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Analysis of micrometastasis using GFP-expressed metastasis model of oral cancer and inhibition of metastasis by new anti-tumor drugs

Research Project

Project/Area Number 13557178
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section展開研究
Research Field Surgical dentistry
Research InstitutionEhime University

Principal Investigator

HAMAKAWA Hiroyuki  Ehime University School of Medicine, Department of Oral & Maxillofacial Surgery, professor, 医学部, 教授 (20127905)

Co-Investigator(Kenkyū-buntansha) TACHIKAWA Tetsuhiko  Showa University, Dental School, Department of Oral pathology, Professor, 歯学部, 教授 (10085772)
SHINTANI Satoru  Ehime University School of Medicine, Department of Oral & Maxillofacial Surgery, assistant professor, 医学部, 助教授 (80294429)
Project Period (FY) 2001 – 2003
Project Status Completed (Fiscal Year 2003)
Budget Amount *help
¥13,900,000 (Direct Cost: ¥13,900,000)
Fiscal Year 2003: ¥3,200,000 (Direct Cost: ¥3,200,000)
Fiscal Year 2002: ¥3,300,000 (Direct Cost: ¥3,300,000)
Fiscal Year 2001: ¥7,400,000 (Direct Cost: ¥7,400,000)
Keywordsoral cancer / GFP / micrometastasis / CXCR4 / SDF1 / Akt / PI3K / VEGF / 舌正所性腫瘍移植 / green fluorescent protein / 口腔扁平上皮癌 / リアルタイム定量PCR法 / 頸部リンパ節転移 / SCCA / 絶対的定量法
Research Abstract

We established a stably transfected cell line which expresses high levels of green fluorescent protein (GFP), thus permitting the detection and visualization of developing tumors and lymph node metastases after injection into nude mice. Cells of the human oral squamous carcinoma cell line (SAS-L1) were transfected with an expression vector containing a CDNA encoding humanized GFP and the neomycin resistance gene. A clone with stable high-level expression of GFP was selected in vitro using G418. To study metastasis formation, GFP-expressing cells were injected orthotopically into the tongue of nude mice. The resultant tumor growth in the tongue and micrometastases in the lymph nodes could be visualized by GFP fluorescence. Therefore a useful model has been developed for the study of oral cancer, firstly to understand the metastatic process and secondly for the evaluation of potential treatments.
Second, we analyzed the expression of COX2 and checked the effect of COX2 inhibitor. The purpose of this study is to investigate the relationship between the radiation sensitivity and elevated level of COX-2. Radiation sensitivity of the eight oral SCC cell lines differed greatly in their response to radiation. Further, the level of the COX-2 expression correlated inversely with increased tumor radiation sensitivity. The similar significant association between the response to preoperative radiation therapy and COX-2 overexpression was observed in the oral SCC patients. In addition, treatment with a COX-2 selective inhibitor enhanced the radioresponse of HSC-2 cell, which constitutively expressed COX-2. These results suggested that COX-2 expression level correlates to radiation tolerance and the COX-2 selective inhibitor may be a potent enhancer for tumor radioresponse in oral SCC.

Report

(4 results)
  • 2003 Annual Research Report   Final Research Report Summary
  • 2002 Annual Research Report
  • 2001 Annual Research Report
  • Research Products

    (56 results)

All Other

All Publications (56 results)

