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Mechanisms of host-recognition by plant pathogens mediated by signaling factors for pathogenicity

Research Project

Project/Area Number 13660052
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field 植物保護
Research InstitutionTottori University

Principal Investigator

KODAMA Motoichiro  Tottori University, Faculty of Agriculture, Assistant Professor, 農学部, 講師 (00183343)

Co-Investigator(Kenkyū-buntansha) OTANI Hiroshi  Tottori University, Faculty of Agriculture, Assistant Professor, 農学部, 教授 (50032305)
Project Period (FY) 2001 – 2002
Project Status Completed (Fiscal Year 2002)
Budget Amount *help
¥3,300,000 (Direct Cost: ¥3,300,000)
Fiscal Year 2002: ¥1,200,000 (Direct Cost: ¥1,200,000)
Fiscal Year 2001: ¥2,100,000 (Direct Cost: ¥2,100,000)
Keywordsplant pathogen / host-specific toxin / AAL-toxin / AM-toxin / pathogenicity gene / horizontal gene transfer / ポリケチド / CD染色体
Research Abstract

Fungal pathogenicity are predicted to release signaling molecules essential for path ogenicity during the process of infection. Although essential components for fungal pathogenesis are still unknown in many plant pathogenic fungi, certain fungal pathogens, especially the genera Alternaria and Cochliobolus, are known to produce host-specific toxins (HSTs) as compatibility agents. There are now ten or more Alternaria pathogena, mainly A. alternata pathotypes, known to produce HSTs, and the structures of most of the toxins have been elucidated. HSTs from A.alternata pathotypes have been classified into three groups based on their chemical structures, I.e.polyketides, cyclic peptides and decatrienoic acid esters. Recently a polyketied synthetase gene and a cyclic-peptide synthetase gene, involved in AAL-toxin and AM-toxin biosynthesis, respectively, have been cloned and characterized. In both cases, targeted gene disruption lead to elimination of toxin production and loss of pathogenisity indicating that HST biosynthetic genes are fungal pathogenicity determinants. These HST biosynthetic genes also reside on conditionally dispensable chromosomes found only in the pathogenic and HST-producing strains of A.alrernata and homologues of the genes were not detected in nonpathogenic strains of A.alrernata. This suggests that these genes may have been acquired by horizontal gene transfer and provides a possible mechanism whereby new pathotypes could arise in nature.

Report

(3 results)
  • 2002 Annual Research Report   Final Research Report Summary
  • 2001 Annual Research Report
  • Research Products

    (27 results)

All Other

All Publications (27 results)

