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Development of artificial oxygen carriers under consideration of microvascular homeostasis

Research Project

Project/Area Number 13557132
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section展開研究
Research Field Anesthesiology/Resuscitation studies
Research InstitutionKeio University

Principal Investigator

SUEMATSU Makoto  Professor and Chair, Department of Biochemistry and integrative Medical Biology, Keio University, 医学部, 教授 (00206385)

Co-Investigator(Kenkyū-buntansha) TAKEOKA Shinji  Associate Professor, Department of Applied Chemistry, School of Science and Engineering, Waseda University, 理工学部, 助教授 (20222094)
MORISAKI Hiroshi  Assistant Professor, Department of Anesthesiology, School of Medicine, Keio University, 医学部, 専任講師 (60182226)
Project Period (FY) 2001 – 2002
Project Status Completed (Fiscal Year 2002)
Budget Amount *help
¥3,700,000 (Direct Cost: ¥3,700,000)
Fiscal Year 2002: ¥3,700,000 (Direct Cost: ¥3,700,000)
Keywordsheme oxygenase / Oxygen carrier / Hemoglobin / microcirculation / nitric oxide / bilirubin / carbon monoxide / Kupffer cells / NO / CO / 微小循環 / ヘモグロビン / バイオイメージング / ビリルビン / hme oxygenase / リポソーム / 一酸化炭素 / 酸素 / ヘムオキシゲナーゼ / シトクロームP450 / 肝臓
Research Abstract

This study aimed to examine effects of liposome-encapsulated hemoglobin (HbV), a candidate artificial oxygn carrier, on hepatic microvascular hemodynamics under septic conditions, and roles of CO, the gaseous product of heme oxygenase (HO), in ameliorating hepatobiliary dysfunction during catabolism of heme molecules in endotoxemic livers. Vascular resistance and biliary flux of bilirubin-Ixα, an index of HO-derived CO generation, were monitored in perfused livers of endotoxemic rats. Livers were perfused with HbO_2 which captures NO and CO, or metHb, a reagent trapping NO but not CO. Effexts of HbV were also examined. In endotoxin-pretreated livers where inducible NO synthase and HO-1 overproduced NO and CO, HbO_2 caused marked vasoconstriction and cholestasis. These changes were not reproduced by the NO synthase inhibitor aminoguanidine alone, but by co-administration of zinc protoporphyrin-IX, an HO inhibitor. CO supplementation attenuated the events caused by aminoguanidine plus zinc protoporphyrin-IX, suggesting that simultaneous elimination of these vasorelaxing gases accounts for a mechanism for HbO_2-induced changes. This concept was supported by observation that metHb did not cause any cholestasis; the reagent captures NO but triggers CO overproduction through rapid degradation of the heme by HO-1. On the other hand, HbV exhibited only minor changes in sinusoidal patency without eliciting any notable reduction of sinusoidal blood supply. These results suggest protective roles of endogenous CO against hepatobiliary dysfunction caused by heme overloading under stress conditions, and thus extravasation of the candidate carrier should be limited to maintain optimal CO concentrations in the space of Disse.

Report

(3 results)
  • 2002 Annual Research Report   Final Research Report Summary
  • 2001 Annual Research Report
  • Research Products

    (61 results)

All Other

All Publications (61 results)

