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Molecular mechanisms underlying the rearrangement of intermediate filaments networks.

Research Project

Project/Area Number 13670004
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field General anatomy (including Histology/Embryology)
Research InstitutionGunma University

Principal Investigator

HIJIKATA Takao  Gunma University, School of Medicine, Assistant Professor, 医学部, 講師 (70189786)

Project Period (FY) 2001 – 2002
Project Status Completed (Fiscal Year 2002)
Budget Amount *help
¥3,500,000 (Direct Cost: ¥3,500,000)
Fiscal Year 2002: ¥900,000 (Direct Cost: ¥900,000)
Fiscal Year 2001: ¥2,600,000 (Direct Cost: ¥2,600,000)
Keywordsdesmin / plectin / desmusiin / intermediate filaments / トランスロケーション
Research Abstract

In this study I have found that plectin binds a novel intermediate filament protein, desmuslin, and thus cloned desmuslin cDNA from rat skeletal muscle cDNA library. This protein was colocalized with desmin and plectin around Z-discs and beneath the sarcolemma. Desmuslin may play a pivotal role in the rearrangement of intermediate filament networks.
I have examined spatial and temporal sequences of localization of intermediate filament (IF) proteins, desmin and plectin, during the development of rat skeletal muscle fibers. In immature myotubes, desmin IFs were arranged parallel to the longitudinal axis of myotubes. Later desmin IFs oriented transversely and were aligned to Z-discs, as found in adult muscle fibers. Plectin showed similar rearrangement pattern during the maturation of myotubes, but its rearrangement preceded that of desmin IFs.

Report

(3 results)
  • 2002 Annual Research Report   Final Research Report Summary
  • 2001 Annual Research Report
  • Research Products

    (11 results)

All Other

All Publications (11 results)

  • [Publications] Tanaka H, Hijikata T, Murakami T, Fujimaki N, Ishikawa H.: "Localization of plectin and other related proteins along the sarcolemma in smooth muscle cells of rat colon"Cell Struct Funct.. 26(2). 61-70 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] 土方 貴雄: "骨格筋における中間径フィラメントネットワークの分子構築-発生過程における再編成の分子機構、機能的意義そして筋疾患との関連性"生体の科学. 52(4). 287-293 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Hijikata T, Murakami T, Ishikawa, H. Yorifuji H.: "Plectin tethers desmin intermediate filaments onto subsarcolemmal dense plaques containing dystrophin and vinculin"Histochem Cell Biol. 119(2). 109-123 (2003)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] 土方 貴雄: "1.1 骨格筋の解剖学的基礎"筋の科学事典-構造・機能・運動-(福永 哲夫 編)(朝倉書店). 7-23 (2002)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Tanaka, H., Hijikata. T., Murakami, T., Fujimaki, N., Ishikawa, H.: "Localization of plectin and other related proteins along the sarcolemma in smooth muscle cells of rat colon"Cell Struct Funct. 26(2). 61-70 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Hijikata. T.: "Molecular architecture of intermediate filament networks(Japanese)"Seitai no Kagaku. 52(4). 287-293 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Hijikata. T., Murakami, T., Ishikawa, H., Yorifuji, H.: "Plectin tethers desmin intermediate filaments onto subsarcolemmal dense plaques containing dystrophin and vinculin"Histochem Cell Biol. 119(2). 109-123 (2003)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] 土方 貴雄: "骨格筋における中間径フィラメントネットワークの分子構築 -発生過程における再編成の分子機構機能的意義そして筋疾患との関連性"生体の科学. 52(4). 287-293 (2001)

    • Related Report
      2002 Annual Research Report
  • [Publications] Hijikata, T., Murakami, T., Ishikawa, H., Yorifuji, H.: "Plectin tethers desmin intermediate filaments onto subsarcolemmal dense plaques containing dystrophin and vinculin"Histochem Cell Biol. 119(2). 109-123 (2003)

    • Related Report
      2002 Annual Research Report
  • [Publications] 土方 貴雄(分担執筆者): "筋の科学事典 執筆箇所1.1骨格筋の解剖学的基礎pp7-23"朝倉書店 福永 哲夫編. 505 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] 土方 貴雄: "骨格筋における中間径フィラメントネットワークの分子構築 -発生過程における再編成の分子機構、機能的意義そして筋疾患との関連性"生体の科学. 52(4). 287-293 (2001)

    • Related Report
      2001 Annual Research Report

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Published: 2001-04-01   Modified: 2016-04-21  

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