  • [Publications] T Sumida, H Hamakawa.: "Telomerase and oral cancer."Oral Oncol. 37. 333-340 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Kayahara H, Yamagata H, Miki T, Tanioka H, Hamakawa H.: "Frequent loss of heterozygosity at 3p25-p26 is associated with invasive oral squamous cell carcinoma."J Human Genet. 46. 335-341 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Ferlito A, Partridge M, Brennan JA, Hamakawa H.: "Lymph node micrometastasis in head and neck cancer ; a review."Acta Otolaryngol. 121. 660-665 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Mese H, Ueyama Y, Suzuki A, Nakayama S, Sasaki A, Hamakawa H, Matsumura T.: "Inhibition of telomerase activity as a measure of tumor cell killing by cisplatin in squamous cell carcinoma cell line."Chemotherapy. 47. 136-142 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Begum NM, Nakashiro K, Kawamata H, Uchida D, Shintani S, Ikawa Y, Sato M, Hamakawa H: "Expression of peroxisome proliferator-activated receptor gamma and the growthinhibitory effect of its synthetic ligands in human salivary gland cancer cell lines."Int J Oncol. 20(3). 599-605 (2002)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] S.Shintani, M.Mihara, Y Nakahara, T.Aida, T.Tachikawa, H.Hamakawa.: "Lymph node metastasis of oral cancer visualised inlive tissue by green fluorescent protein expression."Oral Oncology. 38(7). 664 (2002)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Li C, Shintani S, Terakado N, Nakashiro K, Hamakawa H.: "Infiltration of tumor-associated macrophages in human oralsquamous cell carcinoma."Oncol Rep. 9. 1219-1223 (2002)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Mihara M, Shintani S, Kiyota A, Matsumura T, Wong DTW: "Cyclin-dependent kinase inhibitor (Roscovitine) suppresses the growth and induce apoptosis by regulating Bcl-x in head and neck squamous cell carcinoma cells"Int J Oncol. 21. 95-101 (2002)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Kiyota A, Shintani S, Mihara M, Nakahara Y, Ueyama U, Matsumura T, Tachikawa T, Wong DTW.: "Anti-epidermal growth factor receptor monoclonal antibody 225 up-regulates p27KIP1 and p15INK4B, and induces G1 arrest in oral squamous carcinoma cell lines."Oncology. 63. 92-98 (2002)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] M.Mihara, S.Shintani, K.Nakashiro, H.Hamakawa.: "Flavopiridol, a cyclin dependent kinase (CDK) inhibitor, induces apoptosis by regulating Bcl-x in oral cancer cells."Oral Oncology. 39. 49-55 (2003)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Shintani S, Kiyota A, Mihara M, Sumida T, Kayahara H, Nakashiro K, Hamakawa H.: "Enhancement of radiosensitivity inhead and neck cancer cells by ZD1839 ('Iressa'), aselectiveepidermal growth factor receptor tyrosine kinase inhibitor."Am J Clin Oncol. 26(5). E150-E156 (2003)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Zen H, Nakashiro K, Shintani S, Sumida T, Aramoto T, Hamakawa H.: "Detection of circulating cancer cells in human oral squamous cell carcinoma."Int J Oncol. 23(3). 605-610 (2003)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] S Shintani, C Li, M Mihara, N Terakado, K Nakashiro, Hamakawa H.: "Enhancement of tumor radioresponse by combined treatment with gefitinib (Iressa, ZD1839), an epidermal growth factor receptor tyrosine kinase inhibitor, is accompanied by inhibition of DNA damage repair and cell growth in oral cancer."Int J Cancer. 107. 1030-1037 (2003)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] S Shintani, M Mihara, C Li, Y Nakahara, K Nakashiro, Hamakawa H.: "Up-regulation of DNA-dependent protein kinase correlates with radiation resistance in oral squamous cell carcinoma."Cancer Sci. 94. 894-900 (2003)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Nakashiro K, Begum NM, Uchida D, Kawamata H, Shintani S, Sato M, Hamakawa H.: "Thiazolidinediones inhibit cell growth of human oral squamous cell carcinoma in vitro independent of peroxisome proliferator-activated receptor gamma."Oral Oncol. 39(8). 855-861 (2003)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Uchida D, Begum NM, Almofti A, Nakashiro K, Kawamata H, Tateishi Y, Hamakawa H, Yoshida H, Sato M.: "Possible role of stromal-cell-derived factor-1/CXCR4 signaling on lymph node metastasis of oral squamous cell carcinoma."Exp Cell Res. 290(2). 289-302 (2003)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] S Shintani, C Li, M Mihara, T Isikawa, M Mihara, K Nakashiro, H Hamakawa: "Expression of vascular endothelial growth factor A, B, C, and D in oral squamous cell carcinoma."Oral Oncol. 40(1). 