  • [Publications] Kyokane, T., Norimizu, S., Taniai, H., Naito, M., Takeoka, S., Tsuchida, E., Nimura, Y., Ishimura, Y., Suematsu, M.: "Carbon monoxide from heme catabolism protects against hepatobiliary dysfunction in endotoxin-treated rat liver"Gastroenterology. 120. 1227-1240 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Taniai, H., Suematsu, M., Suzuki, T., Hori, R., Ishimura, Y., Nimura, Y.: "Protective roles of endothelin B receptor-mediated nitric oxide generation in hepatobiliary dysfunction in anoxia-reoxygenated perfused rat liver"Hepatology. 33. 894-901 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Kashiba, M., Ishimura, Y., Suematsu, M.: "Carbon monoxide reception in biological systems"Porphyrins. 9. 150-157 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Tanimoto, A., Oshio, K., Suematsu, M., Pouliquen, D., Stark, D.: "Relaxation effects of clustered particles"J.Magnet.Reson.Imag.. 14(1). 72-77 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Suematsu, M., Aiso, S.: "Professor Toshio Ito : a clairvoyant in pericyte biology"Keio J.Med.. 50(2). 66-71 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Imai T, Morita T, Shindo T, Nagai R, Yazaki Y, Kurihara H, Suematsu M, Katayama S.: "Vascular smooth muscle cell-directed overexpression of heme oxygenase-1 elevates blood prssure through attenuation of nitric oxide-induced vasodilation in mice"Circ Res.. 89(1). 55-62 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Hirano, K., Kobayashi, T., Watanabe, T., Yamamoto, T., Hasegawa, G., Hatakeyama, K., Suematsu, M., Naito, M.: "Role of heme oxygenase-1 and Kupffer cells inthe production of bilirubin in the rat liver"Arch Histol Cytol.. 64(2). 169-178 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Morisaki, H., Katayama, T., Kotake, Y., Ito, M., Ishimura, Y., Takeda, J., Suematsu, M.: "Roles of carbon monoxide in leukocyte and platelet dynamics in rat mesentery during sevoflurane anesthesia"Anesthesiology. 95. 192-199 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Suzuki, T., Makino, R., Suematsu, M.: "Organic phosphates as a new class of soluble guanylate cyclase inhibitors"FEBS Lett.. 507. 49-53 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Uwatoku, R., Suematsu, M., Ezaki, T., Saiki, T., Suganuma, T., Naito, M., Ando, M., Matsuno, K.: "Kupffer cell-mediated recruitment of rat dendritic cells to the liver : roles of N-acetylgalactosamine-specific sugar receptors"Gastroenterology. 121. 1460-1472 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Hori, R., Kashiba, M., Goda, N., Kajimura, M., Yachi, A., Toma, K., Makino, N., Soejima, A., Nagasawa, T., Nakabayshi, K., Suematsu, M.: "Gene transfer of H25A mutant heme oxygenase-1 protects cells against hydroperoxide-induced cytotoxicity"J.Biol.Chem.. 277. 10712-10718 (2002)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Ozawa, N., Goda, N., Makino, N., Yamaguchi, T., Yoshimura, Y., Suematsu, M.: "Leydig cell-derived heme oxygenase-1 regulates apoptosis of premeiotic germ cells in response to stress"J.Clin.Invest.. 109. 457-467 (2002)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Kashiba, M., Goda, N., Kajimura, M., Suematsu, M.: "From O2 to H2S : a landscape view of gas biology"Keio J.Med.. 51. 1-10 (2002)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Kajimura, M., Goda, N., Suematsu, M.: "Organ design for generation and reception of CO : Lessons from the liver"Antioxid Redox Signal. 4. 633-637 (2002)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Suematsu, M.: "COHb : A stress-induced marker reflecting surgical insults?"J Gastroenterol Hepatol (Editorial). 17. 519-520 (2002)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Takamiya, R., Murakami, M., Goda, N., makino, N., Kajimura, M., Takamiya, Y., Yamaguchi, T., Ishimura, Y., Hozumi, N., Suematsu, M.: "Stabilization of mast cells by heme oxygenase-1: an anti-inflammatory role"Am.J.Physiol.Heart Circ.Physiol.. 283. H861-H870 (2002)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Morisaki, H., Katayama, T., Kotake, Y., Handa, M., Ikeda, Y., Takeda, J., Ito, M., Suematsu, M.: "Carbon monoxide modulates endotoxin-induced microvascular leukocyte adhesion through platelet-dependent mechanisms"Anesthesiology. 97. 701-709 (2002)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Tsuchida, E., Komatsu, T., Matsukawa, Y., Nakagawa, A., Sakai, H., Kobayashi, K., Suematsu, M.: "Human serum albumin incorporating synthetic heme : Red blood cell substitute without hypertension by nitric oxide scavenging"J.Biomed Mater Res.. 64A. 257-261 (2003)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Kajimura, M., Shimoyama, M., Tsuyama, S., Suzuki, T., Ihara, H., Kozaki, S., Tsubota, K., Oguchi, Y, Suematsu, M.: "Visualiztion of gaseous monoxide reception by soluble guanylate cyclase in rat retina"FASEB J.. fj.02-0359fje. (2003)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Kashiwagi, S., Kajimura, M., Yoshimura, Y., Suematsu, M.: "Nonendothelial source of nitric oxide in arterioles but not in venules : Alternative source revealed in vivo by diaminofluorescein microfluorography"Circ Res. 91. e55-e64 (2002)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Suematsu, M., Suganuma, K., Kashiwagi, S.: "Mechanistic probing of gaseous signal transduction in microcirculation"(in press). (2003)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Norimizu, S., Kudo, A., Ishikawa, K., Kajimura, M., Yamaguchi, T., Fujii, K., Taniai, H., Nimura, Y., Suematsu, M.: "Carbon monoxide stimulates mrp2-dependent excretion of bilirubin-IXa into bile in the perfused rat liver. Antioxid. Redox Signaling"(in press). (2003)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Kato, Y., shimazu, M., Kondo, M., Kumamoto, Y., Wakabayashi, G., Kitajima, M., Suematsu, M.: "Bilirubin rinse : A simple protectant against the rat liver graft injury mimicking heme oxygenase-1 preconditioning"Hepatology. (in press). (2003)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Egawa, T., Yoshioka, S., Takahashi, S., Hori, H., Nagano, S., Shimada, H., Ishimori, K., Morishima, I., Suematsu, M., Ishimura, Y.: "Kinetic and spectroscopic characterization of hydroperoxy compound in the reaction of native myoglobin with hydrogen peroxide"J.Biol.Chem.. (in press). (2003)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Kyokane, T., Norimizu, S., Taniai, H, Naito, M., Takeoka,S, Tsuchida, E., Nimura, Y., Ishimura, Y., Suematsu, M.: "Carbon monoxide from heme catabdism protects against hepatobiliary dysfunction in endotoxin-treated rat liver"Gastroenterology. 120. 1227-1240 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Taniai, H., Suematsu, M., Suzuki, T, Hori, R., Ishimura,Y., Nimura, Y.: "Protective roles of endothelin B receptor-mediated nitric oxide generation in hepatobiliary dysfunction in anoxia-reoxygenated perfused rat liver"Hepatology. 33. 894-901 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Kashiba, M., Ishimura, Y., Suematsu, M.: "Carbon monoxide reception in biological systems"Porphyrins. 9. 150-157 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Tanimoto, A., Oshio, K., Suematsu, M., Pouliquen, D., Stark, D.: "Relaxation effects of clustered particles"J. Magnet Reson. Imag.. 14(1). 72-77 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Suematsu M., Aiso S.: "Professor Toshio lto: a clairvoyant in pericyte biology"Keio J Med.. 50(2). 66-71 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Imai T, Morita T, Shindo T, Nagai R, Yazaki Y, Kurihara H, Suematsu M, Katayama S.: "Vascular smooth musde cell-directed ovenexpression of heme oxygenase-1 elevates blood pressure through attenuation of nitric oxide-induced vasodilation in mice"Circ Res.. 89(1). 55-62 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Hirano K, Kobayashi T, Watanabe T, Yamamoto T, Hasegawa G, Hatakeyama K, Suematsu M, Naito M.: "Role of heme oxygenase-1 and Kupffer cells in the production of bilirubin in the rat liver"Arch Histol Cytol.. 64(2). 169-78 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Morisaki, H, Katayama, T, Kotake, Y, Ito, M, Ishimura, Y, Takeda, J., Suematsu, M.: "Roles of carbon monoxide in leukocyte and platelet dynamics in rat mesentery during sevoflurane anesthesia"Anesthesiology. 95. 192-199 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Suzuki, T.Makino, R, Suematsu, M.: "Organic phosphates as a new class of soluble guanylate cyclase inhibitors"FEBS Lett.. 507. 49-53 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Uwatoku, R., Suematsu, M., Ezaki, T., Saiki, T., Suganuma, T., Naito, M, Ando, M., Matsuno, K.: "Kupffer cell-mediated recruitment of rat dendritic cells to the liver: roles of N-acetylgalactosamine-specific sugar receptors"Gastroenterology. 121. 1460-1472 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Hori, R., Kashiba, M., Goda, N., Kajimura, M., Yachie, A., Toma, K., Makino, N., Soejima, A., Nagasawa, T., Nakabayashi, K., Suematsu, M.: "Gene transfer of H25A mutant heme oxygenase-1 protects cells against hydroperoxide-induced cytotoxicity"J. Biol. Chem.. 277. 10712-10718 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Ozawa, N., Goda, N., Makino, N., Yamaguchi, T., Yoshimura, Y., Suematsu, M.: "Leydig cell-derived heme oxygenase-1 regulates apoptosis of premeiotic germ cells in response to stress"J. Clin. Invest.. 109. 457-467 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Kashiba, M., Goda, N., Kajimura, M., Suematsu, M.: "From 02 to H2S: A landscape view of gas biology"Keio. J. Med.. 51. 1-10 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Kajimura, M., Goda, N., Suematsu, M.: "Organ design for generation and reception of CO: Lessons from the liver"Antioxid Redox Signal. 4. 633-637 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Suematsu, M.: "COHb: A stress-induced marker reflecting surgical insults?"J Gastroenterol Hepatol (Editorial). 17. 519-520 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Takamiya, R., Murakami, M., Goda, N., Makino, N., Kajimura, M., Takamiya, Y., Yamaguchi, T., Ishimuna, Y., Hozumi, N., Suematsu, M.: "Stabilization of mast cells by heme oxygenase-1: an anti-inflammatory role"Am. J. Physiol. Heart Circ. Physiol.. 283. H861-H870 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Morisaki, H., Katayama, T., Kotake, Y., Handa, M., .Ikeda, Y., Takeda, J., Ito, M., Suematsu, M.: "Carbon monoxide modulates endotoxin-induced microvascular leukocyte adhesion through platelet-dependent mechanisms"Anesthesiology. 97. 701-709 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Tsuchida E., Komatsu T., Matsukawa Y., Nakagawa A., Sakai H., Kobayashi K., Suematsu M.: "Human serum albumin incorporating synthetic heme: Red blood cell substitute without hypertension by nitric oxide scavenging"J Biomed Mater Res.. 64A. 257-261 (2003)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Kajimura, M., Shimoyama, M., Tsuyama, S., Suzuki, T., Ihara, H., Kozaki, S., Tsubota, K., Oguchi, Y., Suematsu, M.: "Visualization of gaseous monoxide reception by soluble guanylate cyclase in rat retina"FASEB J. fj.02-0359fje (2003)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Kashiwagi, S., Kajimura, M., Yoshimura, Y., Suematsu, M.: "Nonendotheliai source of nitric oxide in arterioJes but not in venules: Altemative source revealed in vivo by diaminofluorescein microfluorography"Crc Res. 91. e55-e64 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Suematsu, M., Suganuma, K., Kashiwagi, S.: "Mechanistic probing of gaseous signal transduction in microcirculation"In press. (2003)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Norimizu, S., Kudo, A., Ishikawa, K., Kajimura, M., Yamaguchi, T., Fujii, K., Taniai, H., Mimura, Y., Suematsu, M.: "Carbon monoxide stimulates mrp2-dependent excretion of bilirubin-Ixa into bile in the perfused rat liver. Antioxid. Redox Signaling"In press. (2003)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Kato, Y., Shimazu, M., Kondo, M., Kumamoto, Y., Wakabayashi, G., Kitajima, M., Suematsu, M.: "Bilirubin rinse: A simple protectant against the rat liver graft injury mimicking heme oxygenase-1 preconditioning"Hepatology. in press. (2003)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Egawa, T., Yoshioka, S., Takahashi, S., Hori, H., Nagano, S., Shimada, H., Ishimori, K., Morishima, I., Suematsu, M., Ishimura, Y.: "Kinetic and spectroscopic characterization of hydroperoxy compound in the reaction of native myoglobin with hydrogen peroxide"J. Biol. Chem.In press. in press. (2003)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Kashiwagi, S., et al.: "Nonendothelial source of nitric oxide in arterioles but not in venules: Alternative source revealed in vivo by diaminofluorescein microfluorography"Circulation Research. 91. e55-e64 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] Tsuchida, E, et al.: "Human serum albumin incorporating synthetic heme: Red blood cell substitute without hypertension by nitric oxide scavenging"J Biomed Mater Res.. 64A. 257-261 (2003)

