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Investigation of Natural Drug Resouces in Lam Dong Province, Vietnam and Shan State, Myanmar

Research Project

Project/Area Number 13576027
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section海外学術
Research Field Chemical pharmacy
Research InstitutionTOYAMA MEDICAL AND PHARMACEUTICAL UNIVERSITY

Principal Investigator

KADOTA Shigetoshi  Toyama Med. and Pharm. Univ. Institute of Natural Medicine Professor, 和漢薬研究所, 教授 (90115163)

Co-Investigator(Kenkyū-buntansha) TEZUKA Yasuhiro  Toyama Med. and Pharm. Univ. Institute of Natural Medicine Asso. Professor, 和漢薬研究所, 助教授 (70236975)
SAIKI Ikuo  Toyama Med. and Pharm. Univ. Institute of Natural Medicine Professor, 和漢薬研究所, 教授 (80133776)
WATANABE Hiroshi  Toyama Med. and Pharm. Univ. Institute of Natural Medicine Professor, 和漢薬研究所, 教授 (10012642)
A.H. Banskota  Toyama Med. and Pharm. Univ. Institute of Natural Medicine Assist. Professor, 和漢薬研究所, 助手 (40333497)
Project Period (FY) 2001 – 2002
Project Status Completed (Fiscal Year 2002)
Budget Amount *help
¥5,800,000 (Direct Cost: ¥5,800,000)
Fiscal Year 2002: ¥2,400,000 (Direct Cost: ¥2,400,000)
Fiscal Year 2001: ¥3,400,000 (Direct Cost: ¥3,400,000)
Keywordsagarwood / traditional medicine / Aquilaria crassna / Panax vietnamensis / liver disease / Panax zinziberensis / anti-narcotic action / Orthosiphon stamineus / 薬草栽培 / 癌転移 / 薬用人参 / アーティチョーク / マトリックスメタロプロテアーゼ
Research Abstract

Investigations in Vietnam
1. We have visited traditional medicine practitioners, hospitals, research institutes for science, forestry and cultivation in Hochiminh, Da Lat, Nha Trang, Tuy Hoa and Phan Thiet Cities to study traditional medicine and the cultivation of agarwood and Taxus, cinchona, artichoke. Approximately 260 kinds of crude drugs used by the local traditional medicine practitioners have been sampled.
2. A natural alive Aquilaria crassna tree, which is known to produce agarwood, has been found in Khanh Hoa Province. We also have questioned the local people, who earn their living on agarwood, to learn about agarwood resources, proccessing, cultivation, grading and qualification. In order to preserve the natural resource of agarwood, the cultivation of A. crassna have been started in several places in Vietnam.
Investigations in Myanmar
1. We have visited traditional medicine practitioners, clinics, hospitals and drug stores in Shan State, mainly in Taunggyi and Lashio. We have interviewed traditional medicine practitioners in Taunggyi and Kyaukme to learn about proccessing and production of Shan State traditonal medicine and 75 kinds of crude drugs have been sampled. Moreover, a wild ginseng plant was found for the first time in Taunggyi.
Research in Japan
1. Extracts of Vietnamese crude drugs were prepared, creened for anti-metastasis, hepatoprotection searched for active constituents. The results have been reported in 30 articles in international scientific journal.
2. The ginseng plant collected in Myanmar was identified to be Panax zingiberensis, which faces extinction in China and is highly protected. An article on the research result is in press.
3. The result of the investigation on agarwood is to be published.
4. A review on the research of Vietnamese crude drug Alpinia blepharocalyx has been published.
5. Result on the study of the chemical constituents of a Vietnamese, Myanmar and Southeast Asian medicinal plant Orthosiphon stamineus has been published.

