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Analysis of spatio-temporal light responses of retinal cells using a new multi-electrode array on integrated circuit

Research Project

Project/Area Number 13559003
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section展開研究
Research Field 広領域
Research InstitutionToyohashi University of Technology

Principal Investigator

USUI Shiro  Toyohashi University of Technology, Engineering, Professor, 工学部, 教授 (40023337)

Co-Investigator(Kenkyū-buntansha) ISHIDA Makoto  Toyohashi University of Technology, Engineering, Professor, 工学部, 教授 (30126924)
石原 彰人  豊橋技術科学大学, 未来技術流動研究センター, 研究機関研究員
Project Period (FY) 2001 – 2002
Project Status Completed (Fiscal Year 2002)
Budget Amount *help
¥4,700,000 (Direct Cost: ¥4,700,000)
Fiscal Year 2002: ¥2,400,000 (Direct Cost: ¥2,400,000)
Fiscal Year 2001: ¥2,300,000 (Direct Cost: ¥2,300,000)
Keywordsretina / multi-electrode array / neuron / modeling simulation / neural signal recording / synapse / bipolar cell / ganglion cell / 集積型微小電極アレイ / 網膜神経節細胞 / 網膜双極細胞 / シナプス終末
Research Abstract

The purpose of our research is the elucidation of neural circuit mechanisms concerning with spatio-temporal visual processing in retina by the approach of both electrophysiological experiment using multi-electrode and modeling simulation.
We developed the new multi-microelectrode array which is suitable to record light responses from retinal ganglion cell. The array was developed using selective vapor-liquid-sold (VLS) growth method and integrated circuit (IC) process on Si(111) substrate. The length and diameter of probes on the array was controlled in a few micrometers. We also established the electrophysiological recording system using the array based on the ordinary system.
In the modeling approach, we developed mathematical model of synaptic mechanisms between bipolar cell and ganglion cell. The model described intracellular transmission mechanisms in synapse of bipolar cell based on their physiological evidence, and well reproduced the I-V relationship and the capacitance jump responses to pulses with various durations. The model would allow us to construct network model from photoreceptor to ganglion cell, and to analyze neural mechanisms in direct pathway of visual information in retina.

Report

(3 results)
  • 2002 Annual Research Report   Final Research Report Summary
  • 2001 Annual Research Report
  • Research Products

    (24 results)

All Other

All Publications (24 results)