    • Related Report
      2002 Annual Research Report
  • [Publications] Morisaki, H., et al.: "Carbon monoxide modulates endotoxin-induced microvascular leukocyte adhesion through platelet-dependent mechanisms"Anesthesiology. 97. 701-709 (2003)

    • Related Report
      2002 Annual Research Report
  • [Publications] Suematsu, M., et al.: "The inflammatory aspect of the microcirculation in hypertension"Microcirculation. 9. 259-276 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] Takamiya, R, et al.: "Stabilization of mast cells by heme oxygenase-1 : an anti-inflammatory role"Am J Physiol Heart Circ Physiol. 283. H861-H870 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] Hori, R, et al.: "Gene transfer of H25A mutant heme oxygenase-1 protects cells against hydroperoxide-induced cytotoxicity"J. Biol. Chem.. 277. 10712-10718 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] Taniai, H., Suematsu, M., et al.: "Protective roles of enddothelin B receptor-mediated nitric oxide generation in hepatobiliary dysfunction in anoxiareoxygenated perfuse rat liver"Hepatology. 33. 894-901 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] Kyokane, T., Suematsu, M., et al.: "Carbon monoxide from heme catabolism proyects against hepatobiliary dysfun-ction in endotoxin-treated rat liver"Gastroenterology. 120. 1227-1240 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] Imai, T., Suematsu, M., et al.: "Vascular smooth muscle cell-direct overexpression of heme oxygenase-1 elevates blood pressure through attenuation of nitric oxide-Induced vasodilation in mice"Circ Res. 89. 55-62 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] Morisaki, H., Suematsu, M., et al.: "Role of carbon monoxide In leukocyte and platelet dynamics in rat mesentery during sevoflurane anesthesia"Anesthesiology. 95. 192-199 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] Uwatoku, R., Suematsu, M., et al.: "Kupper cell-mediated recruitment of rat dendritic cells to the liver: roles of Nacetylgalactosamine-specific sugar receptors"Gastroenterology. 121. 1460-1472 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] Ozawa, N., Suematsu, M., et al.: "Leydig cell-derived heme oxygenase-1 regulates apotosis of premeiotic germ cell in response to stress"J.Clin.Invest. 109. 457-467 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] Suematsu, M., Makino, N., et al.: "In Free Radicals In Digestive Disease(eds.Yoshikawa, T., Niki, E.)Karger"Mechanisms for carbon monoxide-mediated protection against hepatobiliary dysfunction(in press).

    • Related Report
      2001 Annual Research Report

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Published: 2002-04-01   Modified: 2016-04-21  

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