| Project/Area Number |
13558118
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 展開研究 |
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| Research Field |
Biomedical engineering/Biological material science
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| Research Institution | TOKYO WOMEN'S MEDICAL UNIVERSITY |
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Principal Investigator |
MINESHIMA Michio TOKYO WOMEN'S MEDICAL UNIVERSITY, DEPARTMENT OF MEDCINE, PROFESSOR, 医学部, 教授 (50166097)
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| Co-Investigator(Kenkyū-buntansha) |
HATTORI Hiroyuki HEAD OF RESEARCH & DEVELOPMENT LABORATORY, 総合研究所, 所長
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| Project Period (FY) |
2001 – 2004
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| Project Status |
Completed (Fiscal Year 2004)
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| Budget Amount *help |
¥9,100,000 (Direct Cost: ¥9,100,000)
Fiscal Year 2004: ¥1,900,000 (Direct Cost: ¥1,900,000)
Fiscal Year 2003: ¥1,900,000 (Direct Cost: ¥1,900,000)
Fiscal Year 2002: ¥1,900,000 (Direct Cost: ¥1,900,000)
Fiscal Year 2001: ¥3,400,000 (Direct Cost: ¥3,400,000)
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| Keywords | MEDICAL CHEMICAL ENGINEERING / DIALYZER / PERITONEAL DIALYSIS / REGENARATION OF THE SPENT DIALYSATE / ALBUMIN / CANINE MODEL / SOLUTE REMOVAL EFFICIENCY / 装着型人工腎 / アルブミン / 除水コントロール / 腹膜カテーテル / 高効率化 |
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| Research Abstract |
In this study, we introduced a modified CRPD/BPD system with a newly developed wearable artificial kidney and utilizing albumin solution as an osmotic agent. Water and solute removal characteristics in this system were examined during an canine in vitro experiemts.
1)Wearable artificial kidney : As a result of preliminary study beased on parformance of a test daialyzer with a specific cellulose triacetate membrane, specifications of the optimum dialyzer colud be determined during an analytical study. This dialyzer will be used for the regeneration of the spent peritoneal dialysate in the CRPD/BPD system. A wearable dialyzer was developed by a co-investigator in this research, Hiroyuki Hattori, belonging to Nipro Company Limited on an account of an economical viewpoint.
2)Canine in vitro experiments : Peritoneal dialysis experiments using bilaterally nephrectomized dogs were carried out to examine the water and solute removal characteristics in this system. Before the start of the experiment, an solution involving several marker solutes was infused ti the dog. Time corce of solute concentration of the marker was obtained and sevreal parameters such as nass transfer-area coefficient was determined by a simulation method.
3)Albumin additive dialysate : In order to exmine a validity of the dialysate containing albumin as an osmotic agent, canine in vitro experiemnts were carried out. A combination of 10 % albumin with 1.0 % glucose was most effective for water removal in a clinical situation.
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