Phosphoinositide 3-Kinase/AKT Pathway by Utilizing Focal Adhesion Kinase and H-Ras"Mol Cell Biol.. Oct ; 22(20). 7015-7023 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Kobayashi Y, Watanabe M, Okada Y, Sawa H, Takai H, Nakanishi M, Kawase Y, Suzuki H, Nagashima K, Ikeda K, Motoyama N: "Hydrocephalus, situs inversus, chronic sinusitis, and male infertility in DNA polymerase λ-deficient mice : Possible implications for the pathogenesis of immotile cilia syndrome"Mole Cell Biol. 22. 2769-2776 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Takahashi H, Sawa H, Hasegawa H, Sata T, Hall WW, Nagashima K, Kurata T: "Reconstitution of cleavage of human immunodeficiency virus type-1 (HIV-1) RNAs"Biochem Biophys Res Commun. 293. 1084-1091 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Matsumoto K, Sawa H, Sato M, Orba Y, Nagashima K, Ariga H: "Distribution of extracellular matrix tenascin-X in sciatic nerves"Acta Neuropathol. 104. 448-454 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Takahashi H, Sawa H, Hasegawa H, Shoya Y, Sata T, Hall WW, Nagashima K, Kurata T: "Topoisomerase I and ATP activate cDNA synthesis of human immunodeficiency virus type-1 (HIV-1)"Biochem Biophys Res Commun. 294. 509-517 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Makita N, Horie M, Nakamura T, Ai T, Otani H, Sawa H, Kitabatake A: "Drug-induced long-QT syndrome associated with a subclinical SCN5A mutation"Circulation. 106. 1269-1274 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Hasegawa H, Tatsumi M, Ogawa-Goto K, Takahashi H, Iwasaki T, Kurata T, Sata T, Takeuchi T, Sheehy N, Sawa H, Nagashima K, Hall WW: "Processing of the HTLV-II envelope precursor glycoprotein, gp63 by furin is essential for cell fusion activity"AIDS Res Hum Retroviruses. 18. 1253-1260 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Yoshida H, Okada Y, Kinoshita N, Hara H, Sasaki M, Sawa H, Nagashima K, Mak TW, Motoyama N: "Differential requirement for Apaf1 and Bcl-X_L in the regulation of programmed cell death during development"Cell Death Differ. 9. 1273-1276 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Takai H, Naka K, Okada Y, Watanabe M, Harada N, Saito S, Anderson CW, Appella E, Nakanishi M, Suzuki H, Nagashima K, Sawa H, Ikeda K, Motoyama N: "Chk2-deficient mice exhibit increased resistance to ionizing radiation and defective p53-mediated transcription"EMBO J. 21. 5195-5205 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Takahashi H, Sawa H, Hasegawa H, Sata T, Hall WW, Kurata T: "Binding and dissociation of human topoisomerase 1 with hair-pin loop RNAs : implications for the regulation of HIV-1 replication"Biochem Biophys Res Commun. 297. 593-599 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Nishihara, H., et al.: "Molecular and immunohistochemical analysis of adaptor protein Crk in human cancers"Cancer Letter. 180. 55-61 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] Okamoto, T., et al.: "Advanced glycation end products induce angiogenesis in vivo"Microvascular Res. 63. 186-195 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] Tsuda, M., et al.: "Signaling adaptor protein v-Crk activates Rho and regulates cell motility in 3Y1 rat fibroblast cell line"Cell Growth Differ. 13. 131-139 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] Nishihara, H., et al.: "DOCK2 associates with CrkL and regulates Rac1 in hematopoietic cells"Blood. 100. 3968-3974 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] Nishihara, H., et al.: "DOCK2 mediates T cell receptor-induced activation of Rac2 and IL-2 transcription"Biochem Biophys Res Comm. 296. 716-720 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] Komagome, R., et al.: "Oligosaccharides as receptors for JC virus"J. Virol. 76. 12992-13000 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] Nagai, M., et al.: "Analysis of transforming activity of human synovial sarcoma-associated chimeric protein SYT-SSX1bound to chromatin remodeling factor hBRM/hSNF2α"Proc. Natl.Acad.Sci.USA. 98. 3843-3848 (2001)

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      2001 Annual Research Report
  • [Publications] Tanaka, S., et al.: "HHV8-negative primary effusion lymphoma of the peritoneal cavity presenting with a distinct immunohistochemical phenotype"Pathol.International. 51. 293-300 (2001)

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      2001 Annual Research Report
  • [Publications] suzuki, S., et al.: "Broad distribution of the JC virus receptor contrasts with a marked cellular restriction of virus replication"Virology. 286. 100-112 (2001)

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      2001 Annual Research Report
  • [Publications] Ishimori, N., et al.: "Mixed allogeneic chimerism with wild-type strains ameliorates atherosclerosis in apoprotein E-deficeinetmice"J.Leukocyte Biolo.. 69. 732-740 (2001)

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      2001 Annual Research Report
  • [Publications] Kamimura, E., et al.: "New rat model for attention deficit hyperactive disorder (ADHD)"Comparative Medicine. 51. 245-251 (2001)

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      2001 Annual Research Report
  • [Publications] Fujioka, Y., et al.: "MM-1, a c-Myc-binding Protein, Is a Candidate for a Tumor Suppressor in Leukemia/Lymphoma and Tongue Cancer"J.Biol Chem.. 276. 45137-45144 (2001)

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      2001 Annual Research Report

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Published: 2001-04-01   Modified: 2016-04-21  

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