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Research on Porphyrin-Chlorin Co-assemblies and Revival of Their Dioxygen-coordination Abilities Photoirradiation

Research Project

Project/Area Number 13650938
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field 高分子合成
Research InstitutionWaseda University

Principal Investigator

KAMATSU Teruyuki  Waseda University, Advanced Research Institute for Science and Engineering, Lecturer, 理工学総合研究センター, 講師 (30298187)

Co-Investigator(Kenkyū-buntansha) TSUCHIDA Eishun  Advanced Research Institute for Science and Engineering, Professor Emeritus, 理工学総合研究センター, 名誉教授 (90063461)
SO Keitaro  Advanced Research Institute for Science and Engineering, Research Associate, 理工学総合研究センター, 助手 (20318835)
Project Period (FY) 2001 – 2002
Project Status Completed (Fiscal Year 2002)
Budget Amount *help
¥3,700,000 (Direct Cost: ¥3,700,000)
Fiscal Year 2002: ¥700,000 (Direct Cost: ¥700,000)
Fiscal Year 2001: ¥3,000,000 (Direct Cost: ¥3,000,000)
KeywordsPorphyrin / Chlorin / Molecular Assembly / Dioxygen Coordination / Lipidporphyrin / Photoirradiation / Electron Transfer / Photoreduction
Research Abstract

The aim of this investigation is to revive the dioxygen-coordination ability of the auto-oxidized amphiphilic porphyrinatoiron(III) (lipidporphyrinatoiron(III)) by photoirradiation of the co-assembled free-base chlorine or porphyrin derivatives.
In the first year, a new lipidporphyrin with four phospholipid-like substituents was synthesizes, It can be easily dispersed and self-assembled in aqueous system, to give spherical bi layer membranes with a diameter of 100 nm. The obtained lipidporphyrin vesicles can reversibly bind and release dioxygen under physiological conditions. The IR and MCD spectroscopies showed the coordination structure of the dioxygen. The dioxygen-binding affinity and dioxygen association and dissociation rate constants were also carefully measured.
In the second year. electron transfer process from the excited state of the incorporated protoporphyrin derivative in the lipidporphyrin bilayer membrane to the iron(III) center was investigated. Under the co-existence of the electron donor (sacrificial regent) in outer aqueous phase, this reaction became irreversible, which is photoreduction system of the lipidporphyrinatoiron(III).
During the research period, we found some new phenomena related on this project. For example, in co-assembled bi layer vesicles made of Zn(II) complex and free-base lipidporphyrins, high-efficient energy transfer took place from the singlet state of the porphyricatozinc(II). It could be a new light-harvesting model in aqueous medium.

Report

(3 results)
  • 2002 Annual Research Report   Final Research Report Summary
  • 2001 Annual Research Report
  • Research Products

    (18 results)

All Other

All Publications (18 results)

  • [Publications] T.Komatsu et al.: "Effect of Heme Structure on O_2-Binding Properties of Human Serum Albumin-Heme Hybrids : Intramolecular Histidine Coordination Provides a Stable O_2-Adduct Complex"Bioconjugate Chem.. 13. 397-402 (2002)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] T.Komatsu et al.: "Human Serum Albumin Incorporating Synthetic Hemes as an O_2-Carrying Hemoprotein : Control of O_2-Binding Affinity by Heme Structure"Macromol.Symp.. 186. 1-6 (2002)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] T.Komatsu et al.: "Self-organized Lipid-porphyrin Bilayer Membranes in Vesicular Form : nanostructure, Photophysical Properties and Dioxygen Coordination"Chem. Eur. J. 8. 5469-5480 (2002)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] 小松晃之: "自己組織化リピドヘム小胞体のナノ構造と酸素結合能"人工血液. 10. 120-125 (2002)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] T.Komatsu et al.: "meso-Tetrakis[o-(N-methyl)pyridinium]porphyrin Ensemble with Axially Coordinated Cyclodextrin-penetrating Phenethylimidazole : Reversible Dioxygen-binding in Aqueous DMF Solution O_2-Adduct Complex"Chem Commun.. 2003. 50-51 (2003)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] T.Komatsu et al.: "Synthetic Dioxygen-carrying Hemoprotein : Human Serum Albumin Including Iron(II) Complex of Protoporphyrin IX with an Axially Coordinated Histidylglycyl-propionate"Chem. Lett.. 32. 504-505 (2003)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] T.Komatsu et al.: "Molecular Energy and Electron Transfer Assemblies Made of Self-organized Lipid-porphyrin Bilayer Vesicles"Chem. Eur. J.. 9. 4626-4633 (2003)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] T.Komatsu, Y.Matsukawa, E.Tsuchida: "Effect of Heme Structure on O_2-Binding Properties of Human Serum Albumin-Heme Hybrids : Intramolecular Histidine Coordination Provides a Stable O_2-Adduct Complex"Bioconjugate Chem.. 13. 397-402 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] E.Tsuchida, T.Komatsu, Y.Matsukawa, T.Okada: "Human Serum Albumin Incorporating Synthetic Hemes as an O_2-Carrying Hemoprotein : Control of O_2-Binding Ability by Heme Structure"Macromol.Sym. 186. 1-6 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] T.Komatsu, M.Moritake, A.Nakagawa, E.Tsuchida: "Self-organized Lipid-porphyrin Bilayer Membrances in Vesicular Form : Nanostructure, Photophysical Properties and Dioxygen Coordination"Chem.Eur.J.. 8. 5469-5480 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] T.Komatsu, M.Moritake, E.Tsuchida: "Nano-structure and Oxygen-binding Ability of Self-assembled Lipid-heme Vesicles"Artif.Blood. 10. 120-125 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] T.Komatsu, S.Hayakawa, E.Tsuchida, H.Nishide: "meso-Tetrakis[o-(N-methyl)pyridinium]porphyrin Ensemble with Axially Coordinated Cyclodextrin-penetrating Phenethylimidazole : Reversible Dioxygen-binding in Aqueous DMF Solution"Chem.Commun.. 2003. 50-51 (2003)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] A.Nakagawa, T.Komatsu, N.Ohmichi, E.Tsuchida: "Synthetic Dioxygen-carrying Hemoprotein : Human Serum Albumin Including Iron(II) Complex of Protoporphyrin IX with an Axially Coordinated Histidylglycyl-propionate"Chem.Lett.. 32. 504-505 (2003)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] T.Komatsu, M.Moritake, E.Tsuchida: "Molecular Energy and Electron Transfer Assemblies Made of Self-organized Lipid-porphyrin Bilayer Vesicles"Chem.Eur.J.. 9. 4626-4633 (2003)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] T.Komatsu et al.: "Self-Organized Lipid-Porphyrin Bilayer Membranes in Vesicular Form : Nanostructure, Photochemical Properties, and Dioxvgen Coordination"Chemistry European Journal. 8. 5469-5480 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] 小松 晃之: "自己組織化リピドヘム小胞体のナノ構造と酸素結合能"人工血液. 10. 120-125 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] T.Komatsu, et al.: "Meso-Tetrakis[N-methyl]pyridinuium]prorphyrin Ensembles with axially coordinated cyclodextrin-penetrating phenethylimidazole : reversible dioxygen-binding in aqueous DMF solution"Chemical Communications. 2003. 50-51 (2003)

    • Related Report
      2002 Annual Research Report
  • [Publications] T.Komatsu et al.: "Iron(II) Complex of Octopus-Porphyrin with a Covalently Linked Proximal Imidazole ; Self-Assembly and O_2-Coordination in Aqueous Media"Bulletin of the Chemical Society of Japan. 74. 1703-1707 (2001)

    • Related Report
      2001 Annual Research Report

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Published: 2001-04-01   Modified: 2016-04-21  

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