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The development of functional collagen material which has a property of controlled growth factor release, and its application for tissue regeneration therapy.

Research Project

Project/Area Number 13557166
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section展開研究
Research Field 補綴理工系歯学
Research InstitutionOsaka University

Principal Investigator

TAKAHASHI Junzo  Osaka University, Professor, 大学院・歯学研究科, 教授 (80029149)

Co-Investigator(Kenkyū-buntansha) HAMADA Yoshinosuke  Osaka University, Assistant Professor, 大学院・歯学研究科, 助手 (10362683)
TERAOKA Fumio  Osaka University, Assistant Professor, 大学院・歯学研究科, 講師 (00099805)
SOHMURA Taiji  Osaka University, Associate Professor, 大学院・歯学研究科, 助教授 (10154692)
松本 卓也  大阪大学, 大学院・歯学研究科, 助手 (40324793)
Project Period (FY) 2001 – 2003
Project Status Completed (Fiscal Year 2003)
Budget Amount *help
¥11,700,000 (Direct Cost: ¥11,700,000)
Fiscal Year 2003: ¥1,400,000 (Direct Cost: ¥1,400,000)
Fiscal Year 2002: ¥4,300,000 (Direct Cost: ¥4,300,000)
Fiscal Year 2001: ¥6,000,000 (Direct Cost: ¥6,000,000)
KeywordsFunctional material / Collagen / Hydroxyapatite / Biodegradable / Controlled release of protein / Bone regeneration / 機能性ペプチド / 血管新生 / 徐放性 / ゼラチン / 担体 / 代謝性
Research Abstract

We could realize a large numbers of new genes and proteins with their functions by the advance of the molecular biology and the developmental biology during the last decade, and the people's expectation is growing towards the clinical application of the regenerative medicine by using such obtained knowledge. Bone and tooth, especially among the numerous living tissues, is expected as a regenerativable tissue in near future, because the mechanism of bone formation has well studied and understood. However, we have had few concrete strategies to create new bone for the clinical application at this point. In this study, in order to create a new methodology of generating new bone for clinical application, we tried to make a new functional material with specific property "controlled release of growth factors" by using collagen and hydroxyapatite.
It was confirmed that hydroxyapatite synthesized at different temperature showed different bioabsorbability, and protein adsorption. When we prepared hydroxyapatite particles adsorbed protein and investigated the protein release from this apatite in several biologic conditions, the protein release could be controlled by apatite dissolution. When we combined apatite particles in collagen gel and investigated the biodegradation of this collagen/apatite composite material, the degradation of this material is depended on the containing amount of apatite. Moreover, it was confirmed that the apatite was released from the composite material during its degradation period. These results suggest that this composite material has a property of controlled release of protein.

Report

(4 results)
  • 2003 Annual Research Report   Final Research Report Summary
  • 2002 Annual Research Report
  • 2001 Annual Research Report
  • Research Products

    (21 results)

All Other

All Publications (21 results)

  • [Publications] T.Matsumoto, J.Takahashi et al.: "Crystallinity and solubility characteristics of hydroxyapatite adsorbed amino acid."Biomaterials. 23. 2241-2247 (2002)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] T.Matsumoto, J.Takahashi et al.: "Biodegradation of carbonate apatite / collagen composite membrane and its controlled release of carbonate apatite."J Biomed Mater Res. 60. 651-656 (2002)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Y.Yamazaki, J.Takahashi et al.: "Synthesis of functionally graded MgCO_3 apatite accelerating osteoblast adhesion."J Biomed Mater Res. 62. 99-105 (2002)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Y.Hamada, J Takahashi, N Matsuura, et al.: "Angiogenic activity of osteopontin-derived peptide SVVYGLR."Biochem Biophys Res Commun. 310. 153-157 (2003)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] H.Nakao, J.Takahashi et al.: "Control of pore size In L-lactide/epsilon-caprolactone copolymer foams for tissue regeneration by the freeze-drying method."Dent Mater J. 22. 262-271 (2003)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] T.Matsumoto, J.Takahashi et al.: "Hydroxyapatite particles as a controlled release carrier of protein."Biomaterials. 25. 3807-3812 (2004)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] T.Matsumoto, J.Takahashi et al.: "Crystallinity and solubility characteristics of hydroxyapatite adsorbed amino acid."Biomaterials. 23. 2241-2247 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] T.Matsumoto, J.Takahashi et al.: "Biodegradation of carbonate apatite / collagen composite membrane and its controlled release of carbonate apatite."J.Biomed.Mater.Res.. 60. 651-656 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Y.Yamazaki, J.Takahashi et al.: "Synthesis of functionally graded MgCO_3 apatite accelerating osteoblast adhesion."J.Biomed.Mater.Res.. 62. 99-15 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Y.Hamada, J.Takahashi, N.Matsuura et al.: "Angiogenic activity of steropontin-derived peptide SVVYGLR."Biochem.Biophys.Res.Commun.. 310. 153-157 (2003)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] H.Nakano, J.Takahashi et al.: "Control of pore size in L-lactide/epsilon-caprolactone copolymer foams for tissue regeneration by the freeze-drying method."Dent.Mater.J.. 22. 262-271 (2003)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] T.Matsumoto, J.Takahashi et al.: "Hydroxyapatite particles as a controlled release carrier of protein."Biomaterials. 25. 3807-3812 (2004)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Hamada Y et al.: "Angiogenic activity of osteopontin-derived peptide SVVYGLR"Biochemical and Biophysical Research Communication. 310・1. 153-157 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] Nakao H et al.: "Control of pore size in L-lactide/epsilon-caprolactone copolymer foams for tissue regeneration by the freeze-drying method"Dental Materials Journal. 22. 262-271 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] Matsumoto T et al.: "Hydroxyapatite particles as a controlled release carrier of protein"Biomaterials. in press.

    • Related Report
      2003 Annual Research Report
  • [Publications] T.Matsumoto, M.Okazaki, J.Takahashi: "Crystallinity and solubility characteristics of hydroxyapatite adsorbed amino acid"Biomaterials. 23. 2241-2247 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] T.Matsumoto, M.Okazaki, J.Takahashi: "Biodegradation of carbonate apatite / collagen composite membrane and its controlled"Journal of Biomedical and Material Research. 60・4. 651-656 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] T.Matsumoto, M.Inoue, J.Takahashi: "Surface-Modified Hydroxyapatite as Carrier for Drug Delivery System"Journal Dental Research. 80. 1116 (2001)

    • Related Report
      2002 Annual Research Report
  • [Publications] T.Matsumoto, M.Okazaki, J.Takahashi: "Low crystalline hydroxyapatite as the controlled release carrier of basic protein"Journal Dental Research. 81. A191 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] T.Hasegawa, T.Matsumoto, J.Takahashi: "Release kinetics of hyaluronan from gelatin/hyaluronan composite gel"Dental Materials Transaction. 16. 303 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] T.Matsumoto: "Biodegradation of carbonate apatite / collagen composite membrane and its controlled release of carbonate apatite"Journal of Biomedical Materials Research. (In press).

    • Related Report
      2001 Annual Research Report

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Published: 2001-04-01   Modified: 2016-04-21  

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