13-20 (2004)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] S Shintani, C Li, M Mihara, J Yano, N Terakado, K Nakashiro, H Hamakawa.: "Gefinitib ('Iressa', ZD1839), an eppidermal growth factor receptor tyrosine kinase inhibitor, up-regulates p27KIP1 and induces G1 arrest in oral squamous cell carcinoma cell lines."Oral Oncol. 40(1). 43-51 (2004)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] A Onishi, K Nakashiro, M Mihara, T Sumida, H Kawamata, S Shintani, T Aida, T Tachikawa, H Hamakawa.: "Basic and clinical studies on quantitative analysis of lymph node micrometastasis in oral cancer."Oncol Rep. 11(1). 33-39 (2004)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] N Terakado, S Shintani, J Yano, C Li, M Mihara, K Nakashiro, Hamakawa H.: "Overexpression of cyclooxygenase-2 is associated with radioresistance in oral squamous cell carcinoma."Oral Oncol. 40(4). 383-389 (2004)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Shintani S, T.Ishikawa, T.Nonaka, C.Li, K.Nakashiro, D.T.W Wong, H.Hamakawa: "Growth regulated oncogene 1 expression is associated with angiogenesis and lymph node metastasis in human oral cancer."Oncol. (in press). (2004)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] S Shintani, C Li, M Mihara, S Hino, K Nakashiro, H Hamakawa: "Skp2 and Jab1 expression are associated with inverse expression of p27KIP1 and poor prognosis in oral squamous cell carcinomas."Oncol. (in press). (2004)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] H Hamakawa, A Onishi, T Sumida, N Terakado, S Hino, K Nakashiro, S Shintani.: "Intraoperative real-time genetic diagnosis for sentinel node navigation surgery."Int J Oral Max-fac Surg. (in press). (2004)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] T Smida, H Hamakawa.: "Telomerase and oral cancer"Oral Oncol. 37. 333-340 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Kayahara H, Yamagata H, Miki T, Tanioka H, Hamakawa H: "Frequent loss of heterozygosity at 3p25-p26 is associated with invasive oral squamous Cell carcinoma."J Human Genet. 46. 335-341 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Ferlito A, Partridge M, Brennan JA, Hamakawa H: "Lymph node micrometastasis in head and neck cancer ; a review."Acta Otolaryngol. 121. 660-665 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Mese H, Ueyama Y, Suzuki A, Nakayama S, Sasaki A, Hamakawa H, Matsumura T: "Inhibition of telomerase activity as a measure of tumor cell killing by cisplatin in squamous cell carcinoma cell line."Chemotherapy. 47. 136-142 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Begum NM, Nakashiro K, Kawamata H, Uchida D, Shintami S, Ikawa Y, Sato M, Hamakawa H: "Expression of peroxisome proliferator-activated receptor gamma and the growth inhibitory effect of its synthetic ligands in human salivary gland cancer cell lines."Int J Oncol. 20(3). 599-605 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] S.Shintani, M.Mihara, Y.Nakahara, T.Aida, T.Tachikawa, H.Hamakawa: "Lymph node metastasis of oral cancer visualized in live tissue by green fluorescent protein expression."Oral Oncology. 38(7). 664 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Li C, Shintani S, Terakado N, Nakashiro K, Hamakawa H: "Infiltration of tumor-associated macrophages in human oral squamous cell carcinoma."Oncol Rep. 9. 1219-1223 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Mihara M, Shintani S, Kiyota A, Matsumura T, Wong DT W: "Cyclin-dependent kinase inhibitor (Roscovitine) suppresses the growth and induce apoptosis by regulating Bcl-x in head and neck squamous cell carcinoma cells"Int J Oncol. 21. 95-101 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Kiyota A, Shintani S, Mihara M, Nakahara Y, Ueyama U, Matsumura T, Tachikawa T, Wong DT W: "Anti-epidermal growth factor receptor monoclonal antibody 225 up-regulates p27KIP1 and p15INK4B, and induces G1 arrest in oral squamous carcinoma cell lines."Oncology. 63. 92-98 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] M.Mihara, S.Shintani, K.Nakashiro, H.Hamakawa: "Flavopiridol, a cyclin dependent kinase (CDK) inhibitor, induces apoptosis by regulating Bcl-x in oral cancer cells."Oral Oncology. 39(1). 49-55 (2003)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Shintani S, Kiyota A, Mihara M, Sumida T, Kayahara H, Nakashiro K, Hamakawa H: "Enhancement of radiosensitivity in head and neck cancer cells by ZD1839 ('Iressa'), a selectiveepidermal growth factor receptor tyrosine kinase inhibitor."Am J Ciin Oncol. 26(5). E150-E156 (2003)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Zen H, Nakashiro K, Shintam S, Sumida T, Aramoto T, Hamakawa H: "Detection of circulating cancer cells in human oral squamous cell carcinoma."Int J Oncol. 23(3). 