  • [Publications] Salamiah: "Genetic analysis of pathogenicity and host-specific toxin production of Alternaria alternata tomato pathotype by protoplast fusion"J. Gen. Plant Pathol. 67. 7-14 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Salamiah: "Construction and genetic analysis of hybrid strains between apple and tomato pathotypes of Alternaria alternata by protoplast fusion"J. Gen. Plant Pathol. 67. 97-105 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] L.J.Johnson: "Spotaneou loss of conditionally dispensable chromosome from the Alternaria alternata apple pathotype leads to loss of toxin production and pathogenicity"Curr. Genet.. 40. 65-72 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] 児玉基一朗: "Alternaria alternata病原菌群における宿主特異的毒素生産と病原性の分子遺伝"植物感染生理談話会論文集. 37. 115-128 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Otani, H.: "Infection mechanism of black spot pathogen in Japanese pear"Acta Horticulturae. 587. 623-630 (2002)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Singh, P.: "Host-specific SV-toxin of the fungal pathogen causing brown spot of European pear"Acta Horticulturae. 596. 507-511 (2002)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] 柘植尚志: "植物病原糸状菌の宿主特異的毒素生合成の分子機構.毒素生合成遺伝子群をコードするCD染色体"化学と生物. 40. 654-659 (2002)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Otani, H.: "Delivery and Perception of Pathogen Signals in Plant (N.Keen et al. Eds.)"APS Press, St.Paul.. 268 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Otani, H.: "Plant Diseases and Their Control"China Agricultural Scientech Press, Beijing, China. 171 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Salamiah, Fukumasa-Nakai,Y., Akamatsu,H., Kohmoto,K., Otani,H., Kodama,M.: "Genetic analysis of pathogenicity and host-specific toxin production of Alternaria alternata tomato pathotype by protoplast fusion"Journal of General Plant Pathology. 67. 7-14 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Salamiah, Akamatsu,H., Fukumasa-Nakai,Y., Otani,H., Kodama,M.: "Construction and genetic analysis of hybrid strains between the apple and tomato pathotypes of Alternaria alternata by protoplast fusion"Journal of General Plant Pathology. 67. 97-105 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Johnson,L.J., Johnson,R.D., Akamatsu,H., Sakamiah,A., Otani,H., Kohmoto,K., Kodama,M.: "Spontaneous loss of a conditionally dispensable chromosome from the Alternaria alternata apple pathotype leads to loss of toxin production and pathogenicity"Current Genetics. 40. 65-72 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Kodama,M., Akamatsu,H., Otani,H.: "Molecular genetics of host-specific toxin biosynthesis and pathogenicity of Alternaria alternata pathogens(in Japanese)"PSJ Plant-Microbe Interactions Symposium Report. 37. 115-128 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Otani,H., Kodama,M., Kohmoto,K.: "Infection mechanism of black spot pathogen in Japanese pear"Acta Horticulturae. 587. 623-630 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Otani,H., Kodama,M., Kohmoto,K.: "Host-specific SV-toxin of the fungal pathogen causing brown spot of European pear"Acta Horticulturae. 596. 507-511 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Tsuge,T., Kodama,M., Akimitsu,K., Yamamoto,M.: "Molecular mechanisms of host-specific toxin biosynthesis in the plant pathogenic fungi - CD chromosomes encoding toxin biosynthesis genes (in Japanese)"Kagaku to Seibutsu. 40. 654-659 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Otani,H., Kohnobe,A., Narita,M., Kodama,M., Kohmoto,K., Ed. By N.T.Keen et al.: "A new type of host-selective toxin, a protein produced from Alternaria brassicicola, In Delivery of Pathogen Signals to Plants"American Phytopathological Society Press. 68-76 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Otani,H., Kodama,M., Akamatsu,H., Salamiah, Kohmoto,K., Ed. By Z.Shimai et al.: "Molecular basis of host-specific toxins: host specificity and genetic analysis in Alternaria pathogens, In Plant Diseases and Their Contorol,56"China Agricultural Scientech Press. 53-56 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Otani, H.: "Infection mechanism of black spot pathogen in Japanese pear"Acta Horticulturae. 587. 623-630 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] Singh, P.: "Host-specific SV-toxin of the fungal pathogen causing brown spot of European pear"Acta Horiticulturae. 596. 507-551 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] 柘植尚志: "植物病原糸状菌の宿主特異的毒素生合成の分子機構.毒素生合成遺伝子群をコードするCD染色体"化学と生物. 40. 654-659 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] Aremu, E.A.: "Specific inhibition of spore germination of Alternaria brassicicola by fistupyrone from Streptomyces sp. TP-A0569"Journal of General Plant Pathology. (in press).

    • Related Report
      2002 Annual Research Report
  • [Publications] Salamiah: "Genetic analysis of pathogenicity and host-specific toxin production of Alternaria alternata tomato pathotype by protoplast fusion"J. Gen. Plant Pathol. 67. 7-14 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] Salamiah: "Construction and genetic analysis of hybrid strains between apple and tomato pathotypes of Alternaria alternata by protoplast fusion"J. Gen. Plant Pathol. 67. 97-105 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] L.J.Johnson: "Spontaneou loss of conditionally dispensable chromosome from the Alternaria alternata apple pathotype leads to loss of toxin production and pathogenicity"Curr. Genet.. 40. 65-72 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] 児玉基一朗: "Alternaria alternata病原菌群における宿主特異的毒素生産と病原性の分子遺伝"植物感染生理談話会論文集. 37. 115-128 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] Otani, H.: "Delivery and Perception of Pathogen Signals in Plant (N.Keen et al. Eds.)"APS Press, St. Paul.. 268 (2001)

    • Related Report
      2001 Annual Research Report

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Published: 2001-04-01   Modified: 2016-04-21  

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