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Effects of cell adhesion and aggregation on the flow in microvessels

Research Project

Project/Area Number 13650199
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Fluid engineering
Research InstitutionKansai University

Principal Investigator

SEKI Masako  Kansai University, Faculty of Engineering, Associate Professor, 工学部, 助教授 (80150225)

Project Period (FY) 2001 – 2003
Project Status Completed (Fiscal Year 2003)
Budget Amount *help
¥2,300,000 (Direct Cost: ¥2,300,000)
Fiscal Year 2003: ¥500,000 (Direct Cost: ¥500,000)
Fiscal Year 2002: ¥800,000 (Direct Cost: ¥800,000)
Fiscal Year 2001: ¥1,000,000 (Direct Cost: ¥1,000,000)
Keywordsred blood cells / leukocytes / blood flow / adhesion / fluid stress / numerical simulation / vascular resistance / microvessels / ローリング / 高密度流れ / 血液
Research Abstract

Fluid-dynamic study has been performed on the effects of adhesion and cohesion of cells on the flow in microvessels. Microscopic models for blood cells have been made to analyze numerically the motion of individual blood cells in microvessels and the flow filed around them. Special emphasis was put on the adhesion of leukocytes on the venular wall and flow of red cells with high concentration which is observed in the upstream of a leukocyte in capillaries. In each case, the resistance to flow has been calculated. It was found that, in the former case, the flow resistance strongly depends on the ratio of cell height to vessel diameter and the number of adherent cells, and its increase is more pronounced in venules with smaller diameters. In the latter case, our model simulation predicted an increase in flow resistance which accounts for an in vivo observation in skeletal muscle microcirculation. Based on this result, a mechanism was proposed whereby the interaction between a leukocyte and red cells in capillaries serves to elevate flow resistance in the capillary network. When a leukocyte is (1)freely floating in microvessels, (2)adherent to the venular wall, and (3)rolling along the wall, the shear stresses acting on the membrane of the leukocyte and vascular endothelial cells exerted by the fluid flow were computed. The results indicate that the shear stress distributions on the leukocyte membrane are nonuniform in all cases. The magnitudes of the fluid stresses in cases (2) and (3) are about ten times larger than in case (1), while their high temporal gradient is significant in case (1).

Report

(4 results)
  • 2003 Annual Research Report   Final Research Report Summary
  • 2002 Annual Research Report
  • 2001 Annual Research Report
  • Research Products

    (29 results)

All Other

All Publications (29 results)

  • [Publications] Sugihara-Seki, Masako: "Blood Flow and Permeability in Microvessels."Fluid Dynamics Research. (in press).

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Sugihara-Seki, Masako: "Motion of a Sphere in a Cylindrical Tube Filled with a Brinkman Medium."Fluid Dynamics Research. 34. 59-76 (2004)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Sugihara-Seki, Masako: "The Fluid Shear Stress Distribution on the Membrane of Leukocytes in the Microcirculation."Trans.ASME J.Biomech.Eng.. 125. 628-638 (2003)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] 関 眞佐子: "微小血管内の流れ"混相流. 16. 120-129 (2002)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Sugihara-Seki, Masako: "Flow around Cells Adhered to a Microvessel Wall III : Effects of Neighboring Cells in Channel Flow."JSME International Journal Series C. 44. 990-995 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Sugihara-Seki, Masako: "Flow around Cells Adhered to a Microvessel Wall II : Comparison to Flow around Adherent Cells in Channel Flow."Biorheology. 38. 3-13 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Sugihara-Seki, Masako: "Blood Flow and Permeability in Microvessels."Fluid Dynamics Research. (in press).

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Sugihara-Seki, Masako: "Motion of a Sphere in a Cylindrical Tube Filled with a Brinkman Medium."Fluid Dynamics Research. 34. 59-76 (2004)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Sugihara-Seki, Masako: "The Fluid Shear Stress Distribution on the Membrane of Leukocytes in the Microcirculation."Trans.ASME J.Biomech.Eng.. 125. 628-638 (2003)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Seki, Masako: "Blood Flow in Microvessels(in Japanese)"Japanese Journal of Multiphase Flow. 16. 120-129 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Sugihara-Seki, Masako: "Flow around Cells Adhered to a Microvessel Wall III : Effects of Neighboring Cells in Channel Flow."JSME International Journal Series C. 44. 990-995 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Sugihara-Seki, Masako: "Flow around Cells Adhered to a Microvessel Wall II : Comparison to Flow around Adherent Cells in Channel Flow."Biorheology. 38. 3-13 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Sugihara-Seki, Masako: "Blood Flow and Permeability in Microvessels."Fluid Dynamics Research. (in press). (2004)

    • Related Report
      2003 Annual Research Report
  • [Publications] Sugihara-Seki, Masako: "Motion of a Sphere in a Cylindrical Tube Filled with a Brinkman Medium."Fluid Dynamics Research. 34. 59-76 (2004)

    • Related Report
      2003 Annual Research Report
  • [Publications] Sugihara-Seki, Masako: "The Fluid Shear Stress Distribution on the Membrane of Leukocytes in the Microcirculation."Trans. ASME J.Biomech.Eng.. 125. 628-638 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] Sugihara-Seki, Masako: "Distribution of the Fluid Shear Stress on the Membrane of Leukocytes in Microvessles."Proceedings of the 2003 Summer Bioengineering Conference. (CD). (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] Sugihara-Seki, Masako: "Shear Stress Distribution on the Membrane of Leukocytes and the Vascular Endothelium in the Microcirculation."Proceedings of the IEEE EMBS Asian-Pacific Conference on Biomedical Engineering 2003. (CD). (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] 関 眞佐子: "糖鎖のある細孔内の物質輸送"日本流体力学会年会2003 講演論文集. 68-69 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] 関 眞佐子: "微小血管内の血液流れ"日本混相流学会誌「混相流」. 16. 120-129 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] 関 眞佐子: "微小血管内の白血球運動-浮遊白血球表面の応力分布"日本機械学会講演論文集. 024-1. 15-27 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] 関 眞佐子: "浮遊白血球表面の応力分布の解析"第25回バイオレオロジー学会年会抄録集. 55 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] 関 眞佐子: "内皮細胞間隙の流れのモデル"日本流体力学会年会2002講演論文集. 304-305 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] Masako Sugihara-Seki: "Stress distribution on a leukocyte flowing through a non-uniform microvessel with an endothelial surface layer"Abstracts of The 4th World Congress of Biomechanics. (CD). (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] 関 眞佐子: "高分子を含む細孔の物質透過性のモデル解析"日本物理学会講演概要集第2分冊. 214 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] Masako Sugihara-Seki: "Flow around cells adhered to a microvessel wall II : Comparison to flow around adherent cells in channel flow"Biorheology. 38. 3-13 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] Masako Sugihara-Seki: "Flow around cells adhered to a microvessel wall III : Effects of neighboring cells in channel flow"JSME International Journal Series C. 44・4. 990-995 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] 関眞佐子: "円管内流れと2次元流流路内流れが粘着粒子に及ぼす力の比較II"第24回日本バイオレオロジー学会年会抄録集. 72-72 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] Masako Sugihara-Seki: "Effects of the flow on a cell adhered to a microvessel wall and a channel wall"Proceedings of the 2001 Bioengineering Conference. BED-Vol.50. 177-178 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] 関眞佐子: "二平行平板流路壁に粘着している白血球に働く力の評価"日本流体力学会年会2001講演論文集. ながれ20巻別冊. 615-616 (2001)

    • Related Report
      2001 Annual Research Report

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Published: 2001-04-01   Modified: 2016-04-21  

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