| Project/Area Number |
13610088
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
実験系心理学
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| Research Institution | Kobe University |
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Principal Investigator |
SUGIOKA Kozo Kobe University, Graduate School of Medicine, Lecturer, 大学院・医学系研究科, 講師 (90112127)
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| Co-Investigator(Kenkyū-buntansha) |
OKAICHI Hiroshige Doshisha University, Dept Psychology, Professor, 文学部, 教授 (40066288)
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| Project Period (FY) |
2001 – 2003
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| Project Status |
Completed (Fiscal Year 2003)
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| Budget Amount *help |
¥4,000,000 (Direct Cost: ¥4,000,000)
Fiscal Year 2003: ¥500,000 (Direct Cost: ¥500,000)
Fiscal Year 2002: ¥900,000 (Direct Cost: ¥900,000)
Fiscal Year 2001: ¥2,600,000 (Direct Cost: ¥2,600,000)
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| Keywords | attention-deficit / hyperactivity disorder / methylazoxymethanol / spontaneous activity / shuttle-box avoidance learning / radial maze learning / water-maze learning / hippocampus / cerebellum / 空間認知障害 / 注意欠陥多動障害 / 活動性 / 神経行動奇形学 / 自発運動量 / 放射線状迷路学習 |
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| Research Abstract |
We examined the correlation of the behavioral disorders with the morphogenetical abnormality of the brain in the attention-deficit/hyperactivity disorder (ADHD) model animals which were induced by methylazoxymethanol (MAM) injection on the prenatal 15-day (MAM-15 group) or 19-day (MAM-19 group).
Behaviorally, 1) the MAM-15 rat showed a hyperactive tendency and the MAM-19 rat showed a hypoactive tendency during dark phase in a home-cage compared with the control rats, although no statistical difference among the groups was found in the open-field activity, during weaning, juvenile and adult periods, 2) the MAM-15 rat showed a facilitated avoidance and the MAM-19 rat showed a retarded avoidance in the shuttle-box avoidance learning situation during adulthood, but not during juvenile period, 3) the MAM-15 rat showed a severe impaired spatial cognition in the radial-maze and the Morris-type water maze learning situations, although the MAM-19 rat showed a moderate deficit, during each developmental stage. The behavioral disorder obtained in the MAM-15 rat correlated with a morphological abnormality of the hippocampus (disruption of the CA1 pyramidal layer and ectopic neuron mass), and the behavioral disorder obtained in the MAM-19 rat correlated with a disorder in foliation of the anterior cerebellum, which were histologically observed in these groups. Our behavioral and histological results suggest that the ADHD-like behavioral disorder may be derived from the hippocampal dysfunction induced by abnormal morphogenesis of the hippocampus.
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