  • [Publications] Kawano, T., Kato, Y., Futagawa, M., Tani, R., Takao, H., Sawada, K., Ishida, M: "Fabrication and Properties of Ultra Small Si Wire Arrays by Vapor-Liquid-Solid Growth with Circuits"Sensors and Actuators A. 97-98. 709-715 (2002)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Kato, Y., Kawano, T., Ito, Y., Ashiki, M., Takao, H., Sawada, K., Ishida, M: "Signal Conditioning CMOS Circuit Integrated on Si (111) for Neural Activity Image Recording"IEEJ The 19th Sensor Symposium. 421-424 (2002)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Kawano, T., Takao, H., Sawada, H., Ishida, M.: "Multichannel 5×5-site 3D Si Micro-Probe Electrode Array for Neural Activity Recording System"International Conference on Solid Device and Materials. 324-325 (2002)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Kawakita, T., Ishihara, A., Usui, S., Tachibana, M.: "Mathematical model study of continuous transmitter release in the synaptic terminal of goldfish retinal bipolar cells"The Keio J. Medicine. 51・Sup.1. 57 (2002)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Ishihara, A., Kamiyama, Y., Usui, S.: "The role of calcium spike in shaping light responses of retinal bipolar cell"The Keio J. Medicine. 51・Sup.1. 58 (2002)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Usui, S., Ishihara, A., Kawano, T., Ishida, M.: "Multi-recording multi-microelectrode array from the retina"Proceedings of the First Symposium on Intelligent Human Sensing. 141-144 (2003)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Kawano,T., Kato,Y., Futagawa,M., Tani,R., Takao,H., Sawada,K., and Ishida,M.: "Fabrication and Properties of Ultra Small Si Wire Arrays by Vapor-Liquid-Solid Growth with Circuits"Sensors and Actuators A. vol.97-98. 709-715 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Kato,Y., Kawano,T., Ito,Y., Ashiki,M., Takao,H., Sawada,K., and Ishida,M.: "Signal Conditioning CMOS Circuit Integrated on Si (111) for Neural Activity Image Recording"IEEJ The 19th Sensor Symposium. 421-424 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Kawano,T., Takao,H., Sawada,H., and Ishida,M.: "Multichannel 5×5-site 3D Si Micro-Probe Electrode Array for Neural Activity Recording System"International Conference on Solid State Device and Materials. 324-325 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Kawakita,T., Ishihara,A., Usui,S., and Tachibana,M.: "Mathematical model study of continuous transmitter release in the synaptic terminal of goldfish retinal bipolar cells"The Keio J.Medicine. 51(Sup.1). 57 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Ishihara,A., Kamiyama,Y., and Usui,S.: "The role of calcium spike in shaping light responses of retinal bipolar cell"The Keio J.Medicine. 51(Sup.1). 58 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Usui,S., Ishihara,A., Kawano,T., Ishida,M.: "Multi-recording using the multi-microelectrode array from the retina"Proceedings of the First Symposium on Intelligent Human Sensing. 141-144 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] 河北友克, 石原彰人, 臼井支朗, 立花政夫: "網膜双極細胞シナプス終末の伝達物質放出モデル"電子情報通信学会技術研究報告. 102・508. 29-34 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] Ishihara, A., Kamiyama, Y., Usui, S.: "The roll of calcium spike in shaping light responses of retinal bipolar cell"The Keio J, Medicine. 51・Sup.1. 58 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] Usui, S., Ishihara, A., Kawano, T., Ishida, M.: "Multi-recording multi-microelectrode array from the retina"Proceedings of the First Symposium on Intelligent Human Sensing. 141-144 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] Kawano, T., Kato Y., Futagawa M., Tani, R., Takao, H., Sawada, K., Ishida, M.: "Fabrication and Properties of Ultra Small Si Wire Arrays by Vapor-Liquid -Solid Growth with Circuits"Sensors and Actuators A. 97・98. 709-715 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] Kato, Y., Kawano, T., Ito, Y., Ashiki, M., Takao, H., Sawada, K., Ishida, M.: "Signal Conditioning CMOS Circuit Integrated on Si(111) for Neural Activity Image Recording"IEEJ The 19th Sensor Symposium. 421-424 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] Kawano, T., Kato, Y., Futagawa, M., Tani, R., Takao, H., Sawada, K., Ishida, M: "Vapor-liquid-solid Graon Si Probe Array Chip for Penetrating and Recording in the Nervous System"IEEJ The 19th Sensor Symposium. 487-490 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] 加藤陶子, 高尾英邦, 澤田和明, 石田 誠: "Si(111)上への微小Si電極を用いた神経電位計測センサの回路設計"平成13年度電気関係学会東海支部連合大会講演論文集. 346. 164-164 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] M.Ishida, F.Komakine, H.Takao, M.Futagawa, T.Kawano, K.Sawada: "Properties of CMOS on Si(111)for nerve-potential smart sensor with Si probe array"Proceedings of The International Conference on Electrical Engineering 2001. 1580-1583 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] T.Kawano, Y.Kato, M.Futagawa, H.Takao, K.Sawada, M.Ishida: "Fabrication and Properties of Ultra Small Si Wire Arrays by Vapor-Liquid-Solid Growth with Circuits"Digest of Technical Papers of The 11th International Conference on Solid & State Sensors and Actuators. 2. 1066-1069 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] 河野剛士, 加藤陶子, 二川雅登, 谷 良司, 高尾英邦, 澤田和明, 石田誠: "スマート微小Siプローブの神経細胞電位計測による評価"第62回応用物理学会学術講演会. (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] 河北友克, 石原彰人, 臼井支朗, 立花政夫: "網膜双極細胞シナプス終末の二相性放出現象を再現するモデル"平成13年度電気関係学会東海支部連合大会講演論文集. 346. 11-11 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] 石原彰人, 林宏治, 神山斉己, 臼井支朗: "ON型杆体双極細胞の光応答反転電位に関するシミュレーション解析"日本神経回路学会第11回全国大会講演論文集. 233-234 (2001)

    • Related Report
      2001 Annual Research Report

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Published: 2001-04-01   Modified: 2016-04-21  

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