Report

(3 results)
  • 2002 Annual Research Report   Final Research Report Summary
  • 2001 Annual Research Report
  • Research Products

    (39 results)

All Other

All Publications (39 results)

  • [Publications] Shigetoshi Kadota: "Novel Diarylheptanoides of Alpinia blepharocalyx"Current Topics in Medicinal Chemistry. 3. 203-225 (2003)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Arjun H.Banskota: "Chemical Constituents and Biological Activities of Vietnamese Medicinal Plants"Current Topics in Medicinal Chemistry. 3. 227-248 (2003)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Suresh Awale: "Siphonols A-E : Novel Nitric Oxide Inhibitors from Orthosiphon stamineus of Indonesia"Bioorganic & Medicinal Chemistry Letters. 13. 31-35 (2003)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Jun-ya Ueda: "Antiproliferative activity of Vietnamese Medicinal Plants"Biological Pharmaceutical Bulletin. 25・6. 753-760 (2002)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Suresh Awale: "Secoorthosiphols A-C ; three highly oxygenated secoisopimarane-type diterpenes from Otrhosiphon Stamineus"Tertrahedron Letters. 43. 1473-1475 (2002)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Quan Le Tran: "Hepatoprotective Effect of Majonoside R2, the Major Saponin from Vitnamese Ginseng (Panax vietnamensis)"Planta Medica. 68. 402-406 (2002)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Tezuka Y.: "Eleven Novel Diarylheptanoids and Two Unusual Diarylheptanoid Derivatives from the Seeds of Alpinia blepharocalyx."J. Nat. Prod.. 64. 208-213 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Ali M. S.: "Six New Diarylheptanoids from the Seeds of Alpinia blepharocalyx."J. Nat. Prod.. 64. 289-293 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Adnyana I K.: "Three New Triterpenes from the Seeds of Combretum quadrangulare and Their Hepatoprotective Activity."J. Nat. Prod.. 64. 360-363 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Tran Q. L.: "Triterpene saponins from Vietnamese ginseng (Panax vietnamensis) and their hepatocytoprotective activity."J. Nat. Prod.. 64. 456-461 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Ali M. S.: "Blepharocalyxins C-E, Three New Dimeric Diarylheptanoids, and Related Compounds from the Seeds of Alpinia blepharocalyx."J. Nat. Prod.. 64. 491-496 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Ali M. S.: "Antiproliferative Activity of Diarylheptanoids from the Seeds of Alpinia blepharocalyx."Biol. Pharm. Bull.. 24. 525-528 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Adnyana I K.: "1-O-Galloy1-6-O-(4-hydroxy-3,5-dimethoxy) benzoyl-β-D-glucose, a New Hepatoprotective Constituent from Combretum quadrangulare."Planta Med.. 67. 370-371 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Awale S.: "Five Novel Highly Oxygenated Diterpenes of Orthosiphon stamineus from Myanmar."J. Nat. Prod.. 64. 592-596 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Tran Q. L.: "New Spirostanol Steroids and Steroidal Saponins from Roots and Rhizomes of Dracaena angustifolia, and Their Antiproliferative Activity."J. Nat. Prod.. 64. 1127-1132 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Awale S.: "Secoorthosiphols A-C ; Three Highly Oxygenated Secoisopimarane-type Diterpenes From Orthosiphonstamineus."Tetrahedron Lett.. 43. 1473-1475 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Awale S.: "Four Highly Oxygenated Isopimarane-Type Diterpenes of Orthosiphon stamineus from Myanmar."Planta Med.. 68. 286-288 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Ueda J.: "Antiproliferative Activity of Vietnamese Medicinal Plants."Biol. Pharm. Bull.. 25. 753-760 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Tran Q. L.: "Hepatoprotective Effect of Majonoside R2, The Major Saponin from Vietnamese Ginseng (Panax vietnamensis)."Planta Med.. 68. 402-406 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Awale S.: "Norstaminane- and Isopimarane-type Diterpenes of Orthosiphon stamineus from Okinawa."Tetrahedron. 58. 5503-5512 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Awale S.: "Siphonols A-E : Novel Nitric Oxide Inhibitors from Orthosiphon Stamineus of Indenesia."Bioorg. Med. Chem. Lett.. 13. 31-35 (2003)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Awale S.: "Highly-Oxygenated Isopimarane-Type Diterpenes from Orthosiphon stamineus of Indonesia and Their Nitric Oxide Inhibitory Activity."Chem. Pharm. Bull.. 51. 268-275 (2003)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Awale S.: "Inhibition of NO production by Highly-ozygenated Diterpenes of Orthosiphon stamineus and Their Structure-Activity Relationship."Biol. Pharm. Bull.. 26. 468-473 (2003)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Awale S.: "Nitric Oxide Inhibitory Isopimarane-type Diterpenes from Orthosiphon stamineus of Indonesia."J. Nat. Prod.. 66. 255-258 (2003)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Tran Q. L.: "Wild Ginseng Grows in Myanmar."Chem. Pharm. Bull., in press.

