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Neural mechanism and relationship between cutaneous active vasodilation and sweating and the role of vasodilative peptides and nitric oxide

Research Project

Project/Area Number 13670073
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Environmental physiology (including Physical medicine and Nutritional physiology)
Research InstitutionAichi Medical University School of Medicine

Principal Investigator

MATSUMOTO Takaaki  Aichi Medical University, Department of Physiology, Associate Professor, 医学部, 助教授 (60199875)

Co-Investigator(Kenkyū-buntansha) KATO Masako  KATO,Masako, 医学部, 助手 (70308956)
NISHIMURA Naoki  NISHIMURA,Naoki, 医学部, 助手 (40278362)
SUGENOYA Junichi  SUGENOYA,Junichi, 医学部, 教授 (50109352)
李 丁範  愛知医科大学, 医学部, 外国人特別研究員
NISHIYAMA Tetsunari  Nippon Sport Science University, Associate Professor, 体育学部, 助教授 (40257697)
LEE Jeong-beom  LEE,Jeong-beom
Project Period (FY) 2001 – 2002
Project Status Completed (Fiscal Year 2002)
Budget Amount *help
¥3,600,000 (Direct Cost: ¥3,600,000)
Fiscal Year 2002: ¥1,100,000 (Direct Cost: ¥1,100,000)
Fiscal Year 2001: ¥2,500,000 (Direct Cost: ¥2,500,000)
Keywordsthermoregulation / sweating / cutaneous active vasodilation / human / cat / axon-reflex / vasodilative peptide / 皮膚血流 / 一酸化窒素
Research Abstract

On the general skin surface of the humans, cutaneous vasodilation is accompanied by thermal sweating. To elucidate its relationship and neural mechanisms, we studied sweating and skin blood flow responses after administration of nicotine and acetylcholine to the forearm skin. Parallelism of the axone reflex-mediated sweating and skin blood flow indicated that axone reflex sweating is also accompanied by cutaneous vasodilation. Abolishment of sweating but not of cutaneous vasodilation by atropine indicated that vasodilation is mediated by other than muscarinic receptor. In the cat paw sweating model, vasodilation was accompanied by sweating as same as in humans. It is known that acetylcholine, a primary mediator of human sweating, induced vasodilation through NO (nitric oxide) production from the endothelium. Involvement of NO on thermal sweating is strongly expected. Since the vasodilative peptides such as VIP, CGRP and ANP are known to exist around the sweat glands, NO may act on the skin vessels and sweat glands through these peptides. NO-mediated linkage of mechanism of sweating and skin vasodilation is expected to be disclosed in the further studies. The two applied studies using QSART, Quantitative Sudomotor Axone Reflex Test, revealed that thermotolerance of tropical residents is at least in some parts acquired through long-term residence in the tropic environment after the birth and that both of the larger number of forearm sweat glands and the larger sweat output, from a single gland contribute to the men's better thermotolerance compared to the women. In combination of these approaches, studies of the mechanisms on the interrelationship of thermal sweating and active cutaneous vasodilation will be enhanced.

Report

(3 results)
  • 2002 Annual Research Report   Final Research Report Summary
  • 2001 Annual Research Report
  • Research Products

    (30 results)

All Other

All Publications (30 results)

  • [Publications] Kato M, Sugenoya J, Matsumoto T, Nishiyama T, Nishimura N, et al.: "The effects of facial fanning on thermal comfort sensation during hyperthermia."Pflugers Arch Eur J Physiol. 443. 175-179 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Nishiyama T, Sugenoya J, Matsumoto T, Iwase S, Mano T.: "Irregular activation of individual sweat glands in human sole observed by a videomicroscopy."Autonomic Neuroscience : Basic and Clinical. 88. 117-126 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Nishimura N, Sugenoya J, Matsumoto T, et al.: "Effects of repeated carbon dioxide-rich water bathing on core temperature, cutaneous blood flow and thermal sensation."Eur J Appl Physiol. 87. 337-342 (2002)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Okagawa T, Sugenoya J, Iwase S, Mano T, Suzumura A, Matsumoto T, et al.: "Occurrence of the spinal reflex due to skin pressure in sudomotor and cutaneous vasoconstrictor nerve system of humans."Autonom Neurosci : Basic and Clinical. 105. 62-70 (2003)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Sakai A, Matsumoto T, Saito M, Matsuzaki T, Koizumi T, et al.: "Cardiopulmonary hemodynamics of blue-sheep, Pseudois nayaur, as high-altitude adapted mammals."Jpn J Physiol. 53(5). 377-384 (2003)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] 松本孝朗: "民族差と暑熱順化による修飾作用.体温-運動時の体温調節システムとそれを修飾する要因-.(平田耕造、井上芳光、近藤徳彦編)"ナップ、東京. 168-179 (2002)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Shimazu M, Matsumoto T, et al.: "Sweat from xenotransplanted human skin.In : Human Skin and Hair in Immunodeficient Mice.ed.by Ueyama T, et al."Central Institute for Experimental Animals. 13-17 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Kate M, Sugenoya J, Matsumoto T, Nishiyama T, Nishimura N, Inukai Y, Okagawa T, Yonezawa H.: "The effects of facial fanning on thermal comfort sensation during hyperthermia."Pflugers Arch Eur J Physiol. 443. 175-179 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Nishiyama T, Sugenoya J, Matsumoto T, Iwase S, Mano T.: "Irregular activation of individual sweat glands in human sole observed by a videomicroscopy."Autonomic Neuroscience : Basic and Clinical. 88. 117-126 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Othman T, Goto S, Lee JB, Matsumoto T, Kosaka M.: "Hyperthermia enhancement of the apoptotic and antiproliferative activities of paclitaxel."Pharmacol. 62(4). 208-212 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Matsumoto T, Nishiyama T, Nishimura N, Kate M, Inumai, Y, Sugenoya J, Yamauchi M, Kosaka M.: "Endocrine responses to heat and cold stress."Thermotherapy for Neoplasia, Inflamation, and Pain. (ed by Kosaka M, Sugahara T, Schmidt KL, Simon E.) (Springer-Verlag) (Tokyo). 228-241 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Sugenoya J, Matsumoto T, Nishiyama T, Sakamoto Y: "Sympathetic control of sweating and cutaneous active vasodilatation"Thermotherapy for Neoplasia, Inflamation, and Pain. (ed by Kosaka M, Sugahara T, Schmidt KL, Simon E.) (Springer-Verlag) (Tokyo). 166-181 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Kosaka M, Othman T, Matsumoto T, Taimura A, Ohwatari, N: "Central and peripheral control of sweating mechanisms : modifications by thermal acclimatization and physical training."Thermotherapy for Neoplasia, Inflamation, and Pain. (ed by Kosaka M, Sugahara T, Schmidt KL, Simon E.) (Springer-Verlag) (Tokyo). 95-106 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Nishimura N, Sugenoya J, Matsumoto T, Kate M, Sakakibara H, Nishiyama T, Sakamoto (Inukai) Y, Okagawa A: "Effects of repeated carbon dioxide-rich water bathing on core temperature, cutaneous blood flow and thermal sensation."Eur J Appl Physiol. 87. 337-342 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Lee JB, Othman T, Lee JS, Quan FS, Choi JH, Min YK, Yang HM, Matsumoto T, Kosaka M.: "Sudomotor modifications by acclimatization of stay in temperate Japan of Malaysian native tropical subjects."Jpn J Trop Med Hyg. 30(3). 295-299 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Okagawa T, Sugenoya J, Iwase 5, Mano T, Suzumura A, Matsumoto T, Sugiyama Y.: "Occurrence of the spinal reflex due to skin pressure in sudomotor and cutaneous vasoconstrictor nerve system of humans."Autonom Neurosci : Basic and Clinical. 105. 62-70 (2003)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Sakai A, Matsumoto T, Saito M, Matsuzaki T, Koizumi T, Ishizaki T, Ruan ZH, Wang ZG, Chen QH, Wang XQ.: "Cardiopulmonary hemodynamics of blue-sheep, Pseudois nayaur, as high-altitude adapted mammals."Jpn J Physiol. 53(5). 377-384 (2003)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] 西山哲成, 菅屋潤壹, 松本孝朗,他: "サーモグラフを用いた汗腺活動観察法"発汗学. 9(1). 15-18 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] 酒井秋男, 松本孝朗, 他: "チベットヒツジの高地順応特性"信州大学環境科学年報. 24. 87-98 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] 西山哲成, 菅屋潤壹, 松本孝朗,他: "ビデオマイクロスコープを用いて観察した個々の汗腺の分泌動態"日本体育大学紀要. 31(2). 111-120 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] Nishimura N, Sugenoya J, Matsumoto T, et al.: "Effects of repeated carbon dioxide-rich water bathing on core temperature, cutaneous blood flow and thermal sensation"Eur J Appl Physiol. 87. 337-342 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] 菅屋潤壹, 松本孝朗, 他: "睡眠と体温調節の相互作用"睡眠と環境. 6(1). 26-33 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] Lee JB, et al.: "Sudomotor modification by acclimatization of stay in temperate Japan of Malaysian native tropical subjects"Jpn J Trop Med Hyg. 30(3). 295-299 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] 松本孝朗: "民俗差と暑熱順化による修飾作用.体温-運動時の体温調節システムとそれを修飾する要因-.平田耕造、井上芳光、近藤徳彦編."ナップ、東京. 168-179 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] Shimazu M, Matsumoto T, et al.: "Sweat from xenotransplanted human skin. In : Human Skin and Hair in Immunodeficient Mice. ed. by Ueyama t, et al."Central Institute for Experimental Animals. 13-17 (2001)

    • Related Report
      2002 Annual Research Report
  • [Publications] Nishiyama T, Sugenoya J, Matsumoto T, et al.: "Irregular activation of individual sweat glands in human sole observed by a videomicroscopy"Autonomic Neuroscience : Basic and Clinical. 88. 117-126 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] Kato M, Sugenoya J, Matsumoto T, et al.: "The effects of facial fanning on thermal comfort sensation during hyperthermia"Pflugers Arch Eur J Physiol. 443. 175-179 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] Othman T, Goto S, Lee JB, Matsumoto T, Kosaka M.: "Hyperthermia enhancement of the apoptotic and antiproliferative activities of paclitaxel"Pharmacol. 62(4). 208-212 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] 西村直記, 松本孝朗, 他: "発汗活動と皮膚血流反応との関係-軸索反射性発汗における検討-"発汗学. 8(1). 26-29 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] Matsumoto T, et al.: "Endocrine responses to heat and cold stress. In Thermotherapy for Neoplasia, Inflamation, and Pain. ed by Kosaka M, et al."Springer-Verlag, Tokyo. 228-241 (2001)

    • Related Report
      2001 Annual Research Report

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Published: 2001-04-01   Modified: 2016-04-21  

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