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Electrophysiological analysis of feeding-related network in the hypothalamus, based on the gluco-static and lipo-static theories

Research Project

Project/Area Number 13670056
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Environmental physiology (including Physical medicine and Nutritional physiology)
Research InstitutionToyama University

Principal Investigator

SASAKI Kazuo  Toyama University, Toyama Univ., Fac.of Engineering, Lecturer (60042826)

Co-Investigator(Kenkyū-buntansha) BABA Yoshichika  Toyama Univ., Fac.of engineering, Lecturer (30238232)
TSUKADA Akira  Toyama National College of maritime Technology, Accociate Professor (40236849)
Project Period (FY) 2001 – 2002
Project Status Completed (Fiscal Year 2002)
Budget Amount *help
¥4,000,000 (Direct Cost: ¥4,000,000)
Fiscal Year 2002: ¥2,000,000 (Direct Cost: ¥2,000,000)
Fiscal Year 2001: ¥2,000,000 (Direct Cost: ¥2,000,000)
KeywordsLeptin / Ghrelin / Orexin / Arcuate nucleus / Rat / カルシウム / 室傍核
Research Abstract

1. In brain slice experiments, neuronal activity of the ventro-medial part of the arcuate nucleus (mARC) in rats was excited dose-dependently by application of leptin. The ratio of neurons excited by 10^<-10>M leptin was about 60%. The excitation was observed in low Ca^<2+>, high Mg^<2+> Ringer's solution as well as in normal Ringer's solution.
2. Neuronal activity of the mARC was excited dose-dependently by application of orexin-A. The ratio of mARC neurons excited by 10^<-7>M orexin-A was about 70%. The excitation was observed in low Ca^<2+>, high Mg^<2+> Ringer's solution as well as in normal Ringer's solution. Neurons excited by orexin-A were also excited by orexin-B. The magnitude of excitation induced by orexin-B was greater than that induced by orexin-A.
3. Neuronal activity of the mARC was excited dose-dependently by ghrelin. The ratio of mARC neurons excited by 10^<-7>M ghrelin was about 70%. The excitation was observed in low Ca^<2+>, high Mg^<2+> Ringer's solution as well as in normal Ringer's solution. About a half of neurons excited by ghrelin was also excited by orexin.

Report

(3 results)
  • 2002 Annual Research Report   Final Research Report Summary
  • 2001 Annual Research Report
  • Research Products

    (9 results)

All 2002 2001 Other

All Journal Article (6 results) Publications (3 results)

  • [Journal Article] Effect of chronic acetyl-L-carnitine treatment on brain lipid hydroperoxide level and passive avoidance learning in senescence-accelerated mice.2002

    • Author(s)
      Yasui Fumihiko
    • Journal Title

      Neurosci. Lett. 334

      Pages: 177-180

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Journal Article] Antioxidant and/or prooxidant activities of carnitine and its derivative on the hydroxyl radical generation by the Fenton reaction.2002

    • Author(s)
      Yasui Fumihiko
    • Journal Title

      ITE Lett. on Batt. New Technol. & Med. 3

      Pages: 58-62

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Journal Article] Effect of chronic acetyl-L-carnitine treatment on brain lipid hydroperoxide level and passive avoidance learning in senescence-accelerated mice.2002

    • Author(s)
      Yasui Fumihiko, et al.
    • Journal Title

      Neurosci. Lett. 334

      Pages: 177-180

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Journal Article] Antioxidant and/or prooxidant activities of carnitine and its derivative on the hydroxyl radical generation by the Fenton reaction.2002

    • Author(s)
      Yasui Fumihiko, et al.
    • Journal Title

      ITE Lett. on Batt. New Technol. & Med. 3

      Pages: 58-62

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Journal Article] Demonstration of acidic fibroblast growth factor (FGF-1) in rat adrenal gland2001

    • Author(s)
      Matsuoka Yasuji
    • Journal Title

      Acta Histochem. Cytochem. 34・2

      Pages: 129-134

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Journal Article] Demonstration of acidic fibroblast growth factor (FGF-1) in rat adrenal gland.2001

    • Author(s)
      Matsuoka Yasuji, et al.
    • Journal Title

      Acta Histochem. Cytochem. 34

      Pages: 129-134

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Yasui Fumihiko: "Antioxidant and/or prooxidant activities of carnitine and its derivative on the hydroxyl radical generation by the Fenton reaction"ITE Lett.on Batt.New Technol. & Med.. 3. 58-62 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] Yasui Fumihiko: "Effect of chronic acetyl-L-carnitine treatment on brain lipid hydroperoxide level and passive avoidance learning in senescence-accelerated mice"Neurosci.Lett.. 334. 177-180 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] Matsuoka Yasuji: "Demonstration of acidic fibroblast growth factor (FGF-1) in rat adrenal gland"Acta Histochem. Cytochem.. 34・2. 129-134 (2001)

    • Related Report
      2001 Annual Research Report

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Published: 2001-04-01   Modified: 2016-04-21  

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