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Tran Q. L.: "A survey on agarwood in Vietnam."J. Trad. Med., in press.

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Tezuka Y.: "Studies on Biologically Active Constituenta in Southeast Asian Medicinal Plants."Natural Medicines. 56. 78-83 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Kadota S.: "Novel Diarylheptanoids of Alpinia blepharocalyx."Current Topics in Medicinal Chemistry. 3. 203-225 (2003)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Banskota A. H.: "Chemical Constituents and Biological Activities of Vietnamese-Medicinal Plants."Current Topics in Medicinal Chemistry. 3. 227-248 (2003)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Shigetoshi Kadota: "Novel Diarylheptanoides of Alpinia blepharocalyx"Current Topics in Medicinal Chemistry. 3. 203-225 (2003)

    • Related Report
      2002 Annual Research Report
  • [Publications] Arjun H.Banskota: "Chemical Constituents and Biological Activities of Vietnamese Medicinal Plants"Current Topics in Medicinal Chemistry. 3. 227-248 (2003)

    • Related Report
      2002 Annual Research Report
  • [Publications] Suresh Awale: "Siphonols A-E : Novel Nitric Oxide Inhibitors from Orthosiphon stamineus of Indonesia"Bioorganic & Medicinal Chemistry Letters. 13. 31-35 (2003)

    • Related Report
      2002 Annual Research Report
  • [Publications] Jun-ya Ueda: "Antiproliferative activity of Vietnamese Medicinal Plants"Biological Pharmaceutical Bulletin. 25・6. 753-760 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] Suresh Awale: "Secoorthosiphols A-C : three highly oxygenated secoisopimarane-type diterpenes from Otrhosiphon Stamineus"Tetrahedron Letters. 43. 1473-1475 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] Quan Le Tran: "Hepatoprotective Effect of Majonoside R2, the Major Saponin from Vitnamese Ginseng (Panax vietnamensis)"Planta Medica. 68. 402-406 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] Suresh Awale: "Five Novel Highly Oxygenated Diperpenes of Orthosiphon stamineus from Myanmar"Journal of Natural Products. 64・5. 592-596 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] Quan Le Tran: "New Spirostanol Steroids and Steroidal Saponins from Roots and Rhizomes of Dracaena Angustifolia and Their Antiproliferative Activity"Journal of Natural Products. 64・9. 1127-1132 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] Suresh Awale: "Secoorthosiphols A-C : three highly oxygenated secoisopimarane-type diterpenes from Orthosirhon Stamineus"Tetrahedron Letters. 43・8. 1473-1475 (2002)

    • Related Report
      2001 Annual Research Report
  • [Publications] Quan Le Tran: "Hepatoprotecctive Effects of Majonoside R2, the Major Saponin from Vietnamese Ginseng (Panax vietnamensis)"Planta Medica. (印刷中). (2002)

    • Related Report
      2001 Annual Research Report

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Published: 2001-04-01   Modified: 2016-04-21  

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