605-610 (2003)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] S Shintani, C Li, M Mihara, N Terakado, K Nakashiro, Hamakawa H: "Enhancement of tumor radioresponse by combined treatment with gefitinib (Iressa, ZD1839), an epidermal growth factor receptor tyrosine kinase inhibitor, is accompanied by inhibition of DNA damage repair and cell growth in oral cancer."Int J Cancer. 107. 1030-1037 (2003)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] S Shintani, M Mihara, C Li, Y Nakahara, K Nakashiro, Hamakawa H: "Up-regulation of DNA-dependent protein kinase correlates with radiation resistance in oral squamous cell carcinoma."Cancer Sci. 94. 894-900 (2003)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Nakashiro K, Begum NM, Uchida D, Kawamata H, Shintani S, Sato M, Hamakawa H: "Thiazolidinediones inhibit cell growth of human oral squamous cell carcinoma in vitro independent of peroxisome proliferator-activated receptor gamma."Oral Oncol. 39(8). 855-861 (2003)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Uchida D, Begum NM, Almofti A, Nakashiro K, Kawamata H, Tateishi Y, Hamakawa H, Yoshida H, Sato M: "Possible role of stromal-cell-derived factor-1/CXCR4 signaling on lymph node metastasis of oral squamous cell carcinoma."Exp Cell Res. 290(2). 289-302 (2003)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] S Shintani, C Li, M Mihara, T Isikawa, M Mihara, K Nakashiro, H Hamakawa: "Expression of vascular endothelial growth factor A,B,C, and D in oral squamous cell carcinoma."Oral Oncol. 40(1). 13-20 (2004)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] S Shintani, C Li, M Mihara, J Yano, N Terakado, K Nakashiro, H Hamakawa: "Gefinitib ('Iressa', ZD1839), an eppidermal growth factor receptor tyrosine kinase inhibitor, up-regulates p27KIP1 and induces G1 arrest in oral squamous cell carcinoma cell lines."Oral Oncol. 40(1). 43-51 (2004)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] A Onishi, K Nakashiro, M Mihara, T Sumida, H Kawamata, S Shintani, T Aida, T Tachikawa, H Hamakawa: "Basic and clinical studies on quantitative analysis of lymph node micrometastasis in oral cancer."Oncol Rep. 11(1). 33-39 (2004)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] N Terakado, S Shintani, J Yano, C Li, M Mihara, K Nakashiro, Hamakawa H: "Overexpression of cyclooxygenase-2 is associated with radioresistance in oral squamous cell carcinoma."Oral Oncol.. 40(4). 383-389 (2004)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Shintani S, T.Ishikawa, T.Nonaka, C.Li, K.Nakashiro, D.T.W.Wong, H.Hamakawa: "Growth regulated oncogene 1 expression is associated with angiogenesis and lymph node metastasis in human oral cancer."Oncol. (in press). (2004)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] S Shintani, C Li, M Mihara, S Hino, K Nakashiro, H Hamakawa: "Skp2 and Jab1 expression are associated with inverse expression of p27KIP1 and poor prognosis in oral squamous cell carcinomas."Oncol. (in press). (2004)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] H Hamakawa, A Onlshi, T Sumida, N Terakado, S Hino, K Nakashiro, S Shintani: "Intraoperative real-time genetic diagnosis for sentinel node navigation surgery."Int J Oral Max-fac Surg. (in press). (2004)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] M.Mihara, S.Shintani, K.Nakashiro, H.Hamakawa: "Flavopiridol, a cyclin dependent kinase (CDK) inhibitor, induces apoptosis by regulating Bcl-x in oral cancer cells."Oral Oncology. 39(1). 49-55 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] Shintani s, Kiyota A, Mihara M, Sumida T, Kayahara H, Nakashiro K, Hamakawa H.: "Enhancement of radiosensitivity in head and neck cancer cells by ZD1839 ('Iressa'), a selective epidermal growth factor receptor tyrosine kinase inhibitor"Am J Clin Oncol. (In press). (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] Begum NM, Nakashiro K, Kawamata H, Uchida D, Shintani S, Ikawa Y, Sato M, Hamakawa H: "Expression of peroxisome proliferator-activated receptor gamma and the growth inhibitory effect of its synthetic ligands in human salivary gland cancer cell lines"Int J Oncol. 20(3). 599-605 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] S.Shintani, M.Mihara, Y.Nakahara, T.Aida, T.Tachikawa, H.Hamakawa: "Lymph node metastasis of oral cancer visualised in live tissue by green fluorescent protein expression"Oral Oncology. 38(7). 644-649 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] Li C, Shintani S, Terakado N Nakashiro K, Hamakawa H: "Infiltration of tumor-associated macrophages in human oral squamous cell carcinoma"Oncol Rep. 9. 1219-1223 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] M.Mihara, S.Shintani, K.Nakashiro, H.Hamakawa: "Flavopiridol, a cyclin dependent kinase(CDK)inhibitor, induces apoptosis by regulating Bcl-x in oral cancer cells"Oral Oncology. 39(1). 49-55 (2003)

