• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

Topological analysis of GPI-80 in human neutrophils

Research Project

Project/Area Number 13670022
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field General anatomy (including Histology/Embryology)
Research InstitutionJichi Medical School

Principal Investigator

MATSUBARA Shigeki  Jichi Medical School, Medicine, Professor, 医学部, 教授 (20209597)

Co-Investigator(Kenkyū-buntansha) TAKAHASHI Katsumasa  Gunma University, Medicine, Researcher, 医学部, 助手 (30326839)
Project Period (FY) 2001 – 2002
Project Status Completed (Fiscal Year 2002)
Budget Amount *help
¥3,200,000 (Direct Cost: ¥3,200,000)
Fiscal Year 2002: ¥1,500,000 (Direct Cost: ¥1,500,000)
Fiscal Year 2001: ¥1,700,000 (Direct Cost: ¥1,700,000)
Keywordshuman neutrophils / GPI-80 / GPI-anchored protein / CD18 / intracellular granules / immunocytochemistry / cell biology / 細胞内穎粒
Research Abstract

GPI-80 is a novel GPI-anchored protein on human phagocytes that may regulate leukocyte adherence, locomotion, and extravasation. A unique intracellular compartment that contains GPI-80 is distinct from the previously characterized azurophil and specific granules. The GPI-80-containing compartments rapidly undergo a dramatic reorganization upon cell stimulation with a chemoattractant. By high-resolution immunofluorescence microscopy using ultrathin cryosections, after fMLP-stimulation, some GPI-80 molecules were co localized with beta 2 integrin molecules (CD18) on the cell surface. These results suggest that GPI-80 is physically associated with beta 2 integrin in human neutrophils.

Report

(3 results)
  • 2002 Annual Research Report   Final Research Report Summary
  • 2001 Annual Research Report

Research Products

(6 results)

All Other

All Publications

  • [Publications] Matsubara, Shigeki: "Immuno-electron microscopic localization of endothelial nitric oxide synthase in human placental terminal villous trophoblasts-normal and pre-eclamptic pregnancy"Placenta. 22. 782-786 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Yamada, Tetsuo: "Changes in the number of polymorphonuclear leukocytes and concentrations of IL-8 and granulocyte elastase in the vaginas of normal pregnant women"Am J Reprod Immunol. 47. 98-103 (2002)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Matsubara,Shigeki: "Immuno-electron microscopic localization of endothelial nitric oxide synthase in human placental terminal villous trophoblasts-normal and pre-eclamptic pregnancy"Placenta. 22. 782-786 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Yamada,Tetsuo: "Changes in the number of polymorphonuclear leukocytes and concentrations of IL-8 and granulocyte elastase in the vaginas of normal pregnant women"Am J Reprod Immunol. 47. 98-103 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Yamada, Tetsuo: "Changes in the number of polymorphonuclear leukocytes and concentrations of IL-8 and granulocyte elastase in the vaginas of normal pregnant women"Am J Reprod Immunol. 47. 98-103 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] Matsubara, Shigeki: "Immuno-electron microscopic localization of endothelial nitric oxide synthase in human placental terminal villous trophoblasts-normal and pre-eclamptic pregnancy"Placenta. 22. 782-786 (2001)

    • Related Report
      2001 Annual Research Report

URL: 

Published: 2001-03-31   Modified: 2016-04-21  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi