• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

ANALYSIS OF THE SUSCEPTIBILITY GENES FOR OBESE DIABETES IN THE DOMINICAN REPUBLIC

Research Project

Project/Area Number 13576024
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section海外学術
Research Field Metabolomics
Research InstitutionOITA MEDICAL UNIVERSITY

Principal Investigator

YOSHIMATSU Hironobu (2002)  OITA MEDICAL UNIVERSITY, FACULTY OF MEDICINE, PROFESSOR, 医学部, 教授 (00166993)

坂田 利家 (2001)  大分医科大学, 医学部, 教授 (50037420)

Co-Investigator(Kenkyū-buntansha) TERAO Hideo  OITA MEDICAL UNIVERSITY, DEPARTMENT OF HEALTH SCIENCE CENTER, PROFESSOR, 保健管理センター, 教授 (10128192)
HAMAGUCHI Kazuyuki  OITA MEDICAL UNIVERSITY, FACULTY OF MEDICINE, ASSOCIATE PROFESSOR, 医学部, 助教授 (60180931)
SAKATA Toshiie  NAKAMURA GAKUEN UNIVERSITY, PROFESSOR, 栄養科学研究部, 教授 (50037420)
AONO Hirohi  OITA MEDICAL UNIVERSITY, FACULTY OF MEDICINE, ASSOCIATE PROFESOR, 医学部, 助教授 (80150936)
吉松 博信  大分医科大学, 医学部, 助教授 (00166993)
Project Period (FY) 2001 – 2002
Project Status Completed (Fiscal Year 2002)
Budget Amount *help
¥11,100,000 (Direct Cost: ¥11,100,000)
Fiscal Year 2002: ¥2,200,000 (Direct Cost: ¥2,200,000)
Fiscal Year 2001: ¥8,900,000 (Direct Cost: ¥8,900,000)
KeywordsDominican Republic / diabetes mellitus / obesity / genetic analysis / insulin resistance / PC-1 / 多型 / 生活習慣病 / SNP / 糖尿病 / 疫学 / 高脂血症 / 遺伝子多型
Research Abstract

The human glycoprotein PC-1 codon Q121 allele has been correlated with insulin resistance, but not with type 2 diabetes or obesity. We investigated the prevalence of PC-1 Q121 in the Dominican Republic population (755 subjects studied), and whether this variant is associated with insulin resistance, obesity or type 2 diabetes. The prevalence of PC-1 Q121 was high compared to other populations. The proportions of genotypes detected were KK 21.6%, KQ 48.3%, and QQ 30.1%. This compares to 〜74%, 〜24% and 〜2% in other populations. Among non-obese, non-diabetic subjects, the insulin response of KQ (Pz0.027) and QQ (Pz0.031) subjects was greater during the oral glucose tolerance test than the KK subjects, while plasma glucose profiles were. comparable. The Q allele was more prevalent in obese type 2 diabetics than in controls (Th0.026, 0R1.56). Multiple regression analysis after adjusting for age, gender and BMI showed the QQ genotype was associated with type 2 diabetes (Pz0.043, 0R2.74) but not obesity (P0.068). These results indicate that the PC-1 Q121 allele is exceptionally prevalent in the Dominican Republic, contributing to both insulin resistance and type 2 diabetes.

Report

(3 results)
  • 2002 Annual Research Report   Final Research Report Summary
  • 2001 Annual Research Report
  • Research Products

    (29 results)

All Other

All Publications (29 results)

  • [Publications] Yoshimatsu H, et al.: "Histamine neurons down-regulate ob gene expression in rat white adipose tissue"Inflamm Res. 50Suppl2. S72-S73 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Yoshimichi G, et al.: "Orexin-A regulates body temperature in coordination with arousal status"Exp Bio Med. 226. 468-476 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Masaki T, et al.: "Targeted disruption of histamine H1-receptor attenuates regulatory effects of leptin on feeding, adiposity, and UCP family in mice"Diabetes. 50. 385-391 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Masaki T, et al.: "Central infusion of histamine reduces fat accumulation and upregulates UCP family in leptin-resistant obese mice"Diabetes. 50. 376-384 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Yoshimatsu H, et al.: "Histidine suppresses food intake through its conversion into neuronal histamine"Exp.Bio.Med.. 227. 63-68 (2002)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Yoshimatsu H, et al.: "Histidine induces lipolysis through sympathetic nerve in white adipose tissue"Eur J Clin Invest. 32. 236-241 (2002)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Ooie T, Takahashi N, Saikawa T, Nawata T, Arikawa M, Yamanaka K, Hara M, Shimada T, Sakata T.: "Single oral dose of geranylgeranylacetone induces heat-shock protein 72 and renders protection against ischemia/reperfusion injury in rat heart"Circulation. 104. 1837-1843 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Takahashi N, Nakagawa M, Saikawa T, Ooie T, Yufu K, Shigematsu S, Hara M, Sakino H, Katsuragi I, Okeda T, Yoshimatsu H, Sakata T.: "Effect of essential hypertension on cardiac autonomic function in type 2 diabetic patients"J Am Coll Cardiol. 38. 232-237 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Katsuragi I, Okeda T, Yoshimatsu H, Utsunomiya N, Ina K, Sakata T.: "Transplantation of normal islets into, the portal vein of Otsuka Long Evans Tokushima Fatty rats prevents diabetic progression"Exp Bio Med. 226. 681-685

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Yoshimatsu H, Hidaka S, Niijima A, Sakata T.: "Histamine neurons down-regulate ob gene expression in rat white adipose tissue"Inflamm Res. 50 Suppl 2. S72-S73 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Yoshimichi G, Yoshimatsu H, Masaki T, Sakata T.: "Orexin-A regulates body temperature in coordination with arousal status"Exp Biol Med. 226. 438-476 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Hidaka S, Yoshimatsu H, Koridou S, Oka K, Tsuruta Y, Sakino H, Itateyama B, Noguchi H, Himeno K, Okamoto K, Teshima Y, Okeda T, Sakata T.: "Hypoleptinemia, but not hypoinsulinemia, induces hyperphagia in streptozotocin-induced diabetic rats"J Neurochem. 77. 993-1000 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Masaki T, Yoshimatsu H, Chiba S, Watanabe T, Sakata T.: "Targeted disruption of histamine Hi-receptor attenuates regulatory effects of leptin on feeding, adiposity, and UCP family in mice"Diabetes. 50. 385-391 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Masaki T, Yoshimatsu H, Chiba S, Watanabe T, Sakata T.: "Central infusion of histamine reduces fat accumulation and upregulates UCP family in leptin-resistant obese mice"Diabetes. 50. 376-384 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Yoshimatsu H, Chiba S, Tajima D, Akehi Y, Sakata T.: "Histidine suppresses food intake through its conversion into neuronal histamine"Exp Biol Med. 227. 63-68 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Hidaka S, Yoshimatsu H, Kondou S, Tsuruta Y, Oka K, Noguchi H, Okamoto K, Sakino H, Teshima Y, Okeda T, Sakata T.: "Chronic central leptin infusion restores hyperglycemia independently of food intake and insulin level in streptozotocin-induced diabetic rats"FASEB J. 16. 509-518 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Tsuda K, Yoshimatsu H, Nijima A, Chiba S, Sakata T.: "Hypothalamic histamine neurons activate lipolysis in rat adipose tissue"Exp Biol Med. 227. 208-213 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Yoshimatsu H, Tsuda K, Niijima A, Tatsukawa M, Chiba S, Sakata T.: "Histidine induces lipolysis through sympathetic nerve in white adipose tissue"Eur J Clin Invest. 32. 236-241 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Tsuruta Y, Yoshimatsu H, Hidaka S, Kondou S, Okamoto K, Sakata T.: "Hyperleptinemia in A y/a mice upregulates arcuate cocaine-and amphetamine-regulated transcript expression"Am J Physiol Endocrinol Metab. 282. E967-E973 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Kudo' Y, Terao H, Arita T, Kawasaki H, Sato S, Abe H, Kodama M, Fujioka T, Murakami K, Nasu M.: "Interferon therapy for hepatitis C virus (HCV)-related advanced chronic hepatitis after treatment of recurrent hepatocellular carcinoma : a successful case"Intern Med. 41. 202-206 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Yoshimatsu H, et al.: "Histidine Suppresses Food Intake through Its Conversion into Neuronal Histamine"Exp. Biol. Med.. 227. 63-68 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] Hidaka S, et al.: "Chronic central leptin infusion restores hyperglycemia independently of food intake and insulin level in streptozotocin-induced diabetic rats"FASEB J.. 16. 509-518 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] Yoshimatsu H, et al.: "Histidine induces lipolysis through sympathetic nerve in white adipose tissue"Eur. J. Clin. Invest.. 32. 236-241 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] Katsuragi I, et al.: "Transplantation of normal islets into the portal vein of Otsuka Long Evans Tokushima Fatty rats prevents diabetic progression"Exp Biol Med. 226. 681-685 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] Hanada R, et al.: "A role for neuromedin U in stress response"Biochem Biophys Res Commun. 289. 225-228 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] Yoshimichi G, et al.: "Orexin-A regulates body temperature in coordination with arousal status"Exp Biol Med. 226. 468-476 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] Hidaka S, et al.: "Hypoleptinemia, but not hypoinsulinemia, induces hyperphagia in streptozotocin-induced diabetic rats"J Neurochem. 77. 993-1000 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] Masaki T, et al.: "Targeted disruption of histamine H1-receptor attenuates regulatory effects of leptin on feeding, adiposity, and UCP family in mice"Diabctes. 50. 385-391 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] Masaki T, et al.: "Central infusion of histamine reduces fat accumulation and upregulates UCP family in letin-resistant obese mice"Diabctes. 50. 376-384 (2001)

    • Related Report
      2001 Annual Research Report

URL: 

Published: 2001-04-01   Modified: 2016-04-21  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi