| Project/Area Number |
13557129
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 展開研究 |
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| Research Field |
Anesthesiology/Resuscitation studies
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| Research Institution | Chiba University |
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Principal Investigator |
YAMAMOTO Tatsuo Chiba University, Graduate School of Medicine, Lecturer, 大学院・医学研究院, 講師 (20200818)
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| Co-Investigator(Kenkyū-buntansha) |
SAITO Osamu Chiba University, University Hospital, Assistant, 医学部附属病院, 助手 (90344986)
AOE Tomohiko Chiba University, Graduate School of Medicine, Associate Professor, 大学院・医学研究院, 助教授 (90311612)
田口 奈津子 千葉大学, 医学部・附属病院, 助手 (80282474)
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| Project Period (FY) |
2001 – 2003
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| Project Status |
Completed (Fiscal Year 2003)
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| Budget Amount *help |
¥13,700,000 (Direct Cost: ¥13,700,000)
Fiscal Year 2003: ¥1,800,000 (Direct Cost: ¥1,800,000)
Fiscal Year 2002: ¥3,000,000 (Direct Cost: ¥3,000,000)
Fiscal Year 2001: ¥8,900,000 (Direct Cost: ¥8,900,000)
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| Keywords | Bone metastasis / Cancer pain / COX-1 / COX-2 / COX-3 / NSAIDs / opioids / WHOの癌性疼痛治療指針 / 癌性疹痛 / インドメタシン / celecoxib / SC560 / indomethacin / NSAID / formalin test |
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| Research Abstract |
Non-steroidal anti-inflammatory drugs (NSAIDs) are clinically used for the treatment of bone cancer pain but the mechanisms NSAIDs use to produce an analgesic effect in patients with bone cancer pain are not fully understood. To explore the mechanisms NSAIDs use to produce an analgesic effect on bone cancer pain, the authors examined the effects of oral administration of a COX-1 selective inhibitor (SC560), a COX-2 selective inhibitor (celecoxib) and a non-selective 4 COX inhibitor (indomethacin) in a mouse bone cancer pain model and compared these effects to the effect of orally administered morphine. Recently, the third COX, COX-3, has been reported. Acetaminophen has been reported to be a selective COX-3 inhibitor. We also examined the effect of acetaminophen on bone cancer pain. Acetaminophen and indomethacin, but not of SC560 and celecoxib, produced an analgesic effect on bone cancer pain. Co-administration of sub-analgesic doses of morphine with acetaminophen enhanced an analgesic effect of acetaminophen. Our data suggested that the oral administration of acetaminophen, but not a COX-1 selective inhibitor and a COX-2 selective inhibitor, produces an analgesic effect on bone cancer pain. The co-administration of acetaminophen with an opioid provides a beneficial effect in the treatment of bone cancer pain.
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