    • Related Report
      2002 Annual Research Report
  • [Publications] Kiyota A, Shintani S, Mihara M, Nakahara Y, Ueyama U, Matsumura T, Tachikawa T, Wong DT W.: "Anti-epidermal growth factor receptor monoclonal antibody 225 up-regulates p27KIP1 and p15INK4B, and induces G1 arrest in oral squamous carcinoma cell lines"Oncology. 63. 92-98 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] Mihara M, Shintani S, Kiyota A, Matsumura T, Wong DT W.: "Cyclin-dependent kinase inhibitor (Roscovitine) suppresses the growth and induce apoptosis by regulating Bcl-x in head and neck squamous cell carcinoma cells"Int J Oncol. 21. 95-101 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] Shintani S, Kiyota A, Mihara M, Sumida T, Kayahara H, Nakashiro K, Hamakawa H.: "Enhancement of radiosensitivity in head and neck cancer cells by ZD1839 ('Iressa'), a selective epidermal growth factor receptor tyrosine kinase inhibitor"Am J Clin Oncol. (In press). (2003)

    • Related Report
      2002 Annual Research Report
  • [Publications] S.Shintani, M.Mihara, Y.Nakahara, T.Aida, T.Tachikawa, H.Hamakawa: "Lymph node metastasis of oral cancer visualised in live tissue by green fluorescent protein expression"Oral Oncology. (in press). (2002)

    • Related Report
      2001 Annual Research Report

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Published: 2001-04-01   Modified: 